Oas2 ELISA Kit for Rat(Rattus norvegicus) | EIAab.comOas2 ELISA Kit for Rat(Rattus norvegicus)

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Oas2 (Gene name),

2'-5'-oligoadenylate synthase 2 (Protein name ), OAS2_RAT from NCBI database.

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General Annotation

Antigen Annotation

Predicted Eptitope

Vaild Sequence

Related Databases

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Gene name:

Oas2;

Protein name:

2'-5'-oligoadenylate synthase 2((2-5')oligo(A) synthase 2);

Alternative:

Organism:

Rat (Rattus norvegicus).

General Annotation

Sub Unit:

Homodimer.

Function:

Interferon-induced, dsRNA-activated antiviral enzyme which plays a critical role in cellular innate antiviral response. In addition, it may also play a role in other cellular processes such as apoptosis, cell growth, differentiation and gene regulation. Synthesizes higher oligomers of 2'-5'-oligoadenylates (2-5A) from ATP which then bind to the inactive monomeric form of ribonuclease L (RNase L) leading to its dimerization and subsequent activation. Activation of RNase L leads to degradation of cellular as well as viral RNA, resulting in the inhibition of protein synthesis, thus terminating viral replication. Can mediate the antiviral effect via the classical RNase L-dependent pathway or an alternative antiviral pathway independent of RNase L.

Subcellular Location:

Cytoplasm Cytoplasm Perinuclear region Mitochondrion Nucleus Microsome Endoplasmic reticulum Associated with different subcellular fractions such as mitochondrial, nuclear, and rough/smooth microsomal fractions.

Protein Attributes:

Sequence length:

733

Sequence:

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733:

VEPKSPVQPW | KVPVVQTPGS | CGAQIYPVVG | GVY

3D Structure:

N/A

Predicted Eptitope:

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Vaild Sequence:

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Related Databases

UniGene:

Rn.136740

Pfam:

PF01909

KEGG:

rno:363938

Uniprot:

Q5MYU0

FOR

ELISA Kit for Rat (2-5')oligo(A) synthase 2

CLIA Kit for Rat (2-5')oligo(A) synthase 2

Polyclonal Antibody for Rat (2-5')oligo(A) synthase 2

Monoclonal Antibody for Rat (2-5')oligo(A) synthase 2

Protein for Rat (2-5')oligo(A) synthase 2

R&D Technical Data

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Precision

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Recovery

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Linearity

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

References

1.

"The mammalian 2'-5' oligoadenylate synthetase gene family: evidence for concerted evolution of paralogous Oas1 genes in Rodentia and Artiodactyla."
Perelygin A.A. , Zharkikh A.A. , Scherbik S.V. , Brinton M.A.
J. Mol. Evol.63:562-576(2006) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA]
strain: Sprague-Dawley.
tissue: Ovary.

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