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Index > Protein center > PDHX(Gene name) > Human
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  • PDHX (Gene name),
  • Pyruvate dehydrogenase protein X component, mitochondrial (Protein name ),  ODPX_HUMAN from NCBI database.
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  • General Annotation
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  • Antigen Annotation
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  • Predicted Eptitope
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  • Vaild Sequence
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  • Gene name:
    PDHX(PDX1);
    Protein name:
    Pyruvate dehydrogenase protein X component, mitochondrial;
    Alternative:
    E3-binding protein(E3BP);Dihydrolipoamide dehydrogenase-binding protein of pyruvate dehydrogenase complex;proX;Lipoyl-containing pyruvate dehydrogenase complex component X;
    Organism:
    Human (Homo sapiens). 
    General Annotation
    Sub Unit:
    Eukaryotic pyruvate dehydrogenase complexes are organized about a core consisting of the oligomeric dihydrolipoamide acetyl-transferase, around which are arranged multiple copies of pyruvate dehydrogenase, dihydrolipoamide dehydrogenase and protein X bound by non-covalent bonds.
    Function:
    Required for anchoring dihydrolipoamide dehydrogenase (E3) to the dihydrolipoamide transacetylase (E2) core of the pyruvate dehydrogenase complexes of eukaryotes. This specific binding is essential for a functional PDH complex.
    Subcellular Location:
    Mitochondrion matrix
    Protein Attributes:
    Sequence length:
    501
    Sequence:
    50:
    MAASWRLGCD | PRLLRYLVGF | PGRRSVGLVK | GALGWSVSRG | ANWRWFHSTQ | 
    100:
    WLRGDPIKIL | MPSLSPTMEE | GNIVKWLKKE | GEAVSAGDAL | CEIETDKAVV | 
    150:
    TLDASDDGIL | AKIVVEEGSK | NIRLGSLIGL | IVEEGEDWKH | VEIPKDVGPP | 
    200:
    PPVSKPSEPR | PSPEPQISIP | VKKEHIPGTL | RFRLSPAARN | ILEKHSLDAS | 
    250:
    QGTATGPRGI | FTKEDALKLV | QLKQTGKITE | SRPTPAPTAT | PTAPSPLQAT | 
    300:
    AGPSYPRPVI | PPVSTPGQPN | AVGTFTEIPA | SNIRRVIAKR | LTESKSTVPH | 
    350:
    AYATADCDLG | AVLKVRQDLV | KDDIKVSVND | FIIKAAAVTL | KQMPDVNVSW | 
    400:
    DGEGPKQLPF | IDISVAVATD | KGLLTPIIKD | AAAKGIQEIA | DSVKALSKKA | 
    450:
    RDGKLLPEEY | QGGSFSISNL | GMFGIDEFTA | VINPPQACIL | AVGRFRPVLK | 
    500:
    LTEDEEGNAK | LQQRQLITVT | MSSDSRVVDD | ELATRFLKSF | KANLENPIRL | 
    501:
    A
    3D Structure:
    N/A
    Predicted Eptitope:
    Please Sign in.
    EIAab Sequence  Vaild Sequence:
    Please Sign in.
    Related Databases
    SMR:
    KEGG:
    Pfam:
    String:
    UniGene:
    MIM:
    Uniprot:
     
    FOR
    ELISA Kit for Human Pyruvate dehydrogenase protein X component, mitochondrial
    ELISA Kit for Human Pyruvate dehydrogenase protein X component, mitochondrial
    ELISA Kit for Human Pyruvate dehydrogenase protein X component, mitochondrial
    CLIA Kit for Human Pyruvate dehydrogenase protein X component, mitochondrial
    CLIA Kit for Human Pyruvate dehydrogenase protein X component, mitochondrial
    CLIA Kit for Human Pyruvate dehydrogenase protein X component, mitochondrial
    Polyclonal Antibody for Human Pyruvate dehydrogenase protein X component, mitochondrial
    Polyclonal Antibody for Human Pyruvate dehydrogenase protein X component, mitochondrial
    Polyclonal Antibody for Human Pyruvate dehydrogenase protein X component, mitochondrial
    Monoclonal Antibody for Human Pyruvate dehydrogenase protein X component, mitochondrial
    Monoclonal Antibody for Human Pyruvate dehydrogenase protein X component, mitochondrial
    Monoclonal Antibody for Human Pyruvate dehydrogenase protein X component, mitochondrial
    Protein for Human Pyruvate dehydrogenase protein X component, mitochondrial
    Protein for Human Pyruvate dehydrogenase protein X component, mitochondrial
    Protein for Human Pyruvate dehydrogenase protein X component, mitochondrial

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    Precision
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    Linearity
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    References
    1. 1.
      "Dihydrolipoamide dehydrogenase-binding protein of the human pyruvate dehydrogenase complex. DNA-derived amino acid sequence, expression, and reconstitution of the pyruvate dehydrogenase complex."
      Harris R.A. , Bowker-Kinley M.M. , Wu P. , Jeng J. , Popov K.M.
      J. Biol. Chem.272:19746-19751(1997) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1);VARIANT CYS-23
    2. 2.
      "Mutations in PDX1, the human lipoyl-containing component X of the pyruvate dehydrogenase-complex gene on chromosome 11p1, in congenital lactic acidosis."
      Aral B. , Benelli C. , Ait-Ghezala G. , Amessou M. , Fouque F. , Maunoury C. , Creau N. , Kamoun P. , Marsac C.
      Am. J. Hum. Genet.61:1318-1326(1997) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1);INVOLVEMENT IN PDHXD
      tissue: Liver.
    3. 3.
      "Detection of a homozygous four base pair deletion in the protein X gene in a case of pyruvate dehydrogenase complex deficiency."
      Ling M. , McEachern G. , Seyda A. , Mackay N. , Scherer S.W. , Bratinova S. , Beatty B. , Giovannucci-Uzielli M.L. , Robinson B.H.
      Hum. Mol. Genet.7:501-505(1998) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1)
    4. 4.
      "Human gene sequence for PDX1, the human lipoyl-containing component X of the pyruvate dehydrogenase complex."
      Aral B. , Dey R. , Marsac C.
      Submitted (2000-12) to the EMBL/GenBank/DDBJ databases
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]
    5. 5.
      "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T. , Suzuki Y. , Nishikawa T. , Otsuki T. , Sugiyama T. , Irie R. , Wakamatsu A. , Hayashi K. , Sato H. , Nagai K. , Kimura K. , Makita H. , Sekine M. , Obayashi M. , Nishi T. , Shibahara T. , Tanaka T. , Ishii S. , more...
      Nat. Genet.36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]
      tissue: Synovium.
    6. 6.
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
    7. 7.
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
    8. 8.
      "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res.14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1);VARIANT VAL-370
      tissue: Brain.
    9. 9.
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 127-501 (ISOFORM 1)
      tissue: Brain.
    10. 10.
      "Organization of the cores of the mammalian pyruvate dehydrogenase complex formed by E2 and E2 plus the E3-binding protein and their capacities to bind the E1 and E3 components."
      Hiromasa Y. , Fujisawa T. , Aso Y. , Roche T.E.
      J. Biol. Chem.279:6921-6933(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: SUBUNIT
    11. 11.
      "Lysine acetylation targets protein complexes and co-regulates major cellular functions."
      Choudhary C. , Kumar C. , Gnad F. , Nielsen M.L. , Rehman M. , Walther T.C. , Olsen J.V. , Mann M.
      Science325:834-840(2009) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT LYS-194;IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
    12. 12.
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
    13. 13.
      "How dihydrolipoamide dehydrogenase-binding protein binds dihydrolipoamide dehydrogenase in the human pyruvate dehydrogenase complex."
      Ciszak E.M. , Makal A. , Hong Y.S. , Vettaikkorumakankauv A.K. , Korotchkina L.G. , Patel M.S.
      J. Biol. Chem.281:648-655(2006) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: X-RAY CRYSTALLOGRAPHY (2.59 ANGSTROMS) OF 54-274 IN COMPLEX WITH DLD
    14. 14.
      "Structural insight into interactions between dihydrolipoamide dehydrogenase (E3) and E3 binding protein of human pyruvate dehydrogenase complex."
      Brautigam C.A. , Wynn R.M. , Chuang J.L. , Machius M. , Tomchick D.R. , Chuang D.T.
      Structure14:611-621(2006) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: X-RAY CRYSTALLOGRAPHY (1.55 ANGSTROMS) OF 174-230 IN COMPLEX WITH DLD;MUTAGENESIS OF ARG-183; SER-185; PRO-186; ALA-187; ARG-189; ASN-190; GLU-193; ARG-208; ILE-210; LYS-213 AND GLU-214
    15. 15.
      "Solution structure of RSGI RUH-054, a lipoyl domain from human 2-oxoacid dehydrogenase."
      RIKEN structural genomics initiative (RSGI)
      Submitted (2006-10) to the PDB data bank
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: STRUCTURE BY NMR OF 57-141
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