Protein name:
Oncostatin-M (OSM) ;
Alternative:
Organism:
Human (Homo sapiens).
General Annotation
Function:
Growth regulator. Inhibits the proliferation of a number of tumor cell lines. Stimulates proliferation of AIDS-KS cells. It regulates cytokine production, including IL-6, G-CSF and GM-CSF from endothelial cells. Uses both type I OSM receptor (heterodimers composed of LIPR and IL6ST) and type II OSM receptor (heterodimers composed of OSMR and IL6ST). Involved in the maturation of fetal hepatocytes, thereby promoting liver development and regeneration.
Subcellular Location:
Secreted
Protein Attributes:
50:
MGVLLTQRTL | LSLVLALLFP | SMASMAAIGS | CSKEYRVLLG | QLQKQTDLMQ |
100:
DTSRLLDPYI | RIQGLDVPKL | REHCRERPGA | FPSEETLRGL | GRRGFLQTLN |
150:
ATLGCVLHRL | ADLEQRLPKA | QDLERSGLNI | EDLEKLQMAR | PNILGLRNNI |
200:
YCMAQLLDNS | DTAEPTKAGR | GASQPPTPTP | ASDAFQRKLE | GCRFLHGYHR |
250:
FMHSVGRVFS | KWGESPNRSR | RHSPHQALRK | GVRRTRPSRK | GKRLMTRGQL |
Vaild Sequence:
Related Databases
Uniprot:
ELISA Kit
CLIA Kit
Polyclonal Antibody
Monoclonal Antibody
Protein
FOR
Mouse
Human
Rat
Bovine
Polyclonal Antibody for Human OSM
Polyclonal Antibody for Human OSM
Polyclonal Antibody for Human OSM
Polyclonal Antibody for Human OSM
Monoclonal Antibody for Human OSM
Monoclonal Antibody for Human OSM
Monoclonal Antibody for Human OSM
Monoclonal Antibody for Human OSM
R&D Technical Data
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Precision
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Recovery
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Linearity
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Cited for : NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]
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[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
5.
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more...
Submitted (2005-07) to the EMBL/GenBank/DDBJ databases
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
6.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]
tissue :
Lung .
7.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : PROTEIN SEQUENCE OF 26-51
8.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : PROTEIN SEQUENCE OF 26-45;FUNCTION
tissue :
T-cell .
9.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : PROTEOLYTIC PROCESSING;MUTAGENESIS OF ARG-220 AND ARG-221
10.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : DISULFIDE BONDS
11.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : INHIBITION OF M1 MYELOID LEUKEMIC CELLS
12.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : FUNCTION
13.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : INTERACTION WITH OSMR AND IL6ST
14.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : X-RAY CRYSTALLOGRAPHY (2.2 ANGSTROMS) OF 26-212