Otud7b ELISA Kit for Mouse(Mus musculus) | EIAab.comOtud7b ELISA Kit for Mouse(Mus musculus)

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Otud7b (Gene name),

OTU domain-containing protein 7B (Protein name ), OTU7B_MOUSE from NCBI database.

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General Annotation

Antigen Annotation

Predicted Eptitope

Vaild Sequence

Related Databases

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Gene name:

Otud7b;

Protein name:

OTU domain-containing protein 7B;

Alternative:

Zinc finger A20 domain-containing protein 1;Cellular zinc finger anti-NF-kappa-B protein;Zinc finger protein Cezanne;

Organism:

Mouse (Mus musculus).

General Annotation

Sub Unit:

Interacts with TRAF6. Interacts with PARK7, leading to inhibit deubiquitinase activity. Interacts with EGFR, ITCH and NEDD4 (By similarity). Interacts with TRAF3.

Function:

Negative regulator of the non-canonical NF-kappa-B pathway that acts by mediating deubiquitination of TRAF3, an inhibitor of the NF-kappa-B pathway, thereby acting as a negative regulator of B-cell responses. In response to non-canonical NF-kappa-B stimuli, deubiquitinates 'Lys-48'-linked polyubiquitin chains of TRAF3, preventing TRAF3 proteolysis and over-activation of non-canonical NF-kappa-B. Negatively regulates mucosal immunity against infections. Mediates deubiquitination of EGFR. Has deubiquitinating activity toward 'Lys-11', 'Lys-48' or 'Lys-63'-linked polyubiquitin chains. In vitro, has preference for 'Lys-11'-linked polyubiquitin chains; however such data are unsure in vivo. Hydrolyzes both linear and branched forms of polyubiquitin.

Subcellular Location:

Cytoplasm Nucleus Shuttles be cytoplasm and the nucleus in a XPO1/CRM1-dependent manner.

Protein Attributes:

Sequence length:

840

Sequence:

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840:

QPNCSFYGHP | ETNNLCSCCY | REELRRRERE | PGGELLAHRF |

3D Structure:

N/A

Predicted Eptitope:

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Vaild Sequence:

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Related Databases

Pfam:

PF02338

STRING:

10090.ENSMUSP00000088291

SMR:

B2RUR8

UniGene:

Mm.272336

KEGG:

mmu:229603

Uniprot:

B2RUR8

FOR

ELISA Kit for Mouse OTU domain-containing protein 7B

CLIA Kit for Mouse OTU domain-containing protein 7B

Polyclonal Antibody for Mouse OTU domain-containing protein 7B

Monoclonal Antibody for Mouse OTU domain-containing protein 7B

Protein for Mouse OTU domain-containing protein 7B

R&D Technical Data

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Precision

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Recovery

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Linearity

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

References

1.

"Lineage-specific biology revealed by a finished genome assembly of the mouse."
Church D.M. , Goodstadt L. , Hillier L.W. , Zody M.C. , Goldstein S. , She X. , Bult C.J. , Agarwala R. , Cherry J.L. , DiCuccio M. , Hlavina W. , Kapustin Y. , Meric P. , Maglott D. , Birtle Z. , Marques A.C. , Graves T. , Zhou S. , more...
PLoS Biol.7:E1000112-E1000112(2009) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
strain: C57BL/6J.
2.

Mural R.J. , Adams M.D. , Myers E.W. , Smith H.O. , Venter J.C.
Submitted (2005-07) to the EMBL/GenBank/DDBJ databases

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
3.

"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res.14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]
tissue: Brain.
tissue: Eye.
4.

"Large-scale phosphorylation analysis of mouse liver."
Villen J. , Beausoleil S.A. , Gerber S.A. , Gygi S.P.
Proc. Natl. Acad. Sci. U.S.A.104:1488-1493(2007) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
tissue: Liver.
5.

"OTUD7B controls non-canonical NF-kappaB activation through deubiquitination of TRAF3."
Hu H. , Brittain G.C. , Chang J.H. , Puebla-Osorio N. , Jin J. , Zal A. , Xiao Y. , Cheng X. , Chang M. , Fu Y.X. , Zal T. , Zhu C. , Sun S.C.
Nature494:371-374(2013) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;DISRUPTION PHENOTYPE;INTERACTION WITH TRAF3;MUTAGENESIS OF CYS-194 AND HIS-358

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