Otub1 ELISA Kit for Rat(Rattus norvegicus) | EIAab.comOtub1 ELISA Kit for Rat(Rattus norvegicus)

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Otub1 (Gene name),

Ubiquitin thioesterase OTUB1 (Protein name ), OTUB1_RAT from NCBI database.

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General Annotation

Antigen Annotation

Predicted Eptitope

Vaild Sequence

Related Databases

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Gene name:

Otub1;

Protein name:

Ubiquitin thioesterase OTUB1;

Alternative:

OTU domain-containing ubiquitin aldehyde-binding protein 1;Deubiquitinating enzyme OTUB1;Ubiquitin-specific-processing protease OTUB1;Otubain-1;

Organism:

Rat (Rattus norvegicus).

General Annotation

Sub Unit:

Interacts with RNF128. Forms a ternary complex with RNF128 and USP8. Interacts with FUS, ESR1 and GNB2L1/RACK1.

Function:

Hydrolase that can remove conjugated ubiquitin from proteins in vitro and may therefore play an important regulatory role at the level of protein turnover by preventing degradation. Regulator of T-cell anergy, a phenomenon that occurs when T-cells are rendered unresponsive to antigen rechallenge and no longer respond to their cognate antigen. Acts via its interaction with RNF128/GRAIL. Surprisingly, it regulates RNF128-mediated ubiquitination, but does not deubiquitinate polyubiquitinated RNF128. Deubiquitinates estrogen receptor alpha (ESR1). Mediates deubiquitination of 'Lys-48'-linked polyubiquitin chains, but not 'Lys-63'-linked polyubiquitin chains. Not able to cleave di-ubiquitin. Also capable of removing NEDD8 from NEDD8 conjugates, but with a nuch lower preference compared to 'Lys-48'-linked ubiquitin.

Subcellular Location:

Cytoplasm

Protein Attributes:

Sequence length:

271

Sequence:

50:

100:

150:

200:

250:

271:

EGSEPKVYLL | YRPGHYDILY | K

3D Structure:

N/A

Predicted Eptitope:

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Vaild Sequence:

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Related Databases

KEGG:

rno:293705

String:

B2RYG6

UniGene:

Rn.9218

SMR:

B2RYG6

STRING:

10116.ENSRNOP00000028752

Pfam:

PF10275

Uniprot:

B2RYG6

FOR

ELISA Kit for Rat Ubiquitin thioesterase OTUB1

CLIA Kit for Rat Ubiquitin thioesterase OTUB1

Polyclonal Antibody for Rat Ubiquitin thioesterase OTUB1

Monoclonal Antibody for Rat Ubiquitin thioesterase OTUB1

Protein for Rat Ubiquitin thioesterase OTUB1

R&D Technical Data

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Precision

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Recovery

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Linearity

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

References

1.

Mural R.J. , Adams M.D. , Myers E.W. , Smith H.O. , Venter J.C.
Submitted (2005-07) to the EMBL/GenBank/DDBJ databases

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
strain: Brown Norway.
2.

"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res.14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]
tissue: Prostate.
3.

"Proteome profile of the mature rat olfactory bulb."
Maurya D.K. , Sundaram C.S. , Bhargava P.
Proteomics9:2593-2599(2009) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: IDENTIFICATION BY MASS SPECTROMETRY;SUBCELLULAR LOCATION

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