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Index > Protein center > PLA2G2A(Gene name) > Human
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  • PLA2G2A (Gene name),
  • Phospholipase A2, membrane associated (Protein name ),  PA2GA_HUMAN from NCBI database.
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  • General Annotation
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  • Antigen Annotation
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  • 3D
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  • Predicted Eptitope
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  • Vaild Sequence
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  • Gene name:
    PLA2G2A(PLA2B;PLA2L;RASF-A);
    Protein name:
    Phospholipase A2, membrane associated;
    Alternative:
    Group IIA phospholipase A2;GIIC sPLA2;Phosphatidylcholine 2-acylhydrolase 2A;Non-pancreatic secretory phospholipase A2(NPS-PLA2);
    Organism:
    Human (Homo sapiens). 
    General Annotation
    Sub Unit:
    N/A
    Function:
    Thought to participate in the regulation of the phospholipid metabolism in biomembranes including eicosanoid biosynthesis. Catalyzes the calcium-dependent hydrolysis of the 2-acyl groups in 3-sn-phosphoglycerides.
    Subcellular Location:
    Membrane Peripheral membrane protein
    Protein Attributes:
    Sequence length:
    144
    Sequence:
    50:
    MKTLLLLAVI | MIFGLLQAHG | NLVNFHRMIK | LTTGKEAALS | YGFYGCHCGV | 
    100:
    GGRGSPKDAT | DRCCVTHDCC | YKRLEKRGCG | TKFLSYKFSN | SGSRITCAKQ | 
    144:
    DSCRSQLCEC | DKAAATCFAR | NKTTYNKKYQ | YYSNKHCRGS | TPRC
    3D Structure:
    N/A
    Predicted Eptitope:
    Please Sign in.
    EIAab Sequence  Vaild Sequence:
    Please Sign in.
    Related Databases
    KEGG:
    UniGene:
    MIM:
    SMR:
    Pfam:
    String:
    Uniprot:
     
    FOR
    ELISA Kit for Human Phospholipase A2, membrane associated
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    ELISA Kit for Human Phospholipase A2, membrane associated
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    ELISA Kit for Human Phospholipase A2, membrane associated
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    ELISA Kit for Human Phospholipase A2, membrane associated
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    CLIA Kit for Human Phospholipase A2, membrane associated
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    CLIA Kit for Human Phospholipase A2, membrane associated
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    CLIA Kit for Human Phospholipase A2, membrane associated
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    CLIA Kit for Human Phospholipase A2, membrane associated
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    CLIA Kit for Human Phospholipase A2, membrane associated
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    Polyclonal Antibody for Human Phospholipase A2, membrane associated
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    P8968Rb-h
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    Polyclonal Antibody for Human Phospholipase A2, membrane associated
    Polyclonal Antibody for Human Phospholipase A2, membrane associated
    Polyclonal Antibody for Human Phospholipase A2, membrane associated
    Polyclonal Antibody for Human Phospholipase A2, membrane associated
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    P8968Rb-m
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    Packing:
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    Monoclonal Antibody for Human Phospholipase A2, membrane associated
    Monoclonal Antibody for Human Phospholipase A2, membrane associated
    Monoclonal Antibody for Human Phospholipase A2, membrane associated
    Monoclonal Antibody for Human Phospholipase A2, membrane associated
    Monoclonal Antibody for Human Phospholipase A2, membrane associated
    Protein for Human Phospholipase A2, membrane associated
    Protein for Human Phospholipase A2, membrane associated
    Protein for Human Phospholipase A2, membrane associated
    Protein for Human Phospholipase A2, membrane associated
    Protein for Human Phospholipase A2, membrane associated

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    References
    1. 1.
      "Cloning and recombinant expression of phospholipase A2 present in rheumatoid arthritic synovial fluid."
      Seilhamer J.J. , Pruzanski W. , Vadas P. , Plant S. , Miller J.A. , Kloss J. , Johnson L.K.
      J. Biol. Chem.264:5335-5338(1989) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA]
      tissue: Rheumatoid arthritic synovial fluid.
    2. 2.
      "Structure and properties of a human non-pancreatic phospholipase A2."
      Kramer R.M. , Hession C. , Johansen B. , Hayes G. , McGray P. , Chow E.P. , Tizard R. , Pepinsky R.B.
      J. Biol. Chem.264:5768-5775(1989) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]
    3. 3.
      "Structure and properties of a secretable phospholipase A2 from human platelets."
      Kramer R.M. , Johansen B. , Hession C. , Pepinsky R.B.
      Adv. Exp. Med. Biol.275:35-53(1990) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]
    4. 4.
      "Cloning and sequence determination of human platelet phospholipase A2 from liver tissues."
      Liang N.S. , Fang Z.W. , Li Y. , Yang F. , Lu Y. , Xie Y.A.
      Submitted (2004-06) to the EMBL/GenBank/DDBJ databases
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA]
      tissue: Liver.
    5. 5.
      "Cloning of human full open reading frames in Gateway(TM) system entry vector (pDONR201)."
      Ebert L. , Schick M. , Neubert P. , Schatten R. , Henze S. , Korn B.
      Submitted (2004-06) to the EMBL/GenBank/DDBJ databases
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]
    6. 6.
      NIEHS SNPs program
      Submitted (2003-11) to the EMBL/GenBank/DDBJ databases
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA];VARIANT TYR-19
    7. 7.
      "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T. , Suzuki Y. , Nishikawa T. , Otsuki T. , Sugiyama T. , Irie R. , Wakamatsu A. , Hayashi K. , Sato H. , Nagai K. , Kimura K. , Makita H. , Sekine M. , Obayashi M. , Nishi T. , Shibahara T. , Tanaka T. , Ishii S. , more...
      Nat. Genet.36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]
      tissue: Tongue.
    8. 8.
      "The DNA sequence and biological annotation of human chromosome 1."
      Gregory S.G. , Barlow K.F. , McLay K.E. , Kaul R. , Swarbreck D. , Dunham A. , Scott C.E. , Howe K.L. , Woodfine K. , Spencer C.C.A. , Jones M.C. , Gillson C. , Searle S. , Zhou Y. , Kokocinski F. , McDonald L. , Evans R. , Phillips K. , more...
      Nature441:315-321(2006) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
    9. 9.
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
    10. 10.
      "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res.14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]
      tissue: Prostate.
    11. 11.
      "The primary structure of a membrane-associated phospholipase A2 from human spleen."
      Kanda A. , Ono T. , Yoshida N. , Tojo H. , Okamoto M.
      Biochem. Biophys. Res. Commun.163:42-48(1989) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PROTEIN SEQUENCE OF 21-144
      tissue: Spleen.
    12. 12.
      "Amino acid composition and NH2-terminal amino acid sequence of human phospholipase A2 purified from rheumatoid synovial fluid."
      Hara S. , Kudo I. , Matsuta K. , Miyamoto T. , Inoue K.
      J. Biochem.104:326-328(1988) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PROTEIN SEQUENCE OF 21-54
      tissue: Synovial fluid.
    13. 13.
      "Phospholipase A2 from human synovial fluid: purification and structural homology to the placental enzyme."
      Lai C.Y. , Wada K.
      Biochem. Biophys. Res. Commun.157:488-493(1988) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PROTEIN SEQUENCE OF 21-33
      tissue: Synovial fluid.
    14. 14.
      "Purification and characterization of a phospholipase A2 from human ileal mucosa."
      Minami T. , Tojo H. , Shinomura Y. , Matsuzawa Y. , Okamoto M.
      Biochim. Biophys. Acta1170:125-130(1993) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PROTEIN SEQUENCE OF 21-75
      tissue: Ileal mucosa.
    15. 15.
      "Structure of recombinant human rheumatoid arthritic synovial fluid phospholipase A2 at 2.2-A resolution."
      Wery J.-P. , Schevitz R.W. , Clawson D.K. , Bobbitt J.L. , Dow E.R. , Gamboa G. , Goodson T. Jr. , Hermann R.B. , Kramer R.M. , McClure D.B. , Mihelich E.D. , Putnam J.E. , Sharp J.D. , Stark D.H. , Teater C. , Warrick M.W. , Jones N.D.
      Nature352:79-82(1991) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: X-RAY CRYSTALLOGRAPHY (2.2 ANGSTROMS)
    16. 16.
      "Structures of free and inhibited human secretory phospholipase A2 from inflammatory exudate."
      Scott D.L. , White S.P. , Browning J.L. , Rosa J.J. , Gelb M.H. , Sigler P.B.
      Science254:1007-1010(1991) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: X-RAY CRYSTALLOGRAPHY (2.2 ANGSTROMS)
    17. 17.
      "Structure-based design of the first potent and selective inhibitor of human non-pancreatic secretory phospholipase A2."
      Schevitz R.W. , Bach N.J. , Carlson D.G. , Chirgadze N.Y. , Clawson D.K. , Dillard R.D. , Draheim S.E. , Hartley L.W. , Jones N.D. , Mihelich E.D. , Olkowski J.L. , Snyder D.W. , Dand S.C. , Wery J.-P.
      Nat. Struct. Biol.2:458-465(1995) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: X-RAY CRYSTALLOGRAPHY (2.2 ANGSTROMS)
    18. 18.
      "Crystal structure of human secretory phospholipase A2-IIA complex with the potent indolizine inhibitor 120-1032."
      Kitadokoro K. , Hagishita S. , Sato T. , Ohtan M. , Miki K.
      J. Biochem.123:619-623(1998) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: X-RAY CRYSTALLOGRAPHY (2.2 ANGSTROMS)
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