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Index > Protein center > Pdgfd(Gene name) > Mouse
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  • Pdgfd (Gene name),
  • Platelet-derived growth factor D (Protein name ),  PDGFD_MOUSE from NCBI database.
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  • General Annotation
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  • Antigen Annotation
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  • Gene name:
    Pdgfd(Scdgfb);
    Protein name:
    Platelet-derived growth factor D(PDGF-D);
    Alternative:
    Spinal cord-derived growth factor B(SCDGF-B);
    Organism:
    Mouse (Mus musculus). 
    General Annotation
    Sub Unit:
    Homodimer; disulfide-linked.
    Function:
    Potent mitogen for cells of mesenchymal origin. Binding of this growth factor to its affinity receptor elicits a variety of cellular responses. It is released by platelets upon wounding and plays an important role in stimulating adjacent cells to grow and thereby heals the wound. Activated by proteolytic cleavage and this active form acts as a specific ligand for beta platelet-derived growth factor receptor (By similarity). Has oncogenic potential and can induce tumor formation. Induces macrophage recruitment, increased interstitial pressure, and blood vessel maturation during angiogenesis. Can initiate events that lead to a mesangial proliferative glomerulonephritis, including influx of monocytes and macrophages and production of extracellular matrix.
    Subcellular Location:
    Secreted
    Protein Attributes:
    Sequence length:
    370
    Sequence:
    50:
    MQRLVLVSIL | LCANFSCYPD | TFATPQRASI | KALRNANLRR | DESNHLTDLY | 
    100:
    QREENIQVTS | NGHVQSPRFP | NSYPRNLLLT | WWLRSQEKTR | IQLSFDHQFG | 
    150:
    LEEAENDICR | YDFVEVEEVS | ESSTVVRGRW | CGHKEIPPRI | TSRTNQIKIT | 
    200:
    FKSDDYFVAK | PGFKIYYSFV | EDFQPEAASE | TNWESVTSSF | SGVSYHSPSI | 
    250:
    TDPTLTADAL | DKTVAEFDTV | EDLLKHFNPV | SWQDDLENLY | LDTPHYRGRS | 
    300:
    YHDRKSKVDL | DRLNDDVKRY | SCTPRNHSVN | LREELKLTNA | VFFPRCLLVQ | 
    350:
    RCGGNCGCGT | VNWKSCTCSS | GKTVKKYHEV | LKFEPGHFKR | RGKAKNMALV | 
    370:
    DIQLDHHERC | DCICSSRPPR | 
    3D Structure:
    N/A
    Predicted Eptitope:
    Please Sign in.
    EIAab Sequence  Vaild Sequence:
    Please Sign in.
    Related Databases
    UniGene:
    KEGG:
    SMR:
    Pfam:
    String:
    Uniprot:
     
    FOR
    ELISA Kit for Mouse PDGF-D
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    E1896h
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    ELISA Kit for Mouse PDGF-D
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    E1896r
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    ELISA Kit for Mouse PDGF-D
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    ELISA Kit for Mouse PDGF-D
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    CLIA Kit for Mouse PDGF-D
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    U1896m
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    Packing:
    96T
    CLIA Kit for Mouse PDGF-D
    Cat.:
    U1896r
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    MSDS:
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    Packing:
    96T
    CLIA Kit for Mouse PDGF-D
    Cat.:
    U1896h
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    Range:
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    CLIA Kit for Mouse PDGF-D
    MSDS:
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    Polyclonal Antibody for Mouse PDGF-D
    Polyclonal Antibody for Mouse PDGF-D
    Cat.:
    P1896Rb-r
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    Packing:
    40ug/0.2ml
    Polyclonal Antibody for Mouse PDGF-D
    Cat.:
    P1896Rb-m
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    Packing:
    40ug/0.2ml
    Polyclonal Antibody for Mouse PDGF-D
    Cat.:
    P1896Rb-h
    Price:
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    Packing:
    40ug/0.2ml
    Monoclonal Antibody for Mouse PDGF-D
    Monoclonal Antibody for Mouse PDGF-D
    Monoclonal Antibody for Mouse PDGF-D
    Monoclonal Antibody for Mouse PDGF-D
    Protein for Mouse PDGF-D
    Protein for Mouse PDGF-D
    Protein for Mouse PDGF-D
    Protein for Mouse PDGF-D

    R&D Technical Data
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    Precision
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    Linearity
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    References
    1. 1.
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1)
      strain: BALB/c.
    2. 2.
      "A novel murine PDGF-D splicing variant results in significant differences in peptide expression and function."
      Zhuo Y. , Hoyle G.W. , Zhang J. , Morris G. , Lasky J.A.
      Biochem. Biophys. Res. Commun.308:126-132(2003) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1 AND 3);TISSUE SPECIFICITY
    3. 3.
      "The transcriptional landscape of the mammalian genome."
      Carninci P. , Kasukawa T. , Katayama S. , Gough J. , Frith M.C. , Maeda N. , Oyama R. , Ravasi T. , Lenhard B. , Wells C. , Kodzius R. , Shimokawa K. , Bajic V.B. , Brenner S.E. , Batalov S. , Forrest A.R. , Zavolan M. , Davis M.J. , more...
      Science309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2)
      strain: C57BL/6J.
      tissue: Hippocampus.
    4. 4.
      "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res.14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 3)
      strain: FVB/N.
      tissue: Mammary gland.
    5. 5.
      "PDGF-D is a specific, protease-activated ligand for the PDGF beta-receptor."
      Bergsten E. , Uutela M. , Li X. , Pietras K. , Oestman A. , Heldin C.-H. , Alitalo K. , Eriksson U.
      Nat. Cell Biol.3:512-516(2001) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: TISSUE SPECIFICITY
    6. 6.
      "Platelet-derived growth factor D: tumorigenicity in mice and dysregulated expression in human cancer."
      LaRochelle W.J. , Jeffers M. , Corvalan J.R.F. , Jia X.-C. , Feng X. , Vanegas S. , Vickroy J.D. , Yang X.-D. , Chen F. , Gazit G. , Mayotte J. , Macaluso J. , Rittman B. , Wu F. , Dhanabal M. , Herrmann J. , Lichenstein H.S.
      Cancer Res.62:2468-2473(2002) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION
    7. 7.
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: REVIEW
    8. 8.
      "Exogenous PDGF-D is a potent mesangial cell mitogen and causes a severe mesangial proliferative glomerulopathy."
      Hudkins K.L. , Gilbertson D.G. , Carling M. , Taneda S. , Hughes S.D. , Holdren M.S. , Palmer T.E. , Topouzis S. , Haran A.C. , Feldhaus A.L. , Alpers C.E.
      J. Am. Soc. Nephrol.15:286-298(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;TISSUE SPECIFICITY
    9. 9.
      "Obstructive uropathy in mice and humans: potential role for PDGF-D in the progression of tubulointerstitial injury."
      Taneda S. , Hudkins K.L. , Topouzis S. , Gilbertson D.G. , Ophascharoensuk V. , Truong L. , Johnson R.J. , Alpers C.E.
      J. Am. Soc. Nephrol.14:2544-2555(2003) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: TISSUE SPECIFICITY
    10. 10.
      "PDGF-D induces macrophage recruitment, increased interstitial pressure, and blood vessel maturation during angiogenesis."
      Uutela M. , Wirzenius M. , Paavonen K. , Rajantie I. , He Y. , Karpanen T. , Lohela M. , Wiig H. , Salven P. , Pajusola K. , Eriksson U. , Alitalo K.
      Blood104:3198-3204(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION
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