Gene name:
Pdgfd (Scdgfb) ;
Protein name:
Platelet-derived growth factor D (PDGF-D) ;
Alternative:
Spinal cord-derived growth factor B (SCDGF-B) ;
Organism:
Mouse (Mus musculus).
General Annotation
Sub Unit:
Homodimer; disulfide-linked.
Function:
Potent mitogen for cells of mesenchymal origin. Binding of this growth factor to its affinity receptor elicits a variety of cellular responses. It is released by platelets upon wounding and plays an important role in stimulating adjacent cells to grow and thereby heals the wound. Activated by proteolytic cleavage and this active form acts as a specific ligand for beta platelet-derived growth factor receptor (By similarity). Has oncogenic potential and can induce tumor formation. Induces macrophage recruitment, increased interstitial pressure, and blood vessel maturation during angiogenesis. Can initiate events that lead to a mesangial proliferative glomerulonephritis, including influx of monocytes and macrophages and production of extracellular matrix.
Subcellular Location:
Secreted
Protein Attributes:
50:
MQRLVLVSIL | LCANFSCYPD | TFATPQRASI | KALRNANLRR | DESNHLTDLY |
100:
QREENIQVTS | NGHVQSPRFP | NSYPRNLLLT | WWLRSQEKTR | IQLSFDHQFG |
150:
LEEAENDICR | YDFVEVEEVS | ESSTVVRGRW | CGHKEIPPRI | TSRTNQIKIT |
200:
FKSDDYFVAK | PGFKIYYSFV | EDFQPEAASE | TNWESVTSSF | SGVSYHSPSI |
250:
TDPTLTADAL | DKTVAEFDTV | EDLLKHFNPV | SWQDDLENLY | LDTPHYRGRS |
300:
YHDRKSKVDL | DRLNDDVKRY | SCTPRNHSVN | LREELKLTNA | VFFPRCLLVQ |
350:
RCGGNCGCGT | VNWKSCTCSS | GKTVKKYHEV | LKFEPGHFKR | RGKAKNMALV |
370:
DIQLDHHERC | DCICSSRPPR |
Vaild Sequence:
Related Databases
Uniprot:
ELISA Kit
CLIA Kit
Polyclonal Antibody
Monoclonal Antibody
Protein
FOR
Human
Rat
Mouse
Rabbit
ELISA Kit for Mouse PDGF-D
ELISA Kit for Mouse PDGF-D
ELISA Kit for Mouse PDGF-D
ELISA Kit for Mouse PDGF-D
CLIA Kit for Mouse PDGF-D
CLIA Kit for Mouse PDGF-D
CLIA Kit for Mouse PDGF-D
CLIA Kit for Mouse PDGF-D
Polyclonal Antibody for Mouse PDGF-D
Polyclonal Antibody for Mouse PDGF-D
Polyclonal Antibody for Mouse PDGF-D
Polyclonal Antibody for Mouse PDGF-D
Monoclonal Antibody for Mouse PDGF-D
Monoclonal Antibody for Mouse PDGF-D
Monoclonal Antibody for Mouse PDGF-D
Monoclonal Antibody for Mouse PDGF-D
R&D Technical Data
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Precision
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Recovery
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Linearity
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[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1)
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BALB/c .
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[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1 AND 3);TISSUE SPECIFICITY
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more...
Science309:1559-1563(2005)
[
PubMed ]
[
Europe PMC ]
[
Abstract ]
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2)
strain :
C57BL/6J .
tissue :
Hippocampus .
4.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 3)
strain :
FVB/N .
tissue :
Mammary gland .
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[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : TISSUE SPECIFICITY
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[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : FUNCTION;TISSUE SPECIFICITY
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[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : TISSUE SPECIFICITY
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[
PubMed ]
[
Europe PMC ]
[
Abstract ]
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : FUNCTION