Gene name:
Pdgfd (Iegf;Scdgfb) ;
Protein name:
Platelet-derived growth factor D (PDGF-D) ;
Alternative:
Spinal cord-derived growth factor B (SCDGF-B) ;Iris-expressed growth factor ;
Organism:
Rat (Rattus norvegicus).
General Annotation
Sub Unit:
Homodimer; disulfide-linked.
Function:
Potent mitogen for cells of mesenchymal origin. Binding of this growth factor to its affinity receptor elicits a variety of cellular responses. It is released by platelets upon wounding and plays an important role in stimulating adjacent cells to grow and thereby heals the wound. Activated by proteolytic cleavage and this active form acts as a specific ligand for beta platelet-derived growth factor receptor (By similarity). May play an important role in control of lens epithelial cell proliferation. Can initiate events that lead to a mesangial proliferative glomerulonephritis, including influx of monocytes and macrophages and production of extracellular matrix.
Subcellular Location:
Secreted
Protein Attributes:
50:
MHRLILVSIL | VCANFCCYRD | TFATPQSASI | KALRNANLRR | DESNHLTDLY |
100:
RRDENIRVTG | TGHVQSPRFP | NSYPRNLLLT | WRLHSQEKTR | IQLAFDHQFG |
150:
LEEAENDICR | YDFVEVEDVS | ESSTVVRGRW | CGHKEIPPRI | TSRTNQIKIT |
200:
FQSDDYFVAK | PGFKIYYSFV | EDFQPEAASE | INWESVTSSF | SGVSYHSPSV |
250:
MDSTLTADAL | DKAIAEFDTV | EDLLKYFNPA | SWQDDLENLY | MDTPRYRGRS |
300:
YHERKSKVDL | DRLNDDVKRY | SCTPRNHSVN | LREELKLTNA | VFFPRCLLVQ |
350:
RCGGNCGCGT | LNWKSCTCSS | GKTVKKYHEV | LKFEPGHFKR | RGKAKNMALV |
370:
DIQLDHHERC | DCICSSRPPR |
Vaild Sequence:
Related Databases
Uniprot:
ELISA Kit
CLIA Kit
Polyclonal Antibody
Monoclonal Antibody
Protein
FOR
Human
Rat
Mouse
Rabbit
Polyclonal Antibody for Rat PDGF-D
Polyclonal Antibody for Rat PDGF-D
Polyclonal Antibody for Rat PDGF-D
Polyclonal Antibody for Rat PDGF-D
Monoclonal Antibody for Rat PDGF-D
Monoclonal Antibody for Rat PDGF-D
Monoclonal Antibody for Rat PDGF-D
Monoclonal Antibody for Rat PDGF-D
R&D Technical Data
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Precision
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Recovery
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Linearity
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References
1.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1)
tissue :
Fetal brain .
2.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : IDENTIFICATION OF ISOFORM 2;TISSUE SPECIFICITY;DEVELOPMENTAL STAGE
3.
"A fully human monoclonal antibody (CR002) identifies PDGF-D as a novel mediator of mesangioproliferative glomerulonephritis."
Ostendorf T.
,
van Roeyen C.R.C.
,
Peterson J.D.
,
Kunter U.
,
Eitner F.
,
Hamad A.J.
,
Chan G.
,
Jia X.-C.
,
Macaluso J.
,
Gazit-Bornstein G.
,
Keyt B.A.
,
Lichenstein H.S.
,
LaRochelle W.J.
,
Floege J.
J. Am. Soc. Nephrol.14:2237-2247(2003)
[
PubMed ]
[
Europe PMC ]
[
Abstract ]
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : FUNCTION;TISSUE SPECIFICITY
4.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : FUNCTION;TISSUE SPECIFICITY