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Index > Protein center > Pdgfd(Gene name) > Rat
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  • Pdgfd (Gene name),
  • Platelet-derived growth factor D (Protein name ),  PDGFD_RAT from NCBI database.
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  • General Annotation
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  • Antigen Annotation
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  • Gene name:
    Pdgfd(Iegf;Scdgfb);
    Protein name:
    Platelet-derived growth factor D(PDGF-D);
    Alternative:
    Spinal cord-derived growth factor B(SCDGF-B);Iris-expressed growth factor;
    Organism:
    Rat (Rattus norvegicus). 
    General Annotation
    Sub Unit:
    Homodimer; disulfide-linked.
    Function:
    Potent mitogen for cells of mesenchymal origin. Binding of this growth factor to its affinity receptor elicits a variety of cellular responses. It is released by platelets upon wounding and plays an important role in stimulating adjacent cells to grow and thereby heals the wound. Activated by proteolytic cleavage and this active form acts as a specific ligand for beta platelet-derived growth factor receptor (By similarity). May play an important role in control of lens epithelial cell proliferation. Can initiate events that lead to a mesangial proliferative glomerulonephritis, including influx of monocytes and macrophages and production of extracellular matrix.
    Subcellular Location:
    Secreted
    Protein Attributes:
    Sequence length:
    370
    Sequence:
    50:
    MHRLILVSIL | VCANFCCYRD | TFATPQSASI | KALRNANLRR | DESNHLTDLY | 
    100:
    RRDENIRVTG | TGHVQSPRFP | NSYPRNLLLT | WRLHSQEKTR | IQLAFDHQFG | 
    150:
    LEEAENDICR | YDFVEVEDVS | ESSTVVRGRW | CGHKEIPPRI | TSRTNQIKIT | 
    200:
    FQSDDYFVAK | PGFKIYYSFV | EDFQPEAASE | INWESVTSSF | SGVSYHSPSV | 
    250:
    MDSTLTADAL | DKAIAEFDTV | EDLLKYFNPA | SWQDDLENLY | MDTPRYRGRS | 
    300:
    YHERKSKVDL | DRLNDDVKRY | SCTPRNHSVN | LREELKLTNA | VFFPRCLLVQ | 
    350:
    RCGGNCGCGT | LNWKSCTCSS | GKTVKKYHEV | LKFEPGHFKR | RGKAKNMALV | 
    370:
    DIQLDHHERC | DCICSSRPPR | 
    3D Structure:
    N/A
    Predicted Eptitope:
    Please Sign in.
    EIAab Sequence  Vaild Sequence:
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    Related Databases
    Pfam:
    KEGG:
    UniGene:
    String:
    Uniprot:
     
    FOR
    ELISA Kit for Rat PDGF-D
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    E1896h
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    ELISA Kit for Rat PDGF-D
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    ELISA Kit for Rat PDGF-D
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    ELISA Kit for Rat PDGF-D
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    CLIA Kit for Rat PDGF-D
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    U1896m
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    96T
    CLIA Kit for Rat PDGF-D
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    U1896r
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    MSDS:
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    Packing:
    96T
    CLIA Kit for Rat PDGF-D
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    U1896h
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    MSDS:
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    Packing:
    96T
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    CLIA Kit for Rat PDGF-D
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    Polyclonal Antibody for Rat PDGF-D
    Polyclonal Antibody for Rat PDGF-D
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    P1896Rb-r
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    Packing:
    40ug/0.2ml
    Polyclonal Antibody for Rat PDGF-D
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    P1896Rb-m
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    Packing:
    40ug/0.2ml
    Polyclonal Antibody for Rat PDGF-D
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    P1896Rb-h
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    Packing:
    40ug/0.2ml
    Monoclonal Antibody for Rat PDGF-D
    Monoclonal Antibody for Rat PDGF-D
    Monoclonal Antibody for Rat PDGF-D
    Monoclonal Antibody for Rat PDGF-D
    Protein for Rat PDGF-D
    Protein for Rat PDGF-D
    Protein for Rat PDGF-D
    Protein for Rat PDGF-D

    R&D Technical Data
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    Precision
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    Linearity
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    References
    1. 1.
      "Molecular cloning of SCDGF-B, a novel growth factor homologous to SCDGF/PDGF-C/fallotein."
      Hamada T. , Ui-Tei K. , Imaki J. , Miyata Y.
      Biochem. Biophys. Res. Commun.280:733-737(2001) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1)
      tissue: Fetal brain.
    2. 2.
      "The expression of SCDGF/PDGF-C/fallotein and SCDGF-B/PDGF-D in the rat central nervous system."
      Hamada T. , Ui-Tei K. , Imaki J. , Takahashi F. , Onodera H. , Mishima T. , Miyata Y.
      Mech. Dev.112:161-164(2002) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: IDENTIFICATION OF ISOFORM 2;TISSUE SPECIFICITY;DEVELOPMENTAL STAGE
    3. 3.
      "A fully human monoclonal antibody (CR002) identifies PDGF-D as a novel mediator of mesangioproliferative glomerulonephritis."
      Ostendorf T. , van Roeyen C.R.C. , Peterson J.D. , Kunter U. , Eitner F. , Hamad A.J. , Chan G. , Jia X.-C. , Macaluso J. , Gazit-Bornstein G. , Keyt B.A. , Lichenstein H.S. , LaRochelle W.J. , Floege J.
      J. Am. Soc. Nephrol.14:2237-2247(2003) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;TISSUE SPECIFICITY
    4. 4.
      "Platelet-derived growth factor D, tissue-specific expression in the eye, and a key role in control of lens epithelial cell proliferation."
      Ray S. , Gao C. , Wyatt K. , Fariss R.N. , Bundek A. , Zelenka P. , Wistow G.
      J. Biol. Chem.280:8494-8502(2005) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;TISSUE SPECIFICITY
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