Pdgfrb ELISA Kit for Mouse(Mus musculus) | EIAab.comPdgfrb ELISA Kit for Mouse(Mus musculus)

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Pdgfrb (Gene name),

Beta-type platelet-derived growth factor receptor (Protein name ), PGFRB_MOUSE from NCBI database.

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General Annotation

Antigen Annotation

Predicted Eptitope

Vaild Sequence

Related Databases

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Gene name:

Pdgfrb(Pdgfr;Pdgfr1);

Protein name:

Beta-type platelet-derived growth factor receptor(PDGF-R-beta);

Alternative:

Beta-type platelet-derived growth factor receptor;CD140 antigen-like family member B;Platelet-derived growth factor receptor 1(PDGFR-1);CD140 antigen-like family member B;

CD:

CD140b;

Organism:

Mouse (Mus musculus).

General Annotation

Sub Unit:

Homodimer, and heterodimer with PDGFRA. Interacts with APS. The autophosphorylated form interacts directly with SHB and with PIK3C2B, maybe indirectly. Interacts with GRB7 and GRB10.

Function:

Receptor that binds specifically to PDGFB and PDGFD and has a tyrosine-protein kinase activity. Phosphorylates Tyr residues at the C-terminus of PTPN11 creating a binding site for the SH2 domain of GRB2.

Subcellular Location:

Membrane Single-pass type I membrane protein

Protein Attributes:

Sequence length:

1098

Sequence:

50:

100:

150:

200:

250:

300:

350:

400:

450:

500:

550:

600:

650:

700:

750:

800:

850:

900:

950:

1000:

1050:

1098:

VNTSSTISCD | SPLELQEEPQ | QAEPEAQLEQ | PQDSGCPGPL | AEAEDSFL

3D Structure:

N/A

Predicted Eptitope:

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Vaild Sequence:

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Related Databases

String:

P05622

Pfam:

PF07679

Pfam:

PF00047

KEGG:

mmu:18596

UniGene:

Mm.4146

SMR:

P05622

Uniprot:

P05622

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ELISA Kit for Mouse PDGF-R-beta

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E2061r

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96T

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ELISA Kit for Mouse PDGF-R-beta

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E2061m

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96T

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ELISA Kit for Mouse PDGF-R-beta

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E2061h

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96T

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ELISA Kit for Mouse PDGF-R-beta

Cat.:

E2061d

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96T

CLIA Kit for Mouse PDGF-R-beta

Cat.:

U2061r

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96T

CLIA Kit for Mouse PDGF-R-beta

Cat.:

U2061h

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Looking for manual.

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96T

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CLIA Kit for Mouse PDGF-R-beta

Cat.:

U2061m

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MSDS:

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Packing:

96T

CLIA Kit for Mouse PDGF-R-beta

Cat.:

U2061d

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96T

Polyclonal Antibody for Mouse PDGF-R-beta

Cat.:

P2061Rb-m

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40ug/0.2ml

Polyclonal Antibody for Mouse PDGF-R-beta

Cat.:

P2061Rb-r

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40ug/0.2ml

Polyclonal Antibody for Mouse PDGF-R-beta

Cat.:

P2061Rb-h

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40ug/0.2ml

Monoclonal Antibody for Mouse PDGF-R-beta

Protein for Mouse PDGF-R-beta

R&D Technical Data

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Precision

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Recovery

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Linearity

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References

1.

"Structure of the receptor for platelet-derived growth factor helps define a family of closely related growth factor receptors."
Yarden Y. , Escobedo J.A. , Kuang W.-J. , Yang-Feng T.L. , Daniel T.O. , Tremble P.M. , Chen E.Y. , Ando M.E. , Harkins R.N. , Francke U. , Fried V.A. , Ullrich A. , Williams L.T.
Nature323:226-232(1986) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA];PARTIAL PROTEIN SEQUENCE
tissue: Fibroblast.
2.

"PDGF-AB requires PDGF receptor alpha-subunits for high-affinity, but not for low-affinity, binding and signal transduction."
Seifert R.A. , van Koppen A. , Bowen-Pope D.F.
J. Biol. Chem.268:4473-4480(1993) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION AS RECEPTOR FOR PDGFA AND PDGFB;SUBUNIT;AUTOPHOSPHORYLATION
3.

"Abnormal kidney development and hematological disorders in PDGF beta-receptor mutant mice."
Soriano P.
Genes Dev.8:1888-1896(1994) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: DISRUPTION PHENOTYPE
4.

"Grb10, a positive, stimulatory signaling adapter in platelet-derived growth factor BB-, insulin-like growth factor I-, and insulin-mediated mitogenesis."
Wang J. , Dai H. , Yousaf N. , Moussaif M. , Deng Y. , Boufelliga A. , Swamy O.R. , Leone M.E. , Riedel H.
Mol. Cell. Biol.19:6217-6228(1999) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH GRB10
5.

"Obstructive uropathy in mice and humans: potential role for PDGF-D in the progression of tubulointerstitial injury."
Taneda S. , Hudkins K.L. , Topouzis S. , Gilbertson D.G. , Ophascharoensuk V. , Truong L. , Johnson R.J. , Alpers C.E.
J. Am. Soc. Nephrol.14:2544-2555(2003) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: TISSUE SPECIFICITY
6.

"Additive effects of PDGF receptor beta signaling pathways in vascular smooth muscle cell development."
Tallquist M.D. , French W.J. , Soriano P.
PLoS Biol.1:E52-E52(2003) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;MUTAGENESIS OF TYR-578; TYR-715; TYR-739; TYR-750; TYR-770; TYR-1008 AND TYR-1020
7.

"Insight into the physiological functions of PDGF through genetic studies in mice."
Betsholtz C.
Cytokine Growth Factor Rev.15:215-228(2004) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: REVIEW ON FUNCTION;DISRUPTION PHENOTYPE
8.

"A gain of function mutation in the activation loop of platelet-derived growth factor beta-receptor deregulates its kinase activity."
Chiara F. , Goumans M.J. , Forsberg H. , Ahgren A. , Rasola A. , Aspenstrom P. , Wernstedt C. , Hellberg C. , Heldin C.H. , Heuchel R.
J. Biol. Chem.279:42516-42527(2004) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: MUTAGENESIS OF ASP-849;CATALYTIC ACTIVITY;FUNCTION;INTERACTION WITH PIK3R1
9.

"Site-selective regulation of platelet-derived growth factor beta receptor tyrosine phosphorylation by T-cell protein tyrosine phosphatase."
Persson C. , Saevenhed C. , Bourdeau A. , Tremblay M.L. , Markova B. , Boehmer F.D. , Haj F.G. , Neel B.G. , Elson A. , Heldin C.H. , Roennstrand L. , Ostman A. , Hellberg C.
Mol. Cell. Biol.24:2190-2201(2004) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PHOSPHORYLATION;DEPHOSPHORYLATION BY PTPN2
10.

"Bidirectional signaling links the Abelson kinases to the platelet-derived growth factor receptor."
Plattner R. , Koleske A.J. , Kazlauskas A. , Pendergast A.M.
Mol. Cell. Biol.24:2573-2583(2004) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;PHOSPHORYLATION AT TYR-685; TYR-933 AND TYR-969
11.

"Low density lipoprotein receptor-related protein 1 (LRP1) controls endocytosis and c-CBL-mediated ubiquitination of the platelet-derived growth factor receptor beta (PDGFR beta)."
Takayama Y. , May P. , Anderson R.G. , Herz J.
J. Biol. Chem.280:18504-18510(2005) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH CBL;UBIQUITINATION
12.

"Binding of Cbl to a phospholipase Cgamma1-docking site on platelet-derived growth factor receptor beta provides a dual mechanism of negative regulation."
Reddi A.L. , Ying G. , Duan L. , Chen G. , Dimri M. , Douillard P. , Druker B.J. , Naramura M. , Band V. , Band H.
J. Biol. Chem.282:29336-29347(2007) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH CBL AND PLCG1;FUNCTION
13.

"Platelet-derived growth factor receptor beta signaling is required for efficient epicardial cell migration and development of two distinct coronary vascular smooth muscle cell populations."
Mellgren A.M. , Smith C.L. , Olsen G.S. , Eskiocak B. , Zhou B. , Kazi M.N. , Ruiz F.R. , Pu W.T. , Tallquist M.D.
Circ. Res.103:1393-1401(2008) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION
14.

"PDGF-B signaling is important for murine cardiac development: its role in developing atrioventricular valves, coronaries, and cardiac innervation."
Van den Akker N.M. , Winkel L.C. , Nisancioglu M.H. , Maas S. , Wisse L.J. , Armulik A. , Poelmann R.E. , Lie-Venema H. , Betsholtz C. , Gittenberger-de Groot A.C.
Dev. Dyn.237:494-503(2008) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: DISRUPTION PHENOTYPE
15.

"Comprehensive dissection of PDGF-PDGFR signaling pathways in PDGFR genetically defined cells."
Wu E. , Palmer N. , Tian Z. , Moseman A.P. , Galdzicki M. , Wang X. , Berger B. , Zhang H. , Kohane I.S.
PLoS ONE3:E3794-E3794(2008) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION
16.

"The mouse C2C12 myoblast cell surface N-linked glycoproteome: identification, glycosite occupancy, and membrane orientation."
Gundry R.L. , Raginski K. , Tarasova Y. , Tchernyshyov I. , Bausch-Fluck D. , Elliott S.T. , Boheler K.R. , Van Eyk J.E. , Wollscheid B.
Mol. Cell. Proteomics8:2555-2569(2009) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: GLYCOSYLATION [LARGE SCALE ANALYSIS] AT ASN-306; ASN-312; ASN-467 AND ASN-478
tissue: Myoblast.
17.

"LRP1 regulates architecture of the vascular wall by controlling PDGFRbeta-dependent phosphatidylinositol 3-kinase activation."
Zhou L. , Takayama Y. , Boucher P. , Tallquist M.D. , Herz J.
PLoS ONE4:E6922-E6922(2009) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;INTERACTION WITH PIK3R1
18.

"PDGFRbeta signaling regulates mural cell plasticity and inhibits fat development."
Olson L.E. , Soriano P.
Dev. Cell20:815-826(2011) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION
19.

"Crystal structures of peptide complexes of the amino-terminal SH2 domain of the Syp tyrosine phosphatase."
Lee C.-H. , Kominos D. , Jacques S. , Margolis B. , Schlessinger J. , Shoelson S.E. , Kuriyan J.
Structure2:423-438(1994) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: X-RAY CRYSTALLOGRAPHY (2.05 ANGSTROMS) OF 1005-1015 IN COMPLEX WITH PTPN11;INTERACTION WITH PTPN11

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