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Index > Protein center > Ptgs2(Gene name) > Rat
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  • Ptgs2 (Gene name),
  • Prostaglandin G/H synthase 2 (Protein name ),  PGH2_RAT from NCBI database.
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  • General Annotation
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  • Antigen Annotation
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  • 3D
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  • Predicted Eptitope
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  • Vaild Sequence
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  • Related Databases
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  • Citations  (6)
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  • Gene name:
    Ptgs2(Cox-2;Cox2);
    Protein name:
    Prostaglandin G/H synthase 2;
    Alternative:
    PHS II;Cyclooxygenase-2(COX-2);Prostaglandin-endoperoxide synthase 2;Prostaglandin H2 synthase 2(PGH synthase 2;PGHS-2);
    Organism:
    Rat (Rattus norvegicus). 
    General Annotation
    Sub Unit:
    Homodimer.
    Function:
    Mediates the formation of prostaglandins from arachidonate. May have a role as a major mediator of inflammation and/or a role for prostanoid signaling in activity-dependent plasticity.
    Subcellular Location:
    Microsome membrane Peripheral membrane protein Endoplasmic reticulum membrane Peripheral membrane protein
    Protein Attributes:
    Sequence length:
    604
    Sequence:
    50:
    MLFRAVLLCA | ALALSHAANP | CCSNPCQNRG | ECMSIGFDQY | KCDCTRTGFY | 
    100:
    GENCTTPEFL | TRIKLLLKPT | PNTVHYILTH | FKGVWNIVNN | IPFLRNSIMR | 
    150:
    YVLTSRSHLI | DSPPTYNVHY | GYKSWEAFSN | LSYYTRALPP | VADDCPTPMG | 
    200:
    VKGNKELPDS | KEVLEKVLLR | REFIPDPQGT | NMMFAFFAQH | FTHQFFKTDQ | 
    250:
    KRGPGFTRGL | GHGVDLNHVY | GETLDRQHKL | RLFQDGKLKY | QVIGGEVYPP | 
    300:
    TVKDTQVDMI | YPPHVPEHLR | FAVGQEVFGL | VPGLMMYATI | WLREHNRVCD | 
    350:
    ILKQEHPEWD | DERLFQTSRL | ILIGETIKIV | IEDYVQHLSG | YHFKLKFDPE | 
    400:
    LLFNQQFQYQ | NRIASEFNTL | YHWHPLLPDT | FNIEDQEYTF | KQFLYNNSIL | 
    450:
    LEHGLAHFVE | SFTRQIAGRV | AGGRNVPIAV | QAVAKASIDQ | SREMKYQSLN | 
    500:
    EYRKRFSLKP | YTSFEELTGE | KEMAAELKAL | YHDIDAMELY | PALLVEKPRP | 
    550:
    DAIFGETMVE | LGAPFSLKGL | MGNPICSPQY | WKPSTFGGEV | GFRIINTASI | 
    600:
    QSLICNNVKG | CPFASFNVQD | PQPTKTATIN | ASASHSRLDD | INPTVLIKRR | 
    604:
    STEL
    3D Structure:
    N/A
    Predicted Eptitope:
    Please Sign in.
    EIAab Sequence  Vaild Sequence:
    Please Sign in.
    Related Databases
    SMR:
    UniGene:
    KEGG:
    String:
    UniGene:
    Pfam:
    Uniprot:
     
    FOR
    ELISA Kit for Rat Prostaglandin G/H synthase 2
    Cat.:
    E0699h
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    MSDS:
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    Packing:
    96T
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    ELISA Kit for Rat Prostaglandin G/H synthase 2
    Cat.:
    E0699r
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    MSDS:
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    Packing:
    96T
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    ELISA Kit for Rat Prostaglandin G/H synthase 2
    MSDS:
    Please sign in first.
    ELISA Kit for Rat Prostaglandin G/H synthase 2
    Cat.:
    E0699b
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    MSDS:
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    Packing:
    96T
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    ELISA Kit for Rat Prostaglandin G/H synthase 2
    Cat.:
    E0699m
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    MSDS:
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    Packing:
    96T
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    ELISA Kit for Rat Prostaglandin G/H synthase 2
    MSDS:
    Please sign in first.
    CLIA Kit for Rat Prostaglandin G/H synthase 2
    Cat.:
    U0699b
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    CLIA Kit for Rat Prostaglandin G/H synthase 2
    Cat.:
    U0699m
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    Range:
    Please sign in first.
    CLIA Kit for Rat Prostaglandin G/H synthase 2
    Cat.:
    U0699c
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    CLIA Kit for Rat Prostaglandin G/H synthase 2
    MSDS:
    Please sign in first.
    CLIA Kit for Rat Prostaglandin G/H synthase 2
    Cat.:
    U0699r
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    Range:
    Please sign in first.
    CLIA Kit for Rat Prostaglandin G/H synthase 2
    Cat.:
    U0699h
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    Range:
    Please sign in first.
    Polyclonal Antibody for Rat Prostaglandin G/H synthase 2
    Polyclonal Antibody for Rat Prostaglandin G/H synthase 2
    Polyclonal Antibody for Rat Prostaglandin G/H synthase 2
    Polyclonal Antibody for Rat Prostaglandin G/H synthase 2
    Cat.:
    P0699Rb-h
    Price:
    Please sign in first.
    Packing:
    40ug/0.2ml
    Polyclonal Antibody for Rat Prostaglandin G/H synthase 2
    Cat.:
    P0699Rb-r
    Price:
    Please sign in first.
    Packing:
    40ug/0.2ml
    Polyclonal Antibody for Rat Prostaglandin G/H synthase 2
    Cat.:
    P0699Rb-m
    Price:
    Please sign in first.
    Packing:
    40ug/0.2ml
    Monoclonal Antibody for Rat Prostaglandin G/H synthase 2
    Monoclonal Antibody for Rat Prostaglandin G/H synthase 2
    Monoclonal Antibody for Rat Prostaglandin G/H synthase 2
    Monoclonal Antibody for Rat Prostaglandin G/H synthase 2
    Monoclonal Antibody for Rat Prostaglandin G/H synthase 2
    Monoclonal Antibody for Rat Prostaglandin G/H synthase 2
    Protein for Rat Prostaglandin G/H synthase 2
    Protein for Rat Prostaglandin G/H synthase 2
    Protein for Rat Prostaglandin G/H synthase 2
    Protein for Rat Prostaglandin G/H synthase 2
    Protein for Rat Prostaglandin G/H synthase 2
    Protein for Rat Prostaglandin G/H synthase 2

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    Linearity
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    References
    1. 1.
      "Cloning and expression of rat prostaglandin endoperoxide synthase (cyclooxygenase)-2 cDNA."
      Kennedy B.P. , Chan C.C. , Culp S.A. , Cromlish W.A.
      Biochem. Biophys. Res. Commun.197:494-500(1993) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA]
    2. 2.
      "Expression of a mitogen-inducible cyclooxygenase in brain neurons: regulation by synaptic activity and glucocorticoids."
      Yamagata K. , Andreasson K.I. , Kaufmann W.E. , Barnes C.A. , Worley P.F.
      Neuron11:371-386(1993) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA]
    3. 3.
      "Cloning and characterization of a growth factor-inducible cyclooxygenase gene from rat intestinal epithelial cells."
      Dubois R.N. , Tsujii M. , Bishop P. , Awad J.A. , Makita K. , Lanahan A.
      Am. J. Physiol.266:G822-G827(1994) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA]
      strain: Wistar.
      tissue: Intestine.
    4. 4.
      "Cloning two isoforms of rat cyclooxygenase: differential regulation of their expression."
      Feng L. , Sun W. , Xia Y. , Tang W.W. , Chanmugam P. , Soyoola E. , Wilson C.B. , Hwang D.
      Arch. Biochem. Biophys.307:361-368(1993) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA]
      strain: Fischer 344.
    5. 5.
      "Immediate-early MEK-1-dependent stabilization of rat smooth muscle cell cyclooxygenase-2 mRNA by Galpha(q)-coupled receptor signaling."
      Xu K. , Robida A.M. , Murphy T.J.
      J. Biol. Chem.275:23012-23019(2000) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA]
    6. 6.
      "Purification and characterization of a novel, distinct isoform of prostaglandin endoperoxide synthase induced by human chorionic gonadotropin in granulosa cells of rat preovulatory follicles."
      Sirois J. , Richards J.S.
      J. Biol. Chem.267:6382-6388(1992) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PROTEIN SEQUENCE OF 18-43
    7. 7.
      "Cyclooxygenases: structural, cellular, and molecular biology."
      Smith W.L. , DeWitt D.L. , Garavito R.M.
      Annu. Rev. Biochem.69:145-182(2000) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: REVIEW ON FUNCTION; TISSUE SPECIFICITY AND INHIBITION BY NSAIDS
    8. 8.
      "Aspirin, cyclooxygenase inhibition and colorectal cancer."
      Sostres C. , Gargallo C.J. , Lanas A.
      World J. Gastrointest. Pharmacol. Ther.5:40-49(2014) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: REVIEW ON FUNCTION; INHIBITION BY ASPIRIN AND INVOLVEMENT IN COLORECTAL CANCER
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