Pcbd1 ELISA Kit for Rat(Rattus norvegicus) | EIAab.comPcbd1 ELISA Kit for Rat(Rattus norvegicus)

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Index > Protein center > Pcbd1(Gene name) > Rat

Pcbd1 (Gene name),

Pterin-4-alpha-carbinolamine dehydratase (Protein name ), PHS_RAT from NCBI database.

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General Annotation

Antigen Annotation

Predicted Eptitope

Vaild Sequence

Related Databases

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Gene name:

Pcbd1(Dcoh;Pcbd);

Protein name:

Pterin-4-alpha-carbinolamine dehydratase(PHS);

Alternative:

Dimerization cofactor of hepatocyte nuclear factor 1-alpha(DCoH;Dimerization cofactor of HNF1);4-alpha-hydroxy-tetrahydropterin dehydratase;Pterin carbinolamine dehydratase(PCD);Phenylalanine hydroxylase-stimulating protein;

Organism:

Rat (Rattus norvegicus).

General Annotation

Sub Unit:

Homotetramer and homodimer. Heterotetramer with HNF1A; formed by a dimer of dimers.

Function:

Involved in tetrahydrobiopterin biosynthesis. Seems to both prevent the formation of 7-pterins and accelerate the formation of quinonoid-BH2. Coactivator for HNF1A-dependent transcription. Regulates the dimerization of homeodomain protein HNF1A and enhances its transcriptional activity.

Subcellular Location:

Cytoplasm Nucleus Cytoplasmic and/or nuclear.

Protein Attributes:

Sequence length:

104

Sequence:

50:

100:

104:

VSMT

3D Structure:

N/A

Predicted Eptitope:

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Vaild Sequence:

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Related Databases

SMR:

P61459

Pfam:

PF01329

UniGene:

Rn.81180

String:

P61459

KEGG:

rno:29700

Uniprot:

P61459

FOR

ELISA Kit for Rat PHS

CLIA Kit for Rat PHS

Polyclonal Antibody for Rat PHS

Monoclonal Antibody for Rat PHS

Protein for Rat PHS

R&D Technical Data

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Precision

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Recovery

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Linearity

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

References

1.

"Characterization of a cofactor that regulates dimerization of a mammalian homeodomain protein."
Mendel D.B. , Khavari P.A. , Conley P.B. , Graves M.K. , Hansen L.P. , Admon A. , Crabtree G.R.
Science254:1762-1767(1991) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA];PARTIAL PROTEIN SEQUENCE;FUNCTION;SUBUNIT
tissue: Liver.
2.

"Characterization of the chicken and rat DCoH gene domains using an improved ligation-mediated PCR method."
Bossow S. , Riepl S. , Igo-Kemenes T.
Biol. Chem.379:1359-1365(1998) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]
3.

"Phenylalanine hydroxylase-stimulating protein/pterin-4 alpha-carbinolamine dehydratase from rat and human liver. Purification, characterization, and complete amino acid sequence."
Hauer C.R. , Rebrin I. , Thoeny B. , Neuheiser F. , Curtius H.-C. , Hunziker P. , Blau N. , Ghisla S. , Heizmann C.W.
J. Biol. Chem.268:4828-4831(1993) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PROTEIN SEQUENCE OF 2-104;CLEAVAGE OF INITIATOR METHIONINE;ACETYLATION AT ALA-2;CATALYTIC ACTIVITY;FUNCTION;SUBUNIT;SUBCELLULAR LOCATION;IDENTIFICATION BY MASS SPECTROMETRY
tissue: Liver.
4.

"Identity of 4a-carbinolamine dehydratase, a component of the phenylalanine hydroxylation system, and DCoH, a transregulator of homeodomain proteins."
Citron B.A. , Davis M.D. , Milstien S. , Gutierrez J. , Mendel D.B. , Crabtree G.R. , Kaufman S.
Proc. Natl. Acad. Sci. U.S.A.89:11891-11894(1992) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 21-45;CATALYTIC ACTIVITY
strain: Sprague-Dawley.
tissue: Liver.
5.

"Three-dimensional structure of the bifunctional protein PCD/DCoH, a cytoplasmic enzyme interacting with transcription factor HNF1."
Ficner R. , Sauer U.H. , Stier G. , Suck D.
EMBO J.14:2034-2042(1995) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: X-RAY CRYSTALLOGRAPHY (2.7 ANGSTROMS);SUBUNIT
6.

"High-resolution structures of the bifunctional enzyme and transcriptional coactivator DCoH and its complex with a product analogue."
Cronk J.D. , Endrizzi J.A. , Alber T.
Protein Sci.5:1963-1972(1996) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: X-RAY CRYSTALLOGRAPHY (2.3 ANGSTROMS) IN COMPLEX WITH 7,8-DIHYDROBIOPTERIN;SUBUNIT
7.

"Structural basis of dimerization, coactivator recognition and MODY3 mutations in HNF-1alpha."
Rose R.B. , Bayle J.H. , Endrizzi J.A. , Cronk J.D. , Crabtree G.R. , Alber T.
Nat. Struct. Biol.7:744-748(2000) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: X-RAY CRYSTALLOGRAPHY (2.6 ANGSTROMS);INTERACTION WITH HNF1A;SUBUNIT

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