PHOX2B ELISA Kit for Human(Homo sapiens) | EIAab.comPHOX2B ELISA Kit for Human(Homo sapiens)

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Index > Protein center > PHOX2B(Gene name) > Human

PHOX2B (Gene name),

Paired mesoderm homeobox protein 2B (Protein name ), PHX2B_HUMAN from NCBI database.

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General Annotation

Antigen Annotation

Predicted Eptitope

Vaild Sequence

Related Databases

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Gene name:

PHOX2B(PMX2B);

Protein name:

Paired mesoderm homeobox protein 2B;

Alternative:

PHOX2B homeodomain protein;Neuroblastoma Phox(NBPhox);Paired-like homeobox 2B;

Organism:

Human (Homo sapiens).

General Annotation

Sub Unit:

Interacts with TRIM11.

Function:

Involved in the development of several major noradrenergic neuron populations, including the locus coeruleus. Transcription factor which could determine a neurotransmitter phenotype in vertebrates. Enhances second-messenger-mediated activation of the dopamine beta-hydrolase and c-fos promoters, and of several enhancers including cAMP-response element and serum-response element.

Subcellular Location:

Nucleus

Protein Attributes:

Sequence length:

314

Sequence:

50:

100:

150:

200:

250:

300:

314:

PNGAKAALVK | SSMF

3D Structure:

N/A

Predicted Eptitope:

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Vaild Sequence:

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Related Databases

MIM:

209880

SMR:

Q99453

KEGG:

hsa:8929

String:

Q99453

STRING:

9606.ENSP00000226382

UniGene:

Hs.87202

Pfam:

PF00046

Uniprot:

Q99453

FOR

ELISA Kit for Human Paired mesoderm homeobox protein 2B

CLIA Kit for Human Paired mesoderm homeobox protein 2B

Polyclonal Antibody for Human Paired mesoderm homeobox protein 2B

Monoclonal Antibody for Human Paired mesoderm homeobox protein 2B

Protein for Human Paired mesoderm homeobox protein 2B

R&D Technical Data

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Precision

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Recovery

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Linearity

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

References

1.

"Identification and cloning of neuroblastoma-specific and nerve tissue-specific genes through compiled expression profiles."
Yokoyama M. , Nishi Y. , Yoshii J. , Okubo K. , Matsubara K.
DNA Res.3:311-320(1996) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA]
tissue: Neuroblastoma.
2.

"Paired-like homeodomain proteins Phox2a/Arix and Phox2b/NBPhox have similar genetic organization and independently regulate dopamine beta-hydroxylase gene transcription."
Adachi M. , Browne D. , Lewis E.J.
DNA Cell Biol.19:539-554(2000) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]
3.

"Genomic structure and functional characterization of NBPhox (PMX2B), a homeodomain protein specific to catecholaminergic cells that is involved in second messenger-mediated transcriptional activation."
Yokoyama M. , Watanabe H. , Nakamura M.
Genomics59:40-50(1999) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]
4.

"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res.14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]
tissue: Brain.
5.

"Molecular analysis of congenital central hypoventilation syndrome."
Sasaki A. , Kanai M. , Kijima K. , Akaba K. , Hashimoto M. , Hasegawa H. , Otaki S. , Koizumi T. , Kusuda S. , Ogawa Y. , Tuchiya K. , Yamamoto W. , Nakamura T. , Hayasaka K.
Hum. Genet.114:22-26(2003) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANT CCHS ALA-ALA-ALA-ALA-ALA-ALA-ALA-ALA-ALA-ALA-241 INS;VARIANTS 254-ALA--ALA-258 DEL AND 255-ALA--ALA-259 DEL
6.

"Polyalanine expansion and frameshift mutations of the paired-like homeobox gene PHOX2B in congenital central hypoventilation syndrome."
Amiel J. , Laudier B. , Attie-Bitach T. , Trang H. , de Pontual L. , Gener B. , Trochet D. , Etchevers H. , Ray P. , Simonneau M. , Vekemans M. , Munnich A. , Gaultier C. , Lyonnet S.
Nat. Genet.33:459-461(2003) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INVOLVEMENT IN CCHS;TRIPLET REPEAT EXPANSION
7.

"Germline mutations of the paired-like homeobox 2B (PHOX2B) gene in neuroblastoma."
Trochet D. , Bourdeaut F. , Janoueix-Lerosey I. , Deville A. , de Pontual L. , Schleiermacher G. , Coze C. , Philip N. , Frebourg T. , Munnich A. , Lyonnet S. , Delattre O. , Amiel J.
Am. J. Hum. Genet.74:761-764(2004) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANTS LEU-100 AND GLY-141
8.

"PHOX2B genotype allows for prediction of tumor risk in congenital central hypoventilation syndrome."
Trochet D. , O'Brien L.M. , Gozal D. , Trang H. , Nordenskjoeld A. , Laudier B. , Svensson P.-J. , Uhrig S. , Cole T. , Niemann S. , Munnich A. , Gaultier C. , Lyonnet S. , Amiel J.
Am. J. Hum. Genet.76:421-426(2005) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANTS CCHS GLN-141 AND ARG-143;TRIPLET REPEAT EXPANSION
9.

Trochet D. , O'Brien L.M. , Gozal D. , Trang H. , Nordenskjoeld A. , Laudier B. , Svensson P.-J. , Uhrig S. , Cole T. , Niemann S. , Munnich A. , Gaultier C. , Lyonnet S. , Amiel J.
Am. J. Hum. Genet.76:715-715(2002)

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: ERRATUM
10.

"PHOX2B analysis in non-syndromic neuroblastoma cases shows novel mutations and genotype-phenotype associations."
McConville C. , Reid S. , Baskcomb L. , Douglas J. , Rahman N.
Am. J. Med. Genet. A140:1297-1301(2006) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANT ASP-197;NEUROBLASTOMA SUSCEPTIBILITY

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