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Index > Protein center > PIP4K2B(Gene name) > Human
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  • PIP4K2B (Gene name),
  • Phosphatidylinositol-5-phosphate 4-kinase type-2 beta (Protein name ),  PI42B_HUMAN from NCBI database.
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  • General Annotation
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  • Antigen Annotation
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  • Predicted Eptitope
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  • Vaild Sequence
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  • Gene name:
    PIP4K2B(PIP5K2B);
    Protein name:
    Phosphatidylinositol-5-phosphate 4-kinase type-2 beta;
    Alternative:
    Diphosphoinositide kinase 2-beta;1-phosphatidylinositol-5-phosphate 4-kinase 2-beta;PtdIns(5)P-4-kinase isoform 2-beta;Phosphatidylinositol-5-phosphate 4-kinase type II beta(PI(5)P 4-kinase type II beta;PIP4KII-beta);
    Organism:
    Human (Homo sapiens). 
    General Annotation
    Sub Unit:
    Homodimer. Binds TNFRSF1A.
    Function:
    Participates in the biosynthesis of phosphatidylinositol-4,5-bisphosphate.
    Subcellular Location:
    Endoplasmic reticulum membrane Peripheral membrane protein Cell membrane Peripheral membrane protein Associated with the plasma membrane and the endoplasmic reticulum.
    Protein Attributes:
    Sequence length:
    416
    Sequence:
    50:
    MSSNCTSTTA | VAVAPLSASK | TKTKKKHFVC | QKVKLFRASE | PILSVLMWGV | 
    100:
    NHTINELSNV | PVPVMLMPDD | FKAYSKIKVD | NHLFNKENLP | SRFKFKEYCP | 
    150:
    MVFRNLRERF | GIDDQDYQNS | VTRSAPINSD | SQGRCGTRFL | TTYDRRFVIK | 
    200:
    TVSSEDVAEM | HNILKKYHQF | IVECHGNTLL | PQFLGMYRLT | VDGVETYMVV | 
    250:
    TRNVFSHRLT | VHRKYDLKGS | TVAREASDKE | KAKDLPTFKD | NDFLNEGQKL | 
    300:
    HVGEESKKNF | LEKLKRDVEF | LAQLKIMDYS | LLVGIHDVDR | AEQEEMEVEE | 
    350:
    RAEDEECEND | GVGGNLLCSY | GTPPDSPGNL | LSFPRFFGPG | EFDPSVDVYA | 
    400:
    MKSHESSPKK | EVYFMAIIDI | LTPYDTKKKA | AHAAKTVKHG | AGAEISTVNP | 
    416:
    EQYSKRFNEF | MSNILT
    3D Structure:
    N/A
    Predicted Eptitope:
    Please Sign in.
    EIAab Sequence  Vaild Sequence:
    Please Sign in.
    Related Databases
    SMR:
    Pfam:
    MIM:
    KEGG:
    String:
    UniGene:
    Uniprot:
     
    FOR
    ELISA Kit for Human Phosphatidylinositol-5-phosphate 4-kinase type-2 beta
    ELISA Kit for Human Phosphatidylinositol-5-phosphate 4-kinase type-2 beta
    ELISA Kit for Human Phosphatidylinositol-5-phosphate 4-kinase type-2 beta
    CLIA Kit for Human Phosphatidylinositol-5-phosphate 4-kinase type-2 beta
    CLIA Kit for Human Phosphatidylinositol-5-phosphate 4-kinase type-2 beta
    CLIA Kit for Human Phosphatidylinositol-5-phosphate 4-kinase type-2 beta
    Polyclonal Antibody for Human Phosphatidylinositol-5-phosphate 4-kinase type-2 beta
    Polyclonal Antibody for Human Phosphatidylinositol-5-phosphate 4-kinase type-2 beta
    Polyclonal Antibody for Human Phosphatidylinositol-5-phosphate 4-kinase type-2 beta
    Monoclonal Antibody for Human Phosphatidylinositol-5-phosphate 4-kinase type-2 beta
    Monoclonal Antibody for Human Phosphatidylinositol-5-phosphate 4-kinase type-2 beta
    Monoclonal Antibody for Human Phosphatidylinositol-5-phosphate 4-kinase type-2 beta
    Protein for Human Phosphatidylinositol-5-phosphate 4-kinase type-2 beta
    Protein for Human Phosphatidylinositol-5-phosphate 4-kinase type-2 beta
    Protein for Human Phosphatidylinositol-5-phosphate 4-kinase type-2 beta

    R&D Technical Data
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    Precision
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    Recovery
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    Linearity
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    References
    1. 1.
      "A novel interaction between the juxtamembrane region of the p55 tumor necrosis factor receptor and phosphatidylinositol-4-phosphate 5-kinase."
      Castellino A.M. , Parker G.J. , Boronenkov I.V. , Anderson R.A. , Chao M.V.
      J. Biol. Chem.272:5861-5870(1997) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1);FUNCTION;INTERACTION WITH TNFRSF1A;TISSUE SPECIFICITY
      tissue: Fetal brain.
    2. 2.
      "Cloning of human full-length CDSs in BD Creator(TM) system donor vector."
      Kalnine N. , Chen X. , Rolfs A. , Halleck A. , Hines L. , Eisenstein S. , Koundinya M. , Raphael J. , Moreira D. , Kelley T. , LaBaer J. , Lin Y. , Phelan M. , Farmer A.
      Submitted (2004-10) to the EMBL/GenBank/DDBJ databases
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1)
    3. 3.
      "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res.14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2)
      tissue: Lung.
    4. 4.
      "Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle."
      Daub H. , Olsen J.V. , Bairlein M. , Gnad F. , Oppermann F.S. , Korner R. , Greff Z. , Keri G. , Stemmann O. , Mann M.
      Mol. Cell31:438-448(2008) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-326;IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
      tissue: Cervix carcinoma.
    5. 5.
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
      tissue: Cervix carcinoma.
    6. 6.
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-326;IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
    7. 7.
      "Lysine acetylation targets protein complexes and co-regulates major cellular functions."
      Choudhary C. , Kumar C. , Gnad F. , Nielsen M.L. , Rehman M. , Walther T.C. , Olsen J.V. , Mann M.
      Science325:834-840(2009) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT LYS-150;IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
    8. 8.
      "PIP4Kbeta interacts with and modulates nuclear localization of the high-activity PtdIns5P-4-kinase isoform PIP4Kalpha."
      Bultsma Y. , Keune W.-J. , Divecha N.
      Biochem. J.430:223-235(2010) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: BIOPHYSICOCHEMICAL PROPERTIES;INTERACTION WITH PIP4K2A;SUBCELLULAR LOCATION;UBIQUITINATION;IDENTIFICATION BY MASS SPECTROMETRY
    9. 9.
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
    10. 10.
      "Comparative large-scale characterisation of plant vs. mammal proteins reveals similar and idiosyncratic N-alpha acetylation features."
      Bienvenut W.V. , Sumpton D. , Martinez A. , Lilla S. , Espagne C. , Meinnel T. , Giglione C.
      Mol. Cell. Proteomics11:M111.015131-M111.015131(2012) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT SER-2;IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS];CLEAVAGE OF INITIATOR METHIONINE [LARGE SCALE ANALYSIS]
    11. 11.
      "Structure of type IIbeta phosphatidylinositol phosphate kinase: a protein kinase fold flattened for interfacial phosphorylation."
      Rao V.D. , Misra S. , Boronenkov I.V. , Anderson R.A. , Hurley J.H.
      Cell94:829-839(1998) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: X-RAY CRYSTALLOGRAPHY (3.0 ANGSTROMS) OF 34-416;HOMODIMERIZATION
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