Gene name:
Pip5k1a (Pip5k1b) ;
Protein name:
Phosphatidylinositol-4-phosphate 5-kinase type-1 alpha (PIP5K1-alpha;PtdIns(4)P-5-kinase 1 alpha) ;
Alternative:
Phosphatidylinositol-4-phosphate 5-kinase type I alpha (PIP5KIalpha) ;68 kDa type I phosphatidylinositol-4-phosphate 5-kinase ;Phosphatidylinositol-4-phosphate 5-kinase type I beta (PI4P5KIbeta) ;
Organism:
Mouse (Mus musculus).
General Annotation
Sub Unit:
Interacts with ARF1, RAC1, PLD1, PLD2 and JUB.
Function:
Participates in the biosynthesis of phosphatidylinositol-4,5-bisphosphate. Mediates RAC1-dependent reorganization of actin filaments. Acts as an activator of TUT1 adenylyltransferase activity in nuclear speckles, thereby regulating mRNA polyadenylation of a select set of mRNAs. Contributes to the activation of PLD2.
Subcellular Location:
Cell membrane
Golgi apparatus
Golgi stack
Nucleus speckle
Detected on RAC1-induced plasma membrane ruffles, and on membrane ruffles induced by platelet-derived growth factor (By similarity). Localizes to nuclear speckles and associates with TUT1 to regulate polyadenylation of selected mRNAs.
Protein Attributes:
50:
MASASSGPAA | AGFSSLDAGA | PAGTAAASGI | KRATVSEGPS | ASVMPVKKIG |
100:
HRSVDSSGET | TYKKTTSSAL | KGAIQLGITH | TVGSLSTKPE | RDVLMQDFYV |
150:
VESIFFPSEG | SNLTPAHHYN | DFRFKTYAPV | AFRYFRELFG | IRPDDYLYSL |
200:
CSEPLIELSN | SGASGSLFYV | SSDDEFIIKT | VQHKEAEFLQ | KLLPGYYMNL |
250:
NQNPRTLLPK | FYGLYCVQAG | GKNIRIVVMN | NLLPRSVKMH | MKYDLKGSTY |
300:
KRRASQKERE | KTLPTFKDLD | FLQDIPDGLF | LDADMYSALC | KTLQRDCLVL |
350:
QSFKIMDYSL | LMSIHNMDHA | QREPTSNDTQ | YSADTRRPAP | QKALYSTAME |
400:
SIQGEARRGG | TVETEDHMGG | IPARNNKGER | LLLYIGIIDI | LQSYRFVKKL |
450:
EHSWKALVHD | GDTVSVHRPG | FYAERFQRFM | CNTVFKKIPL | KPSPTKKFRS |
500:
GPSFSRRSGP | SGNSCTSQLM | ASGEHRAQVT | TKAEVEPDVH | LGRPDVLPQT |
546:
PPLEEISEGS | PVPGPSFSPV | VGQPLQILNL | SSTLEKLDVA | ESEFTH
Vaild Sequence:
Related Databases
Uniprot:
ELISA Kit
CLIA Kit
Polyclonal Antibody
Monoclonal Antibody
Protein
FOR
Rat
Human
Mouse
ELISA Kit for Mouse PIP5K1-alpha
ELISA Kit for Mouse PIP5K1-alpha
ELISA Kit for Mouse PIP5K1-alpha
CLIA Kit for Mouse PIP5K1-alpha
CLIA Kit for Mouse PIP5K1-alpha
CLIA Kit for Mouse PIP5K1-alpha
Polyclonal Antibody for Mouse PIP5K1-alpha
Polyclonal Antibody for Mouse PIP5K1-alpha
Polyclonal Antibody for Mouse PIP5K1-alpha
Monoclonal Antibody for Mouse PIP5K1-alpha
Monoclonal Antibody for Mouse PIP5K1-alpha
Monoclonal Antibody for Mouse PIP5K1-alpha
Protein for Mouse PIP5K1-alpha
Protein for Mouse PIP5K1-alpha
Protein for Mouse PIP5K1-alpha
R&D Technical Data
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Precision
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Recovery
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Linearity
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[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1);FUNCTION;ENZYME REGULATION;TISSUE SPECIFICITY
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[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 3)
strain :
C57BL/6J .
tissue :
Inner ear .
tissue :
Macrophage .
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[
PubMed ]
[
Europe PMC ]
[
Abstract ]
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
strain :
C57BL/6J .
4.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2)
tissue :
Eye .
tissue :
Mammary tumor .
5.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : ENZYME REGULATION;BIOPHYSICOCHEMICAL PROPERTIES
6.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : FUNCTION;INTERACTION WITH RAC1
7.
"Loss of PIP5KIbeta demonstrates that PIP5KI isoform-specific PIP2 synthesis is required for IP3 formation."
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Proc. Natl. Acad. Sci. U.S.A.105:14064-14069(2008)
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PubMed ]
[
Europe PMC ]
[
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[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : FUNCTION IN PLATELETS;DISRUPTION PHENOTYPE
8.
"Essential and unique roles of PIP5K-gamma and -alpha in Fcgamma receptor-mediated phagocytosis."
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J. Cell Biol.184:281-296(2009)
[
PubMed ]
[
Europe PMC ]
[
Abstract ]
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : FUNCTION IN PHAGOCYTOSIS;DISRUPTION PHENOTYPE
9.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : FUNCTION IN EMBRYOGENESIS;SUBCELLULAR LOCATION;TISSUE SPECIFICITY;DEVELOPMENTAL STAGE;DISRUPTION PHENOTYPE