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Index > Protein center > Piezo2(Gene name) > Mouse
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  • Piezo2 (Gene name),
  • Piezo-type mechanosensitive ion channel component 2 (Protein name ),  PIEZ2_MOUSE from NCBI database.
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  • Antigen Annotation
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  • Gene name:
    Piezo2(Fam38b);
    Protein name:
    Piezo-type mechanosensitive ion channel component 2;
    Alternative:
    Protein FAM38B;
    Organism:
    Mouse (Mus musculus). 
    General Annotation
    Sub Unit:
    N/A
    Function:
    Component of mechanosensitive channel required for rapidly adaptating mechanically activated (MA) currents in DRG neurons. Overexpression in multiple cell lines generates robust mechanosensitive cation currents that are non-selective, exhibit a linear current voltage relationship, and are sensitive to ruthenium red and gadolinium.
    Subcellular Location:
    Membrane Multi-pass membrane protein
    Protein Attributes:
    Sequence length:
    2822
    Sequence:
    50:
    MASEVVCGLI | FRLLLPICLA | VACAFRYNGL | SFVYLIYLLL | IPLFSEPTKA | 
    100:
    TMQGHTGRLL | QSLCITSLSF | LLLHIIFHIT | LASLEAQHRI | TPAYNCSTWE | 
    150:
    KTFRQIGFES | LKGADAGNGI | RVFVPDIGMF | IASLTIWLVC | RTIVKKPDTE | 
    200:
    EIAQLNSECE | NEELAGGEKM | DSEEALIYEE | DLDGEEGMEG | ELEESTKLKI | 
    250:
    LRRFASVASK | LKEFIGNMIT | TAGKVVVTIL | LGSSGMMLPS | LTSAVYFFVF | 
    300:
    LGLCTWWSWC | RTFDPLLFGC | LCVLLAIFTA | GHLIGLYLYQ | FQFFQEAVPP | 
    350:
    NDYYARLFGI | KSVIQTDCAS | TWKIIVNPDL | SWYHHANPIL | LLVMYYTLAT | 
    400:
    LIRIWLQEPL | VQEEMAKEDE | GALDCSSNQN | TAERRRSLWY | ATQYPTDERK | 
    450:
    LLSMTQDDYK | PSDGLLVTVN | GNPVDYHTIH | PSLPIENGPA | KTDLYTTPQY | 
    500:
    RWEPSEESSE | KKEEEEDKRE | DSEGEGSQEE | KRSVRMHAMV | AVFQFIMKQS | 
    550:
    YICALIAMMA | WSITYHSWLT | FVLLIWSCTL | WMIRNRRKYA | MISSPFMVVY | 
    600:
    ANLLLVLQYI | WSFELPEIKK | VPGFLEKKEP | GELASKILFT | ITFWLLLRQH | 
    650:
    LTEQKALREK | EALLSEVKIG | SQELEEKEDE | ELQDVQVEGE | PTEKEEEEEE | 
    700:
    EIKEERHEVK | KEEEEEVEED | DDQDIMKVLG | NLVVALFIKY | WIYVCGGMFF | 
    750:
    FVSFEGKIVM | YKIIYMVLFL | FCVALYQVHY | EWWRKILKYF | WMSVVIYTML | 
    800:
    VLIFIYTYQF | ENFPGLWQNM | TGLKKEKLED | LGLKQFTVAE | LFTRIFIPTS | 
    850:
    FLLVCILHLH | YFHDRFLELT | DLKSIPSKED | NTIYSHAKVN | GRVYLIINRL | 
    900:
    AHPEGSLPDL | AIMNMTASLD | KPEVQKLAES | GEERPEECVK | KTEKGEAGKD | 
    950:
    SDESEEEEDE | EEESEEEESS | DLRNKWHLVI | DRLTVLFLKF | LEYFHKLQVF | 
    1000:
    MWWILELHII | KIVSSYIIWV | TVKEVSLFNY | VFLISWAFAL | PYAKLRRAAS | 
    1050:
    SVCTVWTCVI | IVCKMLYQLQ | TIKPENFSVN | CSLPNENQTN | IPLHELNKSL | 
    1100:
    LYSAPVDPTE | WVGLRKSSPL | LVYLRNNLLM | LAILAFEVTV | YRHQEYYRGR | 
    1150:
    NNLTAPVSKT | IFHDITRLHL | DDGLINCAKY | FVNYFFYKFG | LETCFLMSVN | 
    1200:
    VIGQRMDFYA | MIHACWLIGV | LYRRRRKAIA | EVWPKYCCFL | ACIITFQYFV | 
    1250:
    CIGIPPAPCR | DYPWRFKGAY | FNDNIIKWLY | FPDFIVRPNP | VFLVYDFMLL | 
    1300:
    LCASLQRQIF | EDENKAAVRI | MAGDNVEICM | NLDAASFSQH | NPVPDFIHCR | 
    1350:
    SYLDMSKVII | FSYLFWFVLT | IIFITGTTRI | SIFCMGYLVA | CFYFLLFGGD | 
    1400:
    LLLKPIKSIL | RYWDWLIAYN | VFVITMKNIL | SIGACGYIGA | LVRNSCWLIQ | 
    1450:
    AFSLACTVKG | YQMPEDDSRC | KLPSGEAGII | WDSICFAFLL | LQRRVFMSYY | 
    1500:
    FLHVVADIKA | SQILASRGAE | LFQATIVKAV | KARIEEEKKS | MDQLKRQMDR | 
    1550:
    IKARQQKYKK | GKERMLSLTQ | ESGEGQDIQK | VSEEDDEREA | DKQKAKGKKK | 
    1600:
    QWWRPWVDHA | SMVRSGDYYL | FETDSEEEEE | EELKKEDEEP | PRKSAFQFVY | 
    1650:
    QAWITDPKTA | LRQRRKEKKK | LAREEQKERR | KGSGDGPVEW | EDREDEPVKK | 
    1700:
    KSDGPDNIIK | RIFNILKFTW | VLFLATVDSF | TTWLNSISRE | HIDISTVLRI | 
    1750:
    ERCMLTREIK | KGNVPTRESI | HMYYQNHIMN | LSRESGLDTI | DEHSGAGSRA | 
    1800:
    QAAHRMDSLD | SRDSISSCYT | EATLLISRQS | TLDDLDGQDP | VPKTSERARP | 
    1850:
    RLRKMFSLDM | SSSSADSGSV | ASSEPTQCTM | LYSRQGTTET | IEEVEAEAEE | 
    1900:
    EVVEGLEPEL | HDAEEKEYAA | EYEAGVEEIS | LTPDEELPQF | STDDCEAPPS | 
    1950:
    YSKAVSFEHL | SFASQDDSGA | KNHMVVSPDD | SRTDKLESSI | LPPLTHELTA | 
    2000:
    SDLLMSKMFH | DDELEESEKF | YVDQPRFLLL | FYAMYNTLVA | RSEMVCYFVI | 
    2050:
    ILNHMTSASI | ITLLLPILIF | LWAMLSVPRP | SRRFWMMAIV | YTEVAIVVKY | 
    2100:
    FFQFGFFPWN | KDLEIYKERP | YFPPNIIGVE | KKEGYVLYDL | IQLLALFFHR | 
    2150:
    SILKCHGLWD | EDDIVDSNTD | KEGSDDELSL | DQGRRGSSDS | LKSINLAASV | 
    2200:
    ESVHVTFPEQ | PAAIRRKRSC | SSSQISPRSS | FSSNRSKRGS | TSTRNSSQKG | 
    2250:
    SSVLSLKQKS | KRELYMEKLQ | EHLIKAKAFT | IKKTLQIYVP | IRQFFYDLIH | 
    2300:
    PDYSAVTDVY | VLMFLADTVD | FIIIVFGFWA | FGKHSAAADI | TSSLSEDQVP | 
    2350:
    GPFLVMVLIQ | FGTMVVDRAL | YLRKTVLGKV | IFQVILVFGI | HFWMFFILPG | 
    2400:
    VTERKFSQNL | VAQLWYFVKC | VYFGLSAYQI | RCGYPTRVLG | NFLTKSYNYV | 
    2450:
    NLFLFQGFRL | VPFLTELRAV | MDWVWTDTTL | SLSSWICVED | IYAHIFILKC | 
    2500:
    WRESEKRYPQ | PRGQKKKKAV | KYGMGGMIIV | LLICIVWFPL | LFMSLIKSVA | 
    2550:
    GVINQPLDVS | VTITLGGYQP | IFTMSAQQSQ | LKVMDNSKYN | EFLKSFGPNS | 
    2600:
    GAMQFLENYE | REDVTVAELE | GNSNSLWTIS | PPSKQKMIQE | LTDPNSCFSV | 
    2650:
    VFSWSIQRNM | TLGAKAEIAT | DKLSFPLAVA | TRNSIAKMIA | GNDTESSNTP | 
    2700:
    VTIEKIYPYY | VKAPSDSNSK | PIKQLLSENN | FMNITIILFR | DNVTKSNSEW | 
    2750:
    WVLNLTGSRI | FNQGSQALEL | VVFNDKVSPP | SLGFLAGYGI | MGLYASVVLV | 
    2800:
    IGKFVREFFS | GISHSIMFEE | LPNVDRILKL | CTDIFLVRET | GELELEEDLY | 
    2822:
    AKLIFLYRSP | ETMIKWTREK | TN
    3D Structure:
    N/A
    Predicted Eptitope:
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    EIAab Sequence  Vaild Sequence:
    Please Sign in.
    Related Databases
    Pfam:
    UniGene:
    Uniprot:
     
    FOR
    ELISA Kit for Mouse Piezo-type mechanosensitive ion channel component 2
    ELISA Kit for Mouse Piezo-type mechanosensitive ion channel component 2
    CLIA Kit for Mouse Piezo-type mechanosensitive ion channel component 2
    CLIA Kit for Mouse Piezo-type mechanosensitive ion channel component 2
    Polyclonal Antibody for Mouse Piezo-type mechanosensitive ion channel component 2
    Polyclonal Antibody for Mouse Piezo-type mechanosensitive ion channel component 2
    Monoclonal Antibody for Mouse Piezo-type mechanosensitive ion channel component 2
    Monoclonal Antibody for Mouse Piezo-type mechanosensitive ion channel component 2
    Protein for Mouse Piezo-type mechanosensitive ion channel component 2
    Protein for Mouse Piezo-type mechanosensitive ion channel component 2

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    Precision
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    Recovery
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    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
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    Linearity
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    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
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    References
    1. 1.
      "Piezo1 and Piezo2 are essential components of distinct mechanically activated cation channels."
      Coste B. , Mathur J. , Schmidt M. , Earley T.J. , Ranade S. , Petrus M.J. , Dubin A.E. , Patapoutian A.
      Science330:55-60(2010) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA];FUNCTION;TISSUE SPECIFICITY
      strain: C57BL/6J.
    2. 2.
      "The transcriptional landscape of the mammalian genome."
      Carninci P. , Kasukawa T. , Katayama S. , Gough J. , Frith M.C. , Maeda N. , Oyama R. , Ravasi T. , Lenhard B. , Wells C. , Kodzius R. , Shimokawa K. , Bajic V.B. , Brenner S.E. , Batalov S. , Forrest A.R. , Zavolan M. , Davis M.J. , more...
      Science309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 109-2822 (ISOFORM 3);NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 2049-2822 (ISOFORM 2);NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 2142-2822 (ISOFORM 1)
      strain: C57BL/6J.
      tissue: Colon.
      tissue: Forelimb.
      tissue: Testis.
    3. 3.
      "Piezo proteins are pore-forming subunits of mechanically activated channels."
      Coste B. , Xiao B. , Santos J.S. , Syeda R. , Grandl J. , Spencer K.S. , Kim S.E. , Schmidt M. , Mathur J. , Dubin A.E. , Montal M. , Patapoutian A.
      Nature483:176-181(2012) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;HOMOOLIGOMERIZATION
    4. 4.
      "Tuning Piezo ion channels to detect molecular-scale movements relevant for fine touch."
      Poole K. , Herget R. , Lapatsina L. , Ngo H.D. , Lewin G.R.
      Nat. Commun.5:3520-3520(2014) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH STOML3
    5. 5.
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: TISSUE SPECIFICITY;FUNCTION
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