Gene name:
Piezo2(Fam38b);
Protein name:
Piezo-type mechanosensitive ion channel component 2;
Alternative:
Protein FAM38B;
Organism:
Mouse (Mus musculus).
General Annotation
Function:
Component of mechanosensitive channel required for rapidly adaptating mechanically activated (MA) currents in DRG neurons. Overexpression in multiple cell lines generates robust mechanosensitive cation currents that are non-selective, exhibit a linear current voltage relationship, and are sensitive to ruthenium red and gadolinium.
Subcellular Location:
Membrane
Multi-pass membrane protein
Protein Attributes:
50:
MASEVVCGLI | FRLLLPICLA | VACAFRYNGL | SFVYLIYLLL | IPLFSEPTKA |
100:
TMQGHTGRLL | QSLCITSLSF | LLLHIIFHIT | LASLEAQHRI | TPAYNCSTWE |
150:
KTFRQIGFES | LKGADAGNGI | RVFVPDIGMF | IASLTIWLVC | RTIVKKPDTE |
200:
EIAQLNSECE | NEELAGGEKM | DSEEALIYEE | DLDGEEGMEG | ELEESTKLKI |
250:
LRRFASVASK | LKEFIGNMIT | TAGKVVVTIL | LGSSGMMLPS | LTSAVYFFVF |
300:
LGLCTWWSWC | RTFDPLLFGC | LCVLLAIFTA | GHLIGLYLYQ | FQFFQEAVPP |
350:
NDYYARLFGI | KSVIQTDCAS | TWKIIVNPDL | SWYHHANPIL | LLVMYYTLAT |
400:
LIRIWLQEPL | VQEEMAKEDE | GALDCSSNQN | TAERRRSLWY | ATQYPTDERK |
450:
LLSMTQDDYK | PSDGLLVTVN | GNPVDYHTIH | PSLPIENGPA | KTDLYTTPQY |
500:
RWEPSEESSE | KKEEEEDKRE | DSEGEGSQEE | KRSVRMHAMV | AVFQFIMKQS |
550:
YICALIAMMA | WSITYHSWLT | FVLLIWSCTL | WMIRNRRKYA | MISSPFMVVY |
600:
ANLLLVLQYI | WSFELPEIKK | VPGFLEKKEP | GELASKILFT | ITFWLLLRQH |
650:
LTEQKALREK | EALLSEVKIG | SQELEEKEDE | ELQDVQVEGE | PTEKEEEEEE |
700:
EIKEERHEVK | KEEEEEVEED | DDQDIMKVLG | NLVVALFIKY | WIYVCGGMFF |
750:
FVSFEGKIVM | YKIIYMVLFL | FCVALYQVHY | EWWRKILKYF | WMSVVIYTML |
800:
VLIFIYTYQF | ENFPGLWQNM | TGLKKEKLED | LGLKQFTVAE | LFTRIFIPTS |
850:
FLLVCILHLH | YFHDRFLELT | DLKSIPSKED | NTIYSHAKVN | GRVYLIINRL |
900:
AHPEGSLPDL | AIMNMTASLD | KPEVQKLAES | GEERPEECVK | KTEKGEAGKD |
950:
SDESEEEEDE | EEESEEEESS | DLRNKWHLVI | DRLTVLFLKF | LEYFHKLQVF |
1000:
MWWILELHII | KIVSSYIIWV | TVKEVSLFNY | VFLISWAFAL | PYAKLRRAAS |
1050:
SVCTVWTCVI | IVCKMLYQLQ | TIKPENFSVN | CSLPNENQTN | IPLHELNKSL |
1100:
LYSAPVDPTE | WVGLRKSSPL | LVYLRNNLLM | LAILAFEVTV | YRHQEYYRGR |
1150:
NNLTAPVSKT | IFHDITRLHL | DDGLINCAKY | FVNYFFYKFG | LETCFLMSVN |
1200:
VIGQRMDFYA | MIHACWLIGV | LYRRRRKAIA | EVWPKYCCFL | ACIITFQYFV |
1250:
CIGIPPAPCR | DYPWRFKGAY | FNDNIIKWLY | FPDFIVRPNP | VFLVYDFMLL |
1300:
LCASLQRQIF | EDENKAAVRI | MAGDNVEICM | NLDAASFSQH | NPVPDFIHCR |
1350:
SYLDMSKVII | FSYLFWFVLT | IIFITGTTRI | SIFCMGYLVA | CFYFLLFGGD |
1400:
LLLKPIKSIL | RYWDWLIAYN | VFVITMKNIL | SIGACGYIGA | LVRNSCWLIQ |
1450:
AFSLACTVKG | YQMPEDDSRC | KLPSGEAGII | WDSICFAFLL | LQRRVFMSYY |
1500:
FLHVVADIKA | SQILASRGAE | LFQATIVKAV | KARIEEEKKS | MDQLKRQMDR |
1550:
IKARQQKYKK | GKERMLSLTQ | ESGEGQDIQK | VSEEDDEREA | DKQKAKGKKK |
1600:
QWWRPWVDHA | SMVRSGDYYL | FETDSEEEEE | EELKKEDEEP | PRKSAFQFVY |
1650:
QAWITDPKTA | LRQRRKEKKK | LAREEQKERR | KGSGDGPVEW | EDREDEPVKK |
1700:
KSDGPDNIIK | RIFNILKFTW | VLFLATVDSF | TTWLNSISRE | HIDISTVLRI |
1750:
ERCMLTREIK | KGNVPTRESI | HMYYQNHIMN | LSRESGLDTI | DEHSGAGSRA |
1800:
QAAHRMDSLD | SRDSISSCYT | EATLLISRQS | TLDDLDGQDP | VPKTSERARP |
1850:
RLRKMFSLDM | SSSSADSGSV | ASSEPTQCTM | LYSRQGTTET | IEEVEAEAEE |
1900:
EVVEGLEPEL | HDAEEKEYAA | EYEAGVEEIS | LTPDEELPQF | STDDCEAPPS |
1950:
YSKAVSFEHL | SFASQDDSGA | KNHMVVSPDD | SRTDKLESSI | LPPLTHELTA |
2000:
SDLLMSKMFH | DDELEESEKF | YVDQPRFLLL | FYAMYNTLVA | RSEMVCYFVI |
2050:
ILNHMTSASI | ITLLLPILIF | LWAMLSVPRP | SRRFWMMAIV | YTEVAIVVKY |
2100:
FFQFGFFPWN | KDLEIYKERP | YFPPNIIGVE | KKEGYVLYDL | IQLLALFFHR |
2150:
SILKCHGLWD | EDDIVDSNTD | KEGSDDELSL | DQGRRGSSDS | LKSINLAASV |
2200:
ESVHVTFPEQ | PAAIRRKRSC | SSSQISPRSS | FSSNRSKRGS | TSTRNSSQKG |
2250:
SSVLSLKQKS | KRELYMEKLQ | EHLIKAKAFT | IKKTLQIYVP | IRQFFYDLIH |
2300:
PDYSAVTDVY | VLMFLADTVD | FIIIVFGFWA | FGKHSAAADI | TSSLSEDQVP |
2350:
GPFLVMVLIQ | FGTMVVDRAL | YLRKTVLGKV | IFQVILVFGI | HFWMFFILPG |
2400:
VTERKFSQNL | VAQLWYFVKC | VYFGLSAYQI | RCGYPTRVLG | NFLTKSYNYV |
2450:
NLFLFQGFRL | VPFLTELRAV | MDWVWTDTTL | SLSSWICVED | IYAHIFILKC |
2500:
WRESEKRYPQ | PRGQKKKKAV | KYGMGGMIIV | LLICIVWFPL | LFMSLIKSVA |
2550:
GVINQPLDVS | VTITLGGYQP | IFTMSAQQSQ | LKVMDNSKYN | EFLKSFGPNS |
2600:
GAMQFLENYE | REDVTVAELE | GNSNSLWTIS | PPSKQKMIQE | LTDPNSCFSV |
2650:
VFSWSIQRNM | TLGAKAEIAT | DKLSFPLAVA | TRNSIAKMIA | GNDTESSNTP |
2700:
VTIEKIYPYY | VKAPSDSNSK | PIKQLLSENN | FMNITIILFR | DNVTKSNSEW |
2750:
WVLNLTGSRI | FNQGSQALEL | VVFNDKVSPP | SLGFLAGYGI | MGLYASVVLV |
2800:
IGKFVREFFS | GISHSIMFEE | LPNVDRILKL | CTDIFLVRET | GELELEEDLY |
2822:
AKLIFLYRSP | ETMIKWTREK | TN

Vaild Sequence:
Related Databases
Uniprot: