Protein name:
Serine/threonine-protein kinase PINK1, mitochondrial ;
Alternative:
PTEN-induced putative kinase protein 1 ;BRPK ;
Organism:
Mouse (Mus musculus).
General Annotation
Sub Unit:
Interats with PARK2.
Function:
Protects against mitochondrial dysfunction during cellular stress, potentially by phosphorylating mitochondrial proteins (By similarity). Involved in the clearance of damaged mitochondria via selective autophagy (mitophagy) (By similarity). It is necessary for PARK2 recruitement to dysfunctional mitochondria to initiate their degradation.
Subcellular Location:
Mitochondrion outer membrane
Single-pass membrane protein
Cytoplasm
cytosol
Protein Attributes:
50:
MAVRQALGRG | LQLGRALLLR | FAPKPGPLFG | WGKPGPAAAW | GRGERPGQVV |
100:
SPGAQPRPVG | LPLPDRYRFF | RQSVAGLAAR | IQRQFMVRAR | GGAGPCGRAV |
150:
FLAFGLGLGL | IEEKQAEGRR | AASACQEIQA | IFTQKTKRVS | DPLDTRCWQG |
200:
FRLEDYLIGQ | AIGKGCNAAV | YEATMPTLPQ | HLEKAKHLGL | IGKGPDVVLK |
250:
GADGEQAPGT | PTFPFAIKMM | WNISAGSSSE | AILSKMSQEL | VPASRVALAG |
300:
EYGAVTYRRS | RDGPKQLAPH | PNIIRVFRAF | TSSVPLLPGA | LADYPDMLPP |
350:
HYYPEGLGHG | RTLFLVMKNY | PCTLRQYLEE | QTPSSRLATM | MTLQLLEGVD |
400:
HLVQQGIAHR | DLKSDNILVE | WDSDGCPWLV | ISDFGCCLAD | QHVGLRLPFN |
450:
SSSVERGGNG | SLMAPEVSTA | HSGPSAVIDY | SKADTWAVGA | IAYEIFGLAN |
500:
PFYGQGSAHL | ESRSYQEAQL | PEMPESVPPE | ARRLVRSLLQ | REASKRPSAR |
550:
LAANVLHLSL | WGEHLLALKN | LKLDKMIAWL | LQQSAATLLA | DRLREKSCVE |
580:
TKLQMLFLAN | LECEALCQAA | LLLSSWRAAP |
Vaild Sequence:
Related Databases
Uniprot:
ELISA Kit
CLIA Kit
Polyclonal Antibody
Monoclonal Antibody
Protein
FOR
Human
Mouse
ELISA Kit for Mouse Serine/threonine-protein kinase PINK1, mitochondrial
ELISA Kit for Mouse Serine/threonine-protein kinase PINK1, mitochondrial
CLIA Kit for Mouse Serine/threonine-protein kinase PINK1, mitochondrial
CLIA Kit for Mouse Serine/threonine-protein kinase PINK1, mitochondrial
Polyclonal Antibody for Mouse Serine/threonine-protein kinase PINK1, mitochondrial
Polyclonal Antibody for Mouse Serine/threonine-protein kinase PINK1, mitochondrial
Monoclonal Antibody for Mouse Serine/threonine-protein kinase PINK1, mitochondrial
Monoclonal Antibody for Mouse Serine/threonine-protein kinase PINK1, mitochondrial
Protein for Mouse Serine/threonine-protein kinase PINK1, mitochondrial
Protein for Mouse Serine/threonine-protein kinase PINK1, mitochondrial
R&D Technical Data
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Precision
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Recovery
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For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
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Linearity
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For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
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References
1.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [MRNA]
strain :
C57BL/6J .
tissue :
Lung .
2.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [MRNA];TISSUE SPECIFICITY
strain :
ICR .
tissue :
Testis .
3.
"Lineage-specific biology revealed by a finished genome assembly of the mouse."
Church D.M.
,
Goodstadt L.
,
Hillier L.W.
,
Zody M.C.
,
Goldstein S.
,
She X.
,
Bult C.J.
,
Agarwala R.
,
Cherry J.L.
,
DiCuccio M.
,
Hlavina W.
,
Kapustin Y.
,
Meric P.
,
Maglott D.
,
Birtle Z.
,
Marques A.C.
,
Graves T.
,
Zhou S.
,
Teague B.
,
Potamousis K.
,
Churas C.
,
Place M.
,
Herschleb J.
,
Runnheim R.
,
Forrest D.
,
Amos-Landgraf J.
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Schwartz D.C.
,
Cheng Z.
,
Lindblad-Toh K.
,
Eichler E.E.
,
Ponting C.P.
more...
PLoS Biol.7:E1000112-E1000112(2009)
[
PubMed ]
[
Europe PMC ]
[
Abstract ]
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
strain :
C57BL/6J .
4.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]
strain :
C57BL/6 .
strain :
Czech II .
tissue :
Eye .
tissue :
Mammary gland .
5.
"Ubiquitin is phosphorylated by PINK1 to activate parkin."
Koyano F.
,
Okatsu K.
,
Kosako H.
,
Tamura Y.
,
Go E.
,
Kimura M.
,
Kimura Y.
,
Tsuchiya H.
,
Yoshihara H.
,
Hirokawa T.
,
Endo T.
,
Fon E.A.
,
Trempe J.F.
,
Saeki Y.
,
Tanaka K.
,
Matsuda N.
Nature510:162-166(2014)
[
PubMed ]
[
Europe PMC ]
[
Abstract ]
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : FUNCTION