PIR ELISA Kit for Human(Homo sapiens) | EIAab.comPIR ELISA Kit for Human(Homo sapiens)

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Index > Protein center > PIR(Gene name) > Human

PIR (Gene name),

Pirin (Protein name ), PIR_HUMAN from NCBI database.

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General Annotation

Antigen Annotation

Predicted Eptitope

Vaild Sequence

Related Databases

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Gene name:

PIR;

Protein name:

Pirin;

Alternative:

Probable quercetin 2,3-dioxygenase PIR(Probable quercetinase);

Organism:

Human (Homo sapiens).

General Annotation

Sub Unit:

May interact with NF1/CTF1. Interacts with BCL3. Identified in a complex comprised of PIR, BLC3, NFKB1 and target DNA.

Function:

Possible transcriptional coregulator. May contribute to the regulation of cellular processes via its interaction with BCL3. May be required for efficient terminal myeloid maturation of hematopoietic cells. May play a role in the regulation of cell migration. May promote apoptosis when overexpressed. Has quercetin 2,3-dioxygenase activity (in vitro).

Subcellular Location:

Nucleus Cytoplasm Predominantly localized in dot-like subnuclear structures. Cytoplasmic localization of PIR seems to positively correlate with melanoma progression.

Protein Attributes:

Sequence length:

290

Sequence:

50:

100:

150:

200:

250:

290:

IQHGPFVMNT | NEEISQAILD | FRNAKNGFER | AKTWKSKIGN |

3D Structure:

N/A

Predicted Eptitope:

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Vaild Sequence:

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Related Databases

String:

O00625

KEGG:

hsa:8544

UniGene:

Hs.495728

MIM:

603329

Pfam:

PF02678

SMR:

O00625

STRING:

9606.ENSP00000369785

Uniprot:

O00625

FOR

ELISA Kit for Human Pirin

CLIA Kit for Human Pirin

Polyclonal Antibody for Human Pirin

Monoclonal Antibody for Human Pirin

Protein for Human Pirin

R&D Technical Data

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Precision

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Recovery

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Linearity

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

References

1.

"Identification of pirin, a novel highly conserved nuclear protein."
Wendler W.M.F. , Kremmer E. , Foerster R. , Winnacker E.-L.
J. Biol. Chem.272:8482-8489(1997) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA];PROPOSED FUNCTION;SUBUNIT;SUBCELLULAR LOCATION;TISSUE SPECIFICITY
tissue: Cervix carcinoma.
2.

"Cloning of human full open reading frames in Gateway(TM) system entry vector (pDONR201)."
Ebert L. , Schick M. , Neubert P. , Schatten R. , Henze S. , Korn B.
Submitted (2004-06) to the EMBL/GenBank/DDBJ databases

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]
3.

"Cloning of human full-length CDSs in BD Creator(TM) system donor vector."
Kalnine N. , Chen X. , Rolfs A. , Halleck A. , Hines L. , Eisenstein S. , Koundinya M. , Raphael J. , Moreira D. , Kelley T. , LaBaer J. , Lin Y. , Phelan M. , Farmer A.
Submitted (2004-10) to the EMBL/GenBank/DDBJ databases

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]
4.

"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res.14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]
tissue: Placenta.
5.

"The Bcl-3 oncoprotein acts as a bridging factor between NF-kappaB/Rel and nuclear co-regulators."
Dechend R. , Hirano F. , Lehmann K. , Heissmeyer V. , Ansieau S. , Wulczyn F.G. , Scheidereit C. , Leutz A.
Oncogene18:3316-3323(1999) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH BCL3;IDENTIFICATION IN A COMPLEX WITH BLC3; NFKB1; PIR AND TARGET DNA
6.

"Structural and biochemical analysis reveal pirins to possess quercetinase activity."
Adams M. , Jia Z.
J. Biol. Chem.280:28675-28682(2005) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: CATALYTIC ACTIVITY;ENZYME REGULATION
7.

"Upregulation of pirin expression by chronic cigarette smoking is associated with bronchial epithelial cell apoptosis."
Gelbman B.D. , Heguy A. , O'Connor T.P. , Zabner J. , Crystal R.G.
Respir. Res.8:10-10(2007) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;INDUCTION
8.

"Pirin delocalization in melanoma progression identified by high content immuno-detection based approaches."
Licciulli S. , Luise C. , Zanardi A. , Giorgetti L. , Viale G. , Lanfrancone L. , Carbone R. , Alcalay M.
BMC Cell Biol.11:5-5(2010) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: SUBCELLULAR LOCATION;TISSUE SPECIFICITY
9.

"Sex-specific effect of Pirin gene on bone mineral density in a cohort of 4000 Chinese."
Tang N.L. , Liao C.D. , Ching J.K. , Suen E.W. , Chan I.H. , Orwoll E. , Ho S.C. , Chan F.W. , Kwok A.W. , Kwok T. , Woo J. , Leung P.C.
Bone46:543-550(2010) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: POSSIBLE INFLUENCE OF PIR POLYMORPHISMS ON BONE MINERAL DENSITY
10.

"Pirin downregulation is a feature of AML and leads to impairment of terminal myeloid differentiation."
Licciulli S. , Cambiaghi V. , Scafetta G. , Gruszka A.M. , Alcalay M.
Leukemia24:429-437(2010) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;INDUCTION
11.

"Initial characterization of the human central proteome."
Burkard T.R. , Planyavsky M. , Kaupe I. , Breitwieser F.P. , Buerckstuemmer T. , Bennett K.L. , Superti-Furga G. , Colinge J.
BMC Syst. Biol.5:17-17(2011) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
12.

"N-terminal acetylome analyses and functional insights of the N-terminal acetyltransferase NatB."
Van Damme P. , Lasa M. , Polevoda B. , Gazquez C. , Elosegui-Artola A. , Kim D.S. , De Juan-Pardo E. , Demeyer K. , Hole K. , Larrea E. , Timmerman E. , Prieto J. , Arnesen T. , Sherman F. , Gevaert K. , Aldabe R.
Proc. Natl. Acad. Sci. U.S.A.109:12449-12454(2012) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
13.

"Crystal structure of human pirin: an iron-binding nuclear protein and transcription cofactor."
Pang H. , Bartlam M. , Zeng Q. , Miyatake H. , Hisano T. , Miki K. , Wong L.L. , Gao G.F. , Rao Z.
J. Biol. Chem.279:1491-1498(2004) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: X-RAY CRYSTALLOGRAPHY (2.1 ANGSTROMS) IN COMPLEX WITH IRON IONS;COFACTOR
14.

"A small-molecule inhibitor shows that pirin regulates migration of melanoma cells."
Miyazaki I. , Simizu S. , Okumura H. , Takagi S. , Osada H.
Nat. Chem. Biol.6:667-673(2010) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: X-RAY CRYSTALLOGRAPHY (2.35 ANGSTROMS) IN COMPLEX WITH A SYNTHETIC INHIBITOR AND IRON IONS;INTERACTION WITH BCL3;COFACTOR;FUNCTION
15.

"Pirin is an iron-dependent redox regulator of NF-kappaB."
Liu F. , Rehmani I. , Esaki S. , Fu R. , Chen L. , de Serrano V. , Liu A.
Proc. Natl. Acad. Sci. U.S.A.110:9722-9727(2013) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: X-RAY CRYSTALLOGRAPHY (1.56 ANGSTROMS);FUNCTION

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