Gene name:
PJA2 (KIAA0438;RNF131) ;
Protein name:
E3 ubiquitin-protein ligase Praja-2 (Praja2) ;
Alternative:
RING finger protein 131 ;
Organism:
Human (Homo sapiens).
General Annotation
Sub Unit:
Binds ubiquitin-conjugating enzymes (E2s). In vitro, interacts with the ubiquitin-conjugating enzyme, UBE2D2. The phosphorylated form interacts with PRKAR1A, PRKAR2A and PRKAR2B. Binds the catalytic subunits of cAMP-dependent protein kinase.
Function:
Has E2-dependent E3 ubiquitin-protein ligase activity. Responsible for ubiquitination of cAMP-dependent protein kinase type I and type II-alpha/beta regulatory subunits and for targeting them for proteasomal degradation. Essential for PKA-mediated long-term memory processes.
Subcellular Location:
Cytoplasm
Cell membrane
Endoplasmic reticulum membrane
Peripheral membrane protein
Golgi apparatus membrane
Peripheral membrane protein
Cell junction
synapse
Cell junction
synapse
postsynaptic cell membrane
postsynaptic density
Localizes at the cytoplasmic side of endoplasmic reticulum and Golgi apparatus. Expressed in the postsynaptic density region of synapses (By similarity). Co-localizes with PRKAR2A and PRKAR2B in the cytoplasm and the cell membrane.
Protein Attributes:
50:
MSQYTEKEPA | AMDQESGKAV | WPKPAGGYQT | ITGRRYGRRH | AYVSFKPCMT |
100:
RHERSLGRAG | DDYEVLELDD | VPKENSSGSS | PLDQVDSSLP | SEPIFEKSET |
150:
EIPTCGSALN | QTTESSQSFV | AVHHSEEGRD | TLGSSTNLHN | HSEGEYIPGA |
200:
CSASSVQNGI | ALVHTDSYDP | DGKHGEDNDH | LQLSAEVVEG | SRYQESLGNT |
250:
VFELENREAE | AYTGLSPPVP | SFNCEVRDEF | EELDSVPLVK | SSAGDTEFVH |
300:
QNSQEIQRSS | QDEMVSTKQQ | NNTSQERQTE | HSPEDAACGP | GHICSEQNTN |
350:
DREKNHGSSP | EQVVRPKVRK | LISSSQVDQE | TGFNRHEAKQ | RSVQRWREAL |
400:
EVEESGSDDL | LIKCEEYDGE | HDCMFLDPPY | SRVITQRETE | NNQMTSESGA |
450:
TAGRQEVDNT | FWNGCGDYYQ | LYDKDEDSSE | CSDGEWSASL | PHRFSGTEKD |
500:
QSSSDESWET | LPGKDENEPE | LQSDSSGPEE | ENQELSLQEG | EQTSLEEGEI |
550:
PWLQYNEVNE | SSSDEGNEPA | NEFAQPAFML | DGNNNLEDDS | SVSEDLDVDW |
600:
SLFDGFADGL | GVAEAISYVD | PQFLTYMALE | ERLAQAMETA | LAHLESLAVD |
650:
VEVANPPASK | ESIDGLPETL | VLEDHTAIGQ | EQCCPICCSE | YIKDDIATEL |
700:
PCHHFFHKPC | VSIWLQKSGT | CPVCRRHFPP | AVIEASAAPS | SEPDPDAPPS |
Vaild Sequence:
Related Databases
Uniprot:
ELISA Kit
CLIA Kit
Polyclonal Antibody
Monoclonal Antibody
Protein
FOR
Mouse
Rat
Human
ELISA Kit for Human Praja2
ELISA Kit for Human Praja2
ELISA Kit for Human Praja2
CLIA Kit for Human Praja2
CLIA Kit for Human Praja2
CLIA Kit for Human Praja2
Polyclonal Antibody for Human Praja2
Polyclonal Antibody for Human Praja2
Polyclonal Antibody for Human Praja2
Monoclonal Antibody for Human Praja2
Monoclonal Antibody for Human Praja2
Monoclonal Antibody for Human Praja2
R&D Technical Data
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Precision
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Recovery
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Linearity
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[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1);VARIANT ARG-297
tissue :
Brain .
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[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : SEQUENCE REVISION
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[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
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[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1);VARIANT ARG-297
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Brain .
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[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
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[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
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[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
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[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
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Cervix carcinoma .
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[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
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[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : FUNCTION;SUBCELLULAR LOCATION;INTERACTION WITH PRKAR1A; PRKAR2A AND PRKAR2B;PHOSPHORYLATION AT SER-342 AND THR-389
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[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-309;IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]