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Index > Protein center > PJA2(Gene name) > Human
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  • PJA2 (Gene name),
  • E3 ubiquitin-protein ligase Praja-2 (Protein name ),  PJA2_HUMAN from NCBI database.
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  • General Annotation
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  • Antigen Annotation
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  • Vaild Sequence
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  • Gene name:
    PJA2(KIAA0438;RNF131);
    Protein name:
    E3 ubiquitin-protein ligase Praja-2(Praja2);
    Alternative:
    RING finger protein 131;
    Organism:
    Human (Homo sapiens). 
    General Annotation
    Sub Unit:
    Binds ubiquitin-conjugating enzymes (E2s). In vitro, interacts with the ubiquitin-conjugating enzyme, UBE2D2. The phosphorylated form interacts with PRKAR1A, PRKAR2A and PRKAR2B. Binds the catalytic subunits of cAMP-dependent protein kinase.
    Function:
    Has E2-dependent E3 ubiquitin-protein ligase activity. Responsible for ubiquitination of cAMP-dependent protein kinase type I and type II-alpha/beta regulatory subunits and for targeting them for proteasomal degradation. Essential for PKA-mediated long-term memory processes.
    Subcellular Location:
    Cytoplasm Cell membrane Endoplasmic reticulum membrane Peripheral membrane protein Golgi apparatus membrane Peripheral membrane protein Cell junction synapse Cell junction synapse postsynaptic cell membrane postsynaptic density Localizes at the cytoplasmic side of endoplasmic reticulum and Golgi apparatus. Expressed in the postsynaptic density region of synapses (By similarity). Co-localizes with PRKAR2A and PRKAR2B in the cytoplasm and the cell membrane.
    Protein Attributes:
    Sequence length:
    708
    Sequence:
    50:
    MSQYTEKEPA | AMDQESGKAV | WPKPAGGYQT | ITGRRYGRRH | AYVSFKPCMT | 
    100:
    RHERSLGRAG | DDYEVLELDD | VPKENSSGSS | PLDQVDSSLP | SEPIFEKSET | 
    150:
    EIPTCGSALN | QTTESSQSFV | AVHHSEEGRD | TLGSSTNLHN | HSEGEYIPGA | 
    200:
    CSASSVQNGI | ALVHTDSYDP | DGKHGEDNDH | LQLSAEVVEG | SRYQESLGNT | 
    250:
    VFELENREAE | AYTGLSPPVP | SFNCEVRDEF | EELDSVPLVK | SSAGDTEFVH | 
    300:
    QNSQEIQRSS | QDEMVSTKQQ | NNTSQERQTE | HSPEDAACGP | GHICSEQNTN | 
    350:
    DREKNHGSSP | EQVVRPKVRK | LISSSQVDQE | TGFNRHEAKQ | RSVQRWREAL | 
    400:
    EVEESGSDDL | LIKCEEYDGE | HDCMFLDPPY | SRVITQRETE | NNQMTSESGA | 
    450:
    TAGRQEVDNT | FWNGCGDYYQ | LYDKDEDSSE | CSDGEWSASL | PHRFSGTEKD | 
    500:
    QSSSDESWET | LPGKDENEPE | LQSDSSGPEE | ENQELSLQEG | EQTSLEEGEI | 
    550:
    PWLQYNEVNE | SSSDEGNEPA | NEFAQPAFML | DGNNNLEDDS | SVSEDLDVDW | 
    600:
    SLFDGFADGL | GVAEAISYVD | PQFLTYMALE | ERLAQAMETA | LAHLESLAVD | 
    650:
    VEVANPPASK | ESIDGLPETL | VLEDHTAIGQ | EQCCPICCSE | YIKDDIATEL | 
    700:
    PCHHFFHKPC | VSIWLQKSGT | CPVCRRHFPP | AVIEASAAPS | SEPDPDAPPS | 
    708:
    NDSIAEAP
    3D Structure:
    N/A
    Predicted Eptitope:
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    EIAab Sequence  Vaild Sequence:
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    Related Databases
    Pfam:
    String:
    UniGene:
    SMR:
    KEGG:
    Pfam:
    Uniprot:
     
    FOR
    ELISA Kit for Human Praja2
    ELISA Kit for Human Praja2
    ELISA Kit for Human Praja2
    CLIA Kit for Human Praja2
    CLIA Kit for Human Praja2
    CLIA Kit for Human Praja2
    Polyclonal Antibody for Human Praja2
    Polyclonal Antibody for Human Praja2
    Polyclonal Antibody for Human Praja2
    Monoclonal Antibody for Human Praja2
    Monoclonal Antibody for Human Praja2
    Monoclonal Antibody for Human Praja2
    Protein for Human Praja2
    Protein for Human Praja2
    Protein for Human Praja2

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    Precision
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    Linearity
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    References
    1. 1.
      "Prediction of the coding sequences of unidentified human genes. VIII. 78 new cDNA clones from brain which code for large proteins in vitro."
      Ishikawa K. , Nagase T. , Nakajima D. , Seki N. , Ohira M. , Miyajima N. , Tanaka A. , Kotani H. , Nomura N. , Ohara O.
      DNA Res.4:307-313(1997) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1);VARIANT ARG-297
      tissue: Brain.
    2. 2.
      "Construction of expression-ready cDNA clones for KIAA genes: manual curation of 330 KIAA cDNA clones."
      Nakajima D. , Okazaki N. , Yamakawa H. , Kikuno R. , Ohara O. , Nagase T.
      Submitted (2004-01) to the EMBL/GenBank/DDBJ databases
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: SEQUENCE REVISION
    3. 3.
      "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T. , Suzuki Y. , Nishikawa T. , Otsuki T. , Sugiyama T. , Irie R. , Wakamatsu A. , Hayashi K. , Sato H. , Nagai K. , Kimura K. , Makita H. , Sekine M. , Obayashi M. , Nishi T. , Shibahara T. , Tanaka T. , Ishii S. , more...
      Nat. Genet.36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1)
      tissue: Placenta.
    4. 5.
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
    5. 6.
      "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res.14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1);VARIANT ARG-297
      tissue: Brain.
    6. 7.
      Bienvenut W.V. , Waridel P. , Quadroni M.
      Submitted (2009-03) to the UniProtKB
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PROTEIN SEQUENCE OF 2-18; 24-34; 59-73; 193-207; 241-258; 388-404 AND 583-610;CLEAVAGE OF INITIATOR METHIONINE;ACETYLATION AT SER-2;IDENTIFICATION BY MASS SPECTROMETRY
      tissue: Embryonic kidney.
    7. 8.
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 456-708 (ISOFORM 2)
      tissue: Liver.
    8. 9.
      "PJA1, encoding a RING-H2 finger ubiquitin ligase, is a novel human X chromosome gene abundantly expressed in brain."
      Yu P. , Chen Y. , Tagle D.A. , Cai T.
      Genomics79:869-874(2002) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;INTERACTION WITH UBE2D2
    9. 10.
      "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks."
      Olsen J.V. , Blagoev B. , Gnad F. , Macek B. , Kumar C. , Mortensen P. , Mann M.
      Cell127:635-648(2006) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-432;IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
      tissue: Cervix carcinoma.
    10. 11.
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
      tissue: Cervix carcinoma.
    11. 12.
      "Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions."
      Mayya V. , Lundgren D.H. , Hwang S.-I. , Rezaul K. , Wu L. , Eng J.K. , Rodionov V. , Han D.K.
      Sci. Signal.2:RA46-RA46(2009) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-323;IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
      tissue: Leukemic T-cell.
    12. 13.
      "Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."
      Olsen J.V. , Vermeulen M. , Santamaria A. , Kumar C. , Miller M.L. , Jensen L.J. , Gnad F. , Cox J. , Jensen T.S. , Nigg E.A. , Brunak S. , Mann M.
      Sci. Signal.3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
      tissue: Cervix carcinoma.
    13. 14.
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;SUBCELLULAR LOCATION;INTERACTION WITH PRKAR1A; PRKAR2A AND PRKAR2B;PHOSPHORYLATION AT SER-342 AND THR-389
    14. 15.
      "System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation."
      Rigbolt K.T. , Prokhorova T.A. , Akimov V. , Henningsen J. , Johansen P.T. , Kratchmarova I. , Kassem M. , Mann M. , Olsen J.V. , Blagoev B.
      Sci. Signal.4:RS3-RS3(2011) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-309;IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
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