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Index > Protein center > PLEKHA1(Gene name) > Human
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  • PLEKHA1 (Gene name),
  • Pleckstrin homology domain-containing family A member 1 (Protein name ),  PKHA1_HUMAN from NCBI database.
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  • General Annotation
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  • Gene name:
    PLEKHA1(TAPP1);
    Protein name:
    Pleckstrin homology domain-containing family A member 1(PH domain-containing family A member 1);
    Alternative:
    Tandem PH domain-containing protein 1(TAPP-1);
    Organism:
    Human (Homo sapiens). 
    General Annotation
    Sub Unit:
    Interacts with MPDZ and PTPN13.
    Function:
    Binds specifically to phosphatidylinositol-3,4-diphosphate (PtdIns3,4P2), but not to other phosphoinositides. May recruit other proteins to the plasma membrane.
    Subcellular Location:
    Cytoplasm Cell membrane Peripheral membrane protein Nucleus Locates to the plasma membrane after treatments that stimulate the production of PtdIns3,4P2.
    Protein Attributes:
    Sequence length:
    404
    Sequence:
    50:
    MPYVDRQNRI | CGFLDIEENE | NSGKFLRRYF | ILDTREDSFV | WYMDNPQNLP | 
    100:
    SGSSRVGAIK | LTYISKVSDA | TKLRPKAEFC | FVMNAGMRKY | FLQANDQQDL | 
    150:
    VEWVNVLNKA | IKITVPKQSD | SQPNSDNLSR | HGECGKKQVS | YRTDIVGGVP | 
    200:
    IITPTQKEEV | NECGESIDRN | NLKRSQSHLP | YFTPKPPQDS | AVIKAGYCVK | 
    250:
    QGAVMKNWKR | RYFQLDENTI | GYFKSELEKE | PLRVIPLKEV | HKVQECKQSD | 
    300:
    IMMRDNLFEI | VTTSRTFYVQ | ADSPEEMHSW | IKAVSGAIVA | QRGPGRSASS | 
    350:
    EHPPGPSESK | HAFRPTNAAT | ATSHSTASRS | NSLVSTFTME | KRGFYESLAK | 
    400:
    VKPGNFKVQT | VSPREPASKV | TEQALLRPQS | KNGPQEKDCD | LVDLDDASLP | 
    404:
    VSDV
    3D Structure:
    N/A
    Predicted Eptitope:
    Please Sign in.
    EIAab Sequence  Vaild Sequence:
    Please Sign in.
    Related Databases
    KEGG:
    MIM:
    Pfam:
    SMR:
    UniGene:
    String:
    Uniprot:
     
    FOR
    ELISA Kit for Human PH domain-containing family A member 1
    ELISA Kit for Human PH domain-containing family A member 1
    CLIA Kit for Human PH domain-containing family A member 1
    CLIA Kit for Human PH domain-containing family A member 1
    Polyclonal Antibody for Human PH domain-containing family A member 1
    Polyclonal Antibody for Human PH domain-containing family A member 1
    Monoclonal Antibody for Human PH domain-containing family A member 1
    Monoclonal Antibody for Human PH domain-containing family A member 1
    Protein for Human PH domain-containing family A member 1
    Protein for Human PH domain-containing family A member 1

    R&D Technical Data
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    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
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    Precision
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    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
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    Recovery
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    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
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    Linearity
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    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    References
    1. 1.
      "Identification of pleckstrin-homology-domain-containing proteins with novel phosphoinositide-binding specificities."
      Dowler S.J. , Currie R.A. , Campbell D.G. , Deak M. , Kular G. , Downes C.P. , Alessi D.R.
      Biochem. J.351:19-31(2000) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1);FUNCTION;MUTAGENESIS OF ARG-28 AND ARG-211;TISSUE SPECIFICITY;VARIANT ALA-320
    2. 2.
      "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T. , Suzuki Y. , Nishikawa T. , Otsuki T. , Sugiyama T. , Irie R. , Wakamatsu A. , Hayashi K. , Sato H. , Nagai K. , Kimura K. , Makita H. , Sekine M. , Obayashi M. , Nishi T. , Shibahara T. , Tanaka T. , Ishii S. , more...
      Nat. Genet.36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2)
      tissue: Testis.
    3. 3.
      "The DNA sequence and comparative analysis of human chromosome 10."
      Deloukas P. , Earthrowl M.E. , Grafham D.V. , Rubenfield M. , French L. , Steward C.A. , Sims S.K. , Jones M.C. , Searle S. , Scott C. , Howe K. , Hunt S.E. , Andrews T.D. , Gilbert J.G.R. , Swarbreck D. , Ashurst J.L. , Taylor A. , Battles J. , more...
      Nature429:375-381(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
    4. 4.
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA];VARIANT ALA-320
    5. 5.
      "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res.14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1)
      tissue: Colon.
      tissue: Testis.
    6. 6.
      "Evidence that the tandem-pleckstrin-homology-domain-containing protein TAPP1 interacts with Ptd(3,4)P2 and the multi-PDZ-domain-containing protein MUPP1 in vivo."
      Kimber W.A. , Trinkle-Mulcahy L. , Cheung P.C.F. , Deak M. , Marsden L.J. , Kieloch A. , Watt S. , Javier R.T. , Gray A. , Downes C.P. , Lucocq J.M. , Alessi D.R.
      Biochem. J.361:525-536(2002) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH MPDZ;SUBCELLULAR LOCATION
    7. 7.
      "TAPP1 and TAPP2 are targets of phosphatidylinositol 3-kinase signaling in B cells: sustained plasma membrane recruitment triggered by the B-cell antigen receptor."
      Marshall A.J. , Krahn A.K. , Ma K. , Duronio V. , Hou S.
      Mol. Cell. Biol.22:5479-5491(2002) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: SUBCELLULAR LOCATION;TISSUE SPECIFICITY
    8. 8.
      "Interaction of the protein tyrosine phosphatase PTPL1 with the PtdIns(3,4)P2-binding adaptor protein TAPP1."
      Kimber W.A. , Deak M. , Prescott A.R. , Alessi D.R.
      Biochem. J.376:525-535(2003) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH PTPN13;FUNCTION
    9. 9.
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-362;IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
      tissue: Cervix carcinoma.
    10. 10.
      "Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions."
      Mayya V. , Lundgren D.H. , Hwang S.-I. , Rezaul K. , Wu L. , Eng J.K. , Rodionov V. , Han D.K.
      Sci. Signal.2:RA46-RA46(2009) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
      tissue: Leukemic T-cell.
    11. 11.
      "System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation."
      Rigbolt K.T. , Prokhorova T.A. , Akimov V. , Henningsen J. , Johansen P.T. , Kratchmarova I. , Kassem M. , Mann M. , Olsen J.V. , Blagoev B.
      Sci. Signal.4:RS3-RS3(2011) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
    12. 12.
      "Crystal structure of the phosphatidylinositol 3,4-bisphosphate-binding pleckstrin homology (PH) domain of tandem PH-domain-containing protein 1 (TAPP1): molecular basis of lipid specificity."
      Thomas C.C. , Dowler S.J. , Deak M. , Alessi D.R. , van Aalten D.M.F.
      Biochem. J.358:287-294(2001) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: X-RAY CRYSTALLOGRAPHY (1.4 ANGSTROMS) OF 190-292;FUNCTION;MUTAGENESIS OF ALA-203; VAL-204; MET-205 AND ASN-207
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