PLEKHA8 ELISA Kit for Bovine(Bos taurus) | EIAab.comPLEKHA8 ELISA Kit for Bovine(Bos taurus)

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Index > Protein center > PLEKHA8(Gene name) > Bovine

PLEKHA8 (Gene name),

Pleckstrin homology domain-containing family A member 8 (Protein name ), PKHA8_BOVIN from NCBI database.

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General Annotation

Antigen Annotation

Predicted Eptitope

Vaild Sequence

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Gene name:

PLEKHA8(FAPP2);

Protein name:

Pleckstrin homology domain-containing family A member 8(PH domain-containing family A member 8);

Alternative:

Phosphatidylinositol-four-phosphate adapter protein 2(FAPP-2);

Organism:

Bovine (Bos taurus).

General Annotation

Sub Unit:

Homodimer (By similarity). Interacts with ARF1; the interaction together with phosphatidylinositol 4-phosphate binding is required for FAPP2 GlcCer transfer ability.

Function:

Cargo transport protein that is required for apical transport from the trans-Golgi network (TGN). Transports AQP2 from the trans-Golgi network (TGN) to sites of AQP2 phosphorylation. Mediates the non-vesicular transport of glucosylceramide (GlcCer) from the trans-Golgi network (TGN) to the plasma membrane and plays a pivotal role in the synthesis of complex glycosphingolipids. Binding of both phosphatidylinositol 4-phosphate (PIP) and ARF1 are essential for the GlcCer transfer ability. Also required for primary cilium formation, possibly by being involved in the transport of raft lipids to the apical membrane, and for membrane tubulation.

Subcellular Location:

Cytoplasm Golgi apparatus Trans-Golgi network membrane Membrane Peripheral membrane protein Mainly localized to the trans-Golgi network (TGN) but also found at the rims of Golgi cisternae. Associates with ARF1 at Golgi apparatus membranes.

Protein Attributes:

Sequence length:

520

Sequence:

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