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Index > Protein center > Plekhb1(Gene name) > Mouse
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  • Plekhb1 (Gene name),
  • Pleckstrin homology domain-containing family B member 1 (Protein name ),  PKHB1_MOUSE from NCBI database.
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  • General Annotation
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  • Antigen Annotation
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  • Predicted Eptitope
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  • Vaild Sequence
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  • Gene name:
    Plekhb1(Evt1;Phr1);
    Protein name:
    Pleckstrin homology domain-containing family B member 1(PH domain-containing family B member 1);
    Alternative:
    PH domain-containing protein in retina 1(PHRET1);Evectin-1;Pleckstrin homology domain retinal protein 1;
    Organism:
    Mouse (Mus musculus). 
    General Annotation
    Sub Unit:
    Binds transducins (By similarity). Homodimer. Interacts (via PH domain) with MYO1C. Interacts (via PH domain) with MYO7A.
    Function:
    Required for proper localization of retinogeniculate projections but not for eye-specific segregation.
    Subcellular Location:
    Membrane Cytoplasm Membrane-associated. Highly expressed in the outer segments of photoreceptor cells, both in rods and cones. Localizes to the apical juxta-nuclear Golgi region of the cytoplasm.
    Protein Attributes:
    Sequence length:
    243
    Sequence:
    50:
    MSPATPVPPD | SILESPFEEM | ALVRGGWLWR | QSSILRRWKR | NWFALWLDGT | 
    100:
    LGYYHDETAQ | DEEDRVVIHF | NVRDIKVGQE | CQDVQPPEGR | SRDGLLTVNL | 
    150:
    REGSRLHLCA | ETRDDAIAWK | TALMEANSTP | APAGATVPPR | SRRVCPKVRC | 
    200:
    TTLSWNPCKV | ERRIWVRVYS | PYQDYYEVVP | PNAHEATYVR | SYYGPPYAGP | 
    243:
    GVTHVIVRED | PCYSSGAPLA | MGMLAGAATG | AALGSLMWSP | CWF
    3D Structure:
    N/A
    Predicted Eptitope:
    Please Sign in.
    EIAab Sequence  Vaild Sequence:
    Please Sign in.
    Related Databases
    UniGene:
    String:
    UniGene:
    Pfam:
    KEGG:
    SMR:
    Uniprot:
     
    FOR
    ELISA Kit for Mouse PH domain-containing family B member 1
    ELISA Kit for Mouse PH domain-containing family B member 1
    ELISA Kit for Mouse PH domain-containing family B member 1
    CLIA Kit for Mouse PH domain-containing family B member 1
    CLIA Kit for Mouse PH domain-containing family B member 1
    CLIA Kit for Mouse PH domain-containing family B member 1
    Polyclonal Antibody for Mouse PH domain-containing family B member 1
    Polyclonal Antibody for Mouse PH domain-containing family B member 1
    Polyclonal Antibody for Mouse PH domain-containing family B member 1
    Monoclonal Antibody for Mouse PH domain-containing family B member 1
    Monoclonal Antibody for Mouse PH domain-containing family B member 1
    Monoclonal Antibody for Mouse PH domain-containing family B member 1
    Protein for Mouse PH domain-containing family B member 1
    Protein for Mouse PH domain-containing family B member 1
    Protein for Mouse PH domain-containing family B member 1

    R&D Technical Data
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    Precision
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    Recovery
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    Linearity
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    References
    1. 1.
      "PHR1 encodes an abundant, pleckstrin homology domain-containing integral membrane protein in the photoreceptor outer segments."
      Xu S. , Ladak R. , Swanson D.A. , Soltyk A. , Sun H. , Ploder L. , Vidgen D. , Duncan A.M.V. , Garami E. , McInnes R.R. , Valle D.
      J. Biol. Chem.274:35676-35685(1999) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA] (ISOFORMS 1; 2; 3 AND 4);TISSUE SPECIFICITY
      tissue: Brain.
      tissue: Retina.
    2. 2.
      "The transcriptional landscape of the mammalian genome."
      Carninci P. , Kasukawa T. , Katayama S. , Gough J. , Frith M.C. , Maeda N. , Oyama R. , Ravasi T. , Lenhard B. , Wells C. , Kodzius R. , Shimokawa K. , Bajic V.B. , Brenner S.E. , Batalov S. , Forrest A.R. , Zavolan M. , Davis M.J. , more...
      Science309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 4)
      strain: C57BL/6J.
      tissue: Cerebellum.
    3. 3.
      "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res.14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1)
      tissue: Eye.
    4. 4.
      "PHR1, an integral membrane protein of the inner ear sensory cells, directly interacts with myosin 1c and myosin VIIa."
      Etournay R. , El-Amraoui A. , Bahloul A. , Blanchard S. , Roux I. , Pezeron G. , Michalski N. , Daviet L. , Hardelin J.-P. , Legrain P. , Petit C.
      J. Cell Sci.118:2891-2899(2005) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH MYO1C AND MYO7A;HOMODIMERIZATION
    5. 5.
      "PHR1, a PH domain-containing protein expressed in primary sensory neurons."
      Xu S. , Wang Y. , Zhao H. , Zhang L. , Xiong W. , Yau K.W. , Hiel H. , Glowatzki E. , Ryugo D.K. , Valle D.
      Mol. Cell. Biol.24:9137-9151(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: TISSUE SPECIFICITY;DISRUPTION PHENOTYPE
    6. 6.
      "Phr1 regulates retinogeniculate targeting independent of activity and ephrin-A signalling."
      Culican S.M. , Bloom A.J. , Weiner J.A. , DiAntonio A.
      Mol. Cell. Neurosci.41:304-312(2009) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;DISRUPTION PHENOTYPE
    7. 7.
      "PHR1 is a vesicle-bound protein abundantly expressed in mature olfactory neurons."
      Tan B. , Brown D. , Xu S. , Valle D.
      Laryngoscope120:1002-1010(2010) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: SUBCELLULAR LOCATION;TISSUE SPECIFICITY
    8. 8.
      "Solution structure of the PH domain of pleckstrin homology domain-containing protein family B member 1 from mouse."
      RIKEN structural genomics initiative (RSGI)
      Submitted (2006-06) to the PDB data bank
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: STRUCTURE BY NMR OF 22-138
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