PLK4 ELISA Kit for Bovine(Bos taurus) | EIAab.comPLK4 ELISA Kit for Bovine(Bos taurus)

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PLK4 (Gene name),

Serine/threonine-protein kinase PLK4 (Protein name ), PLK4_BOVIN from NCBI database.

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General Annotation

Antigen Annotation

Predicted Eptitope

Vaild Sequence

Related Databases

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Gene name:

PLK4(SAK);

Protein name:

Serine/threonine-protein kinase PLK4;

Alternative:

Serine/threonine-protein kinase Sak;Polo-like kinase 4(PLK-4);

Organism:

Bovine (Bos taurus).

General Annotation

Sub Unit:

Homodimer (By similarity). Interacts with CEP152 (via N-terminus).

Function:

Serine/threonine-protein kinase that plays a central role in centriole duplication. Able to trigger procentriole formation on the surface of the parental centriole cylinder, leading to the recruitment of centriole biogenesis proteins such as SASS6, CENPJ/CPAP, CP110, CEP135 and gamma-tubulin. When overexpressed, it is able to induce centrosome amplification through the simultaneous generation of multiple procentrioles adjoining each parental centriole during S phase. Its central role in centriole replication suggests a posible role in tumorigenesis, centrosome aberrations being frequently observed in tumors. Also involved in trophoblast differentiation by phosphorylating HAND1, leading to disrupt the interaction between HAND1 and MDFIC and activate HAND1. Phosphorylates CDC25C and CHEK2/CHK2.

Subcellular Location:

Cytoplasm cytoskeleton centrosome centriole Nucleus nucleolus Associates with centrioles throughout the cell cycle.

Protein Attributes:

Sequence length:

893

Sequence:

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893:

YTSPDGQTTR | YGENEKLPEY | IKQKLQCLSS | ILLMFSNPTP | SFH

3D Structure:

N/A

Predicted Eptitope:

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Vaild Sequence:

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Related Databases

UniGene:

Bt.27553

SMR:

A2VDZ4

STRING:

9913.ENSBTAP00000052630

Pfam:

PF00069

String:

A2VDZ4

KEGG:

bta:514405

Uniprot:

A2VDZ4

FOR

ELISA Kit for Bovine Serine/threonine-protein kinase PLK4

CLIA Kit for Bovine Serine/threonine-protein kinase PLK4

Polyclonal Antibody for Bovine Serine/threonine-protein kinase PLK4

Monoclonal Antibody for Bovine Serine/threonine-protein kinase PLK4

Protein for Bovine Serine/threonine-protein kinase PLK4

R&D Technical Data

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Precision

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Recovery

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Linearity

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

References

1.

NIH - Mammalian Gene Collection (MGC) project
Submitted (2007-02) to the EMBL/GenBank/DDBJ databases

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]
strain: Hereford.
tissue: Thymus.

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