Gene name:
PLXNA2(UNQ209/PRO235;KIAA0463;OCT;PLXN2);
Protein name:
Plexin-A2;
Alternative:
Semaphorin receptor OCT;
Organism:
Human (Homo sapiens).
General Annotation
Sub Unit:
Interacts directly with NRP1 and NRP2 (By similarity). Interacts with RND1.
Function:
Coreceptor for SEMA3A. Necessary for signaling by class 3 semaphorins and subsequent remodeling of the cytoskeleton. Plays a role in axon guidance, invasive growth and cell migration. Class 3 semaphorins bind to a complex composed of a neuropilin and a plexin. The plexin modulates the affinity of the complex for specific semaphorins, and its cytoplasmic domain is required for the activation of down-stream signaling events in the cytoplasm.
Subcellular Location:
Membrane
Single-pass type I membrane protein
Protein Attributes:
50:
MEQRRPWPRA | LEVDSRSVVL | LSVVWVLLAP | PAAGMPQFST | FHSENRDWTF |
100:
NHLTVHQGTG | AVYVGAINRV | YKLTGNLTIQ | VAHKTGPEED | NKSCYPPLIV |
150:
QPCSEVLTLT | NNVNKLLIID | YSENRLLACG | SLYQGVCKLL | RLDDLFILVE |
200:
PSHKKEHYLS | SVNKTGTMYG | VIVRSEGEDG | KLFIGTAVDG | KQDYFPTLSS |
250:
RKLPRDPESS | AMLDYELHSD | FVSSLIKIPS | DTLALVSHFD | IFYIYGFASG |
300:
GFVYFLTVQP | ETPEGVAINS | AGDLFYTSRI | VRLCKDDPKF | HSYVSLPFGC |
350:
TRAGVEYRLL | QAAYLAKPGD | SLAQAFNITS | QDDVLFAIFS | KGQKQYHHPP |
400:
DDSALCAFPI | RAINLQIKER | LQSCYQGEGN | LELNWLLGKD | VQCTKAPVPI |
450:
DDNFCGLDIN | QPLGGSTPVE | GLTLYTTSRD | RMTSVASYVY | NGYSVVFVGT |
500:
KSGKLKKIRA | DGPPHGGVQY | EMVSVLKDGS | PILRDMAFSI | DQRYLYVMSE |
550:
RQVTRVPVES | CEQYTTCGEC | LSSGDPHCGW | CALHNMCSRR | DKCQQAWEPN |
600:
RFAASISQCV | SLAVHPSSIS | VSEHSRLLSL | VVSDAPDLSA | GIACAFGNLT |
650:
EVEGQVSGSQ | VICISPGPKD | VPVIPLDQDW | FGLELQLRSK | ETGKIFVSTE |
700:
FKFYNCSAHQ | LCLSCVNSAF | RCHWCKYRNL | CTHDPTTCSF | QEGRINISED |
750:
CPQLVPTEEI | LIPVGEVKPI | TLKARNLPQP | QSGQRGYECV | LNIQGAIHRV |
800:
PALRFNSSSV | QCQNSSYQYD | GMDISNLAVD | FAVVWNGNFI | IDNPQDLKVH |
850:
LYKCAAQRES | CGLCLKADRK | FECGWCSGER | RCTLHQHCTS | PSSPWLDWSS |
900:
HNVKCSNPQI | TEILTVSGPP | EGGTRVTIHG | VNLGLDFSEI | AHHVQVAGVP |
950:
CTPLPGEYII | AEQIVCEMGH | ALVGTTSGPV | RLCIGECKPE | FMTKSHQQYT |
1000:
FVNPSVLSLN | PIRGPESGGT | MVTITGHYLG | AGSSVAVYLG | NQTCEFYGRS |
1050:
MSEIVCVSPP | SSNGLGPVPV | SVSVDRAHVD | SNLQFEYIDD | PRVQRIEPEW |
1100:
SIASGHTPLT | ITGFNLDVIQ | EPRIRVKFNG | KESVNVCKVV | NTTTLTCLAP |
1150:
SLTTDYRPGL | DTVERPDEFG | FVFNNVQSLL | IYNDTKFIYY | PNPTFELLSP |
1200:
TGVLDQKPGS | PIILKGKNLC | PPASGGAKLN | YTVLIGETPC | AVTVSETQLL |
1250:
CEPPNLTGQH | KVMVHVGGMV | FSPGSVSVIS | DSLLTLPAIV | SIAAGGSLLL |
1300:
IIVIIVLIAY | KRKSRENDLT | LKRLQMQMDN | LESRVALECK | EAFAELQTDI |
1350:
NELTSDLDRS | GIPYLDYRTY | AMRVLFPGIE | DHPVLRELEV | QGNGQQHVEK |
1400:
ALKLFAQLIN | NKVFLLTFIR | TLELQRSFSM | RDRGNVASLI | MTGLQGRLEY |
1450:
ATDVLKQLLS | DLIDKNLENK | NHPKLLLRRT | ESVAEKMLTN | WFAFLLHKFL |
1500:
KECAGEPLFM | LYCAIKQQME | KGPIDAITGE | ARYSLSEDKL | IRQQIEYKTL |
1550:
ILNCVNPDNE | NSPEIPVKVL | NCDTITQVKE | KILDAVYKNV | PYSQRPRAVD |
1600:
MDLEWRQGRI | ARVVLQDEDI | TTKIEGDWKR | LNTLMHYQVS | DRSVVALVPK |
1650:
QTSSYNIPAS | ASISRTSISR | YDSSFRYTGS | PDSLRSRAPM | ITPDLESGVK |
1700:
VWHLVKNHDH | GDQKEGDRGS | KMVSEIYLTR | LLATKGTLQK | FVDDLFETLF |
1750:
STVHRGSALP | LAIKYMFDFL | DEQADRHSIH | DTDVRHTWKS | NCLPLRFWVN |
1800:
VIKNPQFVFD | IHKGSITDAC | LSVVAQTFMD | SCSTSEHRLG | KDSPSNKLLY |
1850:
AKDIPSYKSW | VERYYADIAK | LPAISDQDMN | AYLAEQSRLH | AVEFNMLSAL |
1894:
NEIYSYVSKY | SEELIGALEQ | DEQARRQRLA | YKVEQLINAM | SIES

Vaild Sequence:
Related Databases
Uniprot: