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Index > Protein center > PLXNA2(Gene name) > Human
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  • PLXNA2 (Gene name),
  • Plexin-A2 (Protein name ),  PLXA2_HUMAN from NCBI database.
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  • General Annotation
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  • Antigen Annotation
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  • Gene name:
    PLXNA2(UNQ209/PRO235;KIAA0463;OCT;PLXN2);
    Protein name:
    Plexin-A2;
    Alternative:
    Semaphorin receptor OCT;
    Organism:
    Human (Homo sapiens). 
    General Annotation
    Sub Unit:
    Interacts directly with NRP1 and NRP2 (By similarity). Interacts with RND1.
    Function:
    Coreceptor for SEMA3A. Necessary for signaling by class 3 semaphorins and subsequent remodeling of the cytoskeleton. Plays a role in axon guidance, invasive growth and cell migration. Class 3 semaphorins bind to a complex composed of a neuropilin and a plexin. The plexin modulates the affinity of the complex for specific semaphorins, and its cytoplasmic domain is required for the activation of down-stream signaling events in the cytoplasm.
    Subcellular Location:
    Membrane Single-pass type I membrane protein
    Protein Attributes:
    Sequence length:
    1894
    Sequence:
    50:
    MEQRRPWPRA | LEVDSRSVVL | LSVVWVLLAP | PAAGMPQFST | FHSENRDWTF | 
    100:
    NHLTVHQGTG | AVYVGAINRV | YKLTGNLTIQ | VAHKTGPEED | NKSCYPPLIV | 
    150:
    QPCSEVLTLT | NNVNKLLIID | YSENRLLACG | SLYQGVCKLL | RLDDLFILVE | 
    200:
    PSHKKEHYLS | SVNKTGTMYG | VIVRSEGEDG | KLFIGTAVDG | KQDYFPTLSS | 
    250:
    RKLPRDPESS | AMLDYELHSD | FVSSLIKIPS | DTLALVSHFD | IFYIYGFASG | 
    300:
    GFVYFLTVQP | ETPEGVAINS | AGDLFYTSRI | VRLCKDDPKF | HSYVSLPFGC | 
    350:
    TRAGVEYRLL | QAAYLAKPGD | SLAQAFNITS | QDDVLFAIFS | KGQKQYHHPP | 
    400:
    DDSALCAFPI | RAINLQIKER | LQSCYQGEGN | LELNWLLGKD | VQCTKAPVPI | 
    450:
    DDNFCGLDIN | QPLGGSTPVE | GLTLYTTSRD | RMTSVASYVY | NGYSVVFVGT | 
    500:
    KSGKLKKIRA | DGPPHGGVQY | EMVSVLKDGS | PILRDMAFSI | DQRYLYVMSE | 
    550:
    RQVTRVPVES | CEQYTTCGEC | LSSGDPHCGW | CALHNMCSRR | DKCQQAWEPN | 
    600:
    RFAASISQCV | SLAVHPSSIS | VSEHSRLLSL | VVSDAPDLSA | GIACAFGNLT | 
    650:
    EVEGQVSGSQ | VICISPGPKD | VPVIPLDQDW | FGLELQLRSK | ETGKIFVSTE | 
    700:
    FKFYNCSAHQ | LCLSCVNSAF | RCHWCKYRNL | CTHDPTTCSF | QEGRINISED | 
    750:
    CPQLVPTEEI | LIPVGEVKPI | TLKARNLPQP | QSGQRGYECV | LNIQGAIHRV | 
    800:
    PALRFNSSSV | QCQNSSYQYD | GMDISNLAVD | FAVVWNGNFI | IDNPQDLKVH | 
    850:
    LYKCAAQRES | CGLCLKADRK | FECGWCSGER | RCTLHQHCTS | PSSPWLDWSS | 
    900:
    HNVKCSNPQI | TEILTVSGPP | EGGTRVTIHG | VNLGLDFSEI | AHHVQVAGVP | 
    950:
    CTPLPGEYII | AEQIVCEMGH | ALVGTTSGPV | RLCIGECKPE | FMTKSHQQYT | 
    1000:
    FVNPSVLSLN | PIRGPESGGT | MVTITGHYLG | AGSSVAVYLG | NQTCEFYGRS | 
    1050:
    MSEIVCVSPP | SSNGLGPVPV | SVSVDRAHVD | SNLQFEYIDD | PRVQRIEPEW | 
    1100:
    SIASGHTPLT | ITGFNLDVIQ | EPRIRVKFNG | KESVNVCKVV | NTTTLTCLAP | 
    1150:
    SLTTDYRPGL | DTVERPDEFG | FVFNNVQSLL | IYNDTKFIYY | PNPTFELLSP | 
    1200:
    TGVLDQKPGS | PIILKGKNLC | PPASGGAKLN | YTVLIGETPC | AVTVSETQLL | 
    1250:
    CEPPNLTGQH | KVMVHVGGMV | FSPGSVSVIS | DSLLTLPAIV | SIAAGGSLLL | 
    1300:
    IIVIIVLIAY | KRKSRENDLT | LKRLQMQMDN | LESRVALECK | EAFAELQTDI | 
    1350:
    NELTSDLDRS | GIPYLDYRTY | AMRVLFPGIE | DHPVLRELEV | QGNGQQHVEK | 
    1400:
    ALKLFAQLIN | NKVFLLTFIR | TLELQRSFSM | RDRGNVASLI | MTGLQGRLEY | 
    1450:
    ATDVLKQLLS | DLIDKNLENK | NHPKLLLRRT | ESVAEKMLTN | WFAFLLHKFL | 
    1500:
    KECAGEPLFM | LYCAIKQQME | KGPIDAITGE | ARYSLSEDKL | IRQQIEYKTL | 
    1550:
    ILNCVNPDNE | NSPEIPVKVL | NCDTITQVKE | KILDAVYKNV | PYSQRPRAVD | 
    1600:
    MDLEWRQGRI | ARVVLQDEDI | TTKIEGDWKR | LNTLMHYQVS | DRSVVALVPK | 
    1650:
    QTSSYNIPAS | ASISRTSISR | YDSSFRYTGS | PDSLRSRAPM | ITPDLESGVK | 
    1700:
    VWHLVKNHDH | GDQKEGDRGS | KMVSEIYLTR | LLATKGTLQK | FVDDLFETLF | 
    1750:
    STVHRGSALP | LAIKYMFDFL | DEQADRHSIH | DTDVRHTWKS | NCLPLRFWVN | 
    1800:
    VIKNPQFVFD | IHKGSITDAC | LSVVAQTFMD | SCSTSEHRLG | KDSPSNKLLY | 
    1850:
    AKDIPSYKSW | VERYYADIAK | LPAISDQDMN | AYLAEQSRLH | AVEFNMLSAL | 
    1894:
    NEIYSYVSKY | SEELIGALEQ | DEQARRQRLA | YKVEQLINAM | SIES
    3D Structure:
    N/A
    Predicted Eptitope:
    Please Sign in.
    EIAab Sequence  Vaild Sequence:
    Please Sign in.
    Related Databases
    UniGene:
    String:
    MIM:
    Pfam:
    SMR:
    KEGG:
    Uniprot:
     
    FOR
    ELISA Kit for Human Plexin-A2
    ELISA Kit for Human Plexin-A2
    CLIA Kit for Human Plexin-A2
    CLIA Kit for Human Plexin-A2
    Polyclonal Antibody for Human Plexin-A2
    Polyclonal Antibody for Human Plexin-A2
    Monoclonal Antibody for Human Plexin-A2
    Monoclonal Antibody for Human Plexin-A2
    Protein for Human Plexin-A2
    Protein for Human Plexin-A2

    R&D Technical Data
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    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
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    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
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    Precision
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    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
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    Recovery
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    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
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    Linearity
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    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
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    References
    1. 1.
      "Characterization of cDNA clones in size-fractionated cDNA libraries from human brain."
      Seki N. , Ohira M. , Nagase T. , Ishikawa K. , Miyajima N. , Nakajima D. , Nomura N. , Ohara O.
      DNA Res.4:345-349(1997) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1);VARIANT GLY-369
      tissue: Brain.
    2. 2.
      "The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment."
      Clark H.F. , Gurney A.L. , Abaya E. , Baker K. , Baldwin D.T. , Brush J. , Chen J. , Chow B. , Chui C. , Crowley C. , Currell B. , Deuel B. , Dowd P. , Eaton D. , Foster J.S. , Grimaldi C. , Gu Q. , Hass P.E. , more...
      Genome Res.13:2265-2270(2003) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2);VARIANT GLN-5
    3. 3.
      "The DNA sequence and biological annotation of human chromosome 1."
      Gregory S.G. , Barlow K.F. , McLay K.E. , Kaul R. , Swarbreck D. , Dunham A. , Scott C.E. , Howe K.L. , Woodfine K. , Spencer C.C.A. , Jones M.C. , Gillson C. , Searle S. , Zhou Y. , Kokocinski F. , McDonald L. , Evans R. , Phillips K. , more...
      Nature441:315-321(2006) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
    4. 4.
      "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res.14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1);VARIANT GLY-369
      tissue: Brain.
      tissue: Placenta.
    5. 5.
      "A family of transmembrane proteins with homology to the MET-hepatocyte growth factor receptor."
      Maestrini E. , Tamagnone L. , Longati P. , Cremona O. , Gulisano M. , Bione S. , Tamanini F. , Neel B.G. , Toniolo D. , Comoglio P.M.
      Proc. Natl. Acad. Sci. U.S.A.93:674-678(1996) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 447-1774 (ISOFORM 1);TISSUE SPECIFICITY
      tissue: Skeletal muscle.
    6. 6.
      "Plexins are a large family of receptors for transmembrane, secreted and GPI-anchored semaphorins in vertebrates."
      Tamagnone L. , Artigiani S. , Chen H. , He Z. , Ming G.-L. , Song H.-L. , Chedotal A. , Winberg M.L. , Goodman C.S. , Poo M.-M. , Tessier-Lavigne M. , Comoglio P.M.
      Cell99:71-80(1999) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION
    7. 7.
      "Glycoproteomics analysis of human liver tissue by combination of multiple enzyme digestion and hydrazide chemistry."
      Chen R. , Jiang X. , Sun D. , Han G. , Wang F. , Ye M. , Wang L. , Zou H.
      J. Proteome Res.8:651-661(2009) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: GLYCOSYLATION [LARGE SCALE ANALYSIS] AT ASN-91
      tissue: Liver.
    8. 8.
      "Crystal structure of plexin A2 RBD in complex with RND1."
      Structural genomics consortium (SGC)
      Submitted (2011-01) to the PDB data bank
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: X-RAY CRYSTALLOGRAPHY (1.97 ANGSTROMS) OF 1490-1600 IN COMPLEX WITH RND1
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