Gene name:
PLXNA4(UNQ2820/PRO34003;KIAA1550;PLXNA4A;PLXNA4B);
Protein name:
Plexin-A4;
Alternative:
Organism:
Human (Homo sapiens).
General Annotation
Sub Unit:
Interacts with NRP1 and NRP2.
Function:
Coreceptor for SEMA3A. Necessary for signaling by class 3 semaphorins and subsequent remodeling of the cytoskeleton. Plays a role in axon guidance in the developing nervous system. Class 3 semaphorins bind to a complex composed of a neuropilin and a plexin. The plexin modulates the affinity of the complex for specific semaphorins, and its cytoplasmic domain is required for the activation of down-stream signaling events in the cytoplasm.
Subcellular Location:
Membrane
Single-pass type I membrane protein
Protein Attributes:
50:
MKAMPWNWTC | LLSHLLMVGM | GSSTLLTRQP | APLSQKQRSF | VTFRGEPAEG |
100:
FNHLVVDERT | GHIYLGAVNR | IYKLSSDLKV | LVTHETGPDE | DNPKCYPPRI |
150:
VQTCNEPLTT | TNNVNKMLLI | DYKENRLIAC | GSLYQGICKL | LRLEDLFKLG |
200:
EPYHKKEHYL | SGVNESGSVF | GVIVSYSNLD | DKLFIATAVD | GKPEYFPTIS |
250:
SRKLTKNSEA | DGMFAYVFHD | EFVASMIKIP | SDTFTIIPDF | DIYYVYGFSS |
300:
GNFVYFLTLQ | PEMVSPPGST | TKEQVYTSKL | VRLCKEDTAF | NSYVEVPIGC |
350:
ERSGVEYRLL | QAAYLSKAGA | VLGRTLGVHP | DDDLLFTVFS | KGQKRKMKSL |
400:
DESALCIFIL | KQINDRIKER | LQSCYRGEGT | LDLAWLKVKD | IPCSSALLTI |
450:
DDNFCGLDMN | APLGVSDMVR | GIPVFTEDRD | RMTSVIAYVY | KNHSLAFVGT |
500:
KSGKLKKIRV | DGPRGNALQY | ETVQVVDPGP | VLRDMAFSKD | HEQLYIMSER |
550:
QLTRVPVESC | GQYQSCGECL | GSGDPHCGWC | VLHNTCTRKE | RCERSKEPRR |
600:
FASEMKQCVR | LTVHPNNISV | SQYNVLLVLE | TYNVPELSAG | VNCTFEDLSE |
650:
MDGLVVGNQI | QCYSPAAKEV | PRIITENGDH | HVVQLQLKSK | ETGMTFASTS |
700:
FVFYNCSVHN | SCLSCVESPY | RCHWCKYRHV | CTHDPKTCSF | QEGRVKLPED |
750:
CPQLLRVDKI | LVPVEVIKPI | TLKAKNLPQP | QSGQRGYECI | LNIQGSEQRV |
800:
PALRFNSSSV | QCQNTSYSYE | GMEINNLPVE | LTVVWNGHFN | IDNPAQNKVH |
850:
LYKCGAMRES | CGLCLKADPD | FACGWCQGPG | QCTLRQHCPA | QESQWLELSG |
900:
AKSKCTNPRI | TEIIPVTGPR | EGGTKVTIRG | ENLGLEFRDI | ASHVKVAGVE |
950:
CSPLVDGYIP | AEQIVCEMGE | AKPSQHAGFV | EICVAVCRPE | FMARSSQLYY |
1000:
FMTLTLSDLK | PSRGPMSGGT | QVTITGTNLN | AGSNVVVMFG | KQPCLFHRRS |
1050:
PSYIVCNTTS | SDEVLEMKVS | VQVDRAKIHQ | DLVFQYVEDP | TIVRIEPEWS |
1100:
IVSGNTPIAV | WGTHLDLIQN | PQIRAKHGGK | EHINICEVLN | ATEMTCQAPA |
1150:
LALGPDHQSD | LTERPEEFGF | ILDNVQSLLI | LNKTNFTYYP | NPVFEAFGPS |
1200:
GILELKPGTP | IILKGKNLIP | PVAGGNVKLN | YTVLVGEKPC | TVTVSDVQLL |
1250:
CESPNLIGRH | KVMARVGGME | YSPGMVYIAP | DSPLSLPAIV | SIAVAGGLLI |
1300:
IFIVAVLIAY | KRKSRESDLT | LKRLQMQMDN | LESRVALECK | EAFAELQTDI |
1350:
HELTSDLDGA | GIPFLDYRTY | TMRVLFPGIE | DHPVLRDLEV | PGYRQERVEK |
1400:
GLKLFAQLIN | NKVFLLSFIR | TLESQRSFSM | RDRGNVASLI | MTVLQSKLEY |
1450:
ATDVLKQLLA | DLIDKNLESK | NHPKLLLRRT | ESVAEKMLTN | WFTFLLYKFL |
1500:
KECAGEPLFS | LFCAIKQQME | KGPIDAITGE | ARYSLSEDKL | IRQQIDYKTL |
1550:
VLSCVSPDNA | NSPEVPVKIL | NCDTITQVKE | KILDAIFKNV | PCSHRPKAAD |
1600:
MDLEWRQGSG | ARMILQDEDI | TTKIENDWKR | LNTLAHYQVP | DGSVVALVSK |
1650:
QVTAYNAVNN | STVSRTSASK | YENMIRYTGS | PDSLRSRTPM | ITPDLESGVK |
1700:
MWHLVKNHEH | GDQKEGDRGS | KMVSEIYLTR | LLATKGTLQK | FVDDLFETIF |
1750:
STAHRGSALP | LAIKYMFDFL | DEQADKHGIH | DPHVRHTWKS | NCLPLRFWVN |
1800:
MIKNPQFVFD | IHKNSITDAC | LSVVAQTFMD | SCSTSEHRLG | KDSPSNKLLY |
1850:
AKDIPSYKNW | VERYYSDIGK | MPAISDQDMN | AYLAEQSRMH | MNEFNTMSAL |
1894:
SEIFSYVGKY | SEEILGPLDH | DDQCGKQKLA | YKLEQVITLM | SLDS

Vaild Sequence:
Related Databases
Uniprot: