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Index > Protein center > Bves(Gene name) > Mouse
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  • Bves (Gene name),
  • Blood vessel epicardial substance (Protein name ),  POPD1_MOUSE from NCBI database.
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  • General Annotation
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  • Antigen Annotation
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  • 3D
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  • Predicted Eptitope
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  • Vaild Sequence
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  • Gene name:
    Bves(Pop1;Popdc1);
    Protein name:
    Blood vessel epicardial substance(mBVES);
    Alternative:
    Popeye domain-containing protein 1(Popeye protein 1);
    Organism:
    Mouse (Mus musculus). 
    General Annotation
    Sub Unit:
    Homodimer. Homodimerization requires the C-terminus cytoplasmic region (By similarity). Interacts (via the C-terminus cytoplasmic tail) with TJP1. Interacts (via the C-terminus cytoplasmic tail) with ARHGEF25/GEFT (via the DH domain). Interacts (via the C-terminus cytoplasmic tail) with VAMP3.
    Function:
    Cell adhesion molecule involved in the establishment and/or maintenance of cell integrity. Involved in the formation and regulation of the tight junction (TJ) paracellular permeability barrier in epithelial cells. Plays a role in VAMP3-mediated vesicular transport and recycling of different receptor molecules through its interaction with VAMP3. Plays a role in the regulation of cell shape and movement by modulating the Rho-family GTPase activity through its interaction with ARHGEF25/GEFT. Induces primordial adhesive contact and aggregation of epithelial cells in a Ca(2+)-independent manner. Also involved in striated muscle regeneration and repair and in the regulation of cell spreading.
    Subcellular Location:
    Lateral cell membrane Cell junction tight junction Membrane Multi-pass membrane protein Its movement from the cytoplasm to membrane is an early event occurring concurrently with cell-cell contact. Detected at cell-cell contact but never observed at the free surface of epithelial cells (By similarity). Colocalizes in epithelial cells with OCLN and TJP1 in an apical-lateral position within the z axis. Colocalizes with VAMP3 at the cell-cell contact in cardiac and skeletal muscle.
    Protein Attributes:
    Sequence length:
    358
    Sequence:
    50:
    MNSTESIPLA | QSTVAGFTSE | LESLTPVPSN | ETTCENWREI | HHLVFHVANV | 
    100:
    CFAVGLLIPT | TLHLHMILLR | VMLSLGCTLY | VVWATLYRCA | LDVMIWNSVF | 
    150:
    LGINILHLSY | LLYKKRPVKI | EKELGGVYHR | LFEPLRVPPD | LFRRLTGQFC | 
    200:
    MIQTLKRGQV | YATEDKTSVD | DRLSILLKGR | MKVSYRGHFL | HNIYPCAFID | 
    250:
    SPEFRSTQMH | KGEKFQVTIV | ADDNCRFLCW | SRERLTYFLE | SEPFLYEIFR | 
    300:
    YLIGKDITNK | LYSLNDPTLN | DKKVKKLEPQ | MSLCTQISML | EMRNSITSSS | 
    350:
    DGEDGLHHFL | RGSSSTASLP | MSSPQQRASA | KMKPIEEGVE | DDDEVFVSPD | 
    358:
    ALKVHQLP
    3D Structure:
    N/A
    Predicted Eptitope:
    Please Sign in.
    EIAab Sequence  Vaild Sequence:
    Please Sign in.
    Related Databases
    KEGG:
    UniGene:
    SMR:
    Pfam:
    String:
    Uniprot:
     
    FOR
    ELISA Kit for Mouse mBVES
    ELISA Kit for Mouse mBVES
    ELISA Kit for Mouse mBVES
    ELISA Kit for Mouse mBVES
    ELISA Kit for Mouse mBVES
    CLIA Kit for Mouse mBVES
    CLIA Kit for Mouse mBVES
    CLIA Kit for Mouse mBVES
    CLIA Kit for Mouse mBVES
    CLIA Kit for Mouse mBVES
    Polyclonal Antibody for Mouse mBVES
    Polyclonal Antibody for Mouse mBVES
    Polyclonal Antibody for Mouse mBVES
    Polyclonal Antibody for Mouse mBVES
    Polyclonal Antibody for Mouse mBVES
    Monoclonal Antibody for Mouse mBVES
    Monoclonal Antibody for Mouse mBVES
    Monoclonal Antibody for Mouse mBVES
    Monoclonal Antibody for Mouse mBVES
    Monoclonal Antibody for Mouse mBVES
    Protein for Mouse mBVES
    Protein for Mouse mBVES
    Protein for Mouse mBVES
    Protein for Mouse mBVES
    Protein for Mouse mBVES

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    Precision
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    References
    1. 1.
      "Isolation and characterization of the novel popeye gene family expressed in skeletal muscle and heart."
      Andree B. , Hillemann T. , Kessler-Icekson G. , Schmitt-John T. , Jockusch H. , Arnold H.-H. , Brand T.
      Dev. Biol.223:371-382(2000) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA];POSSIBLE FUNCTION;DEVELOPMENTAL STAGE;TISSUE SPECIFICITY
    2. 2.
      "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res.14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]
      tissue: Brain.
    3. 3.
      "bves: a novel gene expressed during coronary blood vessel development."
      Reese D.E. , Zavaljevski M. , Streiff N.L. , Bader D.
      Dev. Biol.209:159-171(1999) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 4-358
    4. 4.
      "The transcriptional landscape of the mammalian genome."
      Carninci P. , Kasukawa T. , Katayama S. , Gough J. , Frith M.C. , Maeda N. , Oyama R. , Ravasi T. , Lenhard B. , Wells C. , Kodzius R. , Shimokawa K. , Bajic V.B. , Brenner S.E. , Batalov S. , Forrest A.R. , Zavolan M. , Davis M.J. , more...
      Science309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 259-358
      strain: C57BL/6J.
      tissue: Thymus.
    5. 5.
      "Mouse Pop1 is required for muscle regeneration in adult skeletal muscle."
      Andree B. , Fleige A. , Arnold H.H. , Brand T.
      Mol. Cell. Biol.22:1504-1512(2002) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;DISRUPTION PHENOTYPE;TISSUE SPECIFICITY;DEVELOPMENTAL STAGE
    6. 6.
      "Bves modulates epithelial integrity through an interaction at the tight junction."
      Osler M.E. , Chang M.S. , Bader D.M.
      J. Cell Sci.118:4667-4678(2005) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;INTERACTION WITH TJP1;SUBCELLULAR LOCATION;TISSUE SPECIFICITY
    7. 7.
      "Bves directly interacts with GEFT, and controls cell shape and movement through regulation of Rac1/Cdc42 activity."
      Smith T.K. , Hager H.A. , Francis R. , Kilkenny D.M. , Lo C.W. , Bader D.M.
      Proc. Natl. Acad. Sci. U.S.A.105:8298-8303(2008) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;INTERACTION WITH ARHGEF25;TISSUE SPECIFICITY
    8. 8.
      "Identification of a novel Bves function: regulation of vesicular transport."
      Hager H.A. , Roberts R.J. , Cross E.E. , Proux-Gillardeaux V. , Bader D.M.
      EMBO J.29:532-545(2010) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;INTERACTION WITH VAMP3;SUBCELLULAR LOCATION
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