Gene name:
Bves (Pop1;Popdc1) ;
Protein name:
Blood vessel epicardial substance (mBVES) ;
Alternative:
Popeye domain-containing protein 1 (Popeye protein 1) ;
Organism:
Mouse (Mus musculus).
General Annotation
Sub Unit:
Homodimer. Homodimerization requires the C-terminus cytoplasmic region (By similarity). Interacts (via the C-terminus cytoplasmic tail) with TJP1. Interacts (via the C-terminus cytoplasmic tail) with ARHGEF25/GEFT (via the DH domain). Interacts (via the C-terminus cytoplasmic tail) with VAMP3.
Function:
Cell adhesion molecule involved in the establishment and/or maintenance of cell integrity. Involved in the formation and regulation of the tight junction (TJ) paracellular permeability barrier in epithelial cells. Plays a role in VAMP3-mediated vesicular transport and recycling of different receptor molecules through its interaction with VAMP3. Plays a role in the regulation of cell shape and movement by modulating the Rho-family GTPase activity through its interaction with ARHGEF25/GEFT. Induces primordial adhesive contact and aggregation of epithelial cells in a Ca(2+)-independent manner. Also involved in striated muscle regeneration and repair and in the regulation of cell spreading.
Subcellular Location:
Lateral cell membrane
Cell junction
tight junction
Membrane
Multi-pass membrane protein
Its movement from the cytoplasm to membrane is an early event occurring concurrently with cell-cell contact. Detected at cell-cell contact but never observed at the free surface of epithelial cells (By similarity). Colocalizes in epithelial cells with OCLN and TJP1 in an apical-lateral position within the z axis. Colocalizes with VAMP3 at the cell-cell contact in cardiac and skeletal muscle.
Protein Attributes:
50:
MNSTESIPLA | QSTVAGFTSE | LESLTPVPSN | ETTCENWREI | HHLVFHVANV |
100:
CFAVGLLIPT | TLHLHMILLR | VMLSLGCTLY | VVWATLYRCA | LDVMIWNSVF |
150:
LGINILHLSY | LLYKKRPVKI | EKELGGVYHR | LFEPLRVPPD | LFRRLTGQFC |
200:
MIQTLKRGQV | YATEDKTSVD | DRLSILLKGR | MKVSYRGHFL | HNIYPCAFID |
250:
SPEFRSTQMH | KGEKFQVTIV | ADDNCRFLCW | SRERLTYFLE | SEPFLYEIFR |
300:
YLIGKDITNK | LYSLNDPTLN | DKKVKKLEPQ | MSLCTQISML | EMRNSITSSS |
350:
DGEDGLHHFL | RGSSSTASLP | MSSPQQRASA | KMKPIEEGVE | DDDEVFVSPD |
Vaild Sequence:
Related Databases
Uniprot:
ELISA Kit
CLIA Kit
Polyclonal Antibody
Monoclonal Antibody
Protein
FOR
Pig
Mouse
Chicken
Human
Rat
ELISA Kit for Mouse mBVES
ELISA Kit for Mouse mBVES
ELISA Kit for Mouse mBVES
ELISA Kit for Mouse mBVES
ELISA Kit for Mouse mBVES
Polyclonal Antibody for Mouse mBVES
Polyclonal Antibody for Mouse mBVES
Polyclonal Antibody for Mouse mBVES
Polyclonal Antibody for Mouse mBVES
Polyclonal Antibody for Mouse mBVES
Monoclonal Antibody for Mouse mBVES
Monoclonal Antibody for Mouse mBVES
Monoclonal Antibody for Mouse mBVES
Monoclonal Antibody for Mouse mBVES
Monoclonal Antibody for Mouse mBVES
R&D Technical Data
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Precision
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Recovery
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Linearity
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References
1.
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Cited for : NUCLEOTIDE SEQUENCE [MRNA];POSSIBLE FUNCTION;DEVELOPMENTAL STAGE;TISSUE SPECIFICITY
2.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]
tissue :
Brain .
3.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [MRNA] OF 4-358
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Abstract ]
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 259-358
strain :
C57BL/6J .
tissue :
Thymus .
5.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : FUNCTION;DISRUPTION PHENOTYPE;TISSUE SPECIFICITY;DEVELOPMENTAL STAGE
6.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : FUNCTION;INTERACTION WITH TJP1;SUBCELLULAR LOCATION;TISSUE SPECIFICITY
7.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : FUNCTION;INTERACTION WITH ARHGEF25;TISSUE SPECIFICITY
8.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : FUNCTION;INTERACTION WITH VAMP3;SUBCELLULAR LOCATION