Ppp1ca ELISA Kit for Mouse(Mus musculus) | EIAab.comPpp1ca ELISA Kit for Mouse(Mus musculus)

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Ppp1ca (Gene name),

Serine/threonine-protein phosphatase PP1-alpha catalytic subunit (Protein name ), PP1A_MOUSE from NCBI database.

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General Annotation

Antigen Annotation

Predicted Eptitope

Vaild Sequence

Related Databases

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Gene name:

Ppp1ca(Ppp1a);

Protein name:

Serine/threonine-protein phosphatase PP1-alpha catalytic subunit(PP-1A);

Alternative:

Organism:

Mouse (Mus musculus).

General Annotation

Sub Unit:

PP1 comprises a catalytic subunit, PPP1CA, PPP1CB or PPP1CC, which is folded into its native form by inhibitor 2 and glycogen synthetase kinase 3, and then complexed to one or several targeting or regulatory subunits. PPP1R12A, PPP1R12B and PPP1R12C mediate binding to myosin. PPP1R3A, PPP1R3B, PPP1R3C and PPP1R3D mediate binding to glycogen. Component of the MLL5-L complex, at least composed of MLL5, STK38, PPP1CA, PPP1CB, PPP1CC, HCFC1, ACTB and OGT. Interacts with PPP1R9A, PPP1R9B and PPP1R7. Interacts with PPP1R15A; the interaction mediates binding to EIF2S1. Interacts with YLPM1. Forms a complex with ILF2, ILF3, YLPM1, KHDRBS1, RBMX and NCOA5. Interacts with NOM1 and PPP1R8. Interacts with PPP1R16B. Interacts. with RPSA only in the presence of PPP1R16B. Component of the PTW/PP1 phosphatase complex, composed of PPP1R10/PNUTS, TOX4, WDR82, and PPP1CA or PPP1CB or PPP1CC. Interacts with PPP1R10/PNUTS and PPP1R8. Interacts with WDR82 in the presence of PPP1R10/PNUTS. Interacts with SH3RF2. Interacts with TRIM28; the interaction dephosphorylates TRIM28 on 'Ser-824' and forms a complex at the p21 promoter site (By similarity). Interacts with PPP1R15B; the interaction mediates binding to EIF2S1. Part of a complex containing PPP1R15B, PP1 and NCK1/2. Interacts with NEK2.

Function:

Protein phosphatase 1 (PP1) is essential for cell division, and participates in the regulation of glycogen metabolism, muscle contractility and protein synthesis. Involved in regulation of ionic conductances and long-term synaptic plasticity. May play an important role in dephosphorylating substrates such as the postsynaptic density-associated Ca(2+)/calmodulin dependent protein kinase II. Component of the PTW/PP1 phosphatase complex, which plays a role in the control of chromatin structure and cell cycle progression during the transition from mitosis into interphase. Regulates NEK2 function in terms of kinase activity and centrosome number and splitting, both in the presence and absence of radiation-induced DNA damage.

Subcellular Location:

Cytoplasm Nucleus Nucleus nucleoplasm Nucleus nucleolus Primarily nuclear and largely excluded from the nucleolus. Highly mobile in cells and can be relocalized through interaction with targeting subunits. NOM1 plays a role in targeting this protein to the nucleolus. In the presence of PPP1R8 relocalizes from the nucleus to nuclear speckles.

Protein Attributes:

Sequence length:

330

Sequence:

50:

100:

150:

200:

250:

300:

330:

KNKGKYGQFS | GLNPGGRPIT | PPRNSAKAKK |

3D Structure:

N/A

Predicted Eptitope:

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Vaild Sequence:

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Related Databases

KEGG:

mmu:19045

Pfam:

PF00149

UniGene:

Mm.1970

SMR:

P62137

String:

P62137

Uniprot:

P62137

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ELISA Kit for Mouse PP-1A

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E9568h

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ELISA Kit for Mouse PP-1A

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ELISA Kit for Mouse PP-1A

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ELISA Kit for Mouse PP-1A

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E9568m

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96T

ELISA Kit for Mouse PP-1A

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E9568r

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96T

ELISA Kit for Mouse PP-1A

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CLIA Kit for Mouse PP-1A

Cat.:

U9568b

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96T

CLIA Kit for Mouse PP-1A

MSDS:

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CLIA Kit for Mouse PP-1A

Cat.:

U9568h

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96T

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CLIA Kit for Mouse PP-1A

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CLIA Kit for Mouse PP-1A

Cat.:

U9568m

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MSDS:

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Packing:

96T

CLIA Kit for Mouse PP-1A

Cat.:

U9568r

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96T

Polyclonal Antibody for Mouse PP-1A

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P9568Rb-h

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40ug/0.2ml

Polyclonal Antibody for Mouse PP-1A

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P9568Rb-m

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Polyclonal Antibody for Mouse PP-1A

Monoclonal Antibody for Mouse PP-1A

Protein for Mouse PP-1A

R&D Technical Data

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Precision

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Recovery

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Linearity

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References

1.

Ortiz J.M. , Lorenzo M.L. , Eguiraun A. , Andres I. , Sangrador A. , Allshire R. , Hastie N.D.
Submitted (1995-04) to the EMBL/GenBank/DDBJ databases

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA]
2.

"The transcriptional landscape of the mammalian genome."
Carninci P. , Kasukawa T. , Katayama S. , Gough J. , Frith M.C. , Maeda N. , Oyama R. , Ravasi T. , Lenhard B. , Wells C. , Kodzius R. , Shimokawa K. , Bajic V.B. , Brenner S.E. , Batalov S. , Forrest A.R. , Zavolan M. , Davis M.J. , more...
Science309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]
strain: C57BL/6J.
strain: DBA/2.
tissue: Extraembryonic tissue.
tissue: Liver.
tissue: Pancreas.
tissue: Placenta.
3.

"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res.14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]
tissue: Kidney.
4.

Lubec G. , Klug S.
Submitted (2007-03) to the UniProtKB

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PROTEIN SEQUENCE OF 44-74; 114-122 AND 247-260;IDENTIFICATION BY MASS SPECTROMETRY
tissue: Hippocampus.
5.

"Molecular cloning of a protein serine/threonine phosphatase containing a putative regulatory tetratricopeptide repeat domain."
Becker W. , Kentrup H. , Klumpp S. , Schultz J.E. , Joost H.G.
J. Biol. Chem.269:22586-22592(1994) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 69-90
6.

"Inhibition of a constitutive translation initiation factor 2alpha phosphatase, CReP, promotes survival of stressed cells."
Jousse C. , Oyadomari S. , Novoa I. , Lu P. , Zhang Y. , Harding H.P. , Ron D.
J. Cell Biol.163:767-775(2003) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH PPP1R15B
7.

"Nck in a complex containing the catalytic subunit of protein phosphatase 1 regulates eukaryotic initiation factor 2alpha signaling and cell survival to endoplasmic reticulum stress."
Latreille M. , Larose L.
J. Biol. Chem.281:26633-26644(2006) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: IDENTIFICATION IN COMPLEX WITH PPP1R15B AND NCK1
8.

"Phactr4 regulates neural tube and optic fissure closure by controlling PP1-, Rb-, and E2F1-regulated cell-cycle progression."
Kim T.H. , Goodman J. , Anderson K.V. , Niswander L.
Dev. Cell13:87-102(2007) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;INTERACTION WITH PHACTR4
9.

"A novel Akt/PKB-interacting protein promotes cell adhesion and inhibits familial amyotrophic lateral sclerosis-linked mutant SOD1-induced neuronal death via inhibition of PP2A-mediated dephosphorylation of Akt/PKB."
Nawa M. , Kanekura K. , Hashimoto Y. , Aiso S. , Matsuoka M.
Cell. Signal.20:493-505(2008) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH BTBD10
10.

"Large scale localization of protein phosphorylation by use of electron capture dissociation mass spectrometry."
Sweet S.M. , Bailey C.M. , Cunningham D.L. , Heath J.K. , Cooper H.J.
Mol. Cell. Proteomics8:904-912(2009) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT TYR-306;IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
tissue: Embryonic fibroblast.
11.

"Protein phosphatase 1 (PP1) is a post-translational regulator of the mammalian circadian clock."
Schmutz I. , Wendt S. , Schnell A. , Kramer A. , Mansuy I.M. , Albrecht U.
PLoS ONE6:E21325-E21325(2011) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION IN CIRCADIAN CLOCK
12.

"The period of the circadian oscillator is primarily determined by the balance between casein kinase 1 and protein phosphatase 1."
Lee H.M. , Chen R. , Kim H. , Etchegaray J.P. , Weaver D.R. , Lee C.
Proc. Natl. Acad. Sci. U.S.A.108:16451-16456(2011) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION IN CIRCADIAN CLOCK;MUTAGENESIS OF ASP-64 AND ASP-95
13.

"Phactr4 regulates directional migration of enteric neural crest through PP1, integrin signaling, and cofilin activity."
Zhang Y. , Kim T.H. , Niswander L.
Genes Dev.26:69-81(2012) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION
14.

"KCTD20, a relative of BTBD10, is a positive regulator of Akt."
Nawa M. , Matsuoka M.
BMC Biochem.14:27-27(2013) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH KCTD20
15.

"SIRT5-mediated lysine desuccinylation impacts diverse metabolic pathways."
Park J. , Chen Y. , Tishkoff D.X. , Peng C. , Tan M. , Dai L. , Xie Z. , Zhang Y. , Zwaans B.M. , Skinner M.E. , Lombard D.B. , Zhao Y.
Mol. Cell50:919-930(2013) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT LYS-305;IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
tissue: Embryonic fibroblast.

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