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Index > Protein center > ACP1(Gene name) > Human
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  • ACP1 (Gene name),
  • Low molecular weight phosphotyrosine protein phosphatase (Protein name ),  PPAC_HUMAN from NCBI database.
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  • General Annotation
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  • Antigen Annotation
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  • 3D
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  • Predicted Eptitope
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  • Vaild Sequence
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  • Gene name:
    ACP1;
    Protein name:
    Low molecular weight phosphotyrosine protein phosphatase(LMW-PTP;LMW-PTPase);
    Alternative:
    3.1.3.2;Low molecular weight cytosolic acid phosphatase);Adipocyte acid phosphatase;Red cell acid phosphatase 1;
    Organism:
    Human (Homo sapiens). 
    General Annotation
    Sub Unit:
    Isoform 1 interacts with the SH3 domain of SPTAN1. There is no interaction observed for isoforms 2 or 3. Interacts with EPHA2; dephosphorylates EPHA2. Interacts with EPHB1.
    Function:
    Acts on tyrosine phosphorylated proteins, low-MW aryl phosphates and natural and synthetic acyl phosphates. Isoform 3 does not possess phosphatase activity.
    Subcellular Location:
    Cytoplasm
    Protein Attributes:
    Sequence length:
    158
    Sequence:
    50:
    MAEQATKSVL | FVCLGNICRS | PIAEAVFRKL | VTDQNISENW | RVDSAATSGY | 
    100:
    EIGNPPDYRG | QSCMKRHGIP | MSHVARQITK | EDFATFDYIL | CMDESNLRDL | 
    150:
    NRKSNQVKTC | KAKIELLGSY | DPQKQLIIED | PYYGNDSDFE | TVYQQCVRCC | 
    158:
    RAFLEKAH
    3D Structure:
    N/A
    Predicted Eptitope:
    Please Sign in.
    EIAab Sequence  Vaild Sequence:
    Please Sign in.
    Related Databases
    UniGene:
    KEGG:
    MIM:
    SMR:
    Pfam:
    String:
    Uniprot:
     
    FOR
    ELISA Kit for Human LMW-PTP
    ELISA Kit for Human LMW-PTP
    ELISA Kit for Human LMW-PTP
    ELISA Kit for Human LMW-PTP
    ELISA Kit for Human LMW-PTP
    ELISA Kit for Human LMW-PTP
    CLIA Kit for Human LMW-PTP
    CLIA Kit for Human LMW-PTP
    CLIA Kit for Human LMW-PTP
    CLIA Kit for Human LMW-PTP
    CLIA Kit for Human LMW-PTP
    CLIA Kit for Human LMW-PTP
    Polyclonal Antibody for Human LMW-PTP
    Polyclonal Antibody for Human LMW-PTP
    Polyclonal Antibody for Human LMW-PTP
    Polyclonal Antibody for Human LMW-PTP
    Polyclonal Antibody for Human LMW-PTP
    Polyclonal Antibody for Human LMW-PTP
    Monoclonal Antibody for Human LMW-PTP
    Monoclonal Antibody for Human LMW-PTP
    Monoclonal Antibody for Human LMW-PTP
    Monoclonal Antibody for Human LMW-PTP
    Monoclonal Antibody for Human LMW-PTP
    Monoclonal Antibody for Human LMW-PTP
    Protein for Human LMW-PTP
    Protein for Human LMW-PTP
    Protein for Human LMW-PTP
    Protein for Human LMW-PTP
    Protein for Human LMW-PTP
    Protein for Human LMW-PTP

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    References
    1. 1.
      "Human red cell acid phosphatase (ACP1). The amino acid sequence of the two isozymes Bf and Bs encoded by the ACP1*B allele."
      Dissing J. , Johnsen A.H. , Sensabaugh G.F.
      J. Biol. Chem.266:20619-20625(1991) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PROTEIN SEQUENCE (ALLELE B; ISOFORMS 1 AND 2);CLEAVAGE OF INITIATOR METHIONINE;ACETYLATION AT ALA-2
    2. 2.
      "Human red cell acid phosphatase (ACP1): the primary structure of the two pairs of isozymes encoded by the ACP1*A and ACP1*C alleles."
      Dissing J. , Johnsen A.H.
      Biochim. Biophys. Acta1121:261-268(1992) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PROTEIN SEQUENCE (ALLELES A AND C; ISOFORMS 1 AND 2)
    3. 3.
      "Sequencing, cloning, and expression of human red cell-type acid phosphatase, a cytoplasmic phosphotyrosyl protein phosphatase."
      Wo Y.-Y.P. , McCormack A.L. , Shabonowitz J. , Hunt D.F. , Davis J.P. , Mitchell G.L. , van Etten R.L.
      J. Biol. Chem.267:10856-10865(1992) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1 AND 2)
    4. 4.
      "Gene structure, sequence, and chromosomal localization of the human red cell-type low-molecular-weight acid phosphotyrosyl phosphatase gene, ACP1."
      Bryson G.L.M. , Massa H. , Trask B.J. , van Etten R.L.
      Genomics30:133-140(1995) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]
    5. 5.
      "Identification of the adipocyte acid phosphatase as a PAO-sensitive tyrosyl phosphatase."
      Shekels L.L. , Smith A.J. , van Etten R.L. , Bernlohr D.A.
      Protein Sci.1:710-721(1992) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1 AND 2)
      tissue: Adipocyte.
    6. 6.
      "Regulation of the low molecular weight phosphotyrosine phosphatase by phosphorylation at tyrosines 131 and 132."
      Tailor P. , Gilman J. , Williams S. , Couture C. , Mustelin T.
      J. Biol. Chem.272:5371-5374(1997) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE (ISOFORM 2);TISSUE SPECIFICITY;PHOSPHORYLATION AT TYR-132 AND TYR-133;MUTAGENESIS OF CYS-13; TYR-132 AND TYR-133
    7. 7.
      "A novel isoform of the low molecular weight phosphotyrosine phosphatase, LMPTP-C, arising from alternative mRNA splicing."
      Tailor P. , Gilman J. , Williams S. , Mustelin T.
      Eur. J. Biochem.262:277-282(1999) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE (ISOFORM 3)
    8. 8.
      "Cloning of human full-length CDSs in BD Creator(TM) system donor vector."
      Kalnine N. , Chen X. , Rolfs A. , Halleck A. , Hines L. , Eisenstein S. , Koundinya M. , Raphael J. , Moreira D. , Kelley T. , LaBaer J. , Lin Y. , Phelan M. , Farmer A.
      Submitted (2003-05) to the EMBL/GenBank/DDBJ databases
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2)
    9. 9.
      "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T. , Suzuki Y. , Nishikawa T. , Otsuki T. , Sugiyama T. , Irie R. , Wakamatsu A. , Hayashi K. , Sato H. , Nagai K. , Kimura K. , Makita H. , Sekine M. , Obayashi M. , Nishi T. , Shibahara T. , Tanaka T. , Ishii S. , more...
      Nat. Genet.36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2)
      tissue: Hippocampus.
      tissue: Skeletal muscle.
    10. 10.
      "Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes."
      Kimura K. , Wakamatsu A. , Suzuki Y. , Ota T. , Nishikawa T. , Yamashita R. , Yamamoto J. , Sekine M. , Tsuritani K. , Wakaguri H. , Ishii S. , Sugiyama T. , Saito K. , Isono Y. , Irie R. , Kushida N. , Yoneyama T. , Otsuka R. , more...
      Genome Res.16:55-65(2006) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 4)
    11. 11.
      "Generation and annotation of the DNA sequences of human chromosomes 2 and 4."
      Hillier L.W. , Graves T.A. , Fulton R.S. , Fulton L.A. , Pepin K.H. , Minx P. , Wagner-McPherson C. , Layman D. , Wylie K. , Sekhon M. , Becker M.C. , Fewell G.A. , Delehaunty K.D. , Miner T.L. , Nash W.E. , Kremitzki C. , Oddy L. , Du H. , more...
      Nature434:724-731(2005) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
    12. 12.
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
    13. 13.
      "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res.14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2);VARIANT ARG-106
      tissue: Muscle.
      tissue: Placenta.
    14. 14.
      Lubec G. , Vishwanath V.
      Submitted (2007-03) to the UniProtKB
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PROTEIN SEQUENCE OF 42-59;IDENTIFICATION BY MASS SPECTROMETRY
      tissue: Brain.
      tissue: Cajal-Retzius cell.
    15. 15.
      "A TaqI site identifies the *A allele at the ACP1 locus."
      Sensabaugh G.F. , Lazaruk K.A.
      Hum. Mol. Genet.2:1079-1079(1993) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 99-158 (ISOFORMS 1/2)
      tissue: Blood.
    16. 16.
      "Eph receptors discriminate specific ligand oligomers to determine alternative signaling complexes, attachment, and assembly responses."
      Stein E. , Lane A.A. , Cerretti D.P. , Schoecklmann H.O. , Schroff A.D. , Van Etten R.L. , Daniel T.O.
      Genes Dev.12:667-678(1998) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH EPHB1
    17. 17.
      "Regulation of the EphA2 kinase by the low molecular weight tyrosine phosphatase induces transformation."
      Kikawa K.D. , Vidale D.R. , Van Etten R.L. , Kinch M.S.
      J. Biol. Chem.277:39274-39279(2002) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH EPHA2
    18. 18.
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH SPTAN1
    19. 19.
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
    20. 20.
      "Crystal structure of a human low molecular weight phosphotyrosyl phosphatase. Implications for substrate specificity."
      Zhang M. , Stauffacher C.V. , Lin D. , van Etten R.L.
      J. Biol. Chem.273:21714-21720(1998) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: X-RAY CRYSTALLOGRAPHY (2.2 ANGSTROMS)
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