PPP1R15A ELISA Kit for Human(Homo sapiens) | EIAab.comPPP1R15A ELISA Kit for Human(Homo sapiens) | EIAab.com

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PPP1R15A (Gene name),

Protein phosphatase 1 regulatory subunit 15A (Protein name ), PR15A_HUMAN from NCBI database.

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General Annotation

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Antigen Annotation

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3D

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Predicted Eptitope

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Vaild Sequence

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Related Databases

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Gene name:

PPP1R15A(GADD34);

Protein name:

Protein phosphatase 1 regulatory subunit 15A;

Alternative:

Myeloid differentiation primary response protein MyD116 homolog;Growth arrest and DNA damage-inducible protein GADD34;

Organism:

Human (Homo sapiens).

General Annotation

Sub Unit:

Interacts with PCNA (By similarity). Interacts with LYN and MLL. Interacts with PP1, PPP1R1A and SMARCB1. Interacts with SMAD7. Interacts with BAG1.

Function:

Recruits the serine/threonine-protein phosphatase PP1 to dephosphorylate the translation initiation factor eIF-2A/EIF2S1, thereby reversing the shut-off of protein synthesis initiated by stress-inducible kinases and facilitating recovery of cells from stress. Down-regulates the TGF-beta signaling pathway by promoting dephosphorylation of TGFB1 by PP1. May promote apoptosis by inducing TP53 phosphorylation on 'Ser-15'.

Subcellular Location:

Endoplasmic reticulum

Protein Attributes:

Sequence length:

674

Sequence:

50:

MAPGQAPHQA | TPWRDAHPFF | LLSPVMGLLS | RAWSRLRGLG | PLEPWLVEAV |

100:

KGAALVEAGL | EGEARTPLAI | PHTPWGRRPE | EEAEDSGGPG | EDRETLGLKT |

150:

SSSLPEAWGL | LDDDDGMYGE | REATSVPRGQ | GSQFADGQRA | PLSPSLLIRT |

200:

LQGSDKNPGE | EKAEEEGVAE | EEGVNKFSYP | PSHRECCPAV | EEEDDEEAVK |

250:

KEAHRTSTSA | LSPGSKPSTW | VSCPGEEENQ | ATEDKRTERS | KGARKTSVSP |

300:

RSSGSDPRSW | EYRSGEASEE | KEEKAHKETG | KGEAAPGPQS | SAPAQRPQLK |

350:

SWWCQPSDEE | EGEVKALGAA | EKDGEAECPP | CIPPPSAFLK | AWVYWPGEDT |

400:

EEEEDEEEDE | DSDSGSDEEE | GEAEASSSTP | ATGVFLKSWV | YQPGEDTEEE |

450:

EDEDSDTGSA | EDEREAETSA | STPPASAFLK | AWVYRPGEDT | EEEEDEDVDS |

500:

EDKEDDSEAA | LGEAESDPHP | SHPDQRAHFR | GWGYRPGKET | EEEEAAEDWG |

550:

EAEPCPFRVA | IYVPGEKPPP | PWAPPRLPLR | LQRRLKRPET | PTHDPDPETP |

600:

LKARKVRFSE | KVTVHFLAVW | AGPAQAARQG | PWEQLARDRS | RFARRITQAQ |

650:

EELSPCLTPA | ARARAWARLR | NPPLAPIPAL | TQTLPSSSVP | SSPVQTTPLS |

674:

QAVATPSRSS | AAAAAALDLS | GRRG

3D Structure:

N/A

Predicted Eptitope:

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Vaild Sequence:

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Related Databases

UniGene:

Pfam:

KEGG:

STRING:

9606.ENSP00000200453

String:

MIM:

Uniprot:

FOR

ELISA Kit for Human Protein phosphatase 1 regulatory subunit 15A

ELISA Kit for Human Protein phosphatase 1 regulatory subunit 15A

ELISA Kit for Human Protein phosphatase 1 regulatory subunit 15A

ELISA Kit for Human Protein phosphatase 1 regulatory subunit 15A

CLIA Kit for Human Protein phosphatase 1 regulatory subunit 15A

CLIA Kit for Human Protein phosphatase 1 regulatory subunit 15A

CLIA Kit for Human Protein phosphatase 1 regulatory subunit 15A

CLIA Kit for Human Protein phosphatase 1 regulatory subunit 15A

Polyclonal Antibody for Human Protein phosphatase 1 regulatory subunit 15A

Polyclonal Antibody for Human Protein phosphatase 1 regulatory subunit 15A

Polyclonal Antibody for Human Protein phosphatase 1 regulatory subunit 15A

Polyclonal Antibody for Human Protein phosphatase 1 regulatory subunit 15A

Monoclonal Antibody for Human Protein phosphatase 1 regulatory subunit 15A

Monoclonal Antibody for Human Protein phosphatase 1 regulatory subunit 15A

Monoclonal Antibody for Human Protein phosphatase 1 regulatory subunit 15A

Monoclonal Antibody for Human Protein phosphatase 1 regulatory subunit 15A

Protein for Human Protein phosphatase 1 regulatory subunit 15A

Protein for Human Protein phosphatase 1 regulatory subunit 15A

Protein for Human Protein phosphatase 1 regulatory subunit 15A

Protein for Human Protein phosphatase 1 regulatory subunit 15A

R&D Technical Data

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Precision

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Recovery

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Linearity

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References

1.

"GADD34 induces p53 phosphorylation and p21/WAF1 transcription."
Yagi A. , Hasegawa Y. , Xiao H. , Haneda M. , Kojima E. , Nishikimi A. , Hasegawa T. , Shimokata K. , Isobe K.
J. Cell. Biochem.90:1242-1249(2003) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION
2.

"Growth arrest and DNA damage-inducible protein GADD34 targets protein phosphatase 1 alpha to the endoplasmic reticulum and promotes dephosphorylation of the alpha subunit of eukaryotic translation initiation factor 2."
Brush M.H. , Weiser D.C. , Shenolikar S.
Mol. Cell. Biol.23:1292-1303(2003) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;MUTAGENESIS OF 556-VAL--SER-558; ARG-612; ARG-614 AND ARG-618;SUBCELLULAR LOCATION
3.

"Human BAG-1 proteins bind to the cellular stress response protein GADD34 and interfere with GADD34 functions."
Hung W.J. , Roberson R.S. , Taft J. , Wu D.Y.
Mol. Cell. Biol.23:3477-3486(2003) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH BAG1
4.

"GADD34-PP1c recruited by Smad7 dephosphorylates TGFbeta type I receptor."
Shi W. , Sun C. , He B. , Xiong W. , Shi X. , Yao D. , Cao X.
J. Cell Biol.164:291-300(2004) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;INTERACTION WITH SMAD7
5.

"A selective inhibitor of eIF2alpha dephosphorylation protects cells from ER stress."
Boyce M. , Bryant K.F. , Jousse C. , Long K. , Harding H.P. , Scheuner D. , Kaufman R.J. , Ma D. , Coen D.M. , Ron D. , Yuan J.
Science307:935-939(2005) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH PP1
6.

"Association with endoplasmic reticulum promotes proteasomal degradation of GADD34 protein."
Zhou W. , Brush M.H. , Choy M.S. , Shenolikar S.
J. Biol. Chem.286:21687-21696(2011) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: SUBCELLULAR LOCATION;TOPOLOGY;INTRAMEMBRANE REGION;MUTAGENESIS OF VAL-25 AND LEU-29
7.

"Phosphorylation at tyrosine 262 promotes GADD34 protein turnover."
Zhou W. , Jeyaraman K. , Yusoff P. , Shenolikar S.
J. Biol. Chem.288:33146-33155(2013) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PHOSPHORYLATION AT TYR-262; TYR-391; TYR-434 AND TYR-512;UBIQUITINATION;MUTAGENESIS OF TYR-262
8.

"Mammalian GADD34, an apoptosis- and DNA damage-inducible gene."
Hollander M.C. , Zhan Q. , Bae I. , Fornace A.J. Jr.
J. Biol. Chem.272:13731-13737(1997) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1);INDUCTION
9.

"Cloning of human full open reading frames in Gateway(TM) system entry vector (pDONR201)."
Ebert L. , Schick M. , Neubert P. , Schatten R. , Henze S. , Korn B.
Submitted (2004-06) to the EMBL/GenBank/DDBJ databases

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1);VARIANT THR-32
10.

"Complete sequencing and characterization of 21,243 full-length human cDNAs."
Ota T. , Suzuki Y. , Nishikawa T. , Otsuki T. , Sugiyama T. , Irie R. , Wakamatsu A. , Hayashi K. , Sato H. , Nagai K. , Kimura K. , Makita H. , Sekine M. , Obayashi M. , Nishi T. , Shibahara T. , Tanaka T. , Ishii S. , more...
Nat. Genet.36:40-45(2004) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2);VARIANTS GLU-277; SER-312; PRO-316; SER-476 AND ALA-597
tissue: Umbilical cord blood.
11.

Mural R.J. , Istrail S. , Sutton G.G. , Florea L. , Halpern A.L. , Mobarry C.M. , Lippert R. , Walenz B. , Shatkay H. , Dew I. , Miller J.R. , Flanigan M.J. , Edwards N.J. , Bolanos R. , Fasulo D. , Halldorsson B.V. , Hannenhalli S. , Turner R. , more...
Submitted (2005-07) to the EMBL/GenBank/DDBJ databases

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
12.

"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res.14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1)
tissue: Brain.
13.

"The gadd and MyD genes define a novel set of mammalian genes encoding acidic proteins that synergistically suppress cell growth."
Zhan Q. , Lord K.A. , Alamo I. Jr. , Hollander M.C. , Carrier F. , Ron D. , Kohn K.W. , Hoffman B. , Liebermann D.A. , Fornace A.J. Jr.
Mol. Cell. Biol.14:2361-2371(1994) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION
14.

"Leukemic HRX fusion proteins inhibit GADD34-induced apoptosis and associate with the GADD34 and hSNF5/INI1 proteins."
Adler H.T. , Chinery R. , Wu D.Y. , Kussick S.J. , Payne J.M. , Fornace A.J. Jr. , Tkachuk D.C.
Mol. Cell. Biol.19:7050-7060(1999) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH KMT2A/MLL1 AND SMARCB1;INDUCTION
15.

"Interaction between growth arrest-DNA damage protein 34 and Src kinase Lyn negatively regulates genotoxic apoptosis."
Grishin A.V. , Azhipa O. , Semenov I. , Corey S.J.
Proc. Natl. Acad. Sci. U.S.A.98:10172-10177(2001) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH LYN;PHOSPHORYLATION
16.

"Growth arrest and DNA damage-inducible protein GADD34 assembles a novel signaling complex containing protein phosphatase 1 and inhibitor 1."
Connor J.H. , Weiser D.C. , Li S. , Hallenbeck J.M. , Shenolikar S.
Mol. Cell. Biol.21:6841-6850(2001) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH PP1 AND PPP1R1A;FUNCTION
17.

"The human SNF5/INI1 protein facilitates the function of the growth arrest and DNA damage-inducible protein (GADD34) and modulates GADD34-bound protein phosphatase-1 activity."
Wu D.Y. , Tkachuck D.C. , Roberson R.S. , Schubach W.H.
J. Biol. Chem.277:27706-27715(2002) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH SMARCB1 AND PP1;MUTAGENESIS OF 555-LYS--PHE-558
18.

"mda-7 (IL-24) Mediates selective apoptosis in human melanoma cells by inducing the coordinated overexpression of the GADD family of genes by means of p38 MAPK."
Sarkar D. , Su Z.-Z. , Lebedeva I.V. , Sauane M. , Gopalkrishnan R.V. , Valerie K. , Dent P. , Fisher P.B.
Proc. Natl. Acad. Sci. U.S.A.99:10054-10059(2002) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INDUCTION

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