Protein name:
    PML-RARA-regulated adapter molecule 1 (PRAM;PRAM-1) ;
    
    Alternative:
    
    
    
 
    Organism:
        
        
        
        
        
        
    
        Human  (Homo sapiens).  
    
 
General Annotation
    Sub Unit:
    Interacts with SKAP2, LCP2 and DBNL. May interact with LYN. Interacts with NEK6.
    
 
    Function:
    May be involved in myeloid differentiation. May be involved in integrin signaling in neutrophils. Binds to PtdIns(4)P.
    
 
    
        
        Subcellular Location:
        
    
    N/A
    
 
    
    Protein Attributes:
    
    50:
    MAHHLPAAME |  SHQDFRSIKA |  KFQASQPEPS |  DLPKKPPKPE |  FGKLKKFSQP |  
    
 
    100:
    ELSEHPKKAP |  LPEFGAVSLK |  PPQPQFTDLP |  KKPPPPEVTD |  LPKKPPPPEV |  
    
 
    150:
    TDLPKKPPPP |  EVTDLPKKPP |  PPEVTDLPKK |  PPPPEVTDLP |  KKPPPPEVTD |  
    
 
    200:
    LPKKPPPPEV |  TDLPKKPSKL |  ELSDLSKKFP |  QLGATPFPRK |  PLQPEVGEAP |  
    
 
    250:
    LKASLPEPGA |  PARKPLQPDE |  LSHPARPPSE |  PKSGAFPRKL |  WQPEAGEATP |  
    
 
    300:
    RSPQPELSTF |  PKKPAQPEFN |  VYPKKPPQPQ |  VGGLPKKSVP |  QPEFSEAAQT |  
    
 
    350:
    PLWKPQSSEP |  KRDSSAFPKK |  ASQPPLSDFP |  KKPPQPELGD |  LTRTSSEPEV |  
    
 
    400:
    SVLPKRPRPA |  EFKALSKKPP |  QPELGGLPRT |  SSEPEFNSLP |  RKLLQPERRG |  
    
 
    450:
    PPRKFSQPEP |  SAVLKRHPQP |  EFFGDLPRKP |  PLPSSASESS |  LPAAVAGFSS |  
    
 
    500:
    RHPLSPGFGA |  AGTPRWRSGG |  LVHSGGARPG |  LRPSHPPRRR |  PLPPASSLGH |  
    
 
    550:
    PPAKPPLPPG |  PVDMQSFRRP |  SAASIDLRRT |  RSAAGLHFQD |  RQPEDIPQVP |  
    
 
    600:
    DEIYELYDDV |  EPRDDSSPSP |  KGRDEAPSVQ |  QAARRPPQDP |  ALRKEKDPQP |  
    
 
    650:
    QQLPPMDPKL |  LKQLRKAEKA |  EREFRKKFKF |  EGEIVVHTKM |  MIDPNAKTRR |  
    
 
    700:
    GGGKHLGIRR |  GEILEVIEFT |  SNEEMLCRDP |  KGKYGYVPRT |  ALLPLETEVY |  
    
 
    718:
    DDVDFCDPLE |  NQPLPLGR
    
 
      Vaild Sequence:
    
 
Related Databases
Uniprot:
 
 
    
        
        ELISA Kit
         
        
        CLIA Kit
         
        
        Polyclonal Antibody
         
        
        Monoclonal Antibody
         
        
        Protein
         
        
     
FOR
    
        
        Human
         
        
        Mouse
         
        
     
    
        Polyclonal Antibody for Human PRAM
        
     
    
    
    
    
   
    
    
    
    
    
    
 
    
        Polyclonal Antibody for Human PRAM
        
     
    
    
    
    
   
    
    
    
    
    
    
 
    
        Monoclonal Antibody for Human PRAM
        
     
    
    
    
    
    
    
 
    
        Monoclonal Antibody for Human PRAM
        
     
    
    
    
    
    
    
 
 
 
 
 
 
 
 
    R&D Technical Data
    
    
    
        For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    
    
    
        For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    
    
    
        For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    
    
    
        For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    
    
    
        For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    
    
    
        For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    
    
    
        For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    
    
    
        For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    
    
    
        For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    
    
    
        For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    
    
 
    Precision
    
    
    
        For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    
    
    
        For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    
    
    
        For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    
    
    
        For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    
    
    
        For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    
    
    
        For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    
    
    
        For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    
    
    
        For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    
    
    
        For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    
    
    
        For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    
    
 
    Recovery
    
    
    
        For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    
    
    
        For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    
    
    
        For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    
    
    
        For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    
    
    
        For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    
    
    
        For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    
    
    
        For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    
    
    
        For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    
    
    
        For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    
    
    
        For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    
    
 
    Linearity
    
    
    
        For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    
    
    
        For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    
    
    
        For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    
    
    
        For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    
    
    
        For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    
    
    
        For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    
    
    
        For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    
    
    
        For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    
    
    
        For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    
    
    
        For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    
    
 
    
    
    References
    
    
        
            
        
            
                1.
                
                    
                        
                            "PRAM-1 is a novel adaptor protein regulated by retinoic acid (RA) and promyelocytic leukemia (PML)-RA receptor alpha in acute promyelocytic leukemia cells." 
                        
                        
                            Moog-Lutz C. 
                        ,
                            
Peterson E.J. 
                        ,
                            
Lutz P.G. 
                        ,
                            
Eliason S. 
                        ,
                            
Cave-Riant F. 
                        ,
                            
Singer A. 
                        ,
                            
Di Gioia Y. 
                        ,
                            
Dmovski S. 
                        ,
                            
Kamens J. 
                        ,
                            
Cayre Y.E. 
                        ,
                            
Koretzky G. 
                        
                        
                        
                        
                            J. Biol. Chem.276:22375-22381(2001)
                         
                        
                        
                        [
PubMed ]
                        [
Europe PMC ]
                        [
Abstract ]
                        
                    
 
                    
                        [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
                        Cited for NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1);INDUCTION;TISSUE SPECIFICITY;PHOSPHORYLATION;INTERACTION WITH SKAP2; LCP2 AND LYN;VARIANT GLN-57 
                    
                    
                 
             
         
            
        
            
                2.
                
                    
                        
                            "The DNA sequence and biology of human chromosome 19." 
                        
                        
                            Grimwood J. 
                        ,
                            
Gordon L.A. 
                        ,
                            
Olsen A.S. 
                        ,
                            
Terry A. 
                        ,
                            
Schmutz J. 
                        ,
                            
Lamerdin J.E. 
                        ,
                            
Hellsten U. 
                        ,
                            
Goodstein D. 
                        ,
                            
Couronne O. 
                        ,
                            
Tran-Gyamfi M. 
                        ,
                            
Aerts A. 
                        ,
                            
Altherr M. 
                        ,
                            
Ashworth L. 
                        ,
                            
Bajorek E. 
                        ,
                            
Black S. 
                        ,
                            
Branscomb E. 
                        ,
                            
Caenepeel S. 
                        ,
                            
Carrano A.V. 
                        ,
                        
                        
                            Caoile C. 
                        ,
                            Chan Y.M. 
                        ,
                            Christensen M. 
                        ,
                            Cleland C.A. 
                        ,
                            Copeland A. 
                        ,
                            Dalin E. 
                        ,
                            Dehal P. 
                        ,
                            Denys M. 
                        ,
                            Detter J.C. 
                        ,
                            Escobar J. 
                        ,
                            Flowers D. 
                        ,
                            Fotopulos D. 
                        ,
                            Garcia C. 
                        ,
                            Georgescu A.M. 
                        ,
                            Glavina T. 
                        ,
                            Gomez M. 
                        ,
                            Gonzales E. 
                        ,
                            Groza M. 
                        ,
                            Hammon N. 
                        ,
                            Hawkins T. 
                        ,
                            Haydu L. 
                        ,
                            Ho I. 
                        ,
                            Huang W. 
                        ,
                            Israni S. 
                        ,
                            Jett J. 
                        ,
                            Kadner K. 
                        ,
                            Kimball H. 
                        ,
                            Kobayashi A. 
                        ,
                            Larionov V. 
                        ,
                            Leem S.-H. 
                        ,
                            Lopez F. 
                        ,
                            Lou Y. 
                        ,
                            Lowry S. 
                        ,
                            Malfatti S. 
                        ,
                            Martinez D. 
                        ,
                            McCready P.M. 
                        ,
                            Medina C. 
                        ,
                            Morgan J. 
                        ,
                            Nelson K. 
                        ,
                            Nolan M. 
                        ,
                            Ovcharenko I. 
                        ,
                            Pitluck S. 
                        ,
                            Pollard M. 
                        ,
                            Popkie A.P. 
                        ,
                            Predki P. 
                        ,
                            Quan G. 
                        ,
                            Ramirez L. 
                        ,
                            Rash S. 
                        ,
                            Retterer J. 
                        ,
                            Rodriguez A. 
                        ,
                            Rogers S. 
                        ,
                            Salamov A. 
                        ,
                            Salazar A. 
                        ,
                            She X. 
                        ,
                            Smith D. 
                        ,
                            Slezak T. 
                        ,
                            Solovyev V. 
                        ,
                            Thayer N. 
                        ,
                            Tice H. 
                        ,
                            Tsai M. 
                        ,
                            Ustaszewska A. 
                        ,
                            Vo N. 
                        ,
                            Wagner M. 
                        ,
                            Wheeler J. 
                        ,
                            Wu K. 
                        ,
                            Xie G. 
                        ,
                            Yang J. 
                        ,
                            Dubchak I. 
                        ,
                            Furey T.S. 
                        ,
                            DeJong P. 
                        ,
                            Dickson M. 
                        ,
                            Gordon D. 
                        ,
                            Eichler E.E. 
                        ,
                            Pennacchio L.A. 
                        ,
                            Richardson P. 
                        ,
                            Stubbs L. 
                        ,
                            Rokhsar D.S. 
                        ,
                            Myers R.M. 
                        ,
                            Rubin E.M. 
                        ,
                            Lucas S.M. 
                        
                             
                              more...   
                             
                        
                        
                        
                            Nature428:529-535(2004)
                         
                        
                        
                        [
PubMed ]
                        [
Europe PMC ]
                        [
Abstract ]
                        
                    
 
                    
                        [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
                        Cited for NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA] 
                    
                    
                 
             
         
            
        
            
                3.
                
                    
                    
                        [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
                        Cited for NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2) 
                    
                    
                    tissue :
                    
Blood .  
             
         
            
        
            
                4.
                
                    
                    
                        [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
                        Cited for INTERACTION WITH DBNL;INDUCTION 
                    
                    
                 
             
         
            
        
            
                5.
                
                    
                    
                        [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
                        Cited for PHOSPHOINOSITIDE-BINDING 
                    
                    
                 
             
         
            
        
            
                6.
                
                    
                    
                        [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
                        Cited for IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS] 
                    
                    
                 
             
         
            
        
            
                7.
                
                    
                    
                        [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
                        Cited for INTERACTION WITH NEK6