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Index > Protein center > PITRM1(Gene name) > Human
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  • PITRM1 (Gene name),
  • Presequence protease, mitochondrial (Protein name ),  PREP_HUMAN from NCBI database.
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  • General Annotation
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  • Antigen Annotation
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  • 3D
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  • Predicted Eptitope
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  • Vaild Sequence
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  • Gene name:
    PITRM1(KIAA1104;MP1);
    Protein name:
    Presequence protease, mitochondrial(hPreP);
    Alternative:
    Pitrilysin metalloproteinase 1(Metalloprotease 1;hMP1);
    Organism:
    Human (Homo sapiens). 
    General Annotation
    Sub Unit:
    Homodimer.
    Function:
    ATP-independent protease that degrades mitochondrial transit peptides after their cleavage. Also degrades other unstructured peptides. Specific for peptides in the range of 10 to 65 residues. Able to degrade amyloid beta A4 (APP) protein when it accumulates in mitochondrion, suggesting a link with Alzheimer disease. Shows a preference for cleavage after small polar residues and before basic residues, but without any positional preference.
    Subcellular Location:
    Mitochondrion matrix
    Protein Attributes:
    Sequence length:
    1037
    Sequence:
    50:
    MWRCGGRQGL | CVLRRLSGGH | AHHRAWRWNS | NRACERALQY | KLGDKIHGFT | 
    100:
    VNQVTSVPEL | FLTAVKLTHD | DTGARYLHLA | REDTNNLFSV | QFRTTPMDST | 
    150:
    GVPHILEHTV | LCGSQKYPCR | DPFFKMLNRS | LSTFMNAFTA | SDYTLYPFST | 
    200:
    QNPKDFQNLL | SVYLDATFFP | CLRELDFWQE | GWRLEHENPS | DPQTPLVFKG | 
    250:
    VVFNEMKGAF | TDNERIFSQH | LQNRLLPDHT | YSVVSGGDPL | CIPELTWEQL | 
    300:
    KQFHATHYHP | SNARFFTYGN | FPLEQHLKQI | HEEALSKFQK | IEPSTVVPAQ | 
    350:
    TPWDKPREFQ | ITCGPDSFAT | DPSKQTTVSV | SFLLPDITDT | FEAFTLSLLS | 
    400:
    SLLTSGPNSP | FYKALIESGL | GTDFSPDVGY | NGYTREAYFS | VGLQGIVEKD | 
    450:
    IETVRSLIDR | TIDEVVEKGF | EDDRIEALLH | KIEIQMKHQS | TSFGLMLTSY | 
    500:
    IASCWNHDGD | PVELLKLGNQ | LAKFRQCLQE | NPKFLQEKVK | QYFKNNQHKL | 
    550:
    TLSMRPDDKY | HEKQAQVEAT | KLKQKVEALS | PGDRQQIYEK | GLELRSQQSK | 
    600:
    PQDASCLPAL | KVSDIEPTIP | VTELDVVLTA | GDIPVQYCAQ | PTNGMVYFRA | 
    650:
    FSSLNTLPEE | LRPYVPLFCS | VLTKLGCGLL | DYREQAQQIE | LKTGGMSASP | 
    700:
    HVLPDDSHMD | TYEQGVLFSS | LCLDRNLPDM | MQLWSEIFNN | PCFEEEEHFK | 
    750:
    VLVKMTAQEL | ANGIPDSGHL | YASIRAGRTL | TPAGDLQETF | SGMDQVRLMK | 
    800:
    RIAEMTDIKP | ILRKLPRIKK | HLLNGDNMRC | SVNATPQQMP | QTEKAVEDFL | 
    850:
    RSIGRSKKER | RPVRPHTVEK | PVPSSSGGDA | HVPHGSQVIR | KLVMEPTFKP | 
    900:
    WQMKTHFLMP | FPVNYVGECI | RTVPYTDPDH | ASLKILARLM | TAKFLHTEIR | 
    950:
    EKGGAYGGGA | KLSHNGIFTL | YSYRDPNTIE | TLQSFGKAVD | WAKSGKFTQQ | 
    1000:
    DIDEAKLSVF | STVDAPVAPS | DKGMDHFLYG | LSDEMKQAHR | EQLFAVSHDK | 
    1037:
    LLAVSDRYLG | TGKSTHGLAI | LGPENPKIAK | DPSWIIR
    3D Structure:
    N/A
    Predicted Eptitope:
    Please Sign in.
    EIAab Sequence  Vaild Sequence:
    Please Sign in.
    Related Databases
    String:
    Pfam:
    UniGene:
    SMR:
    KEGG:
    Uniprot:
     
    FOR
    ELISA Kit for Human hPreP
    ELISA Kit for Human hPreP
    CLIA Kit for Human hPreP
    CLIA Kit for Human hPreP
    Polyclonal Antibody for Human hPreP
    Polyclonal Antibody for Human hPreP
    Monoclonal Antibody for Human hPreP
    Monoclonal Antibody for Human hPreP
    Protein for Human hPreP
    Protein for Human hPreP

    R&D Technical Data
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    Precision
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    Recovery
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    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
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    Linearity
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    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
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    References
    1. 1.
      "Cloning, expression, and characterization of human metalloprotease 1: a novel member of the pitrilysin family of metalloendoproteases."
      Mzhavia N. , Berman Y.L. , Qian Y. , Yan L. , Devi L.A.
      DNA Cell Biol.18:369-380(1999) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2);TISSUE SPECIFICITY;VARIANTS SER-169; VAL-328; VAL-397; ILE-621 AND ARG-1037
    2. 2.
      "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T. , Suzuki Y. , Nishikawa T. , Otsuki T. , Sugiyama T. , Irie R. , Wakamatsu A. , Hayashi K. , Sato H. , Nagai K. , Kimura K. , Makita H. , Sekine M. , Obayashi M. , Nishi T. , Shibahara T. , Tanaka T. , Ishii S. , more...
      Nat. Genet.36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 3);VARIANTS VAL-328; VAL-397 AND ARG-1037
      tissue: Placenta.
      tissue: Thymus.
    3. 3.
      "The DNA sequence and comparative analysis of human chromosome 10."
      Deloukas P. , Earthrowl M.E. , Grafham D.V. , Rubenfield M. , French L. , Steward C.A. , Sims S.K. , Jones M.C. , Searle S. , Scott C. , Howe K. , Hunt S.E. , Andrews T.D. , Gilbert J.G.R. , Swarbreck D. , Ashurst J.L. , Taylor A. , Battles J. , more...
      Nature429:375-381(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
    4. 4.
      "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res.14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1);VARIANTS ARG-8; VAL-145; VAL-328; VAL-397; ILE-963 AND ARG-1037
      tissue: Brain.
      tissue: Lung.
      tissue: Testis.
    5. 5.
      "Prediction of the coding sequences of unidentified human genes. XIV. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro."
      Kikuno R. , Nagase T. , Ishikawa K. , Hirosawa M. , Miyajima N. , Tanaka A. , Kotani H. , Nomura N. , Ohara O.
      DNA Res.6:197-205(1999) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 402-1037 (ISOFORM 1);VARIANT ARG-1037
      tissue: Brain.
    6. 6.
      "Degradation of the amyloid beta-protein by the novel mitochondrial peptidasome, PreP."
      Falkevall A. , Alikhani N. , Bhushan S. , Pavlov P.F. , Busch K. , Johnson K.A. , Eneqvist T. , Tjernberg L. , Ankarcrona M. , Glaser E.
      J. Biol. Chem.281:29096-29104(2006) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;SUBCELLULAR LOCATION;DISULFIDE BOND;MUTAGENESIS OF GLU-107 AND CYS-119
    7. 7.
      "Mammalian pitrilysin: substrate specificity and mitochondrial targeting."
      Chow K.M. , Gakh O. , Payne I.C. , Juliano M.A. , Juliano L. , Isaya G. , Hersh L.B.
      Biochemistry48:2868-2877(2009) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: TRANSIT PEPTIDE CLEAVAGE SITE;ENZYME REGULATION;SUBSTRATE SPECIFICITY
    8. 8.
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
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