Gene name:
PITRM1 (KIAA1104;MP1) ;
Protein name:
Presequence protease, mitochondrial (hPreP) ;
Alternative:
Pitrilysin metalloproteinase 1 (Metalloprotease 1;hMP1) ;
Organism:
Human (Homo sapiens).
General Annotation
Function:
ATP-independent protease that degrades mitochondrial transit peptides after their cleavage. Also degrades other unstructured peptides. Specific for peptides in the range of 10 to 65 residues. Able to degrade amyloid beta A4 (APP) protein when it accumulates in mitochondrion, suggesting a link with Alzheimer disease. Shows a preference for cleavage after small polar residues and before basic residues, but without any positional preference.
Subcellular Location:
Mitochondrion matrix
Protein Attributes:
50:
MWRCGGRQGL | CVLRRLSGGH | AHHRAWRWNS | NRACERALQY | KLGDKIHGFT |
100:
VNQVTSVPEL | FLTAVKLTHD | DTGARYLHLA | REDTNNLFSV | QFRTTPMDST |
150:
GVPHILEHTV | LCGSQKYPCR | DPFFKMLNRS | LSTFMNAFTA | SDYTLYPFST |
200:
QNPKDFQNLL | SVYLDATFFP | CLRELDFWQE | GWRLEHENPS | DPQTPLVFKG |
250:
VVFNEMKGAF | TDNERIFSQH | LQNRLLPDHT | YSVVSGGDPL | CIPELTWEQL |
300:
KQFHATHYHP | SNARFFTYGN | FPLEQHLKQI | HEEALSKFQK | IEPSTVVPAQ |
350:
TPWDKPREFQ | ITCGPDSFAT | DPSKQTTVSV | SFLLPDITDT | FEAFTLSLLS |
400:
SLLTSGPNSP | FYKALIESGL | GTDFSPDVGY | NGYTREAYFS | VGLQGIVEKD |
450:
IETVRSLIDR | TIDEVVEKGF | EDDRIEALLH | KIEIQMKHQS | TSFGLMLTSY |
500:
IASCWNHDGD | PVELLKLGNQ | LAKFRQCLQE | NPKFLQEKVK | QYFKNNQHKL |
550:
TLSMRPDDKY | HEKQAQVEAT | KLKQKVEALS | PGDRQQIYEK | GLELRSQQSK |
600:
PQDASCLPAL | KVSDIEPTIP | VTELDVVLTA | GDIPVQYCAQ | PTNGMVYFRA |
650:
FSSLNTLPEE | LRPYVPLFCS | VLTKLGCGLL | DYREQAQQIE | LKTGGMSASP |
700:
HVLPDDSHMD | TYEQGVLFSS | LCLDRNLPDM | MQLWSEIFNN | PCFEEEEHFK |
750:
VLVKMTAQEL | ANGIPDSGHL | YASIRAGRTL | TPAGDLQETF | SGMDQVRLMK |
800:
RIAEMTDIKP | ILRKLPRIKK | HLLNGDNMRC | SVNATPQQMP | QTEKAVEDFL |
850:
RSIGRSKKER | RPVRPHTVEK | PVPSSSGGDA | HVPHGSQVIR | KLVMEPTFKP |
900:
WQMKTHFLMP | FPVNYVGECI | RTVPYTDPDH | ASLKILARLM | TAKFLHTEIR |
950:
EKGGAYGGGA | KLSHNGIFTL | YSYRDPNTIE | TLQSFGKAVD | WAKSGKFTQQ |
1000:
DIDEAKLSVF | STVDAPVAPS | DKGMDHFLYG | LSDEMKQAHR | EQLFAVSHDK |
1037:
LLAVSDRYLG | TGKSTHGLAI | LGPENPKIAK | DPSWIIR
Vaild Sequence:
Related Databases
Uniprot:
ELISA Kit
CLIA Kit
Polyclonal Antibody
Monoclonal Antibody
Protein
FOR
Mouse
Human
ELISA Kit for Human hPreP
ELISA Kit for Human hPreP
Polyclonal Antibody for Human hPreP
Polyclonal Antibody for Human hPreP
Monoclonal Antibody for Human hPreP
Monoclonal Antibody for Human hPreP
R&D Technical Data
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Precision
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For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
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Recovery
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Linearity
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Cited for : NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 3);VARIANTS VAL-328; VAL-397 AND ARG-1037
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Placenta .
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Thymus .
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[
Abstract ]
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
4.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1);VARIANTS ARG-8; VAL-145; VAL-328; VAL-397; ILE-963 AND ARG-1037
tissue :
Brain .
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Lung .
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Testis .
5.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 402-1037 (ISOFORM 1);VARIANT ARG-1037
tissue :
Brain .
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J. Biol. Chem.281:29096-29104(2006)
[
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[
Europe PMC ]
[
Abstract ]
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : FUNCTION;SUBCELLULAR LOCATION;DISULFIDE BOND;MUTAGENESIS OF GLU-107 AND CYS-119
7.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : TRANSIT PEPTIDE CLEAVAGE SITE;ENZYME REGULATION;SUBSTRATE SPECIFICITY
8.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]