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Index > Protein center > PPARGC1A(Gene name) > Human
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  • PPARGC1A (Gene name),
  • Peroxisome proliferator-activated receptor gamma coactivator 1-alpha (Protein name ),  PRGC1_HUMAN from NCBI database.
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  • General Annotation
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  • Antigen Annotation
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  • 3D
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  • Predicted Eptitope
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  • Vaild Sequence
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  • Related Databases
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  • Citations  (1)
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  • Gene name:
    PPARGC1A(LEM6;PGC1;PGC1A;PPARGC1);
    Protein name:
    Peroxisome proliferator-activated receptor gamma coactivator 1-alpha(PGC-1-alpha;PPAR-gamma coactivator 1-alpha;PPARGC-1-alpha);
    Alternative:
    Ligand effect modulator 6;
    Organism:
    Human (Homo sapiens). 
    General Annotation
    Sub Unit:
    Binds MYBBP1A, which inhibits transcriptional activation by this protein (By similarity). Interacts with PRDM16 (By similarity). Interacts with LRPPRC. Homooligomer. Interacts with LPIN1.
    Function:
    Transcriptional coactivator for steroid receptors and nuclear receptors. Greatly increases the transcriptional activity of PPARG and thyroid hormone receptor on the uncoupling protein promoter. Can regulate key mitochondrial genes that contribute to the program of adaptive thermogenesis.
    Subcellular Location:
    Nucleus
    Protein Attributes:
    Sequence length:
    798
    Sequence:
    50:
    MAWDMCNQDS | ESVWSDIECA | ALVGEDQPLC | PDLPELDLSE | LDVNDLDTDS | 
    100:
    FLGGLKWCSD | QSEIISNQYN | NEPSNIFEKI | DEENEANLLA | VLTETLDSLP | 
    150:
    VDEDGLPSFD | ALTDGDVTTD | NEASPSSMPD | GTPPPQEAEE | PSLLKKLLLA | 
    200:
    PANTQLSYNE | CSGLSTQNHA | NHNHRIRTNP | AIVKTENSWS | NKAKSICQQQ | 
    250:
    KPQRRPCSEL | LKYLTTNDDP | PHTKPTENRN | SSRDKCTSKK | KSHTQSQSQH | 
    300:
    LQAKPTTLSL | PLTPESPNDP | KGSPFENKTI | ERTLSVELSG | TAGLTPPTTP | 
    350:
    PHKANQDNPF | RASPKLKSSC | KTVVPPPSKK | PRYSESSGTQ | GNNSTKKGPE | 
    400:
    QSELYAQLSK | SSVLTGGHEE | RKTKRPSLRL | FGDHDYCQSI | NSKTEILINI | 
    450:
    SQELQDSRQL | ENKDVSSDWQ | GQICSSTDSD | QCYLRETLEA | SKQVSPCSTR | 
    500:
    KQLQDQEIRA | ELNKHFGHPS | QAVFDDEADK | TGELRDSDFS | NEQFSKLPMF | 
    550:
    INSGLAMDGL | FDDSEDESDK | LSYPWDGTQS | YSLFNVSPSC | SSFNSPCRDS | 
    600:
    VSPPKSLFSQ | RPQRMRSRSR | SFSRHRSCSR | SPYSRSRSRS | PGSRSSSRSC | 
    650:
    YYYESSHYRH | RTHRNSPLYV | RSRSRSPYSR | RPRYDSYEEY | QHERLKREEY | 
    700:
    RREYEKRESE | RAKQRERQRQ | KAIEERRVIY | VGKIRPDTTR | TELRDRFEVF | 
    750:
    GEIEECTVNL | RDDGDSYGFI | TYRYTCDAFA | ALENGYTLRR | SNETDFELYF | 
    798:
    CGRKQFFKSN | YADLDSNSDD | FDPASTKSKY | DSLDFDSLLK | EAQRSLRR
    3D Structure:
    N/A
    Predicted Eptitope:
    Please Sign in.
    EIAab Sequence  Vaild Sequence:
    Please Sign in.
    Related Databases
    SMR:
    MIM:
    KEGG:
    UniGene:
    Pfam:
    String:
    Uniprot:
     
    FOR
    ELISA Kit for Human PGC-1-alpha
    Cat.:
    E1160h
    Price:
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    MSDS:
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    Packing:
    96T
    Range:
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    ELISA Kit for Human PGC-1-alpha
    Cat.:
    E1160r
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    Range:
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    ELISA Kit for Human PGC-1-alpha
    Cat.:
    E1160m
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    Range:
    Please sign in first.
    ELISA Kit for Human PGC-1-alpha
    Cat.:
    E1160p
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    Range:
    Please sign in first.
    ELISA Kit for Human PGC-1-alpha
    Cat.:
    E1160b
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    Range:
    Please sign in first.
    CLIA Kit for Human PGC-1-alpha
    Cat.:
    U1160r
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    Range:
    Please sign in first.
    CLIA Kit for Human PGC-1-alpha
    Cat.:
    U1160h
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    Range:
    Please sign in first.
    CLIA Kit for Human PGC-1-alpha
    Cat.:
    U1160m
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    CLIA Kit for Human PGC-1-alpha
    Cat.:
    U1160p
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    CLIA Kit for Human PGC-1-alpha
    Cat.:
    U1160b
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    Polyclonal Antibody for Human PGC-1-alpha
    Cat.:
    P1160Rb-m
    Price:
    Please sign in first.
    Packing:
    40ug/0.2ml
    Polyclonal Antibody for Human PGC-1-alpha
    Polyclonal Antibody for Human PGC-1-alpha
    Cat.:
    P1160Rb-h
    Price:
    Please sign in first.
    Packing:
    40ug/0.2ml
    Polyclonal Antibody for Human PGC-1-alpha
    Cat.:
    P1160Rb-r
    Price:
    Please sign in first.
    Packing:
    40ug/0.2ml
    Polyclonal Antibody for Human PGC-1-alpha
    Monoclonal Antibody for Human PGC-1-alpha
    Monoclonal Antibody for Human PGC-1-alpha
    Monoclonal Antibody for Human PGC-1-alpha
    Monoclonal Antibody for Human PGC-1-alpha
    Monoclonal Antibody for Human PGC-1-alpha
    Protein for Human PGC-1-alpha
    Protein for Human PGC-1-alpha
    Protein for Human PGC-1-alpha
    Protein for Human PGC-1-alpha
    Protein for Human PGC-1-alpha

    R&D Technical Data
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    s
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    Precision
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    Intra-assay Precision (Precision within an assay):Three samples of known concentration were tested twenty times on one plate to assess intra-assay precision.

    Intra-Assay CV: ≤3.9%

    Inter-assay Precision (Precision between assays):Three samples of known concentration were tested in five separate assays to assess inter-assay precision.

    Inter-Assay CV: ≤7.7%

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    Recovery
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    Recovery was determined by spiking various levels of ACE into serum and plasma .

    Sample Type

    Average(%)

    Recovery Range(%)

    Serum

    99

    91-103

    Plasma

    98

    93-106

     

     

     

     

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    Linearity
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    The linearity of the kit was assayed by testing samples spiked with appropriate concentration of ACE and their serial dilutions. The results were demonstrated by the percentage of calculated concentration to the expected.  

     

    Sample

    1:2

    1:4

    1:8

    1:16

    serum(n=5)

    92-105%

    90-101%

    95-105%

    92-109%

    Saliva(n=3)

    89-95%

    93105%

    89-94%

    90-106%

    heparin plasma(n=5)

    93-104%

     

    94-110%

    101-111%

    91-110%

     

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    References
    1. 1.
      "Human peroxisome proliferator activated receptor gamma coactivator 1 (PPARGC1) gene: cDNA sequence, genomic organization, chromosomal localization, and tissue expression."
      Esterbauer H. , Oberkofler H. , Krempler F. , Patsch W.
      Genomics62:98-102(1999) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA] (ISOFORM 1);TISSUE SPECIFICITY
    2. 2.
      "Cloning and mRNA tissue distribution of human PPARgamma coactivator-1."
      Larrouy D. , Vidal H. , Andreelli F. , Laville M. , Langin D.
      Int. J. Obes. Relat. Metab. Disord.23:1327-1332(1999) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1);TISSUE SPECIFICITY;VARIANT SER-482
      tissue: Skeletal muscle.
    3. 3.
      "A tissue-specific coactivator of steroid receptors, identified in a functional genetic screen."
      Knutti D. , Kaul A. , Kralli A.
      Mol. Cell. Biol.20:2411-2422(2000) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1);FUNCTION;SUBUNIT;SUBCELLULAR LOCATION;TISSUE SPECIFICITY
    4. 4.
      "Characterization of novel peroxisome proliferator-activated receptor gamma coactivator-1alpha (PGC-1alpha) isoform in human liver."
      Felder T.K. , Soyal S.M. , Oberkofler H. , Hahne P. , Auer S. , Weiss R. , Gadermaier G. , Miller K. , Krempler F. , Esterbauer H. , Patsch W.
      J. Biol. Chem.286:42923-42936(2011) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 9);SUBCELLULAR LOCATION (ISOFORM 9)
      tissue: Liver.
    5. 5.
      "A greatly extended PPARGC1A genomic locus encodes several new brain-specific isoforms and influences Huntington disease age of onset."
      Soyal S.M. , Felder T.K. , Auer S. , Hahne P. , Oberkofler H. , Witting A. , Paulmichl M. , Landwehrmeyer G.B. , Weydt P. , Patsch W.
      Hum. Mol. Genet.21:3461-3473(2012) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS B4; B4-3EXT; B4-8A; B5 AND B5-NT);ALTERNATIVE PROMOTER USAGE;ALTERNATIVE SPLICING;SUBCELLULAR LOCATION
      tissue: Brain.
    6. 6.
      "Isoform of PGC-1 generated by alternative splicing."
      Endo H.
      Submitted (2001-05) to the EMBL/GenBank/DDBJ databases
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM NT-7A);ALTERNATIVE SPLICING
      tissue: Skeletal muscle.
    7. 7.
      "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T. , Suzuki Y. , Nishikawa T. , Otsuki T. , Sugiyama T. , Irie R. , Wakamatsu A. , Hayashi K. , Sato H. , Nagai K. , Kimura K. , Makita H. , Sekine M. , Obayashi M. , Nishi T. , Shibahara T. , Tanaka T. , Ishii S. , more...
      Nat. Genet.36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 8A)
    8. 8.
      Rieder M.J. , Johanson E.J. , da Ponte S.H. , Stanaway I.B. , Ahearn M.O. , Bertucci C.B. , Wong M.W. , Yi Q. , Nickerson D.A.
      Submitted (2007-11) to the EMBL/GenBank/DDBJ databases
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]
    9. 9.
      "Generation and annotation of the DNA sequences of human chromosomes 2 and 4."
      Hillier L.W. , Graves T.A. , Fulton R.S. , Fulton L.A. , Pepin K.H. , Minx P. , Wagner-McPherson C. , Layman D. , Wylie K. , Sekhon M. , Becker M.C. , Fewell G.A. , Delehaunty K.D. , Miner T.L. , Nash W.E. , Kremitzki C. , Oddy L. , Du H. , more...
      Nature434:724-731(2005) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
    10. 10.
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
    11. 11.
      "Defects in energy homeostasis in Leigh syndrome French Canadian variant through PGC-1alpha/LRP130 complex."
      Cooper M.P. , Qu L. , Rohas L.M. , Lin J. , Yang W. , Erdjument-Bromage H. , Tempst P. , Spiegelman B.M.
      Genes Dev.20:2996-3009(2006) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH LRPPRC
    12. 12.
      "Nutrient-dependent regulation of PGC-1alpha's acetylation state and metabolic function through the enzymatic activities of Sirt1/GCN5."
      Dominy J.E. Jr. , Lee Y. , Gerhart-Hines Z. , Puigserver P.
      Biochim. Biophys. Acta1804:1676-1683(2010) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;REGULATION BY ACETYLATION
    13. 13.
      "PARIS (ZNF746) repression of PGC-1alpha contributes to neurodegeneration in Parkinson's disease."
      Shin J.H. , Ko H.S. , Kang H. , Lee Y. , Lee Y.I. , Pletinkova O. , Troconso J.C. , Dawson V.L. , Dawson T.M.
      Cell144:689-702(2011) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;INDUCTION
    14. 14.
      "RNF34 is a cold-regulated E3 ubiquitin ligase for PGC-1alpha and modulates brown fat cell metabolism."
      Wei P. , Pan D. , Mao C. , Wang Y.X.
      Mol. Cell. Biol.32:266-275(2012) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: UBIQUITINATION BY RNF34;INTERACTION WITH RNF34
    15. 15.
      "Peroxisome proliferator-activated receptor gamma coactivator 1 (PGC-1)- and estrogen-related receptor (ERR)-induced regulator in muscle 1 (Perm1) is a tissue-specific regulator of oxidative capacity in skeletal muscle cells."
      Cho Y. , Hazen B.C. , Russell A.P. , Kralli A.
      J. Biol. Chem.288:25207-25218(2013) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION
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