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Index > Protein center > PTOV1(Gene name) > Human
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  • PTOV1 (Gene name),
  • Prostate tumor-overexpressed gene 1 protein (Protein name ),  PTOV1_HUMAN from NCBI database.
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  • General Annotation
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  • Antigen Annotation
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  • Gene name:
    PTOV1(PP642;UNQ6127/PRO20092;ACID2);
    Protein name:
    Prostate tumor-overexpressed gene 1 protein(PTOV-1);
    Alternative:
    Activator interaction domain-containing protein 2;
    Organism:
    Human (Homo sapiens). 
    General Annotation
    Sub Unit:
    May interact with CREBBP. Interacts with FLOT1.
    Function:
    May activate transcription. Required for nuclear translocation of FLOT1. Promotes cell proliferation.
    Subcellular Location:
    Cell membrane Cytoplasm perinuclear region Nucleus Translocates from the cytoplasm to the nucleus at the onset of S-phase. Also localizes to lipid rafts.
    Protein Attributes:
    Sequence length:
    416
    Sequence:
    50:
    MVRPRRAPYR | SGAGGPLGGR | GRPPRPLVVR | AVRSRSWPAS | PRGPQPPRIR | 
    100:
    ARSAPPMEGA | RVFGALGPIG | PSSPGLTLGG | LAVSEHRLSN | KLLAWSGVLE | 
    150:
    WQEKRRPYSD | STAKLKRTLP | CQAYVNQGEN | LETDQWPQKL | IMQLIPQQLL | 
    200:
    TTLGPLFRNS | QLAQFHFTNR | DCDSLKGLCR | IMGNGFAGCM | LFPHISPCEV | 
    250:
    RVLMLLYSSK | KKIFMGLIPY | DQSGFVSAIR | QVITTRKQAV | GPGGVNSGPV | 
    300:
    QIVNNKFLAW | SGVMEWQEPR | PEPNSRSKRW | LPSHVYVNQG | EILRTEQWPR | 
    350:
    KLYMQLIPQQ | LLTTLVPLFR | NSRLVQFHFT | KDLETLKSLC | RIMDNGFAGC | 
    400:
    VHFSYKASCE | IRVLMLLYSS | EKKIFIGLIP | HDQGNFVNGI | RRVIANQQQV | 
    416:
    LQRNLEQEQQ | QRGMGG
    3D Structure:
    N/A
    Predicted Eptitope:
    Please Sign in.
    EIAab Sequence  Vaild Sequence:
    Please Sign in.
    Related Databases
    SMR:
    MIM:
    KEGG:
    UniGene:
    Pfam:
    String:
    Uniprot:
     
    FOR
    ELISA Kit for Human PTOV-1
    ELISA Kit for Human PTOV-1
    ELISA Kit for Human PTOV-1
    ELISA Kit for Human PTOV-1
    CLIA Kit for Human PTOV-1
    CLIA Kit for Human PTOV-1
    CLIA Kit for Human PTOV-1
    CLIA Kit for Human PTOV-1
    Polyclonal Antibody for Human PTOV-1
    Polyclonal Antibody for Human PTOV-1
    Polyclonal Antibody for Human PTOV-1
    Polyclonal Antibody for Human PTOV-1
    Monoclonal Antibody for Human PTOV-1
    Monoclonal Antibody for Human PTOV-1
    Monoclonal Antibody for Human PTOV-1
    Monoclonal Antibody for Human PTOV-1
    Protein for Human PTOV-1
    Protein for Human PTOV-1
    Protein for Human PTOV-1
    Protein for Human PTOV-1

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    References
    1. 1.
      "PTOV1, a novel protein overexpressed in prostate cancer containing a new class of protein homology blocks."
      Benedit P. , Paciucci R. , Thomson T.M. , Valeri M. , Nadal M. , Caceres C. , de Torres I. , Estivill X. , Lozano J.J. , Morote J. , Reventos J.
      Oncogene20:1455-1464(2001) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA];SUBCELLULAR LOCATION;TISSUE SPECIFICITY
    2. 2.
      "A novel docking site on Mediator is critical for activation by VP16 in mammalian cells."
      Mittler G. , Stuehler T. , Santolin L. , Uhlmann T. , Kremmer E. , Lottspeich F. , Berti L. , Meisterernst M.
      EMBO J.22:6494-6504(2003) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1);NUCLEOTIDE SEQUENCE [MRNA] OF 260-416 (ISOFORMS 1/3)
      tissue: Colon adenocarcinoma.
    3. 3.
      "Large-scale cDNA transfection screening for genes related to cancer development and progression."
      Wan D. , Gong Y. , Qin W. , Zhang P. , Li J. , Wei L. , Zhou X. , Li H. , Qiu X. , Zhong F. , He L. , Yu J. , Yao G. , Jiang H. , Qian L. , Yu Y. , Shu H. , Chen X. , more...
      Proc. Natl. Acad. Sci. U.S.A.101:15724-15729(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 3)
    4. 4.
      "The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment."
      Clark H.F. , Gurney A.L. , Abaya E. , Baker K. , Baldwin D.T. , Brush J. , Chen J. , Chow B. , Chui C. , Crowley C. , Currell B. , Deuel B. , Dowd P. , Eaton D. , Foster J.S. , Grimaldi C. , Gu Q. , Hass P.E. , more...
      Genome Res.13:2265-2270(2003) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2)
    5. 5.
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
    6. 6.
      "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res.14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1)
      tissue: Brain.
      tissue: Pancreas.
    7. 7.
      "PTOV-1, a novel protein overexpressed in prostate cancer, shuttles between the cytoplasm and the nucleus and promotes entry into the S phase of the cell division cycle."
      Santamaria A. , Fernandez P.L. , Farre X. , Benedit P. , Reventos J. , Morote J. , Paciucci R. , Thomson T.M.
      Am. J. Pathol.162:897-905(2003) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;SUBCELLULAR LOCATION
    8. 8.
      "PTOV1 enables the nuclear translocation and mitogenic activity of flotillin-1, a major protein of lipid rafts."
      Santamaria A. , Castellanos E. , Gomez V. , Benedit P. , Renau-Piqueras J. , Morote J. , Reventos J. , Thomson T.M. , Paciucci R.
      Mol. Cell. Biol.25:1900-1911(2005) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;INTERACTION WITH FLOT1;SUBCELLULAR LOCATION;DEVELOPMENTAL STAGE
    9. 9.
      "Targeted proteomic analysis of 14-3-3 sigma, a p53 effector commonly silenced in cancer."
      Benzinger A. , Muster N. , Koch H.B. , Yates J.R. III , Hermeking H.
      Mol. Cell. Proteomics4:785-795(2005) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: IDENTIFICATION BY MASS SPECTROMETRY
    10. 10.
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: SUBCELLULAR LOCATION;INDUCTION
    11. 11.
      "MED25 is distinct from TRAP220/MED1 in cooperating with CBP for retinoid receptor activation."
      Lee H.-K. , Park U.-H. , Kim E.-J. , Um S.-J.
      EMBO J.26:3545-3557(2007) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;INTERACTION WITH CREBBP
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