PPP2R4;

Serine/threonine-protein phosphatase 2A activator;

Phosphotyrosyl phosphatase activator(PTPA);PP2A, subunit B', PR53 isoform;Serine/threonine-protein phosphatase 2A regulatory subunit B';Serine/threonine-protein phosphatase 2A regulatory subunit 4;

Bovine (Bos taurus). 

Associates with the serine/threonine-protein phosphatase 2A PP2A(D) heterodimeric core enzyme, composed of a 36 kDa catalytic subunit (subunit C) and a 65 kDa constant regulatory subunit (PR65 or subunit A). Interacts with PPP2CB.

PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides. Acts as a regulatory subunit for serine/threonine-protein phosphatase 2A (PP2A) modulating its activity or substrate specificity, probably by inducing a conformational change in the catalytic subunit, a proposed direct target of the PPIase. Can reactivate inactive phosphatase PP2A-phosphatase methylesterase complexes (PP2A(i)) in presence of ATP and Mg(2+) (By similarity). Reversibly stimulates the variable phosphotyrosyl phosphatase activity of PP2A core heterodimer PP2A(D) in presence of ATP and Mg(2+) (in vitro). The phosphotyrosyl phosphatase activity is dependent of an ATPase activty of the PP2A(D):PPP2R4 complex. Is involved in apoptosis; the function appears to be independent from PP2A.

Cytoplasm Nucleus

324

N/A

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PF03095

9913.ENSBTAP00000032642

Q2KJ44

Q2KJ44

bta:514460

Bt.5138