Ptprc ELISA Kit for Mouse(Mus musculus) | EIAab.comPtprc ELISA Kit for Mouse(Mus musculus)

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Ptprc (Gene name),

Receptor-type tyrosine-protein phosphatase C (Protein name ), PTPRC_MOUSE from NCBI database.

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General Annotation

Antigen Annotation

Predicted Eptitope

Vaild Sequence

Related Databases

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Gene name:

Ptprc(Ly-5);

Protein name:

Receptor-type tyrosine-protein phosphatase C;

Alternative:

Lymphocyte antigen 5(Ly-5);Leukocyte common antigen(L-CA);T200;

CD:

CD45;

Organism:

Mouse (Mus musculus).

General Annotation

Sub Unit:

Interacts with SKAP1. Interacts with DPP4; the interaction is enhanced in a interleukin-12-dependent manner in activated lymphocytes (By similarity). Binds GANAB and PRKCSH.

Function:

Protein tyrosine-protein phosphatase required for T-cell activation through the antigen receptor. Acts as a positive regulator of T-cell coactivation upon binding to DPP4. The first PTPase domain has enzymatic activity, while the second one seems to affect the substrate specificity of the first one. Upon T-cell activation, recruits and dephosphorylates SKAP1 and FYN.

Subcellular Location:

Membrane Single-pass type I membrane protein Membrane raft Colocalized with DPP4 in membrane rafts.

Protein Attributes:

Sequence length:

1291

Sequence:

50:

100:

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1050:

1100:

1150:

1200:

1250:

1291:

GPLNKAQEDS | RGVGTPEPTN | SAEEPEHAAN | GSASPAPTQS | S

3D Structure:

N/A

Predicted Eptitope:

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Vaild Sequence:

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Related Databases

UniGene:

Mm.391573

String:

P06800

Pfam:

PF12567

Pfam:

PF00102

STRING:

10090.ENSMUSP00000074352

SMR:

P06800

Uniprot:

P06800

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ELISA Kit for Mouse Receptor-type tyrosine-protein phosphatase C

Cat.:

E1030h

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96T

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ELISA Kit for Mouse Receptor-type tyrosine-protein phosphatase C

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E1030m

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ELISA Kit for Mouse Receptor-type tyrosine-protein phosphatase C

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E1030r

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96T

CLIA Kit for Mouse Receptor-type tyrosine-protein phosphatase C

Cat.:

U1030m

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96T

CLIA Kit for Mouse Receptor-type tyrosine-protein phosphatase C

Cat.:

U1030h

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MSDS:

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96T

CLIA Kit for Mouse Receptor-type tyrosine-protein phosphatase C

Cat.:

U1030r

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96T

Polyclonal Antibody for Mouse Receptor-type tyrosine-protein phosphatase C

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P1030Rb-h

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40ug/0.2ml

Polyclonal Antibody for Mouse Receptor-type tyrosine-protein phosphatase C

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P1030Rb-r

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40ug/0.2ml

Polyclonal Antibody for Mouse Receptor-type tyrosine-protein phosphatase C

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P1030Rb-m

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Packing:

40ug/0.2ml

Monoclonal Antibody for Mouse Receptor-type tyrosine-protein phosphatase C

Protein for Mouse Receptor-type tyrosine-protein phosphatase C

R&D Technical Data

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Precision

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Recovery

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Linearity

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References

1.

"Sequences of Ly-5 cDNA: isoform-related diversity of Ly-5 mRNA."
Saga Y. , Tung J.-S. , Shen F.-W. , Boyse E.A.
Proc. Natl. Acad. Sci. U.S.A.83:6940-6944(1986) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 3)
2.

Saga Y. , Tung J.-S. , Shen F.-W. , Boyse E.A.
Proc. Natl. Acad. Sci. U.S.A.84:1991-1991(1987)

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: ERRATUM;SEQUENCE REVISION
3.

"Comparison of mouse Ly5a and Ly5b leucocyte common antigen alleles."
Zebedee S.L. , Barritt D.S. , Raschke W.C.
Dev. Immunol.1:243-254(1991) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1)
strain: BALB/c.
4.

"Lineage-specific biology revealed by a finished genome assembly of the mouse."
Church D.M. , Goodstadt L. , Hillier L.W. , Zody M.C. , Goldstein S. , She X. , Bult C.J. , Agarwala R. , Cherry J.L. , DiCuccio M. , Hlavina W. , Kapustin Y. , Meric P. , Maglott D. , Birtle Z. , Marques A.C. , Graves T. , Zhou S. , more...
PLoS Biol.7:E1000112-E1000112(2009) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
strain: C57BL/6J.
5.

"Alternative use of 5' exons in the specification of Ly-5 isoforms distinguishing hematopoietic cell lineages."
Saga Y. , Tung J.-S. , Shen F.-W.W. , Boyse E.A.
Proc. Natl. Acad. Sci. U.S.A.84:5364-5368(1987) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 1-226 (ISOFORM 2)
6.

"Organization of the Ly-5 gene."
Saga Y. , Tung J.-S. , Shen F.-W.W. , Pancoast T.C. , Boyse E.A.
Mol. Cell. Biol.8:4889-4895(1988) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-22
7.

"Sequence conservation in potential regulatory regions of the mouse and human leukocyte common antigen gene."
Johnson N.A. , Meyer C.M. , Pingel J.T. , Thomas M.L.
J. Biol. Chem.264:6220-6229(1989) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-22
8.

"Cloning of Ly-5 cDNA."
Shen F.-W. , Saga Y. , Litman G. , Freeman G. , Tung J.-S. , Cantor H. , Boyse E.A.
Proc. Natl. Acad. Sci. U.S.A.82:7360-7363(1985) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 10-263 (ISOFORM 3)
tissue: T-cell.
9.

"Structural features of Ly-5 glycoproteins of the mouse and counterparts in other mammals."
Tung J.-S. , Saga Y. , Boyse E.A.
Immunogenetics28:271-277(1988) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 31-73
10.

"Identification of novel protein tyrosine phosphatases of hematopoietic cells by polymerase chain reaction amplification."
Yi T. , Cleveland J.L. , Ihle J.N.
Blood78:2222-2228(1991) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 730-838
11.

"Cloned murine T200 (Ly-5) cDNA reveals multiple transcripts within B- and T-lymphocyte lineages."
Raschke W.C.
Proc. Natl. Acad. Sci. U.S.A.84:161-165(1987) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 961-1291
12.

"High sequence conservation between rat (T200) and mouse (Ly-5) leukocyte common antigens."
Gonez L.J. , Walker I.D. , Sandrin M.S. , McKenzie I.F.
Immunogenetics25:263-266(1987) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PARTIAL PROTEIN SEQUENCE
13.

"Identification of the CD45-associated 116-kDa and 80-kDa proteins as the alpha- and beta-subunits of alpha-glucosidase II."
Arendt C.W. , Ostergaard H.L.
J. Biol. Chem.272:13117-13125(1997) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH GANAB AND PRKCSH
14.

"CD45 negatively regulates lyn activity by dephosphorylating both positive and negative regulatory tyrosine residues in immature B cells."
Katagiri T. , Ogimoto M. , Hasegawa K. , Arimura Y. , Mitomo K. , Okada M. , Clark M.R. , Mizuno K. , Yakura H.
J. Immunol.163:1321-1326(1999) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION
15.

"The phagosomal proteome in interferon-gamma-activated macrophages."
Trost M. , English L. , Lemieux S. , Courcelles M. , Desjardins M. , Thibault P.
Immunity30:143-154(2009) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-962;IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]

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