ABCG2 Polyclonal Antibody for Human(Homo sapiens) | EIAab.comABCG2 Polyclonal Antibody for Human(Homo sapiens)

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ABCG2 (Gene name),

ATP-binding cassette sub-family G member 2 (Protein name ), ABCG2_HUMAN from NCBI database.

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General Annotation

Antigen Annotation

Predicted Eptitope

Vaild Sequence

Related Databases

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Gene name:

ABCG2(ABCP;BCRP;BCRP1;MXR);

Protein name:

ATP-binding cassette sub-family G member 2;

Alternative:

CDw338;Breast cancer resistance protein;Placenta-specific ATP-binding cassette transporter;Mitoxantrone resistance-associated protein;Urate exporter;

CD:

CD338;

Organism:

Human (Homo sapiens).

General Annotation

Sub Unit:

Monomer or homodimer; disulfide-linked.

Function:

Xenobiotic transporter that may play an important role in the exclusion of xenobiotics from the brain. May be involved in brain-to-blood efflux. Appears to play a major role in the multidrug resistance phenotype of several cancer cell lines. When overexpressed, the transfected cells become resistant to mitoxantrone, daunorubicin and doxorubicin, display diminished intracellular accumulation of daunorubicin, and manifest an ATP-dependent increase in the efflux of rhodamine 123.

Subcellular Location:

Cell membrane Multi-pass membrane protein

Protein Attributes:

Sequence length:

655

Sequence:

50:

100:

150:

200:

250:

300:

350:

400:

450:

500:

550:

600:

650:

655:

LKKYS

3D Structure:

N/A

Predicted Eptitope:

Please Sign in.

Vaild Sequence:

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Related Databases

Pfam:

PF01061

MIM:

603756

MIM:

138900

KEGG:

hsa:9429

UniGene:

Hs.480218

String:

Q9UNQ0

SMR:

Q9UNQ0

Uniprot:

Q9UNQ0

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ELISA Kit for Human ATP-binding cassette sub-family G member 2

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E0960h

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ELISA Kit for Human ATP-binding cassette sub-family G member 2

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E0960b

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96T

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ELISA Kit for Human ATP-binding cassette sub-family G member 2

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E0960m

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ELISA Kit for Human ATP-binding cassette sub-family G member 2

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E0960p

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96T

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ELISA Kit for Human ATP-binding cassette sub-family G member 2

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E0960r

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96T

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CLIA Kit for Human ATP-binding cassette sub-family G member 2

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U0960r

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96T

CLIA Kit for Human ATP-binding cassette sub-family G member 2

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U0960b

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96T

CLIA Kit for Human ATP-binding cassette sub-family G member 2

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U0960p

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96T

CLIA Kit for Human ATP-binding cassette sub-family G member 2

Cat.:

U0960h

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96T

CLIA Kit for Human ATP-binding cassette sub-family G member 2

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U0960m

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96T

Polyclonal Antibody for Human ATP-binding cassette sub-family G member 2

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P0960Rb-m

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40ug/0.2ml

Polyclonal Antibody for Human ATP-binding cassette sub-family G member 2

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P0960Rb-h

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Polyclonal Antibody for Human ATP-binding cassette sub-family G member 2

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P0960Rb-r

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Polyclonal Antibody for Human ATP-binding cassette sub-family G member 2

Monoclonal Antibody for Human ATP-binding cassette sub-family G member 2

Protein for Human ATP-binding cassette sub-family G member 2

R&D Technical Data

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Precision

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Recovery

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Linearity

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References

1.

"A human placenta-specific ATP-binding cassette gene (ABCP) on chromosome 4q22 that is involved in multidrug resistance."
Allikmets R. , Schriml L.M. , Hutchinson A. , Romano-Spica V. , Dean M.
Cancer Res.58:5337-5339(1998) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1);VARIANTS GLU-166 AND SER-208;TISSUE SPECIFICITY
tissue: Placenta.
2.

"A multidrug resistance transporter from human MCF-7 breast cancer cells."
Doyle L.A. , Yang W. , Abruzzo L.V. , Krogmann T. , Gao Y. , Rishi A.K. , Ross D.D.
Proc. Natl. Acad. Sci. U.S.A.95:15665-15670(1998) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1);TISSUE SPECIFICITY
tissue: Mammary cancer.
3.

Doyle L.A. , Yang W. , Abruzzo L.V. , Krogmann T. , Gao Y. , Rishi A.K. , Ross D.D.
Proc. Natl. Acad. Sci. U.S.A.96:2569-2569(1999)

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: ERRATUM
4.

"Breast cancer resistance protein constitutes a 140-kDa complex as a homodimer."
Kage K. , Tsukahara S. , Sugiyama T. , Asada S. , Ishikawa E. , Tsuruo T. , Sugimoto Y.
Submitted (2001-03) to the EMBL/GenBank/DDBJ databases

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1)
5.

"Identification of breast cancer resistant protein/mitoxantrone resistance/placenta-specific, ATP-binding cassette transporter as a transporter of NB-506 and J-107088, topoisomerase I inhibitors with an indolocarbazole structure."
Komatani H. , Kotani H. , Hara Y. , Nakagawa R. , Matsumoto M. , Arakawa H. , Nishimura S.
Cancer Res.61:2827-2832(2001) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1)
6.

"The ABC transporter Bcrp1/ABCG2 is expressed in a wide variety of stem cells and is a molecular determinant of the side-population phenotype."
Zhou S. , Schuetz J.D. , Bunting K.D. , Colapietro A.M. , Sampath J. , Morris J.J. , Lagutina I. , Grosveld G.C. , Osawa M. , Nakauchi H. , Sorrentino B.P.
Nat. Med.7:1028-1034(2001) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1)
7.

"The expression and functional characterization of ABCG2 in brain endothelial cells and vessels."
Zhang W. , Mojsilovic-Petrovic J. , Andrade M.F. , Zhang H. , Ball M. , Stanimirovic D.B.
FASEB J.17:2085-2087(2003) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1);FUNCTION;VARIANTS GLU-166 AND SER-208
tissue: Brain endothelium.
8.

Yoshikawa M. , Yabuuchi H. , Ikegami Y. , Ishikawa T.
Submitted (2001-12) to the EMBL/GenBank/DDBJ databases

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1);VARIANT LYS-141
9.

"Cell line K562 resistant to Hoechst 33342."
Sudarikov A. , Makarik T. , Andreeff M.
Submitted (2003-06) to the EMBL/GenBank/DDBJ databases

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1);VARIANT PRO-316
10.

"Complete sequencing and characterization of 21,243 full-length human cDNAs."
Ota T. , Suzuki Y. , Nishikawa T. , Otsuki T. , Sugiyama T. , Irie R. , Wakamatsu A. , Hayashi K. , Sato H. , Nagai K. , Kimura K. , Makita H. , Sekine M. , Obayashi M. , Nishi T. , Shibahara T. , Tanaka T. , Ishii S. , more...
Nat. Genet.36:40-45(2004) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1)
tissue: Hippocampus.
tissue: Placenta.
11.

SeattleSNPs variation discovery resource
Submitted (2006-09) to the EMBL/GenBank/DDBJ databases

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA];VARIANTS MET-12; LYS-141; HIS-296 AND THR-528
12.

"Generation and annotation of the DNA sequences of human chromosomes 2 and 4."
Hillier L.W. , Graves T.A. , Fulton R.S. , Fulton L.A. , Pepin K.H. , Minx P. , Wagner-McPherson C. , Layman D. , Wylie K. , Sekhon M. , Becker M.C. , Fewell G.A. , Delehaunty K.D. , Miner T.L. , Nash W.E. , Kremitzki C. , Oddy L. , Du H. , more...
Nature434:724-731(2005) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
13.

"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res.14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2);VARIANT LYS-141
tissue: Pancreas.
tissue: PNS.
14.

"Molecular cloning of cDNAs which are highly overexpressed in mitoxantrone-resistant cells: demonstration of homology to ABC transport genes."
Miyake K. , Mickley L. , Litman T. , Zhan Z. , Robey R.W. , Cristensen B. , Brangi M. , Greenberger L. , Dean M. , Fojo T. , Bates S.E.
Cancer Res.59:8-13(1999) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 294-655 (ISOFORM 1)
15.

"Role of ABCG1 and other ABCG family members in lipid metabolism."
Schmitz G. , Langmann T. , Heimerl S.
J. Lipid Res.42:1513-1520(2001) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: REVIEW
16.

"Characterization of oligomeric human half-ABC transporter ATP-binding cassette G2."
Xu J. , Liu Y. , Yang Y. , Bates S. , Zhang J.T.
J. Biol. Chem.279:19781-19789(2004) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: SUBUNIT;SUBCELLULAR LOCATION
17.

"N-linked glycosylation of the human ABC transporter ABCG2 on asparagine 596 is not essential for expression, transport activity, or trafficking to the plasma membrane."
Diop N.K. , Hrycyna C.A.
Biochemistry44:5420-5429(2005) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: SUBCELLULAR LOCATION;GLYCOSYLATION AT ASN-596;MUTAGENESIS OF ASN-418; ASN-557 AND ASN-596
18.

"Single amino acid (482) variants of the ABCG2 multidrug transporter: major differences in transport capacity and substrate recognition."
Oezvegy-Laczka C. , Koebloes G. , Sarkadi B. , Varadi A.
Biochim. Biophys. Acta1668:53-63(2005) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: MUTAGENESIS OF ARG-482
19.

"Effect of Walker A mutation (K86M) on oligomerization and surface targeting of the multidrug resistance transporter ABCG2."
Henriksen U. , Gether U. , Litman T.
J. Cell Sci.118:1417-1426(2005) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: MUTAGENESIS OF LYS-86;SUBCELLULAR LOCATION;HOMODIMERIZATION
20.

"Intramolecular disulfide bond is a critical check point determining degradative fates of ATP-binding cassette (ABC) transporter ABCG2 protein."
Wakabayashi K. , Nakagawa H. , Tamura A. , Koshiba S. , Hoshijima K. , Komada M. , Ishikawa T.
J. Biol. Chem.282:27841-27846(2007) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: SUBUNIT;DISULFIDE BONDS
21.

"Association of three genetic loci with uric acid concentration and risk of gout: a genome-wide association study."
Dehghan A. , Kottgen A. , Yang Q. , Hwang S.J. , Kao W.L. , Rivadeneira F. , Boerwinkle E. , Levy D. , Hofman A. , Astor B.C. , Benjamin E.J. , van Duijn C.M. , Witteman J.C. , Coresh J. , Fox C.S.
Lancet372:1953-1961(2008) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INVOLVEMENT IN UAQTL1 AND GOUT
22.

"Identification of a urate transporter, ABCG2, with a common functional polymorphism causing gout."
Woodward O.M. , Kottgen A. , Coresh J. , Boerwinkle E. , Guggino W.B. , Kottgen M.
Proc. Natl. Acad. Sci. U.S.A.106:10338-10342(2009) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INVOLVEMENT IN UAQTL1;ASSOCIATION OF VARIANT LYS-141 WITH GOUT;CHARACTERIZATION OF VARIANT LYS-141
23.

"Common defects of ABCG2, a high-capacity urate exporter, cause gout: a function-based genetic analysis in a Japanese population."
Matsuo H. , Takada T. , Ichida K. , Nakamura T. , Nakayama A. , Ikebuchi Y. , Ito K. , Kusanagi Y. , Chiba T. , Tadokoro S. , Takada Y. , Oikawa Y. , Inoue H. , Suzuki K. , Okada R. , Nishiyama J. , Domoto H. , Watanabe S. , more...
Sci. Transl. Med.1:5ra11-5ra11(2009) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INVOLVEMENT IN UAQTL1;ASSOCIATION OF VARIANT LYS-141 WITH GOUT
24.

"ABCG2 transports and transfers heme to albumin through its large extracellular loop."
Desuzinges-Mandon E. , Arnaud O. , Martinez L. , Huche F. , Di Pietro A. , Falson P.
J. Biol. Chem.285:33123-33133(2010) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;DOMAIN;MUTAGENESIS OF HIS-583; CYS-603 AND TYR-605
25.

"ABCG2 is a high-capacity urate transporter and its genetic impairment increases serum uric acid levels in humans."
Nakayama A. , Matsuo H. , Takada T. , Ichida K. , Nakamura T. , Ikebuchi Y. , Ito K. , Hosoya T. , Kanai Y. , Suzuki H. , Shinomiya N.
Nucleosides Nucleotides Nucleic Acids30:1091-1097(2011) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION
26.

"Human ABCG2: structure, function, and its role in multidrug resistance."
Mo W. , Zhang J.T.
Int. J. Biochem. Mol. Biol.3:1-27(2012) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: REVIEW
27.

"ABCG2 null alleles define the Jr(a-) blood group phenotype."
Zelinski T. , Coghlan G. , Liu X.Q. , Reid M.E.
Nat. Genet.44:131-132(2012) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INVOLVEMENT IN JR;VARIANT MET-12
28.

"Null alleles of ABCG2 encoding the breast cancer resistance protein define the new blood group system Junior."
Saison C. , Helias V. , Ballif B.A. , Peyrard T. , Puy H. , Miyazaki T. , Perrot S. , Vayssier-Taussat M. , Waldner M. , Le Pennec P.Y. , Cartron J.P. , Arnaud L.
Nat. Genet.44:174-177(2012) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INVOLVEMENT IN JR
29.

"Mitochondrial localization of ABC transporter ABCG2 and its function in 5-aminolevulinic acid-mediated protoporphyrin IX accumulation."
Kobuchi H. , Moriya K. , Ogino T. , Fujita H. , Inoue K. , Shuin T. , Yasuda T. , Utsumi K. , Utsumi T.
PLoS ONE7:E50082-E50082(2012) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;SUBCELLULAR LOCATION
30.

"Catalog of 605 single-nucleotide polymorphisms (SNPs) among 13 genes encoding human ATP-binding cassette transporters: ABCA4, ABCA7, ABCA8, ABCD1, ABCD3, ABCD4, ABCE1, ABCF1, ABCG1, ABCG2, ABCG4, ABCG5, and ABCG8."
Iida A. , Saito S. , Sekine A. , Mishima C. , Kitamura Y. , Kondo K. , Harigae S. , Osawa S. , Nakamura Y.
J. Hum. Genet.47:285-310(2002) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANTS MET-12 AND LYS-141
31.

"Eight novel single nucleotide polymorphisms in ABCG2/BCRP in Japanese cancer patients administered irinotacan."
Itoda M. , Saito Y. , Shirao K. , Minami H. , Ohtsu A. , Yoshida T. , Saijo N. , Suzuki H. , Sugiyama Y. , Ozawa S. , Sawada J.
Drug Metab. Pharmacokinet.18:212-217(2003) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANTS LEU-431 AND LEU-489
32.

"Natural allelic variants of breast cancer resistance protein (BCRP) and their relationship to BCRP expression in human intestine."
Zamber C.P. , Lamba J.K. , Yasuda K. , Farnum J. , Thummel K. , Schuetz J.D. , Schuetz E.G.
Pharmacogenetics13:19-28(2003) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANTS MET-12; LYS-141; LEU-206 AND TYR-590
33.

"Single nucleotide polymorphisms modify the transporter activity of ABCG2."
Morisaki K. , Robey R.W. , Oezvegy-Laczka C. , Honjo Y. , Polgar O. , Steadman K. , Sarkadi B. , Bates S.E.
Cancer Chemother. Pharmacol.56:161-172(2005) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: CHARACTERIZATION OF VARIANTS MET-12; LYS-141 AND ASN-620
34.

"Genetic variation and haplotype structure of the ABC transporter gene ABCG2 in a Japanese population."
Maekawa K. , Itoda M. , Sai K. , Saito Y. , Kaniwa N. , Shirao K. , Hamaguchi T. , Kunitoh H. , Yamamoto N. , Tamura T. , Minami H. , Kubota K. , Ohtsu A. , Yoshida T. , Saijo N. , Kamatani N. , Ozawa S. , Sawada J.
Drug Metab. Pharmacokinet.21:109-121(2006) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANTS MET-12; LEU-13; LYS-141; GLN-160; ARG-354; LEU-431; ASN-441 AND LEU-489

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