ACVR1B Polyclonal Antibody for Human(Homo sapiens) | EIAab.comACVR1B Polyclonal Antibody for Human(Homo sapiens)

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ACVR1B (Gene name),

Activin receptor type-1B (Protein name ), ACV1B_HUMAN from NCBI database.

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General Annotation

Antigen Annotation

Predicted Eptitope

Vaild Sequence

Related Databases

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Gene name:

ACVR1B(ACVRLK4;ALK4);

Protein name:

Activin receptor type-1B;

Alternative:

Activin receptor-like kinase 4(ALK-4);Activin receptor type IB(ACTR-IB);Serine/threonine-protein kinase receptor R2(SKR2);

Organism:

Human (Homo sapiens).

General Annotation

Sub Unit:

Forms an activin receptor complex with activin receptor type-2 (ACVR2A or ACVR2B). Interacts with TDP2 (By similarity). Interacts with AIP1, FKBP1A, IGSF1, TDGF1, SMAD2, SMAD3 and SMAD7.

Function:

Transmembrane serine/threonine kinase activin type-1 receptor forming an activin receptor complex with activin receptor type-2 (ACVR2A or ACVR2B). Transduces the activin signal from the cell surface to the cytoplasm and is thus regulating a many physiological and pathological processes including neuronal differentiation and neuronal survival, hair follicle development and cycling, FSH production by the pituitary gland, wound healing, extracellular matrix production, immunosuppression and carcinogenesis. Activin is also thought to have a paracrine or autocrine role in follicular development in the ovary. Within the receptor complex, type-2 receptors (ACVR2A and/or ACVR2B) act as a primary activin receptors whereas the type-1 receptors like ACVR1B act as downstream transducers of activin signals. Activin binds to type-2 receptor at the plasma membrane and activates its serine-threonine kinase. The activated receptor type-2 then phosphorylates and activates the type-1 receptor such as ACVR1B. Once activated, the type-1 receptor binds and phosphorylates the SMAD proteins SMAD2 and SMAD3, on serine residues of the C-terminal tail. Soon after their association with the activin receptor and subsequent phosphorylation, SMAD2 and SMAD3 are released into the cytoplasm where they interact with the common partner SMAD4. This SMAD complex translocates into the nucleus where it mediates activin-induced transcription. Inhibitory SMAD7, which is recruited to ACVR1B through FKBP1A, can prevent the association of SMAD2 and SMAD3 with the activin receptor complex, thereby blocking the activin signal. Activin signal transduction is also antagonized by the binding to the receptor of inhibin-B via the IGSF1 inhibin coreceptor. ACVR1B also phosphorylates TDP2.

Subcellular Location:

Cell membrane Single-pass type I membrane protein

Protein Attributes:

Sequence length:

505

Sequence:

50:

100:

150:

200:

250:

300:

350:

400:

450:

500:

505:

EDVKI

3D Structure:

N/A

Predicted Eptitope:

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Vaild Sequence:

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Related Databases

KEGG:

hsa:91

UniGene:

Hs.438918

SMR:

P36896

String:

P36896

STRING:

9606.ENSP00000257963

MIM:

601300

Pfam:

PF01064

Uniprot:

P36896

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ELISA Kit for Human Activin receptor type-1B

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E9514r

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96T

ELISA Kit for Human Activin receptor type-1B

Cat.:

E9514m

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96T

ELISA Kit for Human Activin receptor type-1B

Cat.:

E9514h

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96T

CLIA Kit for Human Activin receptor type-1B

Cat.:

U9514r

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MSDS:

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Packing:

96T

CLIA Kit for Human Activin receptor type-1B

Cat.:

U9514h

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MSDS:

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Packing:

96T

CLIA Kit for Human Activin receptor type-1B

Cat.:

U9514m

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MSDS:

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Packing:

96T

Polyclonal Antibody for Human Activin receptor type-1B

Cat.:

P9514Rb-h

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Packing:

40ug/0.2ml

Polyclonal Antibody for Human Activin receptor type-1B

Cat.:

P9514Rb-r

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Packing:

40ug/0.2ml

Polyclonal Antibody for Human Activin receptor type-1B

Cat.:

P9514Rb-m

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Please sign in first.

Packing:

40ug/0.2ml

Monoclonal Antibody for Human Activin receptor type-1B

Protein for Human Activin receptor type-1B

R&D Technical Data

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Precision

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Recovery

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Linearity

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References

1.

"Activin receptor-like kinases: a novel subclass of cell-surface receptors with predicted serine/threonine kinase activity."
ten Dijke P. , Ichijo H. , Franzen P. , Schulz P. , Saras J. , Toyoshima H. , Heldin C.-H. , Miyazono K.
Oncogene8:2879-2887(1993) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1)
tissue: Placenta.
2.

"Type I receptors specify growth-inhibitory and transcriptional responses to transforming growth factor beta and activin."
Carcamo J. , Weis F.M. , Ventura F. , Wieser R. , Wrana J.L. , Attisano L. , Massague J.
Mol. Cell. Biol.14:3810-3821(1994) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1);IDENTIFICATION IN A ACTIVIN RECEPTOR COMPLEX;ACTIVIN-BINDING;FUNCTION
tissue: Kidney.
3.

"Genomic structure and cloned cDNAs predict that four variants in the kinase domain of serine/threonine kinase receptors arise by alternative splicing and poly(A) addition."
Xu J. , Matsuzaki K. , McKeehan K. , Wang F. , Kan M. , McKeehan W.L.
Proc. Natl. Acad. Sci. U.S.A.91:7957-7961(1994) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA] (ISOFORMS 2 AND 3);ALTERNATIVE SPLICING
tissue: Liver.
4.

"Cloning of human full-length CDSs in BD Creator(TM) system donor vector."
Kalnine N. , Chen X. , Rolfs A. , Halleck A. , Hines L. , Eisenstein S. , Koundinya M. , Raphael J. , Moreira D. , Kelley T. , LaBaer J. , Lin Y. , Phelan M. , Farmer A.
Submitted (2003-05) to the EMBL/GenBank/DDBJ databases

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1)
5.

"Complete sequencing and characterization of 21,243 full-length human cDNAs."
Ota T. , Suzuki Y. , Nishikawa T. , Otsuki T. , Sugiyama T. , Irie R. , Wakamatsu A. , Hayashi K. , Sato H. , Nagai K. , Kimura K. , Makita H. , Sekine M. , Obayashi M. , Nishi T. , Shibahara T. , Tanaka T. , Ishii S. , more...
Nat. Genet.36:40-45(2004) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 4 AND 5)
6.

"The finished DNA sequence of human chromosome 12."
Scherer S.E. , Muzny D.M. , Buhay C.J. , Chen R. , Cree A. , Ding Y. , Dugan-Rocha S. , Gill R. , Gunaratne P. , Harris R.A. , Hawes A.C. , Hernandez J. , Hodgson A.V. , Hume J. , Jackson A. , Khan Z.M. , Kovar-Smith C. , Lewis L.R. , more...
Nature440:346-351(2006) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
7.

"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res.14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1)
tissue: Brain.
tissue: Eye.
8.

"Activation of signalling by the activin receptor complex."
Attisano L. , Wrana J.L. , Montalvo E. , Massague J.
Mol. Cell. Biol.16:1066-1073(1996) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH ACVR2B;PHOSPHORYLATION BY ACVR2B;DOMAIN GS;MUTAGENESIS OF THR-206
9.

"Activin and inhibin have antagonistic effects on ligand-dependent heteromerization of the type I and type II activin receptors and human erythroid differentiation."
Lebrun J.J. , Vale W.W.
Mol. Cell. Biol.17:1682-1691(1997) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: SUBUNIT;FUNCTION
10.

"Roles of pathway-specific and inhibitory Smads in activin receptor signaling."
Lebrun J.J. , Takabe K. , Chen Y. , Vale W.
Mol. Endocrinol.13:15-23(1999) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH SMAD2; SMAD3 AND SMAD7;FUNCTION
11.

"Modulation of activin signal transduction by inhibin B and inhibin-binding protein (INhBP)."
Chapman S.C. , Woodruff T.K.
Mol. Endocrinol.15:668-679(2001) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH IGSF1;ENZYME REGULATION
12.

"Phosphorylation regulation of the interaction between Smad7 and activin type I receptor."
Liu X. , Nagarajan R.P. , Vale W. , Chen Y.
FEBS Lett.519:93-98(2002) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PHOSPHORYLATION;INTERACTION WITH SMAD7
13.

"Overexpression of wild-type activin receptor alk4-1 restores activin antiproliferative effects in human pituitary tumor cells."
Danila D.C. , Zhang X. , Zhou Y. , Haidar J.N. , Klibanski A.
J. Clin. Endocrinol. Metab.87:4741-4746(2002) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;PHOSPHORYLATION
14.

"Cripto-1 activates nodal- and ALK4-dependent and -independent signaling pathways in mammary epithelial Cells."
Bianco C. , Adkins H.B. , Wechselberger C. , Seno M. , Normanno N. , De Luca A. , Sun Y. , Khan N. , Kenney N. , Ebert A. , Williams K.P. , Sanicola M. , Salomon D.S.
Mol. Cell. Biol.22:2586-2597(2002) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH TDGF1;ENZYME REGULATION
15.

"Identification of the phosphotyrosine proteome from thrombin activated platelets."
Maguire P.B. , Wynne K.J. , Harney D.F. , O'Donoghue N.M. , Stephens G. , Fitzgerald D.J.
Proteomics2:642-648(2002) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PHOSPHORYLATION AT TYR-380
16.

"Activin signaling through type IB activin receptor stimulates aromatase activity in the ovarian granulosa cell-like human granulosa (KGN) cells."
Mukasa C. , Nomura M. , Tanaka T. , Tanaka K. , Nishi Y. , Okabe T. , Goto K. , Yanase T. , Nawata H.
Endocrinology144:1603-1611(2003) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION
17.

"Activation of the activin A-ALK-Smad pathway in systemic sclerosis."
Takagi K. , Kawaguchi Y. , Kawamoto M. , Ota Y. , Tochimoto A. , Gono T. , Katsumata Y. , Takagi M. , Hara M. , Yamanaka H.
J. Autoimmun.36:181-188(2011) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INVOLVEMENT IN SYSTEMIC SCLEROSIS
18.

"Patterns of somatic mutation in human cancer genomes."
Greenman C. , Stephens P. , Smith R. , Dalgliesh G.L. , Hunter C. , Bignell G. , Davies H. , Teague J. , Butler A. , Stevens C. , Edkins S. , O'Meara S. , Vastrik I. , Schmidt E.E. , Avis T. , Barthorpe S. , Bhamra G. , Buck G. , more...
Nature446:153-158(2007) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANT [LARGE SCALE ANALYSIS] LEU-146;VARIANT [LARGE SCALE ANALYSIS] HIS-478 (ISOFORM 3)
19.

"Identification of a functional binding site for activin on the type I receptor ALK4."
Harrison C.A. , Gray P.C. , Koerber S.C. , Fischer W. , Vale W.
J. Biol. Chem.278:21129-21135(2003) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: MUTAGENESIS OF LEU-40; ILE-70; VAL-73; LEU-75 AND PRO-77;ACTIVIN-BINDING
20.

"FKBP12 functions as an adaptor of the Smad7-Smurf1 complex on activin type I receptor."
Yamaguchi T. , Kurisaki A. , Yamakawa N. , Minakuchi K. , Sugino H.
J. Mol. Endocrinol.36:569-579(2006) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH FKBP1A AND SMAD7;UBIQUITINATION
21.

"Ttrap is an essential modulator of Smad3-dependent Nodal signaling during zebrafish gastrulation and left-right axis determination."
Esguerra C.V. , Nelles L. , Vermeire L. , Ibrahimi A. , Crawford A.D. , Derua R. , Janssens E. , Waelkens E. , Carmeliet P. , Collen D. , Huylebroeck D.
Development134:4381-4393(2007) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;AUTOPHOSPHORYLATION
22.

"Activin A induces neuronal differentiation and survival via ALK4 in a SMAD-independent manner in a subpopulation of human neuroblastomas."
Suzuki K. , Kobayashi T. , Funatsu O. , Morita A. , Ikekita M.
Biochem. Biophys. Res. Commun.394:639-645(2010) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION
23.

"Development and validation of a method for profiling post-translational modification activities using protein microarrays."
Del Rincon S.V. , Rogers J. , Widschwendter M. , Sun D. , Sieburg H.B. , Spruck C.
PLoS ONE5:E11332-E11332(2010) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: UBIQUITINATION

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