AKR1C4 Polyclonal Antibody for Human(Homo sapiens) | EIAab.comAKR1C4 Polyclonal Antibody for Human(Homo sapiens) | EIAab.com

Language:

[Sign in] [Register]

Search Protein-oriented Product center.

For antibodies, ELISA/CLIA, proteins... Product center

Tips

Index > Protein center > AKR1C4(Gene name) > Human

Add your favorite

AKR1C4 (Gene name),

Aldo-keto reductase family 1 member C4 (Protein name ), AK1C4_HUMAN from NCBI database.

top

Come back to page head.

|

General Annotation

|

Antigen Annotation

|

3D

|

Predicted Eptitope

|

Vaild Sequence

|

Related Databases

|

Feedback

Gene name:

AKR1C4(CHDR);

Protein name:

Aldo-keto reductase family 1 member C4;

Alternative:

1.1.1.357;3-alpha-hydroxysteroid dehydrogenase type I);3-alpha-HSD1;Dihydrodiol dehydrogenase 4(DD-4;DD4);1.1.1.225;Chlordecone reductase(CDR);HAKRA;

Organism:

Human (Homo sapiens).

General Annotation

Sub Unit:

Monomer.

Function:

Catalyzes the transformation of the potent androgen dihydrotestosterone (DHT) into the less active form, 5-alpha-androstan-3-alpha,17-beta-diol (3-alpha-diol). Also has some 20-alpha-hydroxysteroid dehydrogenase activity. The biotransformation of the pesticide chlordecone (kepone) to its corresponding alcohol leads to increased biliary excretion of the pesticide and concomitant reduction of its neurotoxicity since bile is the major excretory route.

Subcellular Location:

Cytoplasm

Protein Attributes:

Sequence length:

323

Sequence:

50:

MDPKYQRVEL | NDGHFMPVLG | FGTYAPPEVP | RNRAVEVTKL | AIEAGFRHID |

100:

SAYLYNNEEQ | VGLAIRSKIA | DGSVKREDIF | YTSKLWCTFF | QPQMVQPALE |

150:

SSLKKLQLDY | VDLYLLHFPM | ALKPGETPLP | KDENGKVIFD | TVDLSATWEV |

200:

MEKCKDAGLA | KSIGVSNFNC | RQLEMILNKP | GLKYKPVCNQ | VECHPYLNQS |

250:

KLLDFCKSKD | IVLVAHSALG | TQRHKLWVDP | NSPVLLEDPV | LCALAKKHKQ |

300:

TPALIALRYQ | LQRGVVVLAK | SYNEQRIREN | IQVFEFQLTS | EDMKVLDGLN |

323:

RNYRYVVMDF | LMDHPDYPFS | DEY

3D Structure:

N/A

Predicted Eptitope:

Please Sign in.

Vaild Sequence:

Please Sign in.

Related Databases

KEGG:

String:

Pfam:

SMR:

MIM:

STRING:

9606.ENSP00000263126

UniGene:

Uniprot:

FOR

ELISA Kit for Human Aldo-keto reductase family 1 member C4

Cat.:

E2449h

Price:

Please sign in first.

Manual:

Looking for manual.

MSDS:

Please sign in first.

Packing:

96T

Range:

Please sign in first.

CLIA Kit for Human Aldo-keto reductase family 1 member C4

Cat.:

U2449h

Price:

Please sign in first.

MSDS:

Please sign in first.

Packing:

96T

Polyclonal Antibody for Human Aldo-keto reductase family 1 member C4

Cat.:

P2449Rb-h

Price:

Please sign in first.

Packing:

40ug/0.2ml

Monoclonal Antibody for Human Aldo-keto reductase family 1 member C4

Protein for Human Aldo-keto reductase family 1 member C4

R&D Technical Data

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Precision

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Recovery

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Linearity

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

References

1.

"Molecular cloning of multiple cDNAs encoding human enzymes structurally related to 3 alpha-hydroxysteroid dehydrogenase."
Qin K.-N. , New M.I. , Cheng K.-C.
J. Steroid Biochem. Mol. Biol.46:673-679(1993) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA];VARIANT ARG-250
tissue: Liver.
2.

"Substrate specificity, gene structure, and tissue-specific distribution of multiple human 3 alpha-hydroxysteroid dehydrogenases."
Khanna M. , Qin K.-N. , Wang R.W. , Cheng K.-C.
J. Biol. Chem.270:20162-20168(1995) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA];TISSUE SPECIFICITY;VARIANT ARG-250
3.

"Distribution of 3 alpha-hydroxysteroid dehydrogenase in rat brain and molecular cloning of multiple cDNAs encoding structurally related proteins in humans."
Khanna M. , Qin K.-N. , Cheng K.-C.
J. Steroid Biochem. Mol. Biol.53:41-46(1995) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA];VARIANT ARG-250
4.

"Characterization of a novel variant (S145C/L311V) of 3alpha-hydroxysteroid/dihydrodiol dehydrogenase in human liver."
Kume T. , Iwasa H. , Shiraishi H. , Yokoi T. , Nagashima K. , Otsuka M. , Terada T. , Takagi T. , Hara A. , Kamataki T.
Pharmacogenetics9:763-771(1999) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA];VARIANTS CYS-145; ARG-250 AND VAL-311
tissue: Liver.
5.

"Close kinship of human 20alpha-hydroxysteroid dehydrogenase gene with three aldo-keto reductase genes."
Nishizawa M. , Nakajima T. , Yasuda K. , Kanzaki H. , Sasaguri Y. , Watanabe K. , Ito S.
Genes Cells5:111-125(2000) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA];VARIANT ARG-250
tissue: Liver.
6.

"Human types 1 and 3 3 alpha-hydroxysteroid dehydrogenases: differential lability and tissue distribution."
Dufort I. , Labrie F. , Luu-The V.
J. Clin. Endocrinol. Metab.86:841-846(2001) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA];CHARACTERIZATION OF 3-ALPHA-HSD ACTIVITY;TISSUE SPECIFICITY;VARIANT ARG-250
tissue: Liver.
7.

"The DNA sequence and comparative analysis of human chromosome 10."
Deloukas P. , Earthrowl M.E. , Grafham D.V. , Rubenfield M. , French L. , Steward C.A. , Sims S.K. , Jones M.C. , Searle S. , Scott C. , Howe K. , Hunt S.E. , Andrews T.D. , Gilbert J.G.R. , Swarbreck D. , Ashurst J.L. , Taylor A. , Battles J. , more...
Nature429:375-381(2004) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
8.

"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res.14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA];VARIANTS TYR-170 AND ARG-250
tissue: Liver.
9.

"Isolation and characterization of cloned cDNAs encoding human liver chlordecone reductase."
Winters C.J. , Molowa D.T. , Guzelian P.S.
Biochemistry29:1080-1087(1990) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 2-323;VARIANT ARG-250
tissue: Liver.
10.

"Molecular cloning of two human liver 3 alpha-hydroxysteroid/dihydrodiol dehydrogenase isoenzymes that are identical with chlordecone reductase and bile-acid binder."
Deyashiki Y. , Ogasawara A. , Nakayama T. , Nakanishi M. , Miyabe Y. , Sato K. , Hara A.
Biochem. J.299:545-552(1994) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 3-323;PROTEIN SEQUENCE OF 5-29; 76-131; 184-201 AND 271-294;VARIANT ARG-250
tissue: Liver.
11.

"Human hepatic 3 alpha-hydroxysteroid dehydrogenase: possible identity with human hepatic chlordecone reductase."
Binstock J.M. , Iyer R.B. , Hamby C.V. , Fried V.A. , Schwartz I.S. , Weinstein B.I. , Southren A.L.
Biochem. Biophys. Res. Commun.187:760-766(1992) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PROTEIN SEQUENCE OF 40-54; 105-121; 162-175; 184-196; 277-291 AND 307-321;CHARACTERIZATION AS 3-ALPHA-HSD
12.

"Why boys will be boys: two pathways of fetal testicular androgen biosynthesis are needed for male sexual differentiation."
Fluck C.E. , Meyer-Boni M. , Pandey A.V. , Kempna P. , Miller W.L. , Schoenle E.J. , Biason-Lauber A.
Am. J. Hum. Genet.89:201-218(2011) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INVOLVEMENT IN SRXY8
13.

"Crystal structure of human 3-alpha hydroxysteroid/dihydrodiol dehydrogenase (AKR1C4) complexed with NADP+."
Structural genomics consortium (SGC)
Submitted (2006-02) to the PDB data bank

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: X-RAY CRYSTALLOGRAPHY (2.4 ANGSTROMS) IN COMPLEX WITH NADP

Product Feedback Wall

Hot Genes: Atf2 ASPRO ACE ALCAM C19orf80 Trap1a Gdf5

Top Searches: Ubiquitin-protein ligase metalloproteinase Ubiquitin ELISA Alpha Tumor necrosis Asprosin TRAP1A

Why choose EIAAB: Our products have been quoted by many publications in famous journals such as Cell; Cell Metabolism; Hepatology; Biomaterials.more

Further Information: About us Protein center Bank account Distributors Terms & Conditions Career eiaab.com.cn

Copyright & copy www.eiaab.com2006-2016 All Rights Reserved EIAab Email:eiaab@eiaab.com

鄂ICP备10015095号-1

鄂公网安备 42018502005535号