ATF2 Polyclonal Antibody for Human(Homo sapiens) | EIAab.comATF2 Polyclonal Antibody for Human(Homo sapiens)

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ATF2 (Gene name),

Cyclic AMP-dependent transcription factor ATF-2 (Protein name ), ATF2_HUMAN from NCBI database.

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General Annotation

Antigen Annotation

Predicted Eptitope

Vaild Sequence

Related Databases

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Gene name:

ATF2(CREB2;CREBP1);

Protein name:

Cyclic AMP-dependent transcription factor ATF-2(cAMP-dependent transcription factor ATF-2);

Alternative:

Cyclic AMP-responsive element-binding protein 2(CREB-2;cAMP-responsive element-binding protein 2);Activating transcription factor 2;cAMP response element-binding protein CRE-BP1;HB16;cAMP response element-binding protein CRE-BP1;

Organism:

Human (Homo sapiens).

General Annotation

Sub Unit:

Binds DNA as a dimer and can form a homodimer in the absence of DNA. Can form a heterodimer with JUN. Interacts with SMAD3 and SMAD4. Binds through its N-terminal region to UTF1 which acts as a coactivator of ATF2 transcriptional activity.

Function:

Transcriptional activator, probably constitutive, which binds to the cAMP-responsive element (CRE) (consensus: 5'-GTGACGT[AC][AG]-3'), a sequence present in many viral and cellular promoters. Interaction with JUN redirects JUN to bind to CRES preferentially over the 12-O-tetradecanoylphorbol-13-acetate response elements (TRES) as part of an ATF2/JUN complex.

Subcellular Location:

Nucleus

Protein Attributes:

Sequence length:

505

Sequence:

50:

100:

150:

200:

250:

300:

350:

400:

450:

500:

505:

QPSGS

3D Structure:

N/A

Predicted Eptitope:

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Vaild Sequence:

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Related Databases

Pfam:

PF00170

STRING:

9606.ENSP00000264110

SMR:

P15336

KEGG:

hsa:1386

UniGene:

Hs.592510

String:

P15336

MIM:

123811

Uniprot:

P15336

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ELISA Kit for Human cAMP-dependent transcription factor ATF-2

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E8848r

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96T

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ELISA Kit for Human cAMP-dependent transcription factor ATF-2

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ELISA Kit for Human cAMP-dependent transcription factor ATF-2

Cat.:

E8848h

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96T

ELISA Kit for Human cAMP-dependent transcription factor ATF-2

Cat.:

E8848m

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96T

CLIA Kit for Human cAMP-dependent transcription factor ATF-2

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CLIA Kit for Human cAMP-dependent transcription factor ATF-2

Cat.:

U8848r

Price:

Please sign in first.

Manual:

Looking for manual.

MSDS:

Please sign in first.

Packing:

96T

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Please sign in first.

CLIA Kit for Human cAMP-dependent transcription factor ATF-2

Cat.:

U8848m

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MSDS:

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Packing:

96T

CLIA Kit for Human cAMP-dependent transcription factor ATF-2

Cat.:

U8848h

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96T

Polyclonal Antibody for Human cAMP-dependent transcription factor ATF-2

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P8848Rb-m

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40ug/0.2ml

Polyclonal Antibody for Human cAMP-dependent transcription factor ATF-2

Cat.:

P8848Rb-h

Price:

Please sign in first.

Packing:

40ug/0.2ml

Polyclonal Antibody for Human cAMP-dependent transcription factor ATF-2

Monoclonal Antibody for Human cAMP-dependent transcription factor ATF-2

Protein for Human cAMP-dependent transcription factor ATF-2

R&D Technical Data

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Precision

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Recovery

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Linearity

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References

1.

"Leucine zipper structure of the protein CRE-BP1 binding to the cyclic AMP response element in brain."
Maekawa T. , Sakura H. , Kanei-Ishii C. , Sudo T. , Yoshimura T. , Fujisawa J. , Yoshida M. , Ishii S.
EMBO J.8:2023-2028(1989) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1)
tissue: Fetal brain.
2.

"Identification of a novel, spliced variant of CREB that is preferentially expressed in the thymus."
Yang L. , Lanier E.R. , Kraig E.
J. Immunol.158:2522-2525(1997) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2)
tissue: Thymus.
3.

"Characterization and functional analysis of cAMP response element modulator protein and activating transcription factor 2 (ATF2) isoforms in the human myometrium during pregnancy and labor: identification of a novel ATF2 species with potent transactivation properties."
Bailey J. , Phillips R.J. , Pollard A.J. , Gilmore K. , Robson S.C. , Europe-Finner G.N.
J. Clin. Endocrinol. Metab.87:1717-1728(2002) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 8)
tissue: Myometrium.
4.

"Homo sapiens activating transcription factor 2 (ATF2) mRNA splice variant."
von Hippel A.C.
Submitted (2005-04) to the EMBL/GenBank/DDBJ databases

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1; 5; 6 AND 7)
5.

"Generation and annotation of the DNA sequences of human chromosomes 2 and 4."
Hillier L.W. , Graves T.A. , Fulton R.S. , Fulton L.A. , Pepin K.H. , Minx P. , Wagner-McPherson C. , Layman D. , Wylie K. , Sekhon M. , Becker M.C. , Fewell G.A. , Delehaunty K.D. , Miner T.L. , Nash W.E. , Kremitzki C. , Oddy L. , Du H. , more...
Nature434:724-731(2005) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
6.

Mural R.J. , Istrail S. , Sutton G.G. , Florea L. , Halpern A.L. , Mobarry C.M. , Lippert R. , Walenz B. , Shatkay H. , Dew I. , Miller J.R. , Flanigan M.J. , Edwards N.J. , Bolanos R. , Fasulo D. , Halldorsson B.V. , Hannenhalli S. , Turner R. , more...
Submitted (2005-09) to the EMBL/GenBank/DDBJ databases

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
7.

"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res.14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1; 3 AND 4)
tissue: Brain.
8.

"A cDNA for a human cyclic AMP response element-binding protein which is distinct from CREB and expressed preferentially in brain."
Kara C.J. , Liou H.-C. , Ivashkiv L.B. , Glimcher L.H.
Mol. Cell. Biol.10:1347-1357(1990) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 211-505 (ISOFORMS 1/2)
9.

"Regulation of mitogen-activated protein kinases by a calcium/calmodulin-dependent protein kinase cascade."
Enslen H. , Tokumitsu H. , Stork P.J. , Davis R.J. , Soderling T.R.
Proc. Natl. Acad. Sci. U.S.A.93:10803-10808(1996) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PHOSPHORYLATION BY CAMK4
10.

"Selective activation of p38 mitogen-activated protein (MAP) kinase isoforms by the MAP kinase kinases MKK3 and MKK6."
Enslen H. , Raingeaud J. , Davis R.J.
J. Biol. Chem.273:1741-1748(1998) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PHOSPHORYLATION AT THR-69 AND THR-71
11.

"Characterization of functional domains of an embryonic stem cell coactivator UTF1 which are conserved and essential for potentiation of ATF-2 activity."
Fukushima A. , Okuda A. , Nishimoto M. , Seki N. , Hori T.A. , Muramatsu M.
J. Biol. Chem.273:25840-25849(1998) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH UTF1
12.

"ATF-2 has intrinsic histone acetyltransferase activity which is modulated by phosphorylation."
Kawasaki H. , Schiltz L. , Chiu R. , Itakura K. , Taira K. , Nakatani Y. , Yokoyama K.K.
Nature405:195-200(2000) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;CATALYTIC ACTIVITY;PHOSPHORYLATION;MUTAGENESIS OF THR-69 AND THR-71
13.

"Growth factors can activate ATF2 via a two-step mechanism: phosphorylation of Thr71 through the Ras-MEK-ERK pathway and of Thr69 through RalGDS-Src-p38."
Ouwens D.M. , de Ruiter N.D. , van der Zon G.C. , Carter A.P. , Schouten J. , van der Burgt C. , Kooistra K. , Bos J.L. , Maassen J.A. , van Dam H.
EMBO J.21:3782-3793(2002) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PHOSPHORYLATION AT THR-69 AND THR-71
14.

"Human vaccinia-related kinase 1 (VRK1) activates the ATF2 transcriptional activity by novel phosphorylation on Thr-73 and Ser-62 and cooperates with JNK."
Sevilla A. , Santos C.R. , Vega F.M. , Lazo P.A.
J. Biol. Chem.279:27458-27465(2004) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PHOSPHORYLATION AT SER-62 AND THR-73;SUBCELLULAR LOCATION
15.

"ATM-dependent phosphorylation of ATF2 is required for the DNA damage response."
Bhoumik A. , Takahashi S. , Breitweiser W. , Shiloh Y. , Jones N. , Ronai Z.
Mol. Cell18:577-587(2005) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;INTERACTION WITH NBN AND MRE11A;SUBCELLULAR LOCATION;PHOSPHORYLATION AT SER-490 AND SER-498
16.

"Multiple roles for acetylation in the interaction of p300 HAT with ATF-2."
Karanam B. , Wang L. , Wang D. , Liu X. , Marmorstein R. , Cotter R. , Cole P.A.
Biochemistry46:8207-8216(2007) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: ACETYLATION AT LYS-357 AND LYS-374;IDENTIFICATION BY MASS SPECTROMETRY
17.

"ATF2: a transcription factor that elicits oncogenic or tumor suppressor activities."
Bhoumik A. , Ronai Z.
Cell Cycle7:2341-2345(2008) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: REVIEW
18.

"Regulation of TIP60 by ATF2 modulates ATM activation."
Bhoumik A. , Singha N. , O'Connell M.J. , Ronai Z.A.
J. Biol. Chem.283:17605-17614(2008) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;INTERACTION WITH CUL3 AND KAT5;SUBCELLULAR LOCATION
19.

"Combining protein-based IMAC, peptide-based IMAC, and MudPIT for efficient phosphoproteomic analysis."
Cantin G.T. , Yi W. , Lu B. , Park S.K. , Xu T. , Lee J.-D. , Yates J.R. III
J. Proteome Res.7:1346-1351(2008) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-328;IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
tissue: Cervix carcinoma.
20.

"A quantitative atlas of mitotic phosphorylation."
Dephoure N. , Zhou C. , Villen J. , Beausoleil S.A. , Bakalarski C.E. , Elledge S.J. , Gygi S.P.
Proc. Natl. Acad. Sci. U.S.A.105:10762-10767(2008) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-69 AND SER-112;IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
tissue: Cervix carcinoma.
21.

"Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach."
Gauci S. , Helbig A.O. , Slijper M. , Krijgsveld J. , Heck A.J. , Mohammed S.
Anal. Chem.81:4493-4501(2009) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
22.

"Phosphorylation of activation transcription factor-2 at serine 121 by protein kinase c controls c-Jun-mediated activation of transcription."
Yamasaki T. , Takahashi A. , Pan J. , Yamaguchi N. , Yokoyama K.K.
J. Biol. Chem.284:8567-8581(2009) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PHOSPHORYLATION AT THR-69; THR-71; SER-121; SER-340 AND SER-367;SUBCELLULAR LOCATION
23.

"Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions."
Mayya V. , Lundgren D.H. , Hwang S.-I. , Rezaul K. , Wu L. , Eng J.K. , Rodionov V. , Han D.K.
Sci. Signal.2:RA46-RA46(2009) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-69; THR-71 AND SER-112;IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
tissue: Leukemic T-cell.
24.

"Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."
Olsen J.V. , Vermeulen M. , Santamaria A. , Kumar C. , Miller M.L. , Jensen L.J. , Gnad F. , Cox J. , Jensen T.S. , Nigg E.A. , Brunak S. , Mann M.
Sci. Signal.3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-69; THR-71; SER-112 AND THR-116;IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
tissue: Cervix carcinoma.
25.

"Hyperosmotic stress-induced ATF-2 activation through Polo-like kinase 3 in human corneal epithelial cells."
Wang L. , Payton R. , Dai W. , Lu L.
J. Biol. Chem.286:1951-1958(2011) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PHOSPHORYLATION AT THR-71;SUBCELLULAR LOCATION;MUTAGENESIS OF THR-71
26.

"System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation."
Rigbolt K.T. , Prokhorova T.A. , Akimov V. , Henningsen J. , Johansen P.T. , Kratchmarova I. , Kassem M. , Mann M. , Olsen J.V. , Blagoev B.
Sci. Signal.4:RS3-RS3(2011) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-69; THR-71; SER-90 AND SER-112;IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
27.

"PKCepsilon promotes oncogenic functions of ATF2 in the nucleus while blocking its apoptotic function at mitochondria."
Lau E. , Kluger H. , Varsano T. , Lee K. , Scheffler I. , Rimm D.L. , Ideker T. , Ronai Z.A.
Cell148:543-555(2012) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;SUBCELLULAR LOCATION;INTERACTION WITH HK1/VDAC1 COMPLEX;PHOSPHORYLATION AT THR-52
28.

"Critical role of N-terminal end-localized nuclear export signal in regulation of activating transcription factor 2 (ATF2) subcellular localization and transcriptional activity."
Hsu C.C. , Hu C.D.
J. Biol. Chem.287:8621-8632(2012) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: SUBCELLULAR LOCATION;NUCLEAR EXPORT SIGNAL;INTERACTION WITH XPO1;HETERODIMERIZATION WITH JUN
29.

"ATF2-at the crossroad of nuclear and cytosolic functions."
Lau E. , Ronai Z.A.
J. Cell Sci.125:2815-2824(2012) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: REVIEW
30.

"Solution structure of the transactivation domain of ATF-2 comprising a zinc finger-like subdomain and a flexible subdomain."
Nagadoi A. , Nakazawa K. , Uda H. , Okuno K. , Maekawa T. , Ishii S. , Nishimura Y.
J. Mol. Biol.287:593-607(1999) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: STRUCTURE BY NMR OF 19-56
31.

"The consensus coding sequences of human breast and colorectal cancers."
Sjoeblom T. , Jones S. , Wood L.D. , Parsons D.W. , Lin J. , Barber T.D. , Mandelker D. , Leary R.J. , Ptak J. , Silliman N. , Szabo S. , Buckhaults P. , Farrell C. , Meeh P. , Markowitz S.D. , Willis J. , Dawson D. , Willson J.K.V. , more...
Science314:268-274(2006) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANT [LARGE SCALE ANALYSIS] HIS-352

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