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Index > Protein center > CAPN6(Gene name) > Human
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  • CAPN6 (Gene name),
  • Calpain-6 (Protein name ),  CAN6_HUMAN from NCBI database.
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  • General Annotation
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  • Antigen Annotation
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  • 3D
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  • Predicted Eptitope
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  • Vaild Sequence
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  • Gene name:
    CAPN6(CALPM;CANPX);
    Protein name:
    Calpain-6;
    Alternative:
    Calpamodulin(CalpM);Calpain-like protease X-linked;
    Organism:
    Human (Homo sapiens). 
    General Annotation
    Sub Unit:
    Interacts (via domain III) with microtubules (By similarity). Interacts (via domain II) with ARHGEF2 (via the N-terminal zinc finger).
    Function:
    Microtubule-stabilizing protein that may be involved in the regulation of microtubule dynamics and cytoskeletal organization. May act as a regulator of RAC1 activity through interaction with ARHGEF2 to control lamellipodial formation and cell mobility. Does not seem to have protease activity as it has lost the active site residues.
    Subcellular Location:
    Cytoplasm perinuclear region Cytoplasm cytoskeleton spindle During mitose associated with the mitotic spindle. At telophase colocalized to the midbody spindle.
    Protein Attributes:
    Sequence length:
    641
    Sequence:
    50:
    MGPPLKLFKN | QKYQELKQEC | IKDSRLFCDP | TFLPENDSLF | YNRLLPGKVV | 
    100:
    WKRPQDICDD | PHLIVGNISN | HQLTQGRLGH | KPMVSAFSCL | AVQESHWTKT | 
    150:
    IPNHKEQEWD | PQKTEKYAGI | FHFRFWHFGE | WTEVVIDDLL | PTINGDLVFS | 
    200:
    FSTSMNEFWN | ALLEKAYAKL | LGCYEALDGL | TITDIIVDFT | GTLAETVDMQ | 
    250:
    KGRYTELVEE | KYKLFGELYK | TFTKGGLICC | SIESPNQEEQ | EVETDWGLLK | 
    300:
    GHTYTMTDIR | KIRLGERLVE | VFSAEKVYMV | RLRNPLGRQE | WSGPWSEISE | 
    350:
    EWQQLTASDR | KNLGLVMSDD | GEFWMSLEDF | CRNFHKLNVC | RNVNNPIFGR | 
    400:
    KELESVLGCW | TVDDDPLMNR | SGGCYNNRDT | FLQNPQYIFT | VPEDGHKVIM | 
    450:
    SLQQKDLRTY | RRMGRPDNYI | IGFELFKVEM | NRKFRLHHLY | IQERAGTSTY | 
    500:
    IDTRTVFLSK | YLKKGNYVLV | PTMFQHGRTS | EFLLRIFSEV | PVQLRELTLD | 
    550:
    MPKMSCWNLA | RGYPKVVTQI | TVHSAEDLEK | KYANETVNPY | LVIKCGKEEV | 
    600:
    RSPVQKNTVH | AIFDTQAIFY | RRTTDIPIIV | QVWNSRKFCD | QFLGQVTLDA | 
    641:
    DPSDCRDLKS | LYLRKKGGPT | AKVKQGHISF | KVISSDDLTE | L
    3D Structure:
    N/A
    Predicted Eptitope:
    Please Sign in.
    EIAab Sequence  Vaild Sequence:
    Please Sign in.
    Related Databases
    String:
    SMR:
    UniGene:
    KEGG:
    MIM:
    Pfam:
    Uniprot:
     
    FOR
    ELISA Kit for Human Calpain-6
    Cat.:
    E2252h
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    Range:
    Please sign in first.
    ELISA Kit for Human Calpain-6
    Cat.:
    E2252r
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    Range:
    Please sign in first.
    ELISA Kit for Human Calpain-6
    Cat.:
    E2252m
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    CLIA Kit for Human Calpain-6
    Cat.:
    U2252r
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    CLIA Kit for Human Calpain-6
    Cat.:
    U2252h
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    Range:
    Please sign in first.
    CLIA Kit for Human Calpain-6
    Cat.:
    U2252m
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    Polyclonal Antibody for Human Calpain-6
    Cat.:
    P2252Rb-h
    Price:
    Please sign in first.
    Packing:
    40ug/0.2ml
    Polyclonal Antibody for Human Calpain-6
    Cat.:
    P2252Rb-r
    Price:
    Please sign in first.
    Packing:
    40ug/0.2ml
    Polyclonal Antibody for Human Calpain-6
    Cat.:
    P2252Rb-m
    Price:
    Please sign in first.
    Packing:
    40ug/0.2ml
    Monoclonal Antibody for Human Calpain-6
    Monoclonal Antibody for Human Calpain-6
    Monoclonal Antibody for Human Calpain-6
    Protein for Human Calpain-6
    Protein for Human Calpain-6
    Protein for Human Calpain-6

    R&D Technical Data
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    Precision
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    Recovery
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    Linearity
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    References
    1. 1.
      "A new subfamily of vertebrate calpains lacking a calmodulin-like domain: implications for calpain regulation and evolution."
      Dear T.N. , Matena K. , Vingron M. , Boehm T.
      Genomics45:175-184(1997) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA]
    2. 2.
      Crotty P.L.
      Submitted (1997-10) to the EMBL/GenBank/DDBJ databases
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA]
      tissue: Placenta.
    3. 3.
      "A novel X-linked calpain-like protease."
      Belsito A. , Piluso G. , Nigro V.
      Submitted (1997-07) to the EMBL/GenBank/DDBJ databases
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA]
    4. 4.
      NIEHS SNPs program
      Submitted (2004-10) to the EMBL/GenBank/DDBJ databases
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA];VARIANT LEU-277
    5. 5.
      "The DNA sequence of the human X chromosome."
      Ross M.T. , Grafham D.V. , Coffey A.J. , Scherer S. , McLay K. , Muzny D. , Platzer M. , Howell G.R. , Burrows C. , Bird C.P. , Frankish A. , Lovell F.L. , Howe K.L. , Ashurst J.L. , Fulton R.S. , Sudbrak R. , Wen G. , Jones M.C. , more...
      Nature434:325-337(2005) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
    6. 6.
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
    7. 7.
      "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res.14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]
      tissue: Placenta.
    8. 8.
      "Calpain 6 is involved in microtubule stabilization and cytoskeletal organization."
      Tonami K. , Kurihara Y. , Aburatani H. , Uchijima Y. , Asano T. , Kurihara H.
      Mol. Cell. Biol.27:2548-2561(2007) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: SUBCELLULAR LOCATION;FUNCTION;INTERACTION WITH MICROTUBULE
    9. 9.
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANT [LARGE SCALE ANALYSIS] ARG-358
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