CBL Polyclonal Antibody for Human(Homo sapiens) | EIAab.comCBL Polyclonal Antibody for Human(Homo sapiens)

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CBL (Gene name),

E3 ubiquitin-protein ligase CBL (Protein name ), CBL_HUMAN from NCBI database.

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General Annotation

Antigen Annotation

Predicted Eptitope

Vaild Sequence

Related Databases

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Gene name:

CBL(CBL2;RNF55);

Protein name:

E3 ubiquitin-protein ligase CBL;

Alternative:

Proto-oncogene c-Cbl;Casitas B-lineage lymphoma proto-oncogene;Signal transduction protein CBL;RING finger protein 55;

Organism:

Human (Homo sapiens).

General Annotation

Sub Unit:

Interacts (phosphorylated at Tyr-731) with PIK3R1. Associates with NCK via its SH3 domain. The phosphorylated C-terminus interacts with CD2AP via its second SH3 domain. Binds to UBE2L3. Interacts with adapters SLA, SLA2 and with the phosphorylated C-terminus of SH2B2. Interacts with EGFR, SYK and ZAP70 via the highly conserved Cbl-N region. Also interacts with SORBS1 and INPPL1/SHIP2. Interacts with phosphorylated LAT2. May interact with CBLB (By similarity). Interacts with ALK, AXL, BLK, FGR and FGFR2. Interacts with EPHB1; regulates receptor degradation through ubiquitination.

Function:

Adapter protein that functions as a negative regulator of many signaling pathways that are triggered by activation of cell surface receptors. Acts as an E3 ubiquitin-protein ligase, which accepts ubiquitin from specific E2 ubiquitin-conjugating enzymes, and then transfers it to substrates promoting their degradation by the proteasome. Recognizes activated receptor tyrosine kinases, including KIT, FGFR1, FGFR2, PDGFA, EGF, CSF1, and EPHA8 and terminates signaling. Participates in signal transduction in hematopoietic cells. Plays an important role in the regulation of osteoblast differentiation and apoptosis. Essential for osteoclastic bone resorption. The Tyr-731 phosphorylated form induces the activation and recruitment of phosphatidylinositol 3-kinase to the cell membrane in a signaling pathway that is critical for osteoclast function.

Subcellular Location:

Cytoplasm Cell membrane Colocalizes with FGFR2 in lipid rafts at the cell membrane.

Protein Attributes:

Sequence length:

906

Sequence:

50:

100:

150:

200:

250:

300:

350:

400:

450:

500:

550:

600:

650:

700:

750:

800:

850:

900:

906:

PAHVAT

3D Structure:

N/A

Predicted Eptitope:

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Vaild Sequence:

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Related Databases

String:

P22681

KEGG:

hsa:867

SMR:

P22681

STRING:

9606.ENSP00000264033

UniGene:

Hs.504096

Pfam:

PF02262

MIM:

165360

Uniprot:

P22681

FOR

ELISA Kit for Human E3 ubiquitin-protein ligase CBL

Cat.:

E15462h

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MSDS:

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Packing:

96T

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ELISA Kit for Human E3 ubiquitin-protein ligase CBL

Cat.:

E15462m

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MSDS:

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Packing:

96T

CLIA Kit for Human E3 ubiquitin-protein ligase CBL

Cat.:

U15462m

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MSDS:

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Packing:

96T

CLIA Kit for Human E3 ubiquitin-protein ligase CBL

Cat.:

U15462h

Price:

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MSDS:

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Packing:

96T

Polyclonal Antibody for Human E3 ubiquitin-protein ligase CBL

Cat.:

P15462Rb-m

Price:

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Packing:

40ug/0.2ml

Polyclonal Antibody for Human E3 ubiquitin-protein ligase CBL

Cat.:

P15462Rb-h

Price:

Please sign in first.

Packing:

40ug/0.2ml

Monoclonal Antibody for Human E3 ubiquitin-protein ligase CBL

Protein for Human E3 ubiquitin-protein ligase CBL

R&D Technical Data

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Precision

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Recovery

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Linearity

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References

1.

"The sequences of the human and mouse c-cbl proto-oncogenes show v-cbl was generated by a large truncation encompassing a proline-rich domain and a leucine zipper-like motif."
Blake T.J. , Shapiro M. , Morse H.C. III , Langdon W.Y.
Oncogene6:653-657(1991) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA]
2.

"Human chromosome 11 DNA sequence and analysis including novel gene identification."
Taylor T.D. , Noguchi H. , Totoki Y. , Toyoda A. , Kuroki Y. , Dewar K. , Lloyd C. , Itoh T. , Takeda T. , Kim D.-W. , She X. , Barlow K.F. , Bloom T. , Bruford E. , Chang J.L. , Cuomo C.A. , Eichler E. , FitzGerald M.G. , more...
Nature440:497-500(2006) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
3.

"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res.14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]
4.

"The proto-oncogene p120(Cbl) is a downstream substrate of the Hck protein-tyrosine kinase."
Howlett C.J. , Bisson S.A. , Resek M.E. , Tigley A.W. , Robbins S.M.
Biochem. Biophys. Res. Commun.257:129-138(1999) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PHOSPHORYLATION BY HCK;INTERACTION WITH HCK
5.

"The tyrosine kinase negative regulator c-Cbl as a RING-type, E2-dependent ubiquitin-protein ligase."
Joazeiro C.A. , Wing S.S. , Huang H.-K. , Leverson J.D. , Hunter T. , Liu Y.-C.
Science286:309-312(1999) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION
6.

"The protein product of the c-cbl protooncogene is the 120-kDa tyrosine-phosphorylated protein in Jurkat cells activated via the T cell antigen receptor."
Donovan J.A. , Wange R.L. , Langdon W.Y. , Samelson L.E.
J. Biol. Chem.269:22921-22924(1994) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH BLK
7.

"Tyrosine phosphorylation of the c-cbl proto-oncogene protein product and association with epidermal growth factor (EGF) receptor upon EGF stimulation."
Galisteo M.L. , Dikic I. , Batzer A.G. , Langdon W.Y. , Schlessinger J.
J. Biol. Chem.270:20242-20245(1995) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PHOSPHORYLATION BY EGFR;INTERACTION WITH EGFR
8.

"The Cbl phosphotyrosine-binding domain selects a D(N/D)XpY motif and binds to the Tyr292 negative regulatory phosphorylation site of ZAP-70."
Lupher M.L. Jr. , Songyang Z. , Shoelson S.E. , Cantley L.C. , Band H.
J. Biol. Chem.272:33140-33144(1997) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH ZAP70
9.

"Coordinated regulation of the tyrosine phosphorylation of Cbl by Fyn and Syk tyrosine kinases."
Deckert M. , Elly C. , Altman A. , Liu Y.C.
J. Biol. Chem.273:8867-8874(1998) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PHOSPHORYLATION BY SYK AND FYN
10.

"Non-T cell activation linker (NTAL): a transmembrane adaptor protein involved in immunoreceptor signaling."
Brdicka T. , Imrich M. , Angelisova P. , Brdickova N. , Horvath O. , Spicka J. , Hilgert I. , Luskova P. , Draber P. , Novak P. , Engels N. , Wienands J. , Simeoni L. , Oesterreicher J. , Aguado E. , Malissen M. , Schraven B. , Horejsi V.
J. Exp. Med.196:1617-1626(2002) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH LAT2
11.

"C-Cbl binds the CSF-1 receptor at tyrosine 973, a novel phosphorylation site in the receptor's carboxy-terminus."
Wilhelmsen K. , Burkhalter S. , van der Geer P.
Oncogene21:1079-1089(2002) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH CSF1R;PHOSPHORYLATION
12.

"Membrane-anchored Cbl suppresses Hck protein-tyrosine kinase mediated cellular transformation."
Howlett C.J. , Robbins S.M.
Oncogene21:1707-1716(2002) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;SUBCELLULAR LOCATION;UBIQUITINATION;MUTAGENESIS OF CYS-381;INTERACTION WITH HCK
13.

"Fgr but not Syk tyrosine kinase is a target for beta 2 integrin-induced c-Cbl-mediated ubiquitination in adherent human neutrophils."
Melander F. , Andersson T. , Dib K.
Biochem. J.370:687-694(2003) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH FGR;PHOSPHORYLATION BY FGR
14.

"APS, an adaptor protein containing pleckstrin homology (PH) and Src homology-2 (SH2) domains inhibits the JAK-STAT pathway in collaboration with c-Cbl."
Wakioka T. , Sasaki A. , Mitsui K. , Yokouchi M. , Inoue A. , Komiya S. , Yoshimura A.
Leukemia13:760-767(1999) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH SH2B2
15.

"APS, an adaptor protein containing PH and SH2 domains, is associated with the PDGF receptor and c-Cbl and inhibits PDGF-induced mitogenesis."
Yokouchi M. , Wakioka T. , Sakamoto H. , Yasukawa H. , Ohtsuka S. , Sasaki A. , Ohtsubo M. , Valius M. , Inoue A. , Komiya S. , Yoshimura A.
Oncogene18:759-767(1999) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH SH2B2
16.

"SLAP, a dimeric adapter protein, plays a functional role in T cell receptor signaling."
Tang J. , Sawasdikosol S. , Chang J.-H. , Burakoff S.J.
Proc. Natl. Acad. Sci. U.S.A.96:9775-9780(1999) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH SLA AND ZAP70;MUTAGENESIS OF GLY-306
17.

"Functional cloning of Src-like adapter protein-2 (SLAP-2), a novel inhibitor of antigen receptor signaling."
Holland S.J. , Liao X.C. , Mendenhall M.K. , Zhou X. , Pardo J. , Chu P. , Spencer C. , Fu A.C. , Sheng N. , Yu P. , Pali E. , Nagin A. , Shen M. , Yu S. , Chan E. , Wu X. , Li C. , Woisetschlager M. , more...
J. Exp. Med.194:1263-1276(2001) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH SLA2
18.

"The adapter type protein CMS/CD2AP binds to the proto-oncogenic protein c-Cbl through a tyrosine phosphorylation-regulated Src homology 3 domain interaction."
Kirsch K.H. , Georgescu M.M. , Shishido T. , Langdon W.Y. , Birge R.B. , Hanafusa H.
J. Biol. Chem.276:4957-4963(2001) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH CD2AP
19.

"APS facilitates c-Cbl tyrosine phosphorylation and GLUT4 translocation in response to insulin in 3T3-L1 adipocytes."
Liu J. , Kimura A. , Baumann C.A. , Saltiel A.R.
Mol. Cell. Biol.22:3599-3609(2002) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH SH2B2;MUTAGENESIS OF TYR-371; TYR-700; TYR-731 AND TYR-774;PHOSPHORYLATION AT TYR-371; TYR-700 AND TYR-774
20.

"The c-Cbl-associated protein and c-Cbl are two new partners of the SH2-containing inositol polyphosphate 5-phosphatase SHIP2."
Vandenbroere I. , Paternotte N. , Dumont J.E. , Erneux C. , Pirson I.
Biochem. Biophys. Res. Commun.300:494-500(2003) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH INPPL1
21.

"Profiling of tyrosine phosphorylation pathways in human cells using mass spectrometry."
Salomon A.R. , Ficarro S.B. , Brill L.M. , Brinker A. , Phung Q.T. , Ericson C. , Sauer K. , Brock A. , Horn D.M. , Schultz P.G. , Peters E.C.
Proc. Natl. Acad. Sci. U.S.A.100:443-448(2003) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
22.

"Robust phosphoproteomic profiling of tyrosine phosphorylation sites from human T cells using immobilized metal affinity chromatography and tandem mass spectrometry."
Brill L.M. , Salomon A.R. , Ficarro S.B. , Mukherji M. , Stettler-Gill M. , Peters E.C.
Anal. Chem.76:2763-2772(2004) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
tissue: Leukemic T-cell.
23.

"Cbl-c suppresses v-Src-induced transformation through ubiquitin-dependent protein degradation."
Kim M. , Tezuka T. , Tanaka K. , Yamamoto T.
Oncogene23:1645-1655(2004) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION
24.

"Signal transduction via the stem cell factor receptor/c-Kit."
Ronnstrand L.
Cell. Mol. Life Sci.61:2535-2548(2004) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: REVIEW ON ROLE IN KIT SIGNALING AND KIT DEGRADATION
25.

"Catalytic domains of tyrosine kinases determine the phosphorylation sites within c-Cbl."
Grossmann A.H. , Kolibaba K.S. , Willis S.G. , Corbin A.S. , Langdon W.S. , Deininger M.W. , Druker B.J.
FEBS Lett.577:555-562(2004) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PHOSPHORYLATION AT TYR-700
26.

"Src kinase activity is essential for osteoclast function."
Miyazaki T. , Sanjay A. , Neff L. , Tanaka S. , Horne W.C. , Baron R.
J. Biol. Chem.279:17660-17666(2004) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;PHOSPHORYLATION AT TYR-731;MUTAGENESIS OF TYR-731
27.

"Cbl-mediated degradation of Lyn and Fyn induced by constitutive fibroblast growth factor receptor-2 activation supports osteoblast differentiation."
Kaabeche K. , Lemonnier J. , Le Mee S. , Caverzasio J. , Marie P.J.
J. Biol. Chem.279:36259-36267(2004) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;PHOSPHORYLATION;INTERACTION WITH FGFR2; LYN AND FYN
28.

"ALK receptor tyrosine kinase promotes cell growth and neurite outgrowth."
Motegi A. , Fujimoto J. , Kotani M. , Sakuraba H. , Yamamoto T.
J. Cell Sci.117:3319-3329(2004) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH ALK;PHOSPHORYLATION BY ALK
29.

"Effects of Gas6 and hydrogen peroxide in Axl ubiquitination and downregulation."
Valverde P.
Biochem. Biophys. Res. Commun.333:180-185(2005) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH AXL
30.

"Signaling by Kit protein-tyrosine kinase--the stem cell factor receptor."
Roskoski R. Jr.
Biochem. Biophys. Res. Commun.337:1-13(2005) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: REVIEW ON ROLE IN KIT SIGNALING AND KIT DEGRADATION
31.

"Immunoaffinity profiling of tyrosine phosphorylation in cancer cells."
Rush J. , Moritz A. , Lee K.A. , Guo A. , Goss V.L. , Spek E.J. , Zhang H. , Zha X.-M. , Polakiewicz R.D. , Comb M.J.
Nat. Biotechnol.23:94-101(2005) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
32.

"A probability-based approach for high-throughput protein phosphorylation analysis and site localization."
Beausoleil S.A. , Villen J. , Gerber S.A. , Rush J. , Gygi S.P.
Nat. Biotechnol.24:1285-1292(2006) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-900;IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
tissue: Cervix carcinoma.
33.

"The localization of FGFR3 mutations causing thanatophoric dysplasia type I differentially affects phosphorylation, processing and ubiquitylation of the receptor."
Bonaventure J. , Horne W.C. , Baron R.
FEBS J.274:3078-3093(2007) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;PHOSPHORYLATION
34.

"Binding of Cbl to a phospholipase Cgamma1-docking site on platelet-derived growth factor receptor beta provides a dual mechanism of negative regulation."
Reddi A.L. , Ying G. , Duan L. , Chen G. , Dimri M. , Douillard P. , Druker B.J. , Naramura M. , Band V. , Band H.
J. Biol. Chem.282:29336-29347(2007) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH PDGFRB
35.

"Lyn regulates BCR-ABL and Gab2 tyrosine phosphorylation and c-Cbl protein stability in imatinib-resistant chronic myelogenous leukemia cells."
Wu J. , Meng F. , Lu H. , Kong L. , Bornmann W. , Peng Z. , Talpaz M. , Donato N.J.
Blood111:3821-3829(2008) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH LYN
36.

"FGFR2-Cbl interaction in lipid rafts triggers attenuation of PI3K/Akt signaling and osteoblast survival."
Dufour C. , Guenou H. , Kaabeche K. , Bouvard D. , Sanjay A. , Marie P.J.
Bone42:1032-1039(2008) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;INTERACTION WITH FGFR2;SUBCELLULAR LOCATION
37.

"A quantitative atlas of mitotic phosphorylation."
Dephoure N. , Zhou C. , Villen J. , Beausoleil S.A. , Bakalarski C.E. , Elledge S.J. , Gygi S.P.
Proc. Natl. Acad. Sci. U.S.A.105:10762-10767(2008) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
tissue: Cervix carcinoma.
38.

"Ligand binding induces Cbl-dependent EphB1 receptor degradation through the lysosomal pathway."
Fasen K. , Cerretti D.P. , Huynh-Do U.
Traffic9:251-266(2008) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH EPHB1;PHOSPHORYLATION
39.

"Angiopoietin-1-induced ubiquitylation of Tie2 by c-Cbl is required for internalization and degradation."
Wehrle C. , Van Slyke P. , Dumont D.J.
Biochem. J.423:375-380(2009) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH TEK/TIE2;FUNCTION
40.

"An unbiased screen identifies DEP-1 tumor suppressor as a phosphatase controlling EGFR endocytosis."
Tarcic G. , Boguslavsky S.K. , Wakim J. , Kiuchi T. , Liu A. , Reinitz F. , Nathanson D. , Takahashi T. , Mischel P.S. , Ng T. , Yarden Y.
Curr. Biol.19:1788-1798(2009) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH EGFR
41.

"Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions."
Mayya V. , Lundgren D.H. , Hwang S.-I. , Rezaul K. , Wu L. , Eng J.K. , Rodionov V. , Han D.K.
Sci. Signal.2:RA46-RA46(2009) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-452;IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
tissue: Leukemic T-cell.
42.

"Mutation of tyrosine residue 857 in the PDGF beta-receptor affects cell proliferation but not migration."
Wardega P. , Heldin C.H. , Lennartsson J.
Cell. Signal.22:1363-1368(2010) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH PDGFRB;PHOSPHORYLATION
43.

"Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."
Olsen J.V. , Vermeulen M. , Santamaria A. , Kumar C. , Miller M.L. , Jensen L.J. , Gnad F. , Cox J. , Jensen T.S. , Nigg E.A. , Brunak S. , Mann M.
Sci. Signal.3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
tissue: Cervix carcinoma.
44.

"Initial characterization of the human central proteome."
Burkard T.R. , Planyavsky M. , Kaupe I. , Breitwieser F.P. , Buerckstuemmer T. , Bennett K.L. , Superti-Furga G. , Colinge J.
BMC Syst. Biol.5:17-17(2011) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
45.

"The Casitas B lineage lymphoma (Cbl) mutant G306E enhances osteogenic differentiation in human mesenchymal stromal cells in part by decreased Cbl-mediated platelet-derived growth factor receptor alpha and fibroblast growth factor receptor 2 ubiquitination."
Severe N. , Miraoui H. , Marie P.J.
J. Biol. Chem.286:24443-24450(2011) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;INTERACTION WITH FGFR2
46.

"Fibroblast growth factor signalling: from development to cancer."
Turner N. , Grose R.
Nat. Rev. Cancer10:116-129(2010) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: REVIEW ON FUNCTION IN FGF SIGNALING;UBIQUITINATION OF FGFR1
47.

"Structure of the amino-terminal domain of Cbl complexed to its binding site on ZAP-70 kinase."
Meng W. , Sawasdikosol S. , Burakoff S.J. , Eck M.J.
Nature398:84-90(1999) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: X-RAY CRYSTALLOGRAPHY (2.1 ANGSTROMS) OF 47-350 IN COMPLEX WITH ZAP70 PEPTIDE AND CALCIUM IONS;CALCIUM-BINDING SITE;MUTAGENESIS OF SER-80; PRO-82; ASP-229; GLU-240; ARG-294 AND GLY-306
48.

"Structure of a c-Cbl-UbcH7 complex: RING domain function in ubiquitin-protein ligases."
Zheng N. , Wang P. , Jeffrey P.D. , Pavletich N.P.
Cell102:533-539(2000) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: X-RAY CRYSTALLOGRAPHY (2.9 ANGSTROMS) OF 47-434 IN COMPLEX WITH ZAP70 AND UBE2L3
49.

"Heterozygous germline mutations in the CBL tumor-suppressor gene cause a Noonan syndrome-like phenotype."
Martinelli S. , De Luca A. , Stellacci E. , Rossi C. , Checquolo S. , Lepri F. , Caputo V. , Silvano M. , Buscherini F. , Consoli F. , Ferrara G. , Digilio M.C. , Cavaliere M.L. , van Hagen J.M. , Zampino G. , van der Burgt I. , Ferrero G.B. , Mazzanti L. , more...
Am. J. Hum. Genet.87:250-257(2010) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANTS NSLL PRO-367; GLU-382; TYR-390 AND GLN-420;CHARACTERIZATION OF VARIANTS NSLL PRO-367; GLU-382; TYR-390 AND GLN-420
50.

"Novel oncogenic mutations of CBL in human acute myeloid leukemia that activate growth and survival pathways depend on increased metabolism."
Fernandes M.S. , Reddy M.M. , Croteau N.J. , Walz C. , Weisbach H. , Podar K. , Band H. , Carroll M. , Reiter A. , Larson R.A. , Salgia R. , Griffin J.D. , Sattler M.
J. Biol. Chem.285:32596-32605(2010) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANTS ARG-287; SER-LYS-365 INS; HIS-371 AND LEU-499;CHARACTERIZATION OF VARIANTS SER-LYS-365 INS AND HIS-371;PHOSPHORYLATION AT TYR-674; TYR-700 AND TYR-774

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