Cd79a Polyclonal Antibody for Mouse(Mus musculus) | EIAab.comCd79a Polyclonal Antibody for Mouse(Mus musculus)

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Cd79a (Gene name),

B-cell antigen receptor complex-associated protein alpha chain (Protein name ), CD79A_MOUSE from NCBI database.

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General Annotation

Antigen Annotation

Predicted Eptitope

Vaild Sequence

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Gene name:

Cd79a(Iga;Mb-1);

Protein name:

B-cell antigen receptor complex-associated protein alpha chain;

Alternative:

MB-1 membrane glycoprotein;Ig-alpha;Surface IgM-associated protein;Membrane-bound immunoglobulin-associated protein;

CD:

CD79a;

Organism:

Mouse (Mus musculus).

General Annotation

Sub Unit:

Heterodimer of alpha and beta chains; disulfide-linked. Part of the B-cell antigen receptor complex where the alpha/beta chain heterodimer is non-covalently associated with an antigen-specific membrane-bound surface immunoglobulin of two heavy chains and two light chains. Interacts through its phosphorylated ITAM domain with the SH2 domains of SYK which stimulates SYK autophosphorylation and activation. Also interacts, when phosphorylated on Tyr-204, with the SH2 domain of BLNK/SLP65, bringing BLNK into proximity with SYK and allowing SYK to phosphorylate BLNK which is necessary for trafficking of the BCR to late endosomes. Interacts with Src-family tyrosine kinases including FYN and LYN, increasing their activity.

Function:

Required in cooperation with CD79B for initiation of the signal transduction cascade activated by binding of antigen to the B-cell antigen receptor complex (BCR) which leads to internalization of the complex, trafficking to late endosomes and antigen presentation. Also required for BCR surface expression and for efficient differentiation of pro- and pre-B-cells. Stimulates SYK autophosphorylation and activation. Binds to BLNK, bringing BLNK into proximity with SYK and allowing SYK to phosphorylate BLNK. Also interacts with and increases activity of some Src-family tyrosine kinases. Represses BCR signaling during development of immature B cells.

Subcellular Location:

Cell membrane Single-pass type I membrane protein Following antigen binding, the BCR has been shown to translocate from detergent-soluble regions of the cell membrane to lipid rafts although signal transduction through the complex can also occur outside lipid rafts.

Protein Attributes:

Sequence length:

220

Sequence:

50:

100:

150:

200:

220:

QGTYQDVGNL | HIGDAQLEKP |

3D Structure:

N/A

Predicted Eptitope:

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Vaild Sequence:

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Related Databases

SMR:

P11911

String:

P11911

UniGene:

Mm.1355

KEGG:

mmu:12518

Pfam:

PF00047

STRING:

10090.ENSMUSP00000003469

Uniprot:

P11911

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ELISA Kit for Mouse B-cell antigen receptor complex-associated protein alpha chain

Cat.:

E15278d

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96T

ELISA Kit for Mouse B-cell antigen receptor complex-associated protein alpha chain

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E15278b

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96T

ELISA Kit for Mouse B-cell antigen receptor complex-associated protein alpha chain

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E15278m

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96T

ELISA Kit for Mouse B-cell antigen receptor complex-associated protein alpha chain

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E15278h

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96T

CLIA Kit for Mouse B-cell antigen receptor complex-associated protein alpha chain

Cat.:

U15278b

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Packing:

96T

CLIA Kit for Mouse B-cell antigen receptor complex-associated protein alpha chain

Cat.:

U15278m

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MSDS:

Please sign in first.

Packing:

96T

CLIA Kit for Mouse B-cell antigen receptor complex-associated protein alpha chain

Cat.:

U15278h

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MSDS:

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Packing:

96T

CLIA Kit for Mouse B-cell antigen receptor complex-associated protein alpha chain

Cat.:

U15278d

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MSDS:

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Packing:

96T

Polyclonal Antibody for Mouse B-cell antigen receptor complex-associated protein alpha chain

Cat.:

P15278Rb-m

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40ug/0.2ml

Polyclonal Antibody for Mouse B-cell antigen receptor complex-associated protein alpha chain

Cat.:

P15278Rb-h

Price:

Please sign in first.

Packing:

40ug/0.2ml

Polyclonal Antibody for Mouse B-cell antigen receptor complex-associated protein alpha chain

Monoclonal Antibody for Mouse B-cell antigen receptor complex-associated protein alpha chain

Protein for Mouse B-cell antigen receptor complex-associated protein alpha chain

R&D Technical Data

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Precision

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Recovery

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Linearity

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References

1.

"B lymphocyte lineage-restricted expression of mb-1, a gene with CD3-like structural properties."
Sakaguchi N. , Kashiwamura S. , Kimoto M. , Thalmann P. , Melchers F.
EMBO J.7:3457-3464(1988) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA]
strain: C57BL/6 X DBA/2J.
2.

"Structure of the murine mb-1 gene encoding a putative sIgM-associated molecule."
Kashiwamura S. , Koyama T. , Matsuo T. , Steinmetz M. , Kimoto M. , Sakaguchi N.
J. Immunol.145:337-343(1990) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]
strain: BALB/c.
tissue: Liver.
3.

"Molecular cloning of the Ig-alpha subunit of the human B-cell antigen receptor complex."
Flaswinkel H. , Reth M.
Immunogenetics36:266-269(1992) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE
4.

"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res.14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]
strain: C57BL/6J.
tissue: Mammary gland.
5.

"Heterogeneously initiated transcription from the pre-B- and B-cell-specific mb-1 promoter: analysis of the requirement for upstream factor-binding sites and initiation site sequences."
Travis A. , Hagman J. , Grosschedl R.
Mol. Cell. Biol.11:5756-5766(1991) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-15
6.

"Identification of the genes encoding the IgM-alpha and Ig-beta components of the IgM antigen receptor complex by amino-terminal sequencing."
Hombach J. , Lottspeich F. , Reth M.
Eur. J. Immunol.20:2795-2799(1990) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PROTEIN SEQUENCE OF 29-38
7.

"IgM antigen receptor complex contains phosphoprotein products of B29 and mb-1 genes."
Campbell K.S. , Hager E.J. , Friedrich R.J. , Cambier J.C.
Proc. Natl. Acad. Sci. U.S.A.88:3982-3986(1991) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PROTEIN SEQUENCE OF 29-38
8.

"The MB-1/B29 heterodimer couples the B cell antigen receptor to multiple src family protein tyrosine kinases."
Lin J. , Justement L.B.
J. Immunol.149:1548-1555(1992) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH BLK
9.

"B-cell antigen receptor motifs have redundant signalling capabilities and bind the tyrosine kinases PTK72, Lyn and Fyn."
Law D.A. , Chan V.W. , Datta S.K. , DeFranco A.L.
Curr. Biol.3:645-657(1993) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH LYN;PHOSPHORYLATION
10.

"Dual role of the tyrosine activation motif of the Ig-alpha protein during signal transduction via the B cell antigen receptor."
Flaswinkel H. , Reth M.
EMBO J.13:83-89(1994) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PHOSPHORYLATION AT TYR-182;MUTAGENESIS OF TYR-176; TYR-182 AND TYR-193
11.

"Analysis of Ig-alpha-tyrosine kinase interaction reveals two levels of binding specificity and tyrosine phosphorylated Ig-alpha stimulation of Fyn activity."
Clark M.R. , Johnson S.A. , Cambier J.C.
EMBO J.13:1911-1919(1994) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH FYN AND LYN
12.

"Activation of B- and T-cells by the cytoplasmic domains of the B-cell antigen receptor proteins Ig-alpha and Ig-beta."
Taddie J.A. , Hurley T.R. , Hardwick B.S. , Sefton B.M.
J. Biol. Chem.269:13529-13535(1994) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION
13.

"Syk protein-tyrosine kinase is regulated by tyrosine-phosphorylated Ig alpha/Ig beta immunoreceptor tyrosine activation motif binding and autophosphorylation."
Rowley R.B. , Burkhardt A.L. , Chao H.-G. , Matsueda G.R. , Bolen J.B.
J. Biol. Chem.270:11590-11594(1995) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH SYK
14.

"Reconstitution of the B cell antigen receptor signaling components in COS cells."
Saouaf S.J. , Kut S.A. , Fargnoli J. , Rowley R.B. , Bolen J.B. , Mahajan S.
J. Biol. Chem.270:27072-27078(1995) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH BLK;PHOSPHORYLATION AT TYR-182 AND TYR-193
15.

"A tyrosine-based signal present in Ig alpha mediates B cell receptor constitutive internalization."
Cassard S. , Salamero J. , Hanau D. , Spehner D. , Davoust J. , Fridman W.H. , Bonnerot C.
J. Immunol.160:1767-1773(1998) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;MUTAGENESIS OF TYR-182 AND TYR-193
16.

"A negative regulatory role for Ig-alpha during B cell development."
Torres R.M. , Hafen K.
Immunity11:527-536(1999) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION
17.

"A role for lipid rafts in B cell antigen receptor signaling and antigen targeting."
Cheng P.C. , Dykstra M.L. , Mitchell R.N. , Pierce S.K.
J. Exp. Med.190:1549-1560(1999) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: SUBCELLULAR LOCATION
18.

"Ig alpha and Ig beta are required for efficient trafficking to late endosomes and to enhance antigen presentation."
Siemasko K. , Eisfelder B.J. , Stebbins C. , Kabak S. , Sant A.J. , Song W. , Clark M.R.
J. Immunol.162:6518-6525(1999) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION
19.

"Association of SLP-65/BLNK with the B cell antigen receptor through a non-ITAM tyrosine of Ig-alpha."
Engels N. , Wollscheid B. , Wienands J.
Eur. J. Immunol.31:2126-2134(2001) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH BLNK;PHOSPHORYLATION AT TYR-204;MUTAGENESIS OF TYR-204
20.

"Interference with immunoglobulin (Ig)alpha immunoreceptor tyrosine-based activation motif (ITAM) phosphorylation modulates or blocks B cell development, depending on the availability of an Igbeta cytoplasmic tail."
Kraus M. , Pao L.I. , Reichlin A. , Hu Y. , Canono B. , Cambier J.C. , Nussenzweig M.C. , Rajewsky K.
J. Exp. Med.194:455-469(2001) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;MUTAGENESIS OF TYR-182 AND TYR-193
21.

"Translocation of the B cell antigen receptor into lipid rafts reveals a novel step in signaling."
Cheng P.C. , Brown B.K. , Song W. , Pierce S.K.
J. Immunol.166:3693-3701(2001) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: SUBCELLULAR LOCATION
22.

"Cooperative interaction of Ig(alpha) and Ig(beta) of the BCR regulates the kinetics and specificity of antigen targeting."
Li C. , Siemasko K. , Clark M.R. , Song W.
Int. Immunol.14:1179-1191(2002) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION
23.

"Receptor-facilitated antigen presentation requires the recruitment of B cell linker protein to Igalpha."
Siemasko K. , Skaggs B.J. , Kabak S. , Williamson E. , Brown B.K. , Song W. , Clark M.R.
J. Immunol.168:2127-2138(2002) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;INTERACTION WITH BLNK;MUTAGENESIS OF TYR-176 AND TYR-204
24.

"B cell progenitors are arrested in maturation but have intact VDJ recombination in the absence of Ig-alpha and Ig-beta."
Pelanda R. , Braun U. , Hobeika E. , Nussenzweig M.C. , Reth M.
J. Immunol.169:865-872(2002) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;DISRUPTION PHENOTYPE
25.

"The direct recruitment of BLNK to immunoglobulin alpha couples the B-cell antigen receptor to distal signaling pathways."
Kabak S. , Skaggs B.J. , Gold M.R. , Affolter M. , West K.L. , Foster M.S. , Siemasko K. , Chan A.C. , Aebersold R. , Clark M.R.
Mol. Cell. Biol.22:2524-2535(2002) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH BLNK;MUTAGENESIS OF TYR-176 AND TYR-204
26.

"Ig alpha/Ig beta complexes generate signals for B cell development independent of selective plasma membrane compartmentalization."
Fuentes-Panana E.M. , Bannish G. , van der Voort D. , King L.B. , Monroe J.G.
J. Immunol.174:1245-1252(2005) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;SUBCELLULAR LOCATION
27.

"The B cell receptor promotes B cell activation and proliferation through a non-ITAM tyrosine in the Igalpha cytoplasmic domain."
Patterson H.C.K. , Kraus M. , Kim Y.-M. , Ploegh H. , Rajewsky K.
Immunity25:55-65(2006) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;MUTAGENESIS OF TYR-176 AND TYR-204
28.

"The Ig-alpha ITAM is required for efficient differentiation but not proliferation of pre-B cells."
Storch B. , Meixlsperger S. , Jumaa H.
Eur. J. Immunol.37:252-260(2007) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;MUTAGENESIS OF TYR-176; TYR-182; TYR-193 AND TYR-204
29.

"Arginine methylation of the B cell antigen receptor promotes differentiation."
Infantino S. , Benz B. , Waldmann T. , Jung M. , Schneider R. , Reth M.
J. Exp. Med.207:711-719(2010) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: METHYLATION AT ARG-198 BY PRMT1;MUTAGENESIS OF ARG-198

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