Stub1 Polyclonal Antibody for Mouse(Mus musculus) | EIAab.comStub1 Polyclonal Antibody for Mouse(Mus musculus)

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Stub1 (Gene name),

STIP1 homology and U box-containing protein 1 (Protein name ), CHIP_MOUSE from NCBI database.

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General Annotation

Antigen Annotation

Predicted Eptitope

Vaild Sequence

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Gene name:

Stub1(Chip);

Protein name:

STIP1 homology and U box-containing protein 1;

Alternative:

E3 ubiquitin-protein ligase CHIP;Carboxy terminus of Hsp70-interacting protein;

Organism:

Mouse (Mus musculus).

General Annotation

Sub Unit:

Homodimer. Interacts with BAG2, and with the E2 ubiquitin conjugating enzymes UBE2D1, UBE2D2 and UBE2D3. Interacts with the C-terminal domains of HSPA8 and HSPA1A. Detected in a ternary complex containing STUB1, HSPA1A and HSPBP1 (By similarity). Interacts with MKKS (By similarity). Interacts with DYX1C1 and POLB (By similarity). Interacts (via TPR repeats) with HSP90AA1. Interacts (via the U-box domain) with the UBE2V2-UBE2N heterodimer; the complex has a specific 'Lys-63'-linked polyubiquitination activity.

Function:

E3 ubiquitin-protein ligase which targets misfolded chaperone substrates towards proteasomal degradation. Ubiquitinates NOS1 in concert with Hsp70 and Hsp40. Modulates the activity of several chaperone complexes, including Hsp70, Hsc70 and Hsp90. Mediates transfer of non-canonical short ubiquitin chains to HSPA8 that have no effect on HSPA8 degradation. Mediates polyubiquitination of DNA polymerase beta (POLB) at 'Lys-41', 'Lys-61' and 'Lys-81', thereby playing a role in base-excision repair: catalyzes polyubiquitination by amplifying the HUWE1/ARF-BP1-dependent monoubiquitination and leading to POLB-degradation by the proteasome. Mediates polyubiquitination of CYP3A4. Ubiquitinates EPHA2 and may regulate the receptor stability and activity through proteasomal degradation.

Subcellular Location:

Cytoplasm

Protein Attributes:

Sequence length:

304

Sequence:

50:

100:

150:

200:

250:

300:

304:

VEDY

3D Structure:

N/A

Predicted Eptitope:

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Vaild Sequence:

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Related Databases

SMR:

Q9WUD1

Pfam:

PF00515

String:

Q9WUD1

KEGG:

mmu:56424

UniGene:

Mm.277599

Pfam:

PF04564

Uniprot:

Q9WUD1

FOR

ELISA Kit for Mouse STIP1 homology and U box-containing protein 1

Cat.:

E2375h

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96T

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ELISA Kit for Mouse STIP1 homology and U box-containing protein 1

Cat.:

E2375m

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MSDS:

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Packing:

96T

ELISA Kit for Mouse STIP1 homology and U box-containing protein 1

Cat.:

E2375c

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Packing:

96T

CLIA Kit for Mouse STIP1 homology and U box-containing protein 1

Cat.:

U2375c

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MSDS:

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Packing:

96T

CLIA Kit for Mouse STIP1 homology and U box-containing protein 1

Cat.:

U2375h

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MSDS:

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Packing:

96T

CLIA Kit for Mouse STIP1 homology and U box-containing protein 1

Cat.:

U2375m

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MSDS:

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Packing:

96T

Polyclonal Antibody for Mouse STIP1 homology and U box-containing protein 1

Cat.:

P2375Rb-m

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Packing:

40ug/0.2ml

Polyclonal Antibody for Mouse STIP1 homology and U box-containing protein 1

Cat.:

P2375Rb-h

Price:

Please sign in first.

Packing:

40ug/0.2ml

Monoclonal Antibody for Mouse STIP1 homology and U box-containing protein 1

Protein for Mouse STIP1 homology and U box-containing protein 1

R&D Technical Data

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Precision

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Recovery

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Linearity

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References

1.

"Identification of CHIP, a novel tetratricopeptide repeat-containing protein that interacts with heat shock proteins and negatively regulates chaperone functions."
Ballinger C.A. , Connell P. , Wu Y. , Hu Z. , Thompson L.J. , Yin L.-Y. , Patterson C.
Mol. Cell. Biol.19:4535-4545(1999) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA]
2.

"The transcriptional landscape of the mammalian genome."
Carninci P. , Kasukawa T. , Katayama S. , Gough J. , Frith M.C. , Maeda N. , Oyama R. , Ravasi T. , Lenhard B. , Wells C. , Kodzius R. , Shimokawa K. , Bajic V.B. , Brenner S.E. , Batalov S. , Forrest A.R. , Zavolan M. , Davis M.J. , more...
Science309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]
strain: C57BL/6J.
tissue: Corpora quadrigemina.
tissue: Embryo.
tissue: Kidney.
3.

"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res.14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]
strain: FVB/N.
tissue: Mammary tumor.
tissue: Salivary gland.
4.

"U box proteins as a new family of ubiquitin-protein ligases."
Hatakeyama S. , Yada M. , Matsumoto M. , Ishida N. , Nakayama K.I.
J. Biol. Chem.276:33111-33120(2001) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;CATALYTIC ACTIVITY;PATHWAY;SUBCELLULAR LOCATION;DOMAIN;MUTAGENESIS OF HIS-261 AND PRO-270
5.

"Comprehensive identification of phosphorylation sites in postsynaptic density preparations."
Trinidad J.C. , Specht C.G. , Thalhammer A. , Schoepfer R. , Burlingame A.L.
Mol. Cell. Proteomics5:914-922(2006) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-20;IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
tissue: Brain.
6.

"The phagosomal proteome in interferon-gamma-activated macrophages."
Trost M. , English L. , Lemieux S. , Courcelles M. , Desjardins M. , Thibault P.
Immunity30:143-154(2009) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-20;IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
7.

"Large scale localization of protein phosphorylation by use of electron capture dissociation mass spectrometry."
Sweet S.M. , Bailey C.M. , Cunningham D.L. , Heath J.K. , Cooper H.J.
Mol. Cell. Proteomics8:904-912(2009) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-24 AND SER-26;IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
tissue: Embryonic fibroblast.
8.

"Ube2w and ataxin-3 coordinately regulate the ubiquitin ligase CHIP."
Scaglione K.M. , Zavodszky E. , Todi S.V. , Patury S. , Xu P. , Rodriguez-Lebron E. , Fischer S. , Konen J. , Djarmati A. , Peng J. , Gestwicki J.E. , Paulson H.L.
Mol. Cell43:599-612(2011) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;CATALYTIC ACTIVITY;PATHWAY;INTERACTION WITH UBE2W AND ATXN3;UBIQUITINATION AT LYS-2;MUTAGENESIS OF LYS-2; LYS-4 AND LYS-7
9.

"Chaperoned ubiquitylation -- crystal structures of the CHIP U box E3 ubiquitin ligase and a CHIP-Ubc13-Uev1a complex."
Zhang M. , Windheim M. , Roe S.M. , Peggie M. , Cohen P. , Prodromou C. , Pearl L.H.
Mol. Cell20:525-538(2005) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: X-RAY CRYSTALLOGRAPHY (2.9 ANGSTROMS) OF 24-304 IN COMPLEX WITH UBE2N AND UBE2V1;X-RAY CRYSTALLOGRAPHY (3.3 ANGSTROMS) OF 227-304 IN COMPLEX WITH HSP90AA1;HOMODIMERIZATION

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