Ctcfl Polyclonal Antibody for Mouse(Mus musculus) | EIAab.comCtcfl Polyclonal Antibody for Mouse(Mus musculus)

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Ctcfl (Gene name),

Transcriptional repressor CTCFL (Protein name ), CTCFL_MOUSE from NCBI database.

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General Annotation

Antigen Annotation

Predicted Eptitope

Vaild Sequence

Related Databases

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Gene name:

Ctcfl(Boris);

Protein name:

Transcriptional repressor CTCFL;

Alternative:

CCCTC-binding factor;Brother of the regulator of imprinted sites;CTCF-like protein;CTCF paralog;

Organism:

Mouse (Mus musculus).

General Annotation

Sub Unit:

Interacts with histones, PRMT7 and SETD1A. Interacts (via N-terminus) with BAG6/BAT3.

Function:

Testis-specific DNA binding protein responsible for insulator function, nuclear architecture and transcriptional control, which probably acts by recruiting epigenetic chromatin modifiers. Plays a key role in gene imprinting in male germline, by participating in the establishment of differential methylation at the IGF2/H19 imprinted control region (ICR). Directly binds the unmethylated H19 ICR and recruits the PRMT7 methyltransferase, leading to methylate histone H4 'Arg-3' to form H4R3sme2. This probably leads to recruit de novo DNA methyltransferases at these sites. Seems to act as tumor suppressor. In association with DNMT1 and DNMT3B, involved in activation of BAG1 gene expression by binding to its promoter. Required for dimethylation of H3 lysine 4 (H3K4me2) of MYC and BRCA1 promoters.

Subcellular Location:

Cytoplasm Nucleus

Protein Attributes:

Sequence length:

636

Sequence:

50:

100:

150:

200:

250:

300:

350:

400:

450:

500:

550:

600:

636:

PQCPGEQALG | HQGEAAGSQS | PDHGLTCEII | FNMMDK

3D Structure:

N/A

Predicted Eptitope:

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Vaild Sequence:

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Related Databases

UniGene:

Mm.389396

KEGG:

mmu:664799

String:

A2APF3

SMR:

A2APF3

Pfam:

PF00096

Uniprot:

A2APF3

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ELISA Kit for Mouse Transcriptional repressor CTCFL

Cat.:

E2613h

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Packing:

96T

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ELISA Kit for Mouse Transcriptional repressor CTCFL

Cat.:

E2613m

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Manual:

Looking for manual.

MSDS:

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Packing:

96T

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CLIA Kit for Mouse Transcriptional repressor CTCFL

Cat.:

U2613m

Price:

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MSDS:

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Packing:

96T

CLIA Kit for Mouse Transcriptional repressor CTCFL

Cat.:

U2613h

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MSDS:

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Packing:

96T

Polyclonal Antibody for Mouse Transcriptional repressor CTCFL

Cat.:

P2613Rb-h

Price:

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Packing:

40ug/0.2ml

Polyclonal Antibody for Mouse Transcriptional repressor CTCFL

Cat.:

P2613Rb-m

Price:

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Packing:

40ug/0.2ml

Monoclonal Antibody for Mouse Transcriptional repressor CTCFL

Protein for Mouse Transcriptional repressor CTCFL

R&D Technical Data

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Precision

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Recovery

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Linearity

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References

1.

"BORIS, a novel male germ-line-specific protein associated with epigenetic reprogramming events, shares the same 11-zinc-finger domain with CTCF, the insulator protein involved in reading imprinting marks in the soma."
Loukinov D.I. , Pugacheva E. , Vatolin S. , Pack S.D. , Moon H. , Chernukhin I. , Mannan P. , Larsson E. , Kanduri C. , Vostrov A.A. , Cui H. , Niemitz E.L. , Rasko J.E.J. , Docquier F.M. , Kistler M. , Breen J.J. , Zhuang Z. , Quitschke W.W. , more...
Proc. Natl. Acad. Sci. U.S.A.99:6806-6811(2002) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1)
tissue: Testis.
2.

"Lineage-specific biology revealed by a finished genome assembly of the mouse."
Church D.M. , Goodstadt L. , Hillier L.W. , Zody M.C. , Goldstein S. , She X. , Bult C.J. , Agarwala R. , Cherry J.L. , DiCuccio M. , Hlavina W. , Kapustin Y. , Meric P. , Maglott D. , Birtle Z. , Marques A.C. , Graves T. , Zhou S. , more...
PLoS Biol.7:E1000112-E1000112(2009) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
strain: C57BL/6J.
3.

"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res.14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2)
tissue: Brain.
4.

"The testis-specific factor CTCFL cooperates with the protein methyltransferase PRMT7 in H19 imprinting control region methylation."
Jelinic P. , Stehle J.-C. , Shaw P.
PLoS Biol.4:E355-E355(2006) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;SUBCELLULAR LOCATION;TISSUE SPECIFICITY;DEVELOPMENTAL STAGE;DNA-BINDING;INTERACTION WITH HISTONE AND PRMT7

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