Gene name:
Cyr61 (Ccn1;Igfbp10) ;
Protein name:
Protein CYR61 ;
Alternative:
CCN family member 1 ;3CH61 ;Insulin-like growth factor-binding protein 10 (IBP-10;IGF-binding protein 10;IGFBP-10) ;Cysteine-rich angiogenic inducer 61 ;
Organism:
Mouse (Mus musculus).
General Annotation
Sub Unit:
Interaction with integrins is heparin- and cell-type-dependent and promotes cell adhesion.
Function:
Promotes cell proliferation, chemotaxis, angiogenesis and cell adhesion. Appears to play a role in wound healing by up-regulating, in skin fibroblasts, the expression of a number of genes involved in angiogenesis, inflammation and matrix remodeling including VEGA-A, VEGA-C, MMP1, MMP3, TIMP1, uPA, PAI-1 and integrins alpha-3 and alpha-5 (By similarity). CYR61-mediated gene regulation is dependent on heparin-binding (By similarity). Down-regulates the expression of alpha-1 and alpha-2 subunits of collagen type-1 (By similarity). Promotes cell adhesion and adhesive signaling through integrin alpha-6/beta-1, cell migration through integrin alpha-1/beta-5 and cell proliferation through integrin alpha-v/beta-3.
Subcellular Location:
Secreted
Protein Attributes:
50:
MSSSTFRTLA | VAVTLLHLTR | LALSTCPAAC | HCPLEAPKCA | PGVGLVRDGC |
100:
GCCKVCAKQL | NEDCSKTQPC | DHTKGLECNF | GASSTALKGI | CRAQSEGRPC |
150:
EYNSRIYQNG | ESFQPNCKHQ | CTCIDGAVGC | IPLCPQELSL | PNLGCPNPRL |
200:
VKVSGQCCEE | WVCDEDSIKD | SLDDQDDLLG | LDASEVELTR | NNELIAIGKG |
250:
SSLKRLPVFG | TEPRVLFNPL | HAHGQKCIVQ | TTSWSQCSKS | CGTGISTRVT |
300:
NDNPECRLVK | ETRICEVRPC | GQPVYSSLKK | GKKCSKTKKS | PEPVRFTYAG |
350:
CSSVKKYRPK | YCGSCVDGRC | CTPLQTRTVK | MRFRCEDGEM | FSKNVMMIQS |
379:
CKCNYNCPHP | NEASFRLYSL | FNDIHKFRD
Vaild Sequence:
Related Databases
Uniprot:
ELISA Kit
CLIA Kit
Polyclonal Antibody
Monoclonal Antibody
Protein
FOR
Rat
Mouse
Human
Chicken
ELISA Kit for Mouse Protein CYR61
ELISA Kit for Mouse Protein CYR61
ELISA Kit for Mouse Protein CYR61
ELISA Kit for Mouse Protein CYR61
CLIA Kit for Mouse Protein CYR61
CLIA Kit for Mouse Protein CYR61
CLIA Kit for Mouse Protein CYR61
CLIA Kit for Mouse Protein CYR61
Polyclonal Antibody for Mouse Protein CYR61
Polyclonal Antibody for Mouse Protein CYR61
Polyclonal Antibody for Mouse Protein CYR61
Polyclonal Antibody for Mouse Protein CYR61
Monoclonal Antibody for Mouse Protein CYR61
Monoclonal Antibody for Mouse Protein CYR61
Monoclonal Antibody for Mouse Protein CYR61
Monoclonal Antibody for Mouse Protein CYR61
Protein for Mouse Protein CYR61
Protein for Mouse Protein CYR61
Protein for Mouse Protein CYR61
Protein for Mouse Protein CYR61
R&D Technical Data
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Precision
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Recovery
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Linearity
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References
1.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [MRNA]
strain :
BALB/c .
tissue :
Fibroblast .
2.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [GENOMIC DNA]
strain :
A/J .
tissue :
Embryonic fibroblast .
3.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]
strain :
C57BL/6 .
tissue :
Brain .
4.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : HEPARIN-BINDING DOMAIN