Dnmt1 Polyclonal Antibody for Rat(Rattus norvegicus) | EIAab.comDnmt1 Polyclonal Antibody for Rat(Rattus norvegicus)

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Index > Protein center > Dnmt1(Gene name) > Rat

Dnmt1 (Gene name),

DNA (cytosine-5)-methyltransferase 1 (Protein name ), DNMT1_RAT from NCBI database.

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General Annotation

Antigen Annotation

Predicted Eptitope

Vaild Sequence

Related Databases

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Gene name:

Dnmt1;

Protein name:

DNA (cytosine-5)-methyltransferase 1(Dnmt1);

Alternative:

DNA methyltransferase I;DNA MTase RnoIP(M.RnoIP);MCMT;

Organism:

Rat (Rattus norvegicus).

General Annotation

Sub Unit:

Homodimer. Interacts with HDAC1 and with PCNA. Forms a complex with DMAP1 and HDAC2, with direct interaction. Forms also a stable complex with E2F1, BB1 and HDAC1. Binds MBD2 and MBD3. Component of complexes containing SUV39H1. Interacts with DNMT3A and DNMT3B (By similarity). Binds annexin V (Potential). Interacts with the PRC2/EED-EZH2 complex. Interacts with UBC9 and BAZ2A/TIP5.

Function:

Methylates CpG residues. Preferentially methylates hemimethylated DNA. Associates with DNA replication sites in S phase maintaining the methylation pattern in the newly synthesized strand, that is essential for epigenetic inheritance. Associates with chromatin during G2 and M phases to maintain DNA methylation independently of replication. It is responsible for maintaining methylation patterns established in development. DNA methylation is coordinated with methylation of histones. Mediates transcriptional repression by direct binding to HDAC2. In association with DNMT3B and via the recruitment of CTCFL/BORIS, involved in activation of BAG1 gene expression by modulating dimethylation of promoter histone H3 at H3K4 and H3K9.

Subcellular Location:

Nucleus

Protein Attributes:

Sequence length:

1622

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1622:

LASAQESASA | AVKGKEETTT | ED

3D Structure:

N/A

Predicted Eptitope:

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Vaild Sequence:

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Related Databases

Pfam:

PF01426

STRING:

10116.ENSRNOP00000063029

UniGene:

Rn.6955

String:

Q9Z330

Uniprot:

Q9Z330

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ELISA Kit for Rat Dnmt1

Cat.:

E2102h

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Manual:

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Packing:

96T

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ELISA Kit for Rat Dnmt1

Cat.:

E2102c

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96T

ELISA Kit for Rat Dnmt1

Cat.:

E2102m

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96T

ELISA Kit for Rat Dnmt1

Cat.:

E2102b

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96T

ELISA Kit for Rat Dnmt1

Cat.:

E2102r

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Packing:

96T

CLIA Kit for Rat Dnmt1

Cat.:

U2102m

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Packing:

96T

CLIA Kit for Rat Dnmt1

Cat.:

U2102h

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Manual:

Looking for manual.

MSDS:

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Packing:

96T

Range:

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CLIA Kit for Rat Dnmt1

Cat.:

U2102c

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96T

CLIA Kit for Rat Dnmt1

Cat.:

U2102r

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96T

CLIA Kit for Rat Dnmt1

Cat.:

U2102b

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Packing:

96T

Polyclonal Antibody for Rat Dnmt1

Cat.:

P2102Rb-h

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Packing:

40ug/0.2ml

Polyclonal Antibody for Rat Dnmt1

Cat.:

P2102Rb-r

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Packing:

40ug/0.2ml

Polyclonal Antibody for Rat Dnmt1

Cat.:

P2102Rb-m

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Packing:

40ug/0.2ml

Polyclonal Antibody for Rat Dnmt1

Monoclonal Antibody for Rat Dnmt1

Protein for Rat Dnmt1

R&D Technical Data

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Precision

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Recovery

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Linearity

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

References

1.

"Expression of rat DNA (cytosine-5) methyltransferase (DNA MTase) in rodent trophoblast giant cells: molecular cloning and characterization of rat DNA MTase."
Kimura H. , Takeda T. , Tanaka S. , Ogawa T. , Shiota K.
Biochem. Biophys. Res. Commun.253:495-501(1998) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1)
strain: Sprague-Dawley.
tissue: Brain.
tissue: Placenta.
2.

"Multiple N-terminal isoforms of DNA (cytosine-5-)-methyltransferase in vivo."
Deng J. , Szyf M.
Submitted (1998-12) to the EMBL/GenBank/DDBJ databases

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE OF 1-144 (ISOFORMS 1 AND 9)
tissue: Brain.
3.

"Molecular cloning and characterization of annexin V-binding proteins with highly hydrophilic peptide structure."
Ohsawa K. , Imai Y. , Ito D. , Kohsaka S.
J. Neurochem.67:89-97(1996) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 17-356;IN VITRO BINDING TO ANNEXIN V
strain: Wistar.
tissue: Brain.
4.

"Multiple isoforms of DNA methyltransferase are encoded by the vertebrate cytosine DNA methyltransferase gene."
Deng J. , Szyf M.
J. Biol. Chem.273:22869-22872(1998) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1169-1517 (ISOFORMS 1; 2; 3; 4; 5; 6; 7 AND 8)

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