Esr1(Esr;Estr;Nr3a1);

Estrogen receptor(ER);

Estradiol receptor;ER-alpha;Nuclear receptor subfamily 3 group A member 1;

Rat (Rattus norvegicus). 

Binds DNA as a homodimer (By similarity). Can form a heterodimer with ESR2 (By similarity). Interacts with the NCOA3, NCOA5 and NCOA6 coactivators. Interacts with NCOA7; the interaction is ligand-inducible. Interacts with AKAP13, CUEDC2, HEXIM1, KDM5A, PELP1, PHB2, SLC30A9 and SMARD1. Interacts with MUC1; the interaction is stimulated by 7 beta-estradiol (E2) and enhances ERS1-mediated transcription. Interacts with DNTTIP2, FAM120B and UIMC1. Interacts with MLL2. Interacts with ATAD2; the interaction is enhanced by estradiol. Interacts with KIF18A and LDB1. Interacts with RLIM (via its C-terminus). Interacts with MACROD1. Interacts with FOXL2. Interacts with SH2D4A and PLCG. Interacts with SH2D4A; the interaction blocks binding to PLCG and inhibits estrogen-induced cell proliferation. Interacts with DYNLL1. Interacts with CCDC62; the interaction requires estradiol and appears to enhance the transcription of target genes. Interacts with NR2C1; the interaction prevents homodimerization of ESR1 and suppresses its transcriptional activity and cell growth. Interacts with PRMT2. Interacts with PIK3R1 or PIK3R2, SRC and PTK2. Interacts with RBFOX2. Interacts with EP300; the interaction is estrogen-dependent and enhanced by CITED1. Interacts with CITED1; the interaction is estrogen-dependent (By similarity). Interacts with DYX1C1, MAP1S and UBE1C. Interacts with STK3/MST2 only in the presence of SAV1 and vice-versa.

Nuclear hormone receptor. The steroid hormones and their receptors are involved in the regulation of eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues. Can activate the transcriptional activity of TFF1.

Nucleus Cytoplasm

600

N/A

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Rn.10595

P06211

PF00104

PF12743

P06211

rno:24890

10116.ENSRNOP00000026350