FFAR2 Polyclonal Antibody for Human(Homo sapiens) | EIAab.comFFAR2 Polyclonal Antibody for Human(Homo sapiens)

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Index > Protein center > FFAR2(Gene name) > Human

FFAR2 (Gene name),

Free fatty acid receptor 2 (Protein name ), FFAR2_HUMAN from NCBI database.

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General Annotation

Antigen Annotation

Predicted Eptitope

Vaild Sequence

Related Databases

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Gene name:

FFAR2(GPR43);

Protein name:

Free fatty acid receptor 2;

Alternative:

G-protein coupled receptor 43;

Organism:

Human (Homo sapiens).

General Annotation

Sub Unit:

N/A

Function:

Receptor for short chain fatty acids through a G(i)-protein-mediated inhibition of adenylyl cyclase and elevation of intracellular calcium. The rank order of potency for agonists of this receptor is acetate= propionate = butyrate > pentanoate = formate.

Subcellular Location:

Cell membrane Multi-pass membrane protein

Protein Attributes:

Sequence length:

330

Sequence:

50:

100:

150:

200:

250:

300:

330:

RRGKDTAEGT | NEDRGVGQGE | GMPSSDFTTE |

3D Structure:

N/A

Predicted Eptitope:

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Vaild Sequence:

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Related Databases

UniGene:

Hs.248056

KEGG:

hsa:2867

String:

O15552

Pfam:

PF00001

SMR:

O15552

MIM:

603823

STRING:

9606.ENSP00000246549

Uniprot:

O15552

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ELISA Kit for Human Free fatty acid receptor 2

Cat.:

E9915r

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96T

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ELISA Kit for Human Free fatty acid receptor 2

Cat.:

E9915h

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Packing:

96T

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ELISA Kit for Human Free fatty acid receptor 2

Cat.:

E9915m

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Packing:

96T

CLIA Kit for Human Free fatty acid receptor 2

Cat.:

U9915h

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Packing:

96T

CLIA Kit for Human Free fatty acid receptor 2

Cat.:

U9915r

Price:

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MSDS:

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Packing:

96T

CLIA Kit for Human Free fatty acid receptor 2

Cat.:

U9915m

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MSDS:

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Packing:

96T

Polyclonal Antibody for Human Free fatty acid receptor 2

Cat.:

P9915Rb-h

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Packing:

40ug/0.2ml

Polyclonal Antibody for Human Free fatty acid receptor 2

Cat.:

P9915Rb-r

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Packing:

40ug/0.2ml

Polyclonal Antibody for Human Free fatty acid receptor 2

Cat.:

P9915Rb-m

Price:

Please sign in first.

Packing:

40ug/0.2ml

Monoclonal Antibody for Human Free fatty acid receptor 2

Protein for Human Free fatty acid receptor 2

R&D Technical Data

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Precision

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Recovery

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Linearity

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

References

1.

"A cluster of four novel human G protein-coupled receptor genes occurring in close proximity to CD22 gene on chromosome 19q13.1."
Sawzdargo M. , George S.R. , Nguyen T. , Xu S. , Kolakowski L.F. Jr. , O'Dowd B.F.
Biochem. Biophys. Res. Commun.239:543-547(1997) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]
2.

"The DNA sequence and biology of human chromosome 19."
Grimwood J. , Gordon L.A. , Olsen A.S. , Terry A. , Schmutz J. , Lamerdin J.E. , Hellsten U. , Goodstein D. , Couronne O. , Tran-Gyamfi M. , Aerts A. , Altherr M. , Ashworth L. , Bajorek E. , Black S. , Branscomb E. , Caenepeel S. , Carrano A.V. , more...
Nature428:529-535(2004) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
3.

Kaighin V.A. , Martin A.L. , Aronstam R.S.
Submitted (2007-12) to the EMBL/GenBank/DDBJ databases

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]
4.

"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res.14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]
5.

"Identification of a free fatty acid receptor, FFA2R, expressed on leukocytes and activated by short-chain fatty acids."
Nilsson N.E. , Kotarsky K. , Owman C. , Olde B.
Biochem. Biophys. Res. Commun.303:1047-1052(2003) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;TISSUE SPECIFICITY
6.

"The orphan G protein-coupled receptors GPR41 and GPR43 are activated by propionate and other short chain carboxylic acids."
Brown A.J. , Goldsworthy S.M. , Barnes A.A. , Eilert M.M. , Tcheang L. , Daniels D. , Muir A.I. , Wigglesworth M.J. , Kinghorn I. , Fraser N.J. , Pike N.B. , Strum J.C. , Steplewski K.M. , Murdock P.R. , Holder J.C. , Marshall F.H. , Szekeres P.G. , Wilson S. , more...
J. Biol. Chem.278:11312-11319(2003) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;TISSUE SPECIFICITY
7.

"Functional characterization of human receptors for short chain fatty acids and their role in polymorphonuclear cell activation."
Le Poul E. , Loison C. , Struyf S. , Springael J.Y. , Lannoy V. , Decobecq M.E. , Brezillon S. , Dupriez V. , Vassart G. , Van Damme J. , Parmentier M. , Detheux M.
J. Biol. Chem.278:25481-25489(2003) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION
8.

"Conserved polar residues in transmembrane domains V, VI, and VII of free fatty acid receptor 2 and free fatty acid receptor 3 are required for the binding and function of short chain fatty acids."
Stoddart L.A. , Smith N.J. , Jenkins L. , Brown A.J. , Milligan G.
J. Biol. Chem.283:32913-32924(2008) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;SUBCELLULAR LOCATION;MUTAGENESIS OF HIS-140; ARG-180; HIS-242 AND ARG-255
9.

"Allosteric rescuing of loss-of-function FFAR2 mutations."
Swaminath G. , Jaeckel P. , Guo Q. , Cardozo M. , Weiszmann J. , Lindberg R. , Wang Y. , Schwandner R. , Li Y.
FEBS Lett.584:4208-4214(2010) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: MUTAGENESIS OF GLU-106; TYR-108; ARG-180 AND ARG-255
10.

"Secreted M-ficolin anchors onto monocyte transmembrane G protein-coupled receptor 43 and cross talks with plasma C-reactive protein to mediate immune signaling and regulate host defense."
Zhang J. , Yang L. , Ang Z. , Yoong S.L. , Tran T.T. , Anand G.S. , Tan N.S. , Ho B. , Ding J.L.
J. Immunol.185:6899-6910(2010) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;INTERACTION WITH FCN1
11.

"Mutational analysis of G-protein coupled receptor--FFA2."
Swaminath G. , Jaeckel P. , Guo Q. , Cardozo M. , Weiszmann J. , Lindberg R. , Wang Y. , Schwandner R. , Li Y.
Biochem. Biophys. Res. Commun.405:122-127(2011) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: MUTAGENESIS OF TYR-90; ASN-239 AND HIS-242
12.

"Extracellular ionic locks determine variation in constitutive activity and ligand potency between species orthologs of the free fatty acid receptors FFA2 and FFA3."
Hudson B.D. , Tikhonova I.G. , Pandey S.K. , Ulven T. , Milligan G.
J. Biol. Chem.287:41195-41209(2012) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: MUTAGENESIS OF GLY-159
13.

"Defining the molecular basis for the first potent and selective orthosteric agonists of the FFA2 free fatty acid receptor."
Hudson B.D. , Due-Hansen M.E. , Christiansen E. , Hansen A.M. , Mackenzie A.E. , Murdoch H. , Pandey S.K. , Ward R.J. , Marquez R. , Tikhonova I.G. , Ulven T. , Milligan G.
J. Biol. Chem.288:17296-17312(2013) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;MUTAGENESIS OF TYR-90; HIS-140; GLN-148; TYR-165; ARG-180; TYR-238; HIS-242 AND ARG-255

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