Ffar4 Polyclonal Antibody for Mouse(Mus musculus) | EIAab.comFfar4 Polyclonal Antibody for Mouse(Mus musculus)

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Ffar4 (Gene name),

Free fatty acid receptor 4 (Protein name ), FFAR4_MOUSE from NCBI database.

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General Annotation

Antigen Annotation

Predicted Eptitope

Vaild Sequence

Related Databases

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Gene name:

Ffar4(Gpr120;O3far1);

Protein name:

Free fatty acid receptor 4;

Alternative:

G-protein coupled receptor GT01;G-protein coupled receptor 120;Omega-3 fatty acid receptor 1;

Organism:

Mouse (Mus musculus).

General Annotation

Sub Unit:

Interacts with ARRB2 following docosahexaenoic acid (DHA) stimulation.

Function:

Receptor for medium and long-chain free fatty acids (FFAs). Signals via a G(q)/G(11)-coupled pathway. Acts as a receptor for omega-3 fatty acids and mediates robust anti-inflammatory effects, particularly in macrophages and fat cells. The anti-inflammatory effects involve inhibition of TAK1 through a beta-arrestin 2 (ARRB2)/TAB1-dependent effect, but independent of the G(q)/G(11)-coupled pathway. Mediates potent insulin sensitizing and antidiabetic effects by repressing macrophage-induced tissue inflammation. Mediates the taste of fatty acids. Mediates FFA-induced inhibition of apoptosis in enteroendocrine cells. May play a role in the regulation of adipocyte development and differentiation.

Subcellular Location:

Cell membrane Multi-pass membrane protein Colocalized with ARRB2 following DHA treatment.

Protein Attributes:

Sequence length:

361

Sequence:

50:

100:

150:

200:

250:

300:

350:

361:

VRRNDLSVIS | S

3D Structure:

N/A

Predicted Eptitope:

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Vaild Sequence:

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Related Databases

UniGene:

Mm.35288

SMR:

Q7TMA4

Pfam:

PF00001

KEGG:

mmu:107221

Uniprot:

Q7TMA4

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ELISA Kit for Mouse Free fatty acid receptor 4

Cat.:

E15282r

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96T

ELISA Kit for Mouse Free fatty acid receptor 4

Cat.:

E15282h

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96T

ELISA Kit for Mouse Free fatty acid receptor 4

Cat.:

E15282m

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96T

CLIA Kit for Mouse Free fatty acid receptor 4

Cat.:

U15282m

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MSDS:

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96T

CLIA Kit for Mouse Free fatty acid receptor 4

Cat.:

U15282h

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MSDS:

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Packing:

96T

CLIA Kit for Mouse Free fatty acid receptor 4

Cat.:

U15282r

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MSDS:

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Packing:

96T

Polyclonal Antibody for Mouse Free fatty acid receptor 4

Cat.:

P15282Rb-h

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40ug/0.2ml

Polyclonal Antibody for Mouse Free fatty acid receptor 4

Cat.:

P15282Rb-m

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Packing:

40ug/0.2ml

Polyclonal Antibody for Mouse Free fatty acid receptor 4

Cat.:

P15282Rb-r

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Packing:

40ug/0.2ml

Monoclonal Antibody for Mouse Free fatty acid receptor 4

Protein for Mouse Free fatty acid receptor 4

R&D Technical Data

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Precision

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Recovery

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Linearity

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References

1.

"Seven evolutionarily conserved human rhodopsin G protein-coupled receptors lacking close relatives."
Fredriksson R. , Hoeglund P.J. , Gloriam D.E.I. , Lagerstroem M.C. , Schioeth H.B.
FEBS Lett.554:381-388(2003) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA]
2.

"Free fatty acids regulate gut incretin glucagon-like peptide-1 secretion through GPR120."
Hirasawa A. , Tsumaya K. , Awaji T. , Katsuma S. , Adachi T. , Yamada M. , Sugimoto Y. , Miyazaki S. , Tsujimoto G.
Nat. Med.11:90-94(2005) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA];TISSUE SPECIFICITY;FUNCTION
3.

"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res.14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]
strain: FVB/N.
tissue: Colon.
4.

"Free fatty acids inhibit serum deprivation-induced apoptosis through GPR120 in a murine enteroendocrine cell line STC-1."
Katsuma S. , Hatae N. , Yano T. , Ruike Y. , Kimura M. , Hirasawa A. , Tsujimoto G.
J. Biol. Chem.280:19507-19515(2005) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION
5.

"The regulation of adipogenesis through GPR120."
Gotoh C. , Hong Y.H. , Iga T. , Hishikawa D. , Suzuki Y. , Song S.H. , Choi K.C. , Adachi T. , Hirasawa A. , Tsujimoto G. , Sasaki S. , Roh S.G.
Biochem. Biophys. Res. Commun.354:591-597(2007) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;TISSUE SPECIFICITY;DEVELOPMENTAL STAGE;INDUCTION
6.

"Colocalization of GPR120 with phospholipase-Cbeta2 and alpha-gustducin in the taste bud cells in mice."
Matsumura S. , Eguchi A. , Mizushige T. , Kitabayashi N. , Tsuzuki S. , Inoue K. , Fushiki T.
Neurosci. Lett.450:186-190(2009) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: TISSUE SPECIFICITY
7.

"GPR120 is an omega-3 fatty acid receptor mediating potent anti-inflammatory and insulin-sensitizing effects."
Oh da Y. , Talukdar S. , Bae E.J. , Imamura T. , Morinaga H. , Fan W. , Li P. , Lu W.J. , Watkins S.M. , Olefsky J.M.
Cell142:687-698(2010) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;TISSUE SPECIFICITY;SUBCELLULAR LOCATION;DISRUPTION PHENOTYPE;INDUCTION
8.

"Taste preference for fatty acids is mediated by GPR40 and GPR120."
Cartoni C. , Yasumatsu K. , Ohkuri T. , Shigemura N. , Yoshida R. , Godinot N. , le Coutre J. , Ninomiya Y. , Damak S.
J. Neurosci.30:8376-8382(2010) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: TISSUE SPECIFICITY;FUNCTION;DISRUPTION PHENOTYPE
9.

"Dysfunction of lipid sensor GPR120 leads to obesity in both mouse and human."
Ichimura A. , Hirasawa A. , Poulain-Godefroy O. , Bonnefond A. , Hara T. , Yengo L. , Kimura I. , Leloire A. , Liu N. , Iida K. , Choquet H. , Besnard P. , Lecoeur C. , Vivequin S. , Ayukawa K. , Takeuchi M. , Ozawa K. , Tauber M. , more...
Nature483:350-354(2012) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: DISRUPTION PHENOTYPE

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