Igf1r Polyclonal Antibody for Rat(Rattus norvegicus) | EIAab.comIgf1r Polyclonal Antibody for Rat(Rattus norvegicus)

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Igf1r (Gene name),

Insulin-like growth factor 1 receptor (Protein name ), IGF1R_RAT from NCBI database.

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General Annotation

Antigen Annotation

Predicted Eptitope

Vaild Sequence

Related Databases

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Gene name:

Igf1r;

Protein name:

Insulin-like growth factor 1 receptor;

Alternative:

Insulin-like growth factor I receptor(IGF-I receptor);

CD:

CD221;

Organism:

Rat (Rattus norvegicus).

General Annotation

Sub Unit:

Tetramer of 2 alpha and 2 beta chains linked by disulfide bonds. The alpha chains contribute to the formation of the ligand-binding domain, while the beta chain carries the kinase domain. Interacts with PIK3R1 and with the PTB/PID domains of IRS1 and SHC1 in vitro when autophosphorylated on tyrosine residues. Forms a hybrid receptor with INSR, the hybrid is a tetramer consisting of 1 alpha chain and 1 beta chain of INSR and 1 alpha chain and 1 beta chain of IGF1R. Interacts with ARRB1 and ARRB2. Interacts with GRB10. Interacts with GNB2L1/RACK1.

Function:

This receptor binds insulin-like growth factor 1 (IGF1) with a high affinity and IGF2 with a lower affinity. It has a tyrosine-protein kinase activity, which is necessary for the activation of the IGF1-stimulated downstream signaling cascade (By similarity). When present in a hybrid receptor with INSR, binds IGF1.

Subcellular Location:

Membrane Single-pass type I membrane protein

Protein Attributes:

Sequence length:

1370

Sequence:

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1350:

1370:

HMNGGRANER | ALPLPQSSTC |

3D Structure:

N/A

Predicted Eptitope:

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Vaild Sequence:

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Related Databases

STRING:

10116.ENSRNOP00000019267

SMR:

P24062

String:

P24062

KEGG:

rno:25718

Pfam:

PF00041

UniGene:

Rn.10957

Uniprot:

P24062

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ELISA Kit for Rat Insulin-like growth factor 1 receptor

Cat.:

E1200h

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96T

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ELISA Kit for Rat Insulin-like growth factor 1 receptor

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E1200p

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96T

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ELISA Kit for Rat Insulin-like growth factor 1 receptor

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E1200b

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96T

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ELISA Kit for Rat Insulin-like growth factor 1 receptor

Cat.:

E1200r

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96T

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ELISA Kit for Rat Insulin-like growth factor 1 receptor

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E1200m

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96T

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CLIA Kit for Rat Insulin-like growth factor 1 receptor

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CLIA Kit for Rat Insulin-like growth factor 1 receptor

Cat.:

U1200p

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Packing:

96T

CLIA Kit for Rat Insulin-like growth factor 1 receptor

Cat.:

U1200m

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96T

CLIA Kit for Rat Insulin-like growth factor 1 receptor

Cat.:

U1200h

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96T

CLIA Kit for Rat Insulin-like growth factor 1 receptor

Cat.:

U1200r

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96T

Polyclonal Antibody for Rat Insulin-like growth factor 1 receptor

Cat.:

P1200Rb-h

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40ug/0.2ml

Polyclonal Antibody for Rat Insulin-like growth factor 1 receptor

Cat.:

P1200Rb-r

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40ug/0.2ml

Polyclonal Antibody for Rat Insulin-like growth factor 1 receptor

Cat.:

P1200Rb-m

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40ug/0.2ml

Polyclonal Antibody for Rat Insulin-like growth factor 1 receptor

Monoclonal Antibody for Rat Insulin-like growth factor 1 receptor

Protein for Rat Insulin-like growth factor 1 receptor

R&D Technical Data

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Precision

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Recovery

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Linearity

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References

1.

"Inhibition of vascular smooth muscle cell growth through antisense transcription of a rat insulin-like growth factor I receptor cDNA."
Du J. , Delafontaine P.
Circ. Res.76:963-972(1995) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA]
tissue: Brain.
2.

"Developmental regulation of the rat insulin-like growth factor I receptor gene."
Werner H. , Woloschak M. , Adamo M. , Shen-Orr Z. , Roberts C.T. Jr. , Leroith D.
Proc. Natl. Acad. Sci. U.S.A.86:7451-7455(1989) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 1-364
strain: Sprague-Dawley.
3.

"A new member of the insulin receptor family, insulin receptor-related receptor, is expressed preferentially in the kidney."
Kurachi H. , Jobo K. , Ohta M. , Kawasaki T. , Itoh N.
Biochem. Biophys. Res. Commun.187:934-939(1992) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 913-1017
4.

"Insulin and IGF-I action on insulin receptors, IGF-I receptors, and hybrid insulin/IGF-I receptors in vascular smooth muscle cells."
Johansson G.S. , Arnqvist H.J.
Am. J. Physiol.291:E1124-E1130(2006) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;FORMATION OF A HYBRID RECEPTOR WITH INSR

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