Protein name:
Insulin receptor substrate 4 (IRS-4) ;
Alternative:
Phosphoprotein of 160 kDa (pp160) ;
Organism:
Mouse (Mus musculus).
General Annotation
Sub Unit:
Interacts with CRK and CRKL. Interaction with CRK is stronger than with CRKL. Interacts with CRK via the phosphorylated YXXM motifs. Interacts with PLC-gamma, SHC1, PTK6, PPP4C and NISCH (By similarity). Interacts with SOCS6 in response to stimulatiom with either insulin or IGF1. Interacts with PIK3R1 and GRB2.
Function:
Acts as an interface between multiple growth factor receptors possessing tyrosine kinase activity, such as insulin receptor, IGF1R and FGFR1, and a complex network of intracellular signaling molecules containing SH2 domains. Involved in the IGF1R mitogenic signaling pathway. Promotes the AKT1 signaling pathway and BAD phosphorylation during insulin stimulation without activation of RPS6KB1 or the inhibition of apoptosis. Interaction with GRB2 enhances insulin-stimulated mitogen-activated protein kinase activity. May be involved in nonreceptor tyrosine kinase signaling in myoblasts. Plays a pivotal role in the proliferation/differentiation of hepatoblastoma cell through EPHB2 activation upon IGF1 stimulation. May play a role in the signal transduction in response to insulin and to a lesser extent in response to IL4 and GH on mitogenesis. Plays a role in growth, reproduction and glucose homeostasis. May acts as negative regulators of the IGFI signaling pathway by suppressing the function of IRS1 and IRS2.
Subcellular Location:
Cell membrane
Peripheral membrane protein
Cytoplasmic side
Protein Attributes:
50:
MASCSFSGHQ | ALRRLRASAA | AAASAALAAV | ATTPLLSSGT | RTALIGTGSS |
100:
CPGAMWLSTA | TGSRSDSESE | EEDLPVGDEV | CKRGYLRKQK | HGHRRYFVLK |
150:
LETADAPARL | EYYRNARKFR | HSVRAAAAAA | EAAASGAAVP | ALIPPRRVII |
200:
LYQCFSVSQR | ADARYRHLIA | LFTQDEYFAM | VAENESEQES | WYLLLSRLIL |
250:
ESKRRRCGTL | GALPDGEPAA | LAAAAAAEPP | FYKDVWQVVV | KPRGLGHRKE |
300:
LSGVFRLCLT | DEEVVFVRLN | TEVASVVVQL | LSIRRCGHSE | QYFFLEVGRS |
350:
TVIGPGELWM | QVDDSVVAQN | MHELFLEKMR | ALCADEYRAR | CRSYSISIGA |
400:
HLLTLLSTRR | HLGLLPLEPG | GWLRRYGLEQ | FCRLRAIRER | EEMLFTRRFI |
450:
SPREPPPPFR | RGRGHLPRAR | RSRRAASVPP | SLFRRSAPSP | GRIPQPEDVP |
500:
NDRAREASGS | SSGNTEEKDK | EGEEGNRGDC | IPMNNWGSGN | GRGSGGGRGS |
550:
SGQGSSSQGS | GGRQGSGGGQ | GSGGQGAGGN | QCSGNGQGTA | GGHGSGGGGH |
600:
GSGGGQRPGD | GHGSGGGKNS | GSGKNSDDGD | RGKSVKKRSY | FGKFTQSKQQ |
650:
QTLPPPPPPP | PAAGATGGKG | KSGGRFRLYF | CADRGTKERK | EAKEVRDMET |
700:
SGGATRGPYR | ARAFDEDEDD | PYVPMRPGVA | APLACSSDYM | PMAPQNSSAS |
750:
TKRHSRSPFE | DSRGYMMMFP | RVSPPPPVPS | APKAPDTNKG | DDSKDNDSDS |
800:
DYMFMAPGAG | AIPKNPPNAQ | GGSSSKSWSS | YFSLPSPFQS | SPLGQSDHSE |
850:
YVPMLPGKFL | GSGLHKEASF | SQGTKNVSSK | PSTEASFSKP | EDKGSSAKPS |
900:
DDVPPMNKAK | EPNHLSFIAK | GTQVKPKPLN | PTQERREAAG | SRDYINIDFI |
950:
KRERLVLPSS | AQGLPDMRGV | VTDPAPTAFS | GYLNVEFGVP | FPNPTIRLSD |
1000:
LLRVLPGANS | IPLAGTRWPF | PGSAIGSIVE | AGEYIEVIFN | PAMTPAMSFA |
1050:
DSAICYDAQT | GQIYVVDPFS | ECCMDVSLSP | GRCSEPPPVA | RLRREEAQER |
1100:
RRPQSRSQSL | FASTRAAVSA | FPTDSLDRDF | PAASAVIAAP | AEAPLLAVSR |
1150:
ALAVVSALAA | APSIGDVFAG | FRAAAGVDSA | SARGFQPVAG | AQAVREFQDL |
1200:
AAGWNPGALN | HRARGEDLAA | GAAAPPPPPR | QIWVLRPQER | ADSEDDDDDD |
1216:
DDIYVRMDFA | RRDYRK
Vaild Sequence:
Related Databases
Uniprot:
ELISA Kit
CLIA Kit
Polyclonal Antibody
Monoclonal Antibody
Protein
FOR
Mouse
Human
ELISA Kit for Mouse IRS-4
ELISA Kit for Mouse IRS-4
Polyclonal Antibody for Mouse IRS-4
Polyclonal Antibody for Mouse IRS-4
Monoclonal Antibody for Mouse IRS-4
Monoclonal Antibody for Mouse IRS-4
R&D Technical Data
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
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For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
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Precision
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For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
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For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
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Recovery
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For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
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Linearity
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For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
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[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
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strain :
C57BL/6J .
tissue :
Embryo .
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[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
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Cited for : FUNCTION;INTERACTION WITH PHOSPHATIDYLINOSITOL 3-KINASE;PHOSPHORYLATION